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1. Mbomson IG, Tabor S, Lahiri B, Sharp G, McMeekin SG, De La Rue RM, Johnson NP: Asymmetric split H-shape nanoantennas for molecular sensing. Biomed Opt Express; 2017 Jan 01;8(1):395-406
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The nanoantennas are arranged as arrays of asymmetric-split H-shape (ASH) structures, tuned to produce plasmonic resonances with reflectance double peaks within the mid-infrared vibrational resonances of C-H bonds for the assay of deposited films of the molecule 17β-estradiol (E2), used as an analyte.
  • Measurements and numerical simulations of the reflectance spectra have enabled an estimated enhancement factor on the order of 10<sup>5</sup> to be obtained for a thin film of E2 on the ASH array.
  • A high sensitivity value of 2335 nm/RIU was achieved, together with a figure of merit of approximately 8.
  • Our experimental results were corroborated using numerical simulations for the C-H stretch vibrational resonances from the analyte, superimposed on the plasmonic resonances of the ASH nanoantennas.

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  • (PMID = 28101426.001).
  • [Journal-full-title] Biomedical optics express
  • [ISO-abbreviation] Biomed Opt Express
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; (130.6010) Sensors / (250.5403) Plasmonics
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2. Stojkovic Lalosevic M, Stankovic S, Stojkovic M, Markovic V, Dimitrijevic I, Lalosevic J, Petrovic J, Brankovic M, Pavlovic Markovic A, Krivokapic Z: Can preoperative CEA and CA19-9 serum concentrations suggest metastatic disease in colorectal cancer patients? Hell J Nucl Med; 2017 Jan-Apr;20(1):41-45
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  • Tumor markers were measured with an electrochemiluminescent assay and the reference value was 5ng/ml for CEA and for Ca19-9, 37u/ml.
  • We noticed a cut-off value for lymph nodes involvement, for CEA and CA 19-9, 3.5 ng/mL and 7.5 U/mL, respectively.
  • While, a cut-off value for the presence of synchronous liver metastases of these two markers was 3.5ng/mL AND 5.5 U/mL.
  • [MeSH-minor] Biomarkers, Tumor / blood. Comorbidity. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Preoperative Care / statistics & numerical data. Prevalence. Reproducibility of Results. Risk Factors. Sensitivity and Specificity. Serbia / epidemiology. Survival Rate

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  • (PMID = 28315907.001).
  • [ISSN] 1790-5427
  • [Journal-full-title] Hellenic journal of nuclear medicine
  • [ISO-abbreviation] Hell J Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CA-19-9 Antigen
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3. Hur H, Yu EJ, Ham IH, Jin HJ, Lee D: Preoperative serum levels of insulin-like growth factor-binding protein 2 predict prognosis of gastric cancer patients. Oncotarget; 2017 Feb 14;8(7):10994-11003
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  • We tested IGFBP2 levels in the sera of 118 gastric cancer patients and 34 healthy controls using enzyme-linked immunosorbent assay (ELISA).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Enzyme-Linked Immunosorbent Assay / statistics & numerical data. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Predictive Value of Tests. Preoperative Period. Prognosis. Proportional Hazards Models. Reference Values

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  • (PMID = 28036255.001).
  • [ISSN] 1949-2553
  • [Journal-full-title] Oncotarget
  • [ISO-abbreviation] Oncotarget
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Insulin-Like Growth Factor Binding Protein 2
  • [Keywords] NOTNLM ; gastric cancer / insulin-like growth factor-binding protein 2 / prognosis / tumor marker
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4. Swinney DC: The value of translational biomarkers to phenotypic assays. Front Pharmacol; 2014;5:171

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of translational biomarkers to phenotypic assays.
  • Phenotypic assays are tools essential for drug discovery.
  • Phenotypic assays have different types of endpoints depending on the goals;.
  • The value of phenotypic assays is increased through effective alignment of phenotypic assay endpoints with the objectives of the relevant stage in the drug discovery and development cycle.

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  • (PMID = 25076910.001).
  • [ISSN] 1663-9812
  • [Journal-full-title] Frontiers in pharmacology
  • [ISO-abbreviation] Front Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC4097030
  • [Keywords] NOTNLM ; MMOA / biomarkers / drug discovery / molecular mechanism of action / phenotypic screening / target-based
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5. Stone R, Coppock JS, Dawes PT, Bacon PA, Scott DL: Clinical value of ELISA assays for IgM and IgG rheumatoid factors. J Clin Pathol; 1987 Jan;40(1):107-11
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  • [Title] Clinical value of ELISA assays for IgM and IgG rheumatoid factors.
  • The clinical value of enzyme linked immunosorbent assays (ELISA) assays for IgM and IgG rheumatoid factors was assessed in a series of studies using rabbit IgG as antigen.
  • The tests were reproducible with intra-assay coefficients of variation of 6% and could be simply and rapidly performed.
  • In a cross sectional study of 208 rheumatoid patients these assays were compared with the Rose-Waaler and laser nephelometric assessments of rheumatoid factor.
  • [MeSH-minor] Arthritis, Rheumatoid / immunology. Enzyme-Linked Immunosorbent Assay. Hemagglutination Tests. Humans. Nephelometry and Turbidimetry

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  • (PMID = 3818968.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Immunoglobulin G; 0 / Immunoglobulin M; 9009-79-4 / Rheumatoid Factor
  • [Other-IDs] NLM/ PMC1140839
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6. McNaughton CD, Brown NJ, Rothman RL, Liu D, Kabagambe EK, Levy PD, Self WH, Storrow AB, Collins SP, Roumie CL: Systolic Blood Pressure and Biochemical Assessment of Adherence: A Cross-Sectional Analysis in the Emergency Department. Hypertension; 2017 Aug;70(2):307-314
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Biochemical assessment of antihypertensive adherence was performed using a mass spectrometry blood assay, and the primary outcome was average ED SBP.
  • [MeSH-minor] Aged. Blood Pressure / drug effects. Blood Pressure Determination / methods. Cross-Sectional Studies. Emergency Medical Services / methods. Emergency Service, Hospital / statistics & numerical data. Female. Health Literacy / methods. Humans. Male. Medication Adherence. Medication Therapy Management / statistics & numerical data. Middle Aged. United States / epidemiology

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  • [Copyright] © 2017 American Heart Association, Inc.
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  • (PMID = 28652467.001).
  • [ISSN] 1524-4563
  • [Journal-full-title] Hypertension (Dallas, Tex. : 1979)
  • [ISO-abbreviation] Hypertension
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / K12 HL109019; United States / NHLBI NIH HHS / HL / K23 HL125670; United States / NCATS NIH HHS / TR / UL1 TR000445
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Biomarkers
  • [Keywords] NOTNLM ; blood pressure / emergency medical services / hypertension / literacy / mass spectrometry / medication adherence
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7. Oyaert M, Boel A, Jacobs J, Van den Bremt S, De Sloovere M, Vanpoucke H, Van Hoovels L: Analytical performance and diagnostic accuracy of six different faecal calprotectin assays in inflammatory bowel disease. Clin Chem Lab Med; 2017 Aug 28;55(10):1564-1573
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analytical performance and diagnostic accuracy of six different faecal calprotectin assays in inflammatory bowel disease.
  • Analytical performance (imprecision, accuracy, carry-over, correlation and agreement) and diagnostic accuracy (sensitivity, specificity, likelihood ratios) of the different assays were evaluated.
  • RESULTS: All methods demonstrated good analytical performance, but within-run and total imprecision varied depending on the assay methodology used.
  • Using Passing Bablok and Bland-Altman analyses, low quantitative agreement was observed between the assays.
  • All assays showed excellent diagnostic accuracy, with areas under the receiver operating characteristic curves (ROC) ranging from 0.974 to 0.998.
  • The AUCs were not significantly different between assays (p>0.05).
  • Introduction of multiple result intervals increased the clinical interpretation of all the assays.
  • CONCLUSIONS: Analytical and diagnostic performance of the evaluated faecal calprotectin assays is good, but numerical values differ substantially between the assays necessitating the use of different clinical cut-offs.

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  • (PMID = 28222018.001).
  • [ISSN] 1437-4331
  • [Journal-full-title] Clinical chemistry and laboratory medicine
  • [ISO-abbreviation] Clin. Chem. Lab. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Leukocyte L1 Antigen Complex; 0 / Reagent Kits, Diagnostic
  • [Keywords] NOTNLM ; faecal calprotectin / immunoassays / inflammatory bowel disease
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8. Perez Jimenez AI, Challier L, Aït-Yahiatène E, Delacotte J, Labbé E, Buriez O: Selective Electrochemical Bleaching of the Outer Leaflet of Fluorescently Labeled Giant Liposomes. Chemistry; 2017 May 17;23(28):6781-6787

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The relative fluorescence intensity decay was quantified all along the electrochemical extinction through an original fluorescence loss in electrobleaching (FLIE) assay.
  • This was also evidenced by comparison with fluorescence loss in photobleaching (FLIP) and the corresponding numerical model.
  • The value of the lateral diffusion coefficient of phospholipids was found to be similar to that obtained by other methods reported in the literature.

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  • [Copyright] © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • (PMID = 28094889.001).
  • [ISSN] 1521-3765
  • [Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)
  • [ISO-abbreviation] Chemistry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; confocal microscopy / diffusion of phospholipids. / electrochemistry / fluorescence / lipid vesicles
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9. Samandari M, Abrinia K, Mokhtari-Dizaji M, Tamayol A: Ultrasound induced strain cytoskeleton rearrangement: An experimental and simulation study. J Biomech; 2017 Jul 26;60:39-47

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • First, a numerical simulation was performed to reveal the effect of oscillating ultrasonic pressure on induced deformation in the cell with respect to different cell geometries and exposure conditions.
  • Furthermore, strain values found to be less in the nucleus comparing the value in the cytoplasm, but still these strains can affect the behavior of the cell through mechanotransduction mechanisms.
  • Results of Live/Dead assay indicated that high pressure and duration of the exposure had negative effects on the viability of C2C12 cells, while the viability ratio still remained above 85%.

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  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 28757237.001).
  • [ISSN] 1873-2380
  • [Journal-full-title] Journal of biomechanics
  • [ISO-abbreviation] J Biomech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Cytoskeleton / Fluidization / Numerical stimulation / Strain / Ultrasound
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10. Jeong TD, Cho EJ, Ko DH, Lee W, Chun S, Kwon HJ, Hong KS, Kim YM, Min WK: A new strategy for calculating the risk of ovarian malignancy algorithm (ROMA). Clin Chem Lab Med; 2017 Jul 26;55(8):1209-1214
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Reliable quantitative measurements of HE4 and CA125 levels are required to calculate the risk of ovarian malignancy algorithm (ROMA) value.
  • We suggest a new reporting strategy for interpreting ROMA values based on analytical measurement range (AMR) and qualified-intervals of the HE4 and CA125 results.
  • METHODS: HE4 and CA125 assays from Abbott and Roche were used.
  • The AMRs and the qualified-intervals were as follows: Architect HE4 assay, 20-1500 and 17.2-2637.8 pmol/L; Architect CA125 II assay, 1-1000 and 3.9-14,163.0 U/mL; Elecsys HE4 assay, 15-1500 and 28.8-3847 pmol/L; Elecsys CA125 II assay, 0.6-5000 and 6.5-5000 U/mL.
  • These values were used to simulate the ROMA values.
  • RESULTS: Reporting algorithm for the ROMA value could be classified into three categories. (1) If quantitative HE4 and CA125 levels are reliable, the numerical ROMA value can be reported. (2) If HE4 value is <20 and <28.8 for Abbott and Roche in premenopausal woman, the ROMA value should be reported as "low risk" regardless of the CA125 result.
  • In postmenopausal woman, however, it should be reported as "low risk" (CA125<203.0 and <165.8 for Abbott and Roche) or "undetermined" (vice-versa value). (3) If CA125 value is <3.9 and <6.5 for Abbott and Roche, it should be reported as "low risk" (premenopausal HE4<51.5 and <62.2, postmenopausal HE4<323.0 and <281.5 for Abbott and Roche) or "undetermined" (vice-versa value).
  • CONCLUSIONS: New reporting strategy will provide more informative reporting of ROMA values in clinical practice.

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  • (PMID = 28107166.001).
  • [ISSN] 1437-4331
  • [Journal-full-title] Clinical chemistry and laboratory medicine
  • [ISO-abbreviation] Clin. Chem. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / MUC16 protein, human; 0 / Membrane Proteins; 0 / Proteins; 0 / WFDC2 protein, human
  • [Keywords] NOTNLM ; CA125 / HE4 / quantitative measurement / risk of ovarian malignancy algorithm
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11. Zhao Y, Lou J, Sun M, Fu Y, Liu Y: [Analysis of the cause of pregnancy failure with combined MLPA assay for subtelomeric regions and ultrasonography]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2017 Feb 10;34(1):81-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of the cause of pregnancy failure with combined MLPA assay for subtelomeric regions and ultrasonography].
  • OBJECTIVE: To explore the value of multiplex ligation-dependent probe amplification (MLPA) for the detection of chromosome abnormalities in miscarriage tissues, and to correlate the result with ultrasound findings.
  • Among the 117 cases with abnormal ultrasound findings, 33 cases (28.21%) had an abnormal MLPA result, 28 out of the 33 cases were numerical chromosome abnormality, 4 cases were chromosome microdeletion and/or micro duplication, 1 case had both numerical abnormality and microduplication.
  • CONCLUSION: Numerical chromosomal abnormalities account for the majority of cases with spontaneous abortion.
  • Combined ultrasound and MLPA assay can improve the detection rate and accuracy for chromosomal abormalities.

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  • (PMID = 28186601.001).
  • [ISSN] 1003-9406
  • [Journal-full-title] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
  • [ISO-abbreviation] Zhonghua Yi Xue Yi Chuan Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 9007-49-2 / DNA
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12. Haimila K, Sulin K, Kuosmanen M, Sareneva I, Korhonen A, Natunen S, Tuimala J, Sainio S: Targeted antenatal anti-D prophylaxis program for RhD-negative pregnant women - outcome of the first two years of a national program in Finland. Acta Obstet Gynecol Scand; 2017 Oct;96(10):1228-1233
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The main outcome measure was the accuracy of the fetal RHD assay; the secondary variable was compliance with the newly introduced RAADP program.
  • The negative predictive value of the test was 99.97% (95% CI 99.81-99.99).
  • [MeSH-minor] Confidence Intervals. Diagnostic Tests, Routine / statistics & numerical data. Female. Finland. Humans. National Health Programs. Odds Ratio. Pregnancy. Pregnancy Complications, Hematologic / blood. Pregnancy Complications, Hematologic / prevention & control. Rh-Hr Blood-Group System / blood

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  • [Copyright] © 2017 Nordic Federation of Societies of Obstetrics and Gynecology.
  • (PMID = 28718198.001).
  • [ISSN] 1600-0412
  • [Journal-full-title] Acta obstetricia et gynecologica Scandinavica
  • [ISO-abbreviation] Acta Obstet Gynecol Scand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Rh-Hr Blood-Group System; 0 / Rho(D) Immune Globulin
  • [Keywords] NOTNLM ; RHD / anti-D prophylaxis / fetal cell-free DNA / hemolytic disease of the fetus and newborn / immunization / non-invasive testing / routine antenatal anti-D prophylaxis
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13. Deveraux S, Allena R, Aubry D: A numerical model suggests the interplay between nuclear plasticity and stiffness during a perfusion assay. J Theor Biol; 2017 Dec 21;435:62-77

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A numerical model suggests the interplay between nuclear plasticity and stiffness during a perfusion assay.
  • We analyze and discuss the role of the lamina for a wild-type cell model, and a lamin-deficient one, in which the Young's modulus of the lamina is set to 1% of its nominal value.

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  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 28919399.001).
  • [ISSN] 1095-8541
  • [Journal-full-title] Journal of theoretical biology
  • [ISO-abbreviation] J. Theor. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Finite element / Nucleus / Plasticity / Viscoelasticity / Viscoplasticity
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14. Sandoval Y, Smith SW, Love SA, Sexter A, Schulz K, Apple FS: Single High-Sensitivity Cardiac Troponin I to Rule Out Acute Myocardial Infarction. Am J Med; 2017 Sep;130(9):1076-1083.e1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: This was a prospective, observational study of consecutive patients presenting to the emergency department (n = 1631) in whom cTnI measurements were obtained using an investigational hs-cTnI assay.
  • The goals of the study were to determine 1) negative predictive value (NPV) and sensitivity for the diagnosis of acute myocardial infarction, type 1 myocardial infarction, and type 2 myocardial infarction; and 2) safety outcome of acute myocardial infarction or cardiac death at 30 days using hs-cTnI less than the limit of detection (LoD) (<1.9 ng/L) or the High-STEACS threshold (<5 ng/L) alone and in combination with normal electrocardiogram (ECG).
  • [MeSH-minor] Acute Disease. Biological Assay / methods. Biomarkers / blood. Electrocardiography. Emergency Service, Hospital / statistics & numerical data. Humans. Predictive Value of Tests. Prospective Studies

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  • [Copyright] Copyright © 2017 Elsevier Inc. All rights reserved.
  • (PMID = 28344141.001).
  • [ISSN] 1555-7162
  • [Journal-full-title] The American journal of medicine
  • [ISO-abbreviation] Am. J. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Troponin I
  • [Keywords] NOTNLM ; Acute myocardial infarction / High-sensitivity cardiac troponin / Troponin
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15. Huang Z, Mayr N, Lo S, Winkler S, Yuh K, Lok C, Liu T, Stephenson S, McLawhorn R, Rasmussen K, Rice J, Yuh W: TU-G-108-01: Prediction in Clinical Response to Radiation Therapy for Head and Neck Cancer. Med Phys; 2013 Jun;40(6Part27):453

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Surviving fraction after 2 Gy (SF2), reflecting intrinsic radiosensitivity, was estimated by a soft-agar clonogenic assay (as published in Int J Radiat Oncol Bio Phys, 2000; 46:13-19).
  • Eight of the 18 patients had a >95% calculated tumor control probability and none developed a local recurrence, yielding a negative predictive value of 100%, compared with 67% for population-derived data.

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  • [Copyright] © 2013 American Association of Physicists in Medicine.
  • (PMID = 28518787.001).
  • [ISSN] 2473-4209
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Biomedical modeling / Biophysical techniques / Brachytherapy / Cancer / Cell growth / Computed tomography / Magnetic resonance imaging / Numerical modeling / Radiation monitoring / Radiation therapy
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16. Massart C, Gibassier J, d'Herbomez M: Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. Clin Chim Acta; 2009 Sep;407(1-2):62-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay.
  • BACKGROUND: We compared the clinical performances of two new M22-based assays for TSH-receptor antibody (TRAb) with those of the human TRAb assay (hTRAK) in Graves' disease patients at the end of treatment.
  • RESULTS: At T18, the results were significantly higher by the Cobas assay (median: 2.7 IU/L, range: 1.1-18.5 IU/L) or lower by ELISA (median: 0.56 IU/L, range: 0.22-14.8 IU/L) than those obtained for the hTRAK (median: 1.5 IU/L, range: 0.9-9.8 IU/L).
  • CONCLUSIONS: The M22-based TRAb assays did not improve the predictive value of relapse obtained with the hTRAK measured at the end of treatment.
  • High inter-method variability requires assay harmonization for correct interpretation of results.
  • [MeSH-major] Antithyroid Agents / therapeutic use. Enzyme-Linked Immunosorbent Assay / methods. Graves Disease / drug therapy. Immunoglobulins, Thyroid-Stimulating / analysis

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  • (PMID = 19576193.001).
  • [ISSN] 1873-3492
  • [Journal-full-title] Clinica chimica acta; international journal of clinical chemistry
  • [ISO-abbreviation] Clin. Chim. Acta
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antithyroid Agents; 0 / Immunoglobulins, Thyroid-Stimulating; 0 / thyrotropin-binding inhibitory immunoglobulin
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17. Zwicky C, Theiler L, Zbären K, Ischi E, Tobler A: The predictive value of clonogenic stem cell assays for the diagnosis of polycythaemia vera. Br J Haematol; 2002 Jun;117(3):598-604

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The predictive value of clonogenic stem cell assays for the diagnosis of polycythaemia vera.
  • In vitro clonogenic assays can be used to support the diagnosis of PV.
  • However, clonogenic assays are difficult to standardize, and their diagnostic value is accepted as a minor criteria for PV only in the case of positive results.
  • Clonogenic assays need to be validated and normal ranges established carefully before they can be used for diagnostic purposes.
  • In a retrospective study, we analysed the results of 146 consecutive clonogenic assays performed in patients with erythrocytosis between January 1992 and December 2000.
  • The clonogenic assay results were correlated with the final clinical diagnosis of the patients.
  • At a cut-off value of 5 erythroid colony-forming unit colonies per well, 29 out of 38 patients with PV showed positive results, and 9 out of 38 patients showed false-negative results.
  • Thus the positive predictive value of the clonogenic assay for the diagnosis of PV was 97%.
  • We conclude that clonogenic assays, in the case of positive results, and if carefully validated, are very useful and reliable tools for the diagnosis of PV.
  • [MeSH-major] Colony-Forming Units Assay / methods. Erythroid Precursor Cells / pathology. Polycythemia Vera / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Myeloid Progenitor Cells / pathology. Predictive Value of Tests. Reference Values. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 12028027.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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18. Laborda E, de la Peña E, Valcarce E, Canga C, Sladek F, Barrueco C: [Predictive value of short-term assays of chemical carcinogenesis]. Rev Esp Oncol; 1982;29(3):547-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Predictive value of short-term assays of chemical carcinogenesis].
  • The authors make a summary about the predictive value of the existing assays, and write about the need of the systematic use of a convenient battery of tests to detect carcinogenicity in every product to which the human being may be exposed.

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  • (PMID = 6765349.001).
  • [ISSN] 0482-640X
  • [Journal-full-title] Revista española de oncología
  • [ISO-abbreviation] Rev Esp Oncol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] SPAIN
  • [Chemical-registry-number] 0 / Carcinogens, Environmental; 0 / Mutagens
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19. Renshaw AA, Stelling JM, Doolittle MH: The lack of value of repeated Clostridium difficile cytotoxicity assays. Arch Pathol Lab Med; 1996 Jan;120(1):49-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The lack of value of repeated Clostridium difficile cytotoxicity assays.
  • OBJECTIVE: To determine the value of repeated Clostridium difficile cytotoxicity assays (CA).
  • Assays were grouped into episodes, which were defined as one or more successive tests performed on a single patient within 7 days or less of each other.
  • Of the 947 episodes with two or more CAs, the repeated assays provided new information that was used in patient care in fewer than nine cases.
  • Repeated testing within 7 days of an initial CA accounted for 36% of all assays performed, but provided clinically useful information in only about 1% of cases.

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  • (PMID = 8554444.001).
  • [ISSN] 0003-9985
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Bacterial Toxins; 0 / Enterotoxins; 0 / tcdA protein, Clostridium difficile
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20. Oehninger S, Franken DR, Sayed E, Barroso G, Kolm P: Sperm function assays and their predictive value for fertilization outcome in IVF therapy: a meta-analysis. Hum Reprod Update; 2000 Mar-Apr;6(2):160-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sperm function assays and their predictive value for fertilization outcome in IVF therapy: a meta-analysis.
  • An objective, outcome-based examination of the validity of the currently available assays was performed based upon the results obtained from 2906 subjects evaluated in 34 prospectively designed, controlled studies.
  • The aim was carried out through a meta-analytical approach that examined the predictive value of four categories of sperm functional assays: computer-aided sperm motion analysis (CASA); induced-acrosome reaction testing; sperm penetration assay (SPA); and sperm-zona pellucida binding assays for IVF outcome.
  • Results demonstrated a high predictive power of the sperm-zona pellucida binding and the induced-acrosome reaction assays for fertilization outcome.
  • On the other hand, the findings indicated a poor clinical value of the SPA as predictor of fertilization and a real need for standardization and further investigation of the potential clinical utility of CASA systems.

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  • (PMID = 10782574.001).
  • [ISSN] 1355-4786
  • [Journal-full-title] Human reproduction update
  • [ISO-abbreviation] Hum. Reprod. Update
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Meta-Analysis
  • [Publication-country] ENGLAND
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21. Robinson TJ, Cebelinski EA, Taylor C, Smith KE: Evaluation of the positive predictive value of rapid assays used by clinical laboratories in Minnesota for the diagnosis of cryptosporidiosis. Clin Infect Dis; 2010 Apr 15;50(8):e53-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of the positive predictive value of rapid assays used by clinical laboratories in Minnesota for the diagnosis of cryptosporidiosis.
  • We evaluated the positive predictive value (PPV) of rapid assays used by clinical laboratories in Minnesota to diagnose cryptosporidiosis.
  • The overall PPV was 56% for rapid assays versus 97% for nonrapid assays; clinicians and laboratorians need to be aware of the low PPV of rapid assays when diagnosing cryptosporidiosis.
  • [MeSH-minor] Humans. Minnesota. Predictive Value of Tests

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  • (PMID = 20218890.001).
  • [ISSN] 1537-6591
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Grant] United States / NCEH CDC HHS / EH / 5R01EH000085-05
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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22. Buchanan N: The value of serum drug concentration assays in clinical practice. S Afr Med J; 1978 Jan 21;53(3):103-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of serum drug concentration assays in clinical practice.
  • The value of serum drug assays in clinical practice is assessed, and it is concluded that, except in neonates, elderly persons or patients with hepatic and renal dysfunction, such assays are of little clinical value.
  • However, research projects to obtain clinically applicable pharmacokinetic data are of great value.
  • Routine clinical drug assays should be discouraged on clinical, practical and economic grounds.

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  • (PMID = 653473.001).
  • [ISSN] 0256-9574
  • [Journal-full-title] South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • [ISO-abbreviation] S. Afr. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] SOUTH AFRICA
  • [Chemical-registry-number] 0 / Anti-Arrhythmia Agents; 0 / Anti-Bacterial Agents; 0 / Anticonvulsants; 0 / Antidepressive Agents, Tricyclic; 0 / Pharmaceutical Preparations; 73K4184T59 / Digoxin; C137DTR5RG / Theophylline
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23. Francis JL, Carvalho M, Francis DA: The clinical value of tissue factor assays. Blood Coagul Fibrinolysis; 1995 Jun;6 Suppl 1:S37-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clinical value of tissue factor assays.
  • Urinary TF is increased in cancer and could have diagnostic and prognostic value in a variety of malignant diseases.
  • One such assay is commercially available and is technically simple to perform.
  • The clinical value of such assays, however, must await better understanding of the source and function of soluble TF in plasma.

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  • (PMID = 7647219.001).
  • [ISSN] 0957-5235
  • [Journal-full-title] Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
  • [ISO-abbreviation] Blood Coagul. Fibrinolysis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 9035-58-9 / Thromboplastin
  • [Number-of-references] 65
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24. Queneau P, Lejeune E, Veysseyre C, Decousus H, Perpoint B, Laurent H, Bayle P: [Value of anti hemolysin and anti-gammahemolysin assays for the diagnosis of staphylococcal infections, particularly of osteoarthritis (author's transl)]. Sem Hop; 1982 Feb 25;58(8):457-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of anti hemolysin and anti-gammahemolysin assays for the diagnosis of staphylococcal infections, particularly of osteoarthritis (author's transl)].
  • The authors report the results of more than twelve years' personal research on the value of anti-alphahemolysin (AASTL) and antigammahemolysin (AGSTL) assays for the diagnosis of staphylococcal infections, and particularly of osteoarthritis.
  • These results show that AASTL assay is reliable and often abnormal.
  • However, assay of both hemolysins yields even better results.
  • This dual assay was performed in 57 patients with staphylococcal infection.
  • This represents additional positivity in 15.7% of patients when compared to AASTL assay alone, and in 21% when compared to AGSTL assay alone.
  • The high level of positive results with dual assay is even more striking when only staphylococcal osteoarthritis is considered: one or both hemolysins were increased in 91.1% of these patients (31/34).

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  • (PMID = 6278628.001).
  • [Journal-full-title] La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris
  • [ISO-abbreviation] Sem Hop
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] FRANCE
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Hemolysin Proteins; 0 / Immunoglobulins; 0 / antistaphylolysin
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25. Zhou Y, Wu B, Li H: [The value of serum CA125 assays in the diagnosis of uterine adenomyosis]. Zhonghua Fu Chan Ke Za Zhi; 1996 Oct;31(10):590-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The value of serum CA125 assays in the diagnosis of uterine adenomyosis].
  • OBJECTIVE: To investigate the value of serum CA125 assays in the diagnosis of uterine adenomyosis.
  • CONCLUSIONS: Serum CA125 assay is of great assistance to the diagnosis of uterine adenomyosis as well as to the differential diagnosis between adenomyosis and leiomyoma of uterus.

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  • (PMID = 9275451.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] CHINA
  • [Chemical-registry-number] 0 / CA-125 Antigen
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26. Jenski LJ: Kinetic assay of cytotoxic T lymphocyte clones. II. Comparison of primary and secondary responses and lectin-dependent cytotoxicity. J Immunol Methods; 1989 Feb 24;117(2):191-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kinetic assay of cytotoxic T lymphocyte clones. II. Comparison of primary and secondary responses and lectin-dependent cytotoxicity.
  • A kinetic assay for cytotoxic T lymphocyte (CTL) clones expanded briefly in vitro was used to compare CTL clones developing from the most frequent precursor population in naive spleens, among splenocytes primed in vitro, and among cells mediating lectin-dependent cellular cytotoxicity.
  • The variance and frequency distribution of these parameters, rather than their numerical value, predicted differences in the clonal composition of distinct lymphoid populations assayed independently.

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  • (PMID = 2784154.001).
  • [ISSN] 0022-1759
  • [Journal-full-title] Journal of immunological methods
  • [ISO-abbreviation] J. Immunol. Methods
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Phytohemagglutinins
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27. Molkhou JM, Lacaine F, Houry S, Huguier M: [Detection of hepatic metastasis of digestive cancers. Value of enzyme assays and ultrasonography]. Presse Med; 1989 Sep 16;18(28):1370-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Detection of hepatic metastasis of digestive cancers. Value of enzyme assays and ultrasonography].
  • Alkaline phosphatase (AP), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH) and aspartate aminotransferase (AsT) assays, as well as ultrasonography are the easiest and least expensive examinations to perform in the diagnosis of hepatic metastases.
  • A receiver operating characteristic (ROC) curve was drawn after computing the sensitivity (Se) and specificity (Sp) of each laboratory determination while the threshold indicating that the value was normal was incremented.
  • The examinations were then compared in terms of Se, Sp, positive predictive value and negative predictive value.
  • According to predictive values, laboratory determinations could be classified in decreasing order of usefulness as: AP, LDH, GGT and AsT.
  • Ultrasonography had a positive predictive value of 68 per cent a negative predictive value of 95 per cent, both figures being higher than those of any laboratory examination.
  • These results suggest that ultrasonography has a higher diagnostic value than any of the enzyme assays in the detection of hepatic metastases.

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  • (PMID = 2571989.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 2.3.2.2 / gamma-Glutamyltransferase; EC 2.6.1.1 / Aspartate Aminotransferases; EC 3.1.3.1 / Alkaline Phosphatase
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28. Banfi G, Marinelli M, Casari E, Murone M, Bonini P: Isotopic and nonisotopic assays for measuring somatotropin compared: re-evaluation of cutoff value in provocative tests. Clin Chem; 1991 Feb;37(2):273-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isotopic and nonisotopic assays for measuring somatotropin compared: re-evaluation of cutoff value in provocative tests.
  • Serum hGH can be measured by various immunoassays, isotopic and nonisotopic, with monoclonal or polyclonal antibodies: a cutoff value of 10 micrograms/L after provocative testing is usually used to distinguish normal from hGH-deficient children.
  • Here we evaluated the responses of six different commercial assays, radioisotopic and nonisotopic, with monoclonal or polyclonal antibodies in a series of 16 provocative tests (stimulation with clonidine) in short children.
  • A wide range of discrepant values was obtained with the different kits.
  • A cutoff of 10 micrograms/L produced discordance of diagnosis among assays for two children, whereas complete agreement was reached for a cutoff value of 7 micrograms/L.
  • Cutoff values and reference values must be established separately for each method proposed for routine use.
  • [MeSH-minor] Adolescent. Antibodies, Monoclonal. Child. Diagnosis, Differential. Female. Humans. Immunoradiometric Assay. Male. Radioimmunoassay. Reagent Kits, Diagnostic. Turner Syndrome / blood. Turner Syndrome / diagnosis

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  • (PMID = 1993338.001).
  • [ISSN] 0009-9147
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Reagent Kits, Diagnostic; 9002-72-6 / Growth Hormone
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29. Wagenaar JF, Falke TH, Nam NV, Binh TQ, Smits HL, Cobelens FG, de Vries PJ: Rapid serological assays for leptospirosis are of limited value in southern Vietnam. Ann Trop Med Parasitol; 2004 Dec;98(8):843-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid serological assays for leptospirosis are of limited value in southern Vietnam.
  • In an initial survey, blood samples from 44 patients with undifferentiated fever and 83 healthy subjects were each examined for anti- Leptospira antibodies using three tests: an ELISA; a latex card-agglutination test (Dri Dot); and a lateral-flow assay (LeptoTek Lateral Flow).
  • In the initial survey, although the positive results of the lateral-flow assay, applied to whole blood and serum, showed a good agreement with those of the ELISA (kappa = 0.743), the results of the lateral-flow assay were often indeterminate.
  • When the samples classified as 'indeterminate' in the lateral-flow assay were considered positive, the maximum kappa-value for this assay applied to whole blood was only 0.512.
  • In conclusion, it appears that high seroprevalences of anti- Leptospira IgM and low incidences of acute leptospirosis limit the diagnostic value of the rapid tests that were investigated.
  • The lateral-flow assay is not specific enough.
  • [MeSH-minor] Adolescent. Adult. Antibodies, Bacterial / analysis. Child. Diagnostic Tests, Routine / methods. Enzyme-Linked Immunosorbent Assay / methods. Female. Humans. Immunoglobulin M / analysis. Latex Fixation Tests / methods. Male. Middle Aged. Seroepidemiologic Studies. Serologic Tests. Vietnam / epidemiology

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  • (PMID = 15667716.001).
  • [ISSN] 0003-4983
  • [Journal-full-title] Annals of tropical medicine and parasitology
  • [ISO-abbreviation] Ann Trop Med Parasitol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Immunoglobulin M
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30. Laaban JP, Achkar A, Horellou MH, Conard J, Bouarfa N, Arkam R, Lorut C, Fretault J, Vadrot D, Samama M, Rochemaure J: [Value of plasma D-dimer assays in the diagnosis of venous thromboembolism]. Rev Mal Respir; 1997 Apr;14(2):119-27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of plasma D-dimer assays in the diagnosis of venous thromboembolism].
  • The sensitivity, specificity, negative predictive value and positive predictive value of a D-dimers plasma concentration exceeding 500 ng/ml for the diagnosis of AVTE were respectively 98, 58, 97 and 70% when using the ELISA method, and 86, 71, 84 and 75% when using the latex assay.
  • In 47 patients whose lung scans yielded abnormalities of indeterminate probability of pulmonary embolism, the sensitivity of the ELISA method was very high (94%), but that of latex assay was low (67%).
  • Our results demonstrate that measuring the plasma D-dimers by the latex assay should not be used in the diagnosis of AVTE.
  • [MeSH-minor] Acute Disease. Enzyme-Linked Immunosorbent Assay. Female. Humans. Latex Fixation Tests. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity. Thrombophlebitis / blood. Thrombophlebitis / diagnosis

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  • (PMID = 9198834.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] FRANCE
  • [Chemical-registry-number] 0 / Fibrin Fibrinogen Degradation Products; 0 / fibrin fragment D
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31. Brito VN, Batista MC, Borges MF, Latronico AC, Kohek MB, Thirone AC, Jorge BH, Arnhold IJ, Mendonca BB: Diagnostic value of fluorometric assays in the evaluation of precocious puberty. J Clin Endocrinol Metab; 1999 Oct;84(10):3539-44
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of fluorometric assays in the evaluation of precocious puberty.
  • To establish normative data and determine the value of fluorometric AutoDELFIA assays (Wallac Oy) in the investigation of precocious puberty, we determined serum levels of LH, FSH, testosterone, and estradiol under basal and GnRH-stimulated conditions in 277 normal subjects at various pubertal stages and in 77 patients with precocious puberty.
  • The specificity and positive predicted value were 100% in both sexes for basal and peak LH levels.
  • The negative predicted values for basal and peak LH were 62.5% and 100% in boys, and 40.6% and 76.5% in girls.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Gonadotropin-Releasing Hormone. Gonadotropins / blood. Humans. Male. Reference Values. Steroids / blood

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  • (PMID = 10522992.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Gonadotropins; 0 / Steroids; 33515-09-2 / Gonadotropin-Releasing Hormone
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32. Yu JY, Lin Y: [Clinical value comparison between chemiluminescent immunoassay and immunoradiometric assay in detecting TSH in serum]. Hunan Yi Ke Da Xue Xue Bao; 2003 Jun;28(3):275-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical value comparison between chemiluminescent immunoassay and immunoradiometric assay in detecting TSH in serum].
  • OBJECTIVE: To compare the clinical value between chemiluminescent immunoassay (CLIA) and immunoradiometric assay (IRMA) in detecting TSH in patients with hyperthyroidism and hypothyroidism.
  • [MeSH-minor] Adult. Female. Humans. Immunoassay / methods. Immunoradiometric Assay. Luminescent Measurements. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 14653089.001).
  • [ISSN] 1000-5625
  • [Journal-full-title] Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
  • [ISO-abbreviation] Hunan Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin
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33. Schieder K, Kölbl H, Bieglmayer C: [Value of the tumor colony assay in therapy planning in malignant ovarian tumors]. Geburtshilfe Frauenheilkd; 1987 Jan;47(1):41-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of the tumor colony assay in therapy planning in malignant ovarian tumors].
  • [Transliterated title] Uber den Stellenwert des Tumorkolonie-Assays in der Therapieplanung bei malignen Ovarialtumoren.
  • The aim of our study was to determine the clinical value of the human tumour colony assay for the treatment of patients suffering from advanced malignant ovarian tumours.
  • Cultures were obtained of only 52.6% of the 133 tumour samples; only 33 of 70 assays showed a sufficient growth of colonies.
  • However, the significance of the stem cell assay for clinical use is represented by the prediction of drug resistance.
  • In 17 trials the assay had a 67% true positive rate and a 100% true negative rate for predicting drug sensitivity and resistance, respectively.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Colony-Forming Units Assay. Ovarian Neoplasms / drug therapy. Tumor Stem Cell Assay

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  • (PMID = 3569826.001).
  • [ISSN] 0016-5751
  • [Journal-full-title] Geburtshilfe und Frauenheilkunde
  • [ISO-abbreviation] Geburtshilfe Frauenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] GERMANY, WEST
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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34. Thomas P, Mura P, Tallineau C, Bounaud MP, Reiss D, Bontoux D: [Value of the assay of urinary neopterin in multiple myeloma. Preliminary study]. Rev Rhum Mal Osteoartic; 1985 Jun;52(6):381-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of the assay of urinary neopterin in multiple myeloma. Preliminary study].
  • Urinary neopterin was assayed by HPLC (high performance liquid chromatography).
  • 75 assays were performed in a population of 21 patients with multiple myeloma.
  • This study demonstrates the value of this assay in the monitoring of patients with multiple myeloma.

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  • (PMID = 3901228.001).
  • [ISSN] 0035-2659
  • [Journal-full-title] Revue du rhumatisme et des maladies ostéo-articulaires
  • [ISO-abbreviation] Rev Rhum Mal Osteoartic
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] FRANCE
  • [Chemical-registry-number] 0 / Immunoglobulin A; 0 / Immunoglobulin G; 0 / Pteridines; 0 / beta 2-Microglobulin; 22150-76-1 / Biopterin; 670-65-5 / Neopterin
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35. Rhodes A, Jasani B, Balaton AJ, Barnes DM, Miller KD: Frequency of oestrogen and progesterone receptor positivity by immunohistochemical analysis in 7016 breast carcinomas: correlation with patient age, assay sensitivity, threshold value, and mammographic screening. J Clin Pathol; 2000 Sep;53(9):688-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequency of oestrogen and progesterone receptor positivity by immunohistochemical analysis in 7016 breast carcinomas: correlation with patient age, assay sensitivity, threshold value, and mammographic screening.
  • AIMS: A routine immunohistochemical (IHC) assay is now commonly used for determining the oestrogen receptor (ER) and progesterone receptor (PR) status of women with breast cancer.
  • To date, no large studies have been conducted that report the expected frequency of receptor positivity in relation to patient age and sensitivity of the IHC assay.
  • METHODS: Members of UK NEQAS-ICC (UK National External Quality Assessment Scheme for Immunocytochemistry) provided data on the receptor status of cases routinely assayed in their departments over a period of two to 26 months between June 1996 and September 1998.
  • Frequency of receptor positivity was correlated with IHC assay sensitivity, the threshold value used to determine receptor positivity, and the presence or absence of mammographic screening in the hospitals or clinics served by the laboratories.
  • There was a significant positive correlation between frequency of receptor positivity and the sensitivity of the IHC assay, for both ER (rs = 0.346; p = 0.019; two tailed) and PR (rs = 0.561; p = 0.003; two tailed).
  • The mean frequency of receptor positivity for laboratories using the same 10% threshold value was 77% for ER (95% confidence interval (CI), 74% to 80%) in laboratories with high sensitivity and 72% (95% CI, 68% to 76%) for those with low assay sensitivity (p = 0.025).
  • For PR, the mean frequency of receptor positivity for laboratories using the same 10% threshold value and having high assay sensitivity was 63% (95% CI, 57% to 69%), and 51% (95% CI, 38% to 65%) for laboratories with assays of low sensitivity (p = 0.022).
  • CONCLUSIONS: Of the parameters investigated, patient age and IHC assay sensitivity were found to be the main variables influencing the frequency of receptor positivity.
  • We recommend the range of receptor values obtained by laboratories achieving high assay sensitivity as a useful guide against which all laboratories can gauge their own results.

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  • [Cites] J Clin Pathol. 2000 Feb;53(2):125-30 [10767828.001]
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  • (PMID = 11041059.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ PMC1731243
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36. Dalifard I, Daver A, Cellier P, Larra F: [What value should be given to assays of serum ferritin in breast cancers? Correlation with various biological parameters]. Sem Hop; 1984 Jan 26;60(3):157-62
Hazardous Substances Data Bank. IRON, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [What value should be given to assays of serum ferritin in breast cancers? Correlation with various biological parameters].
  • The aim of this study is to determine the value of serum ferritin assay alone or combined with CEA and beta-2-M.
  • For the diagnosis of breast cancer, serum ferritin is of little value, with 23% false positive and 41% false negative results.
  • Furthermore, combination with CEA and beta-2-M assays does not improve the diagnosis of malignancy.

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  • (PMID = 6320439.001).
  • [Journal-full-title] La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris
  • [ISO-abbreviation] Sem Hop
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] FRANCE
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Transferrin; 0 / beta 2-Microglobulin; 9007-73-2 / Ferritins; E1UOL152H7 / Iron; EC 3.1.3.1 / Alkaline Phosphatase
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37. Liu ZZ, Huang WY, Li XS, Lin JS, Cai XK, Lian KH, Zhou HJ: Prediction value of radiosensitivity of hepatocarcinoma cells for apoptosis and micronucleus assay. World J Gastroenterol; 2005 Nov 28;11(44):7036-9
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prediction value of radiosensitivity of hepatocarcinoma cells for apoptosis and micronucleus assay.
  • AIM: To investigate the prediction value of radiosensitivity of hepatocarcinoma cells for apoptosis and micronucleus assay.
  • METHODS: Clonogenic assay, flow cytometry, and CB micronuclei assay were used to survey the cell survival rate, radiation-induced apoptosis and micronucleus frequency of hepatocarcinoma cell lines SMMC-7721, HL-7702, and HepG2 after being irradiated by X-ray at the dosage ranging 0-8 Gy.
  • [MeSH-minor] Cell Survival. Dose-Response Relationship, Radiation. Humans. Micronuclei, Chromosome-Defective. Predictive Value of Tests. X-Rays

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  • (PMID = 16437613.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4717051
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38. Zittoun R, Garand R, Zittoun J, Pillon-Hardy ME, Cadiou M, Bilski-Pasquier G: [Diagnostic and prognostic value of the assay of lysozyme in acute leukemia (author's transl)]. Ann Med Interne (Paris); 1979;130(2):59-64
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  • [Title] [Diagnostic and prognostic value of the assay of lysozyme in acute leukemia (author's transl)].
  • The diagnostic and prognostic value of the assay of lysozyme in serum and urine was appreciated in 184 cases of acute leukemia.

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  • (PMID = 285635.001).
  • [ISSN] 0003-410X
  • [Journal-full-title] Annales de médecine interne
  • [ISO-abbreviation] Ann Med Interne (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] FRANCE
  • [Chemical-registry-number] EC 3.2.1.17 / Muramidase
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39. Hagen EC, Daha MR, Hermans J, Andrassy K, Csernok E, Gaskin G, Lesavre P, Lüdemann J, Rasmussen N, Sinico RA, Wiik A, van der Woude FJ: Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR Project for ANCA Assay Standardization. Kidney Int; 1998 Mar;53(3):743-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR Project for ANCA Assay Standardization.
  • The objective of this study was to evaluate the diagnostic value of ANCA measurement by the indirect immunofluorescence (IIF) test, and by anti-PR3 and anti-MPO ELISA performed in different locations, in patients with idiopathic small vessel vasculitis.
  • Fourteen centers participated in a standardization study of ANCA assays, and entered a total number of 169 newly diagnosed and 189 historical patients with idiopathic systemic vasculitis or iRPGN.
  • The sensitivities of assays in patients were as follows.
  • The specificity of assays (related to disease controls) was: cANCA 95%, pANCA 81%, anti-PR3 87%, anti-MPO 91%.
  • From this study we conclude that the value of the IIF test for ANCA detection can be greatly increased by the addition of a well standardized antigen-specific ELISA.
  • [MeSH-major] Antibodies, Antineutrophil Cytoplasmic / blood. Enzyme-Linked Immunosorbent Assay / standards. Fluorescent Antibody Technique, Indirect / standards. Glomerulonephritis / diagnosis. Glomerulonephritis / immunology. Vasculitis / diagnosis. Vasculitis / immunology

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  • [CommentIn] Kidney Int. 1998 Mar;53(3):796-8 [9507231.001]
  • (PMID = 9507222.001).
  • [ISSN] 0085-2538
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic; 0 / Biomarkers; EC 1.11.1.7 / Peroxidase; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.76 / Myeloblastin
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40. Coenen D, Verschueren P, Westhovens R, Bossuyt X: Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis. Clin Chem; 2007 Mar;53(3):498-504
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis.
  • BACKGROUND: Several anticitrullinated protein/peptide antibodies (ACPA) assays have been reported to be of diagnostic value for rheumatoid arthritis (RA).
  • METHODS: ACPA were determined in 298 serum samples using 6 commercially available ACPA assays.
  • RESULTS: Variable technical performance was noted among the different ACPA assays, with some assays displaying poor reproducibility and bad linearity.
  • ACPA results were well correlated among assays with the same antigen specificity, but the numerical values reported for each assay differed widely.
  • Using cutoff values proposed by the manufacturer, diagnostic sensitivities ranged between 69.6% and 77.5% and specificities between 87.8% and 96.4%.
  • The areas under the ROC curves were comparable among the different assays.
  • CONCLUSIONS: Overall diagnostic performance of ACPA assays is comparable among the different assays, but standardization is needed.
  • For some assays, analytical characteristics could be improved.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Animals. Enzyme-Linked Immunosorbent Assay / methods. Female. Humans. Male. Middle Aged. Rats. Recombinant Proteins / immunology. Reproducibility of Results

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  • (PMID = 17259232.001).
  • [ISSN] 0009-9147
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Intermediate Filament Proteins; 0 / Peptides, Cyclic; 0 / Recombinant Proteins; 0 / Vimentin; 0 / cyclic citrullinated peptide; 0 / filaggrin; 29VT07BGDA / Citrulline
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41. Meyer G, Fischer AM, Collignon MA, Benazzouz A, Monge F, Sors H, de Raucourt E: Diagnostic value of two rapid and individual D-dimer assays in patients with clinically suspected pulmonary embolism: comparison with microplate enzyme-linked immunosorbent assay. Blood Coagul Fibrinolysis; 1998 Oct;9(7):603-8
MedlinePlus Health Information. consumer health - Pulmonary Embolism.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of two rapid and individual D-dimer assays in patients with clinically suspected pulmonary embolism: comparison with microplate enzyme-linked immunosorbent assay.
  • A semiquantitative enzyme-linked immunosorbent assay (ELISA) test (Instant IA D-dimer) and a new quantitative rapid and individual test (STA-Liatest DDi) were compared with the reference microplate ELISA (Asserachrom D-Di) for D-dimer testing in 142 patients clinically suspected of pulmonary embolism, on the basis of clinical symptoms and signs, electrocardiogram, blood gases and chest X-Ray abnormalities.
  • The cut-off value for the quantitative tests was 500 ng/ml and Instant IA was interpreted by three readers.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biological Assay. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 9863708.001).
  • [ISSN] 0957-5235
  • [Journal-full-title] Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
  • [ISO-abbreviation] Blood Coagul. Fibrinolysis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Fibrin Fibrinogen Degradation Products; 0 / fibrin fragment D
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42. Gamzu R, Yogev L, Amit A, Lessing J, Homonnai ZT, Yavetz H: The hemizona assay is of good prognostic value for the ability of sperm to fertilize oocytes in vitro. Fertil Steril; 1994 Nov;62(5):1056-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The hemizona assay is of good prognostic value for the ability of sperm to fertilize oocytes in vitro.
  • OBJECTIVES: To assess the prognostic value of hemizona assay (HZA) in predicting the success of IVF.
  • RESULTS: The intra-assay and interassay coefficient of variation were 8% and 14%, respectively.
  • Hemizona assay results had the highest correlation with sperm morphology (r = 0.60).
  • The assay was found to have high sensitivity and specificity rates, at a threshold HZI of 23%.
  • With a threshold HZI of 23%, it has a good predictive value for fertilization rates in IVF, and may thus be used for patient preselection before IVF.

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  • (PMID = 7926118.001).
  • [ISSN] 0015-0282
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Berman S, Tanasijevic MJ, Alvarez JG, Ludmir J, Lieberman E, Richardson DK: Racial differences in the predictive value of the TDx fetal lung maturity assay. Am J Obstet Gynecol; 1996 Jul;175(1):73-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Racial differences in the predictive value of the TDx fetal lung maturity assay.
  • Previous studies have demonstrated a difference in the predictive value of the lecithin/sphingomyelin ratio, a test for lung maturity, between races.
  • Our study examines the predictive value of the newer TDx Fetal Lung Maturity Surfactant-to-Albumin assay.
  • STUDY DESIGN: We reviewed the records of 393 nonblack and 87 black infants delivered within 72 hours of the TDx FLM S/A assay testing.
  • To adjust for possible differences in the timing of lung maturation, the results were stratified by the TDx FLM S/A assay result.
  • This significant racial difference remained when both TDx FLM S/A assay result and gestational age were controlled in a multiple logistic regression analysis.
  • CONCLUSIONS: There are differences in the predictive value of the TDx FLM S/A assay among races.
  • Consideration should be given to a lower cutoff value for a mature test result in black women.
  • [MeSH-minor] African Continental Ancestry Group. Female. Fetal Organ Maturity. Gestational Age. Humans. Incidence. Infant, Newborn. Male. Predictive Value of Tests. Regression Analysis. Risk Factors

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  • (PMID = 8694078.001).
  • [ISSN] 0002-9378
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] UNITED STATES
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44. Ye C, Wang D, Wu X, Qu J: k-Value-based ferron assay and its application. J Colloid Interface Sci; 2009 Jul 1;335(1):44-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] k-Value-based ferron assay and its application.
  • It has been believed that Al13 could be assayed in term of Al(b) derived from traditional ferron assay.
  • Here, the new k-value-based ferron assay using nonlinear least squares analysis is suggested to resolve the ambiguity.
  • The experimental results reveal that the moderate kinetics (k value) around 0.001 s(-1) can be ascribed to Al13.
  • In the short-term aging of freshly neutralized aluminum solutions with OH/Al molar ratio of 2.2, the rapid progress of Al13-like transformation into Al13 can be traced by this method, whereas it may be masked by traditional ferron assay because the metastable intermediates also contribute absorbance to Al(b) fraction.

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  • (PMID = 19419729.001).
  • [ISSN] 1095-7103
  • [Journal-full-title] Journal of colloid and interface science
  • [ISO-abbreviation] J Colloid Interface Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Muir D, White D, King J, Verlander N, Pillay D: Predictive value of the ultrasensitive HIV viral load assay in clinical practice. J Med Virol; 2000 Aug;61(4):411-6
MedlinePlus Health Information. consumer health - HIV/AIDS.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive value of the ultrasensitive HIV viral load assay in clinical practice.
  • The aim of this study was to determine whether an HIV viral load of <50 copies/ml (c/ml), in the first available plasma sample to have shown a viral load of <400 c/ml, in patients on antiretroviral therapy, is correlated with longer term suppression of viral load (at <400 c/ml) compared to a viral load of 50-399 c/ml, and secondly, to compare the results obtained by ultrasensitive and standard viral load assays carried out on the same sample.
  • For each patient, the first available specimen showing a viral load of <400 c/ml was tested using the Roche Amplicor ultrasensitive viral load assay, and patients were followed up subsequently for a median period of 52 weeks.
  • Overall, the findings suggest that the advantage in predictive value of the ultrasensitive over the standard HIV viral load assay, shown previously in clinical trials, may be limited in clinical practice.
  • [MeSH-minor] Anti-HIV Agents / therapeutic use. Disease Progression. Follow-Up Studies. Humans. Predictive Value of Tests. Reagent Kits, Diagnostic. Viremia

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  • [Copyright] Copyright 2000 Wiley-Liss, Inc.
  • (PMID = 10897057.001).
  • [ISSN] 0146-6615
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / Reagent Kits, Diagnostic
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46. Nathan DM, Singer DE, Hurxthal K, Goodson JD: The clinical information value of the glycosylated hemoglobin assay. N Engl J Med; 1984 Feb 9;310(6):341-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clinical information value of the glycosylated hemoglobin assay.
  • We evaluated the clinical information value of the glycosylated hemoglobin assay by comparing it with practitioners' estimates of glucose control over the preceding 10 weeks in 216 patients with diabetes.
  • Twenty-four per cent of the practitioners' estimates, which were based on historical and laboratory data collected during a routine office visit, differed by more than +/- 75 mg per deciliter from the actual mean blood glucose levels calculated with the glycosylated hemoglobin assay.
  • We conclude that the glycosylated hemoglobin assay provides information about the degree of long-term glucose control that is not otherwise obtainable in the usual clinical setting.

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  • (PMID = 6690962.001).
  • [ISSN] 0028-4793
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Hemoglobin A, Glycosylated
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47. Grand A, Glaizal S, Caudie C, Schrive I, Matas O, Fichter P, Shibli H: [Value of the assay of serum myoglobin in recent myocardial infarction]. Ann Cardiol Angeiol (Paris); 1990 Mar;39(3):137-42
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  • [Title] [Value of the assay of serum myoglobin in recent myocardial infarction].
  • The serum myoglobin (MG) was assayed by the radio-immunological method in 30 patients, all victims of a recent myocardial infarction (MI) and in 30 tests subjects suffering (21 cases) or not (9 cases) from heart diseases, but none from myocardial infarction (MI).
  • The normal value is less than 85 micrograms/l.
  • The creatine-kinase (CK), the aspartate aminotransferase (ASAT), the alanine aminotransferase (ALAT) and the lactate dehydrogenase (LDH) were also assayed each time.
  • The sensitivity of this assay reaches 97%, its specificity 80%, its positive predictive value 83% and its negative predictive value 96%.
  • Starting from the beginning of the characteristic pain of infarction, the MG level exceeds the normal values after 3.3 +/- 1.6 hours, reaches its maximum after 9.3 +/- 3.7 hours and comes back to normal after 38 +/- 8.1 hours.
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Radioimmunoassay. Time Factors

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  • (PMID = 2188559.001).
  • [ISSN] 0003-3928
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] FRANCE
  • [Chemical-registry-number] 0 / Myoglobin
  • [Number-of-references] 26
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48. Janvier F, Servonnet A, Delacour H, Fontan E, Ceppa F, Burnat P: [Value of assaying adenosine deaminase level in patients with neuromeningeal tuberculosis]. Med Trop (Mars); 2010 Feb;70(1):88-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of assaying adenosine deaminase level in patients with neuromeningeal tuberculosis].
  • The purpose of this review was to describe the diagnostic value of assaying adenosine deaminase activity in cerebrospinal fluid from patients with neuromeningeal tuberculosis.
  • Evidence from studies published over the last 25 years indicate that the sensitivity and specificity of measuring adenosine deaminase activity range from 36 to 92% and 71 to 100% respectively depending of cutoff values used.
  • Before performing this assay, it is necessary to rule out obvious or frequent etiologies such as purulent bacterial meningitis or cryptococcosis in HIV patients.

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  • (PMID = 20337125.001).
  • [ISSN] 0025-682X
  • [Journal-full-title] Médecine tropicale : revue du Corps de santé colonial
  • [ISO-abbreviation] Med Trop (Mars)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] EC 3.5.4.4 / Adenosine Deaminase
  • [Number-of-references] 37
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49. Mohsin S, Anwar M, Rehman ZU, Waqar A, Ayyub M, Ali W: Value of D-dimers assay in diagnosis of pulmonary embolism. J Pak Med Assoc; 2004 Jul;54(7):348-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of D-dimers assay in diagnosis of pulmonary embolism.
  • OBJECTIVE: To determine the value of D-Dimers assay in the diagnosis of Pulmonary Embolism (PE) at Armed Forces Institute of Pathology, Rawalpindi, Pakistan from January to November 2000.
  • D-Dimers were less than the cut off value of 500 ng/ml in 19 (44.2%) patients, whereas in 24 (55.8%) the levels were more than 500 ng/ml.
  • Positive predictive value of the test was 100% whereas negative predictive value was 87.5%.
  • CONCLUSION: D-Dimers assay combined with high clinical evidence is a cost effective, readily available test which can safely exclude the diagnosis of pulmonary embolism in majority of the cases.
  • [MeSH-minor] Adult. Aged. Animals. Blood Platelets / cytology. Blood Platelets / metabolism. Chest Pain / diagnosis. Diagnostic Tests, Routine / methods. Dyspnea / diagnosis. Female. Humans. Male. Middle Aged. Pakistan. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 15449915.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Fibrin Fibrinogen Degradation Products; 0 / fibrin fragment D
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50. Bellon N, André C, Sbidian E, Ortonne N, Wolkenstein P, Chosidow O, Ingen-Housz-Oro S: The value of anti-desmoglein enzyme-linked immunosorbent assay in the immunological follow-up of pemphigus. Dermatology; 2014;229(3):256-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of anti-desmoglein enzyme-linked immunosorbent assay in the immunological follow-up of pemphigus.
  • BACKGROUND: The value of anti-desmoglein 1 and 3 (Dsg1, Dsg3) enzyme-linked immunosorbent assay (ELISA) is controversial in the follow-up of pemphigus.
  • At M12, ELISA values did not differ between CR and active disease.
  • At M24/36, Dsg3 but not Dsg1 ELISA values were lower in CR (p = 0.07).
  • [MeSH-minor] Adult. Aged. Databases, Factual. Disease Progression. Enzyme-Linked Immunosorbent Assay / methods. Female. Fluorescent Antibody Technique, Direct / methods. Fluorescent Antibody Technique, Indirect / methods. Follow-Up Studies. France. Humans. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Severity of Illness Index. Statistics, Nonparametric. Young Adult

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  • (PMID = 25227321.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Desmoglein 1; 0 / Desmoglein 3
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51. Gillet JL, Ffrench P, Hanss M, Allaert FA, Chleir F: [Predictive value of D-dimer assay in superficial thrombophlebitis of the lower limbs]. J Mal Vasc; 2007 Apr;32(2):90-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Predictive value of D-dimer assay in superficial thrombophlebitis of the lower limbs].
  • OBJECTIVE: The negative predictive value of D-dimer (DD) assay in patients with venous thromboembolic disease is well established for deep vein thrombosis and pulmonary embolism.
  • Little is known about the value of DD assay in patients with superficial thrombophlebitis (ST).
  • The purpose of this study was to assess the value of DD assay in patients with ST of the lower limb.
  • Patients with clinical manifestations suggestive of ST of the lower limbs with positive duplex color Doppler evidence confirming the diagnosis and DD assay results (Vidas D-Dimer Exclusion) within 24 hours were included in the study.
  • DD assay was negative (<500 ng/ml) in 32 patients (32%) and positive in 68 (68%).
  • DD assay was always positive (>or=500 ng/ml) in all patients aged over 70 years (n=22).
  • In patients aged less than 70 years (n=78), DD assay was positive in 46 (59%) and negative in 32 (41%).
  • ROC analysis, sensitivity as a function of specificity by thrombus volume for the entire population, determined the usefulness of a negative DD assay.
  • Considering the critical threshold at 5914 mm(3), sensitivity was 1.0 (95CI 0.89-1.0), with 0.29 specificity (95CI 0.19-0.42), 1.00 negative predictive value and 0.75 positive predictive value.
  • However, the thrombus volume was less than this threshold value in three of the nine cases of ST with extension to the terminal portion of the saphenous.
  • CONCLUSION: A positive DD assay was observed in 68% of patients with ST, with no significant difference with or without varicose veins.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Ultrasonography, Doppler, Color

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  • (PMID = 17379463.001).
  • [ISSN] 0398-0499
  • [Journal-full-title] Journal des maladies vasculaires
  • [ISO-abbreviation] J Mal Vasc
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Fibrin Fibrinogen Degradation Products; 0 / fibrin fragment D
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52. Herberman RB, Bordes M, Lambert PH, Luthra HS, Robins RA, Sizaret P, Theofilopoulos A: Report on international comparative evaluation of possible value of assays for immune complexes for diagnosis of human breast cancer. Int J Cancer; 1981 May 15;27(5):569-76
MedlinePlus Health Information. consumer health - Breast Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Report on international comparative evaluation of possible value of assays for immune complexes for diagnosis of human breast cancer.
  • There have been several reports on the possible value of measurements of circulating immune complexes for the diagnosis of human breast cancer.
  • Investigators from four laboratories performing assays for immune complexes were sent coded aliquots of serum specimens from the NCI-Mayo Clinic Serum Bank.
  • Although some significant differences in levels of immune complexes between cancer patients and controls were seen, none of the assays had sufficient discriminatory capacity to support optimism about the diagnostic value of this approach.
  • The CEA assay provided significant discrimination between cancer patients and normal donors but did not significantly discriminate between malignant and benign breast diseases.

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  • (PMID = 7287224.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] DENMARK
  • [Chemical-registry-number] 0 / Antigen-Antibody Complex; 0 / Carcinoembryonic Antigen; 0 / Complement C1; 9009-79-4 / Rheumatoid Factor
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53. Priya K, Madhavan HN: Diagnostic value of enzyme linked immuno-sorbent assay for cytomegalovirus disease. J Postgrad Med; 2002 Jul-Sep;48(3):176-8; discussion 190
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of enzyme linked immuno-sorbent assay for cytomegalovirus disease.
  • BACKGROUND: Since interpretation of results of enzyme linked immuno-sorbent assay (ELISA) for diagnosis of Cytomegalovirus (CMV) infection in India is difficult, its diagnostic value required evaluation.
  • AIMS: To evaluate the diagnostic value of ELISA against polymerase chain reaction (PCR) in CMV disease.
  • METHODS AND MATERIAL: Anti-CMV antibodies were assayed by ELISA on the sera of 26 CMV PCR positive and 21 PCR negative patients and 35 normal healthy blood donors.
  • Of the 28 paediatric patients, ELISA was positive in 14 (73.7%) of 19 PCR positive and three (33.3%) of nine PCR negative patients showing a statistically significant difference (Chi square test, P value 0.038).
  • CONCLUSION: ELISA has no diagnostic value in the detection of CMV activation although it may help in the differential diagnosis of CMV infection in the paediatric age group.
  • [MeSH-major] Antibodies, Viral / analysis. Cytomegalovirus / immunology. Cytomegalovirus Infections / diagnosis. DNA, Viral / analysis. Enzyme-Linked Immunosorbent Assay / methods. Polymerase Chain Reaction / methods
  • [MeSH-minor] Case-Control Studies. Chi-Square Distribution. Female. Humans. Male. Probability. Reference Values. Sensitivity and Specificity

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  • (PMID = 12432189.001).
  • [ISSN] 0022-3859
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / DNA, Viral
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54. Fisken J, Leonard RC, Stewart M, Beattie GJ, Sturgeon C, Aspinall L, Roulston JE: The prognostic value of early CA125 serum assay in epithelial ovarian carcinoma. Br J Cancer; 1993 Jul;68(1):140-5
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  • [Title] The prognostic value of early CA125 serum assay in epithelial ovarian carcinoma.
  • We examined the prognostic value of early serum CA125 assay in 58 patients with advanced epithelial ovarian cancer together with residual disease, age, tumour grade, performance status, and the presence of ascites or adhesions at primary surgery.

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  • (PMID = 8318405.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate
  • [Other-IDs] NLM/ PMC1968323
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55. Forshaw J, Harwood L: Diagnostic value of the serum folate assay. J Clin Pathol; 1971 Apr;24(3):244-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of the serum folate assay.
  • The diagnostic value of the serum folate assay has been assessed in 90 patients, each of whom had a macrocytic anaemia and a low serum vitamin B(12) level.
  • It is concluded that the serum folate assay is a valuable routine test in patients who have a macrocytic anaemia and low serum vitamin B(12).

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  • Hazardous Substances Data Bank. FOLIC ACID .
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  • (PMID = 5573438.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Anticonvulsants; 935E97BOY8 / Folic Acid; P6YC3EG204 / Vitamin B 12
  • [Other-IDs] NLM/ PMC476963
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56. Margalioth EJ, Feinmesser M, Navot D, Mordel N, Bronson RA: The long-term predictive value of the zona-free hamster ova sperm penetration assay. Fertil Steril; 1989 Sep;52(3):490-4
MedlinePlus Health Information. consumer health - Male Infertility.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The long-term predictive value of the zona-free hamster ova sperm penetration assay.
  • Three hundred sixty-nine infertile couples were followed for 2 to 5 years in a study designed to determine the clinical long-term predictive value of the zona-free hamster ova sperm penetration assay (SPA).
  • Sixteen percent of 131 men who had an SPA of 0%, 23% of 120 men with 1% to 19%, and 48% of 118 men who had a penetration of greater than 19% impregnated their wives 2 to 5 years after the assays.
  • Sperm penetration assay greater than 19% was predictive of higher pregnancy rates in both oligospermic (41% versus 17%) and unexplained infertile couples (52% versus 24%).
  • The specificity and positive predictive values of the SPA were higher than those of the SA (77% versus 57% and 48% versus 37%).
  • These findings emphasize the value and importance of the SPA in determining the long-term fertility potential of men.

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  • [CommentIn] Fertil Steril. 1991 Jun;55(6):1212-3 [2037119.001]
  • (PMID = 2776902.001).
  • [ISSN] 0015-0282
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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57. Blank BS, Meenhorst PL, Mulder JW, Weverling GJ, Putter H, Pauw W, van Dijk WC, Smits P, Lie-A-Ling S, Reiss P, Lange JM: Value of different assays for detection of human cytomegalovirus (HCMV) in predicting the development of HCMV disease in human immunodeficiency virus-infected patients. J Clin Microbiol; 2000 Feb;38(2):563-9
MedlinePlus Health Information. consumer health - HIV/AIDS and Infections.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of different assays for detection of human cytomegalovirus (HCMV) in predicting the development of HCMV disease in human immunodeficiency virus-infected patients.
  • In the present prospective study, five blood tests for detection of human cytomegalovirus (HCMV), nucleic acid sequence-based amplification (NASBA) for detection of early (immediate-early antigen) and late (pp67) mRNA, PCR for detection of HCMV DNA (DNA PCR), culture, and pp65 antigenemia assay, and culture and DNA PCR of urine and throat swab specimens were compared for their abilities to predict the development of disease caused by HCMV (HCMV disease).
  • The pp65 antigenemia assay (sensitivity, 50%; specificity, 89%) and DNA PCR of blood (sensitivity, 69%; specificity, 75%) were most accurate in predicting the development of HCMV disease within the next 12 months.
  • The positive predictive values of all tests however, were low and did not exceed 50%.
  • In conclusion, virological screening by these qualitative assays for detection of HCMV is of limited value for prediction of the development of HCMV disease in HIV-infected patients.
  • [MeSH-minor] Adult. Antigens, Viral / analysis. Blood / virology. DNA, Viral / analysis. Female. Humans. Immediate-Early Proteins / analysis. Male. Pharynx / virology. Phosphoproteins / blood. Polymerase Chain Reaction. Predictive Value of Tests. Prospective Studies. Risk. Urine / virology. Viral Matrix Proteins / blood. Viral Proteins / metabolism

  • MedlinePlus Health Information. consumer health - Cytomegalovirus Infections.
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  • (PMID = 10655346.001).
  • [ISSN] 0095-1137
  • [Journal-full-title] Journal of clinical microbiology
  • [ISO-abbreviation] J. Clin. Microbiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / DNA, Viral; 0 / Immediate-Early Proteins; 0 / Phosphoproteins; 0 / Viral Matrix Proteins; 0 / Viral Proteins; 0 / cytomegalovirus matrix protein 65kDa; 0 / immediate-early proteins, cytomegalovirus
  • [Other-IDs] NLM/ PMC86149
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58. Fusegawa H, Miyachi H, Ando Y: [Clinical diagnostic value of the PCR assay for detection of Mycobacterium tuberculosis]. Rinsho Byori; 1996 Apr;44(4):307-13
MedlinePlus Health Information. consumer health - Tuberculosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical diagnostic value of the PCR assay for detection of Mycobacterium tuberculosis].
  • To evaluate the clinical diagnostic value of the PCR assay for detection of M. tuberculosis, a total of 758 samples from 387 patients were assayed by the polymerase chain reaction (PCR) using the IS6110 gene as a target, and the results of the PCR assay were compared with those obtained by conventional culture.
  • The patient's profiles such as clinical situation that required prompt differential diagnosis by the PCR assay, underlying disease and final diagnosis were analyzed.
  • The PCR assay lead to the rapid diagnosis of tuberculosis which was confirmed by culture in all 56 cases including elderly and immunocompromised patients.
  • One hundred and seventy-six of the 231 (76.2%) cases had abnormal shadows in the chest X-ray film that required the PCR assay for diagnosis of tuberculosis and differential diagnosis of pleural effusion, lung cancer or bacterial pneumonia.
  • In 56 smear-negative patients with final diagnosis of pulmonary tuberculosis, the larger the number of specimens received for the PCR assay from each patient, the higher the frequency of positive cases; with 1, 2 and 3 specimens received for the PCR assay, 13.3% (4/30), 45.5% (5/11) and 60.0% (3/5) of cases were PCR positive, respectively.

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  • (PMID = 8847811.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / DNA, Bacterial
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59. Swan A, Amer H, Dieppe P: The value of synovial fluid assays in the diagnosis of joint disease: a literature survey. Ann Rheum Dis; 2002 Jun;61(6):493-8
Hazardous Substances Data Bank. CALCIUM PYROPHOSPHATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of synovial fluid assays in the diagnosis of joint disease: a literature survey.
  • OBJECTIVE: To carry out a critical appraisal of the literature in an attempt to assess the current value of synovial fluid (SF) analysis in the diagnosis of joint disease.
  • Firstly, reports assessing the value of the three traditional assays (microbiology, white blood cell counts, and microscopy for pathogenic crystals).
  • Secondly, claims for the usefulness of "new" assays (cytology and biochemical markers).
  • Interpretation difficulties are a major hindrance to the clinical use of biochemical assays, which remain primarily research tools.
  • Finally, work on the diagnostic value of SF analysis in general.
  • The appraisal confirmed that SF analysis remains of major diagnostic value in acute arthritis, where septic arthritis or crystal arthropathy is suspected, and in intercritical gout.
  • Further investigation is recommended into the contribution of SF inspection and white cell counts to diagnosis, as well as of the specificity and sensitivity of SF microbiological assays, crystal identification, and cytology.

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  • (PMID = 12006320.001).
  • [ISSN] 0003-4967
  • [Journal-full-title] Annals of the rheumatic diseases
  • [ISO-abbreviation] Ann. Rheum. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 268B43MJ25 / Uric Acid; X69NU20D19 / Calcium Pyrophosphate
  • [Number-of-references] 60
  • [Other-IDs] NLM/ PMC1754135
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60. Panteghini M, Pagani F, Bonora R, Alebardi O, Ceriotti F: Diagnostic value of four assays for lipase determination in serum: a comparative reevaluation. Clin Biochem; 1991 Dec;24(6):497-503
MedlinePlus Health Information. consumer health - Pancreatitis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of four assays for lipase determination in serum: a comparative reevaluation.
  • We assessed the diagnostic value of four commercially available methods for determining pancreatic lipase (LPS) in serum (the turbidimetric procedure from Boehringer, two enzymatic approaches from Kodak and Poli, and an immunochemical assay) in a population of 46 hospitalized patients with acute abdominal pain.
  • Concerning clinical efficiency, all the assays had values equal to or greater than 90%.
  • Using the calculation of the overlap index (OI) as a statistical approach to quantify the clinical utility of various LPS assays, the test having the greatest potential for differentiating between patients with and without acute pancreatitis was the turbidimetric assay (OI = 0.14).
  • [MeSH-major] Biological Assay / methods. Lipase / blood. Pancreatitis / diagnosis
  • [MeSH-minor] Acute Disease. Female. Humans. Male. Middle Aged. Predictive Value of Tests

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  • (PMID = 1773490.001).
  • [ISSN] 0009-9120
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article
  • [Publication-country] CANADA
  • [Chemical-registry-number] EC 3.1.1.3 / Lipase
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61. Napoli VM, Krzyzaniak R, Vroon DH, Newton JL: Fluorometric assay of antithrombin III. Diagnostic value in 112 patients with abnormal hemostasis. Am J Clin Pathol; 1985 Aug;84(2):173-9
MedlinePlus Health Information. consumer health - Bleeding Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fluorometric assay of antithrombin III. Diagnostic value in 112 patients with abnormal hemostasis.
  • The authors assessed the diagnostic value of the plasma anti-thrombin III (AT III) assay in 112 adult hospitalized patients with abnormal hemostatic parameters, using the Protopath procedure.
  • The authors conclude that the assay cannot distinguish among disease categories, although it is a sensitive index of DIC.
  • The results suggest enhancement of the diagnostic and prognostic value of the assay with serial testing.

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  • (PMID = 4025221.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 9000-94-6 / Antithrombin III
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62. Gulyás M, Kaposi AD, Elek G, Szollár LG, Hjerpe A: Value of carcinoembryonic antigen (CEA) and cholesterol assays of ascitic fluid in cases of inconclusive cytology. J Clin Pathol; 2001 Nov;54(11):831-5
Hazardous Substances Data Bank. CHOLESTEROL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of carcinoembryonic antigen (CEA) and cholesterol assays of ascitic fluid in cases of inconclusive cytology.
  • AIM: To determine whether assays of carcinoembryonic antigen (CEA) and cholesterol in ascites add diagnostic value to cytology.
  • METHODS: The additional diagnostic efficacy of the biochemical assays was studied in the ascitic fluid from 130 patients, of whom 57 had peritoneal carcinomatosis.
  • However, increased values were significantly more common in cancer with peritoneal involvement (p < 0.01), giving a sensitivity of 51% and specificity of 97% for carcinomatosis.
  • A cholesterol value exceeding 1.21 mmol/litre was found in 93% of cancers with peritoneal involvement, but it was not entirely specific (96%) for carcinomatosis.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Predictive Value of Tests. ROC Curve. Reference Values

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  • (PMID = 11684715.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 97C5T2UQ7J / Cholesterol
  • [Other-IDs] NLM/ PMC1731306
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63. Wolf P, Hartl F, Brischwein M, Wolf B: Determination of dynamic doxorubicin-EC50 value in an automated high-content workstation for cellular assays. Toxicol In Vitro; 2011 Dec;25(8):1889-94
Hazardous Substances Data Bank. DOXORUBICIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Determination of dynamic doxorubicin-EC50 value in an automated high-content workstation for cellular assays.
  • To overcome the problems of endpoint tests routinely required for EC50 determination, we utilized a novel automated high-content workstation and calculated a time-resolved EC50 value of MCF-7 mamma carcinoma cells treated with a pharmacologic agent.
  • In particular, the objective was to compare the measuring data of the workstation with a classical standard resazurin cell assay and to transfer the benefit of continuously recorded metabolic data of the workstation to practical time-resolved information about the effect of the applied active reagent (doxorubicin).
  • MCF-7 cells were treated with a broad range of doxorubicin concentrations (100 μM to 1 nM) over 24 h and cellular activities were investigated with both, the resazurin assay and the automated workstation.
  • Twenty-four hours after treatment, the resazurin assay showed an EC50 value (6.3 μM) which was about one decade above the value obtained from oxygen consumption rate (0.37 μM) and extracellular acidification rate (0.72 μM), measured with the workstation.
  • [MeSH-major] Antibiotics, Antineoplastic / pharmacology. Doxorubicin / pharmacology. Drug Evaluation, Preclinical / methods. High-Throughput Screening Assays / methods

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  • [Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.
  • (PMID = 21693178.001).
  • [ISSN] 1879-3177
  • [Journal-full-title] Toxicology in vitro : an international journal published in association with BIBRA
  • [ISO-abbreviation] Toxicol In Vitro
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Indicators and Reagents; 0 / Oxazines; 0 / Xanthenes; 1FN9YD6968 / resazurin; 80168379AG / Doxorubicin
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64. Walmsley S, O'Rourke K, Mortimer C, Rachlis A, Fong I, Mazzulli T: Predictive value of cytomegalovirus (CMV) antigenemia and digene hybrid capture DNA assays for CMV disease in human immunodeficiency virus-infected patients. Clin Infect Dis; 1998 Sep;27(3):573-81
MedlinePlus Health Information. consumer health - HIV/AIDS and Infections.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive value of cytomegalovirus (CMV) antigenemia and digene hybrid capture DNA assays for CMV disease in human immunodeficiency virus-infected patients.
  • We evaluated urine and peripheral blood mononuclear cell cultures, a qualitative and quantitative antigenemia assay, and a commercially available CMV DNA hybridization assay for their ability to predict CMV disease in 138 HIV-infected patients.
  • The sensitivity, specificity, positive predictive value, negative predictive value, and mean lead times for the antigenemia assay (with use of a threshold of 8 positive cells per 10(5) peripheral blood mononuclear cells as a positive) were 74%, 91%, 63%, 95%, and 95 days, respectively.
  • Corresponding figures for the DNA hybridization assay were 91%, 64%, 34%, 97%, and 152 days.
  • These assays can identify patients at increased risk of CMV disease and should allow a strategy of preemptive therapy to be tested.
  • [MeSH-minor] Adult. Cohort Studies. Female. Humans. Leukocyte Count. Male. Nucleic Acid Hybridization. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 9770159.001).
  • [ISSN] 1058-4838
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / DNA, Viral
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65. Berger DP, Henss H, Winterhalter BR, Fiebig HH: The clonogenic assay with human tumor xenografts: evaluation, predictive value and application for drug screening. Ann Oncol; 1990 Sep;1(5):333-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clonogenic assay with human tumor xenografts: evaluation, predictive value and application for drug screening.
  • The feasibility, evaluation and predictive value of the colony-forming assay with human tumor xenografts for screening anticancer drugs have been studied.
  • Based on in vitro growth characteristics, a quality-controlled assay protocol was developed.
  • With the proposed criteria for standardized evaluation of individual experiments a substantial increase in assay reliability was achieved.
  • The five clinically established agents, cisplatin, doxorubicin, etoposide, mitomycin-C and vindesine, were studied for anticancer activity in the clonogenic assay.
  • The predictive value of the clonogenic assay was determined by treatment of the same tumors in vitro and in vivo in tumor-bearing nude mice.

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  • (PMID = 2261375.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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66. Harper PL, Theakston E, Ahmed J, Ockelford P: D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly. Intern Med J; 2007 Sep;37(9):607-13
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  • [Title] D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly.
  • BACKGROUND: The D-dimer assay is used as an exclusion test in the assessment of suspected venous thromboembolic disease; patients with a negative result have a low probability of thrombosis.
  • We reviewed the D-dimer results from a hospital and community laboratory using the vidas D-dimer test to assess the influence of age on the D-dimer assay.
  • To test the effect of age on the assay specificity, a cohort of 1897 patients with suspected venous thromboembolic disease was analysed separately.
  • RESULTS: The assay specificity decreased with age from 70% in patients less than 40 years to below 5% in patients more than 80 years.
  • Receiver operator curves were prepared for each age group and the effect of altering the threshold value was analysed.
  • In patients 60-80 years old a threshold value of 1000 ng/mL increased assay specificity to 55% without loss of assay sensitivity.
  • CONCLUSION: The vidas D-dimer assay with a threshold value of 500 ng/mL has little clinical value as an exclusion test in patients more than 80 years old.
  • The assay specificity is poor (26%) in patients aged 60-80 years but could be improved by increasing the threshold value to 1000 ng/mL.

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  • [CommentIn] Intern Med J. 2008 Mar;38(3):222-5 [18290823.001]
  • (PMID = 17543005.001).
  • [ISSN] 1445-5994
  • [Journal-full-title] Internal medicine journal
  • [ISO-abbreviation] Intern Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Fibrin Fibrinogen Degradation Products; 0 / fibrin fragment D
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67. Lafeuillade A, Delbeke E, Chaffanjon P, Aubert L, Dhiver C, Gastaut JA, Quilichini R: [Value of anticardiolipin antibody assay in human immunodeficiency virus infection]. Presse Med; 1990 Jun 30;19(26):1225-7
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  • [Title] [Value of anticardiolipin antibody assay in human immunodeficiency virus infection].
  • Recently published encouraging data concerning the value of anticardiolipin antibody assays in patients with HIV infection, both for prognostic purposes and to diagnose pneumocystosis, have prompted us to evaluate these assays in a series of 116 patients.
  • The value and the possible physiopathological role of these antibodies in patients with HIV infection should be reconsidered.
  • [MeSH-minor] Adult. Aged. Autoantibodies / immunology. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Prospective Studies. Toxoplasmosis / complications

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  • (PMID = 2142772.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Cardiolipins
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68. Duriseti RS, Shachter RD, Brandeau ML: Value of quantitative D-dimer assays in identifying pulmonary embolism: implications from a sequential decision model. Acad Emerg Med; 2006 Jul;13(7):755-66
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  • [Title] Value of quantitative D-dimer assays in identifying pulmonary embolism: implications from a sequential decision model.
  • OBJECTIVES: To examine the cost-effectiveness of a quantitative D-dimer assay for the evaluation of patients with suspected pulmonary embolism (PE) in an urban emergency department (ED).
  • METHODS: The authors analyzed different diagnostic strategies over pretest risk categories on the basis of Wells criteria by using the performance profile of the ELISA D-dimer assay (over five cutoff values) and imaging strategies used in the ED for PE: compression ultrasound (CUS), ventilation-perfusion (VQ) scan (over three cutoff values), CUS with VQ (over three cutoff values), computed tomography (CT) angiogram (CTA) with pulmonary portion (CTP) and lower-extremity venous portion, and CUS with CTP.
  • CONCLUSIONS: In patients in whom PE is suspected, when CTA is available, even the most sensitive quantitative D-dimer assay is not likely to be cost-effective.
  • When CTA is not available or if its performance is markedly degraded, use of the D-dimer assay has value in combination with CUS and a pulmonary imaging study.

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  • (PMID = 16723725.001).
  • [ISSN] 1553-2712
  • [Journal-full-title] Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
  • [ISO-abbreviation] Acad Emerg Med
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Fibrinogen Degradation Products; 0 / fibrin fragment D
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69. Le Saché-de Peufeilhoux L, Ingen-Housz-Oro S, Hue S, Sbidian E, Valeyrie-Allanore L, Ortonne N, Roujeau JC, Wolkenstein P, Chosidow O, André C: The value of BP230 enzyme-linked immunosorbent assay in the diagnosis and immunological follow-up of bullous pemphigoid. Dermatology; 2012;224(2):154-9
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  • [Title] The value of BP230 enzyme-linked immunosorbent assay in the diagnosis and immunological follow-up of bullous pemphigoid.
  • BACKGROUND: The value of 230-kDa bullous pemphigoid antibody (BP230) enzyme-linked immunosorbent assay (ELISA) for the diagnosis of bullous pemphigoid (BP) was investigated, but in the immunological follow-up of the disease remains unknown.
  • [MeSH-major] Autoantibodies / blood. Enzyme-Linked Immunosorbent Assay. Membrane Glycoproteins / immunology. Pemphigoid, Bullous / diagnosis. Pemphigoid, Bullous / immunology

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  • [Copyright] Copyright © 2012 S. Karger AG, Basel.
  • (PMID = 22516798.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Carrier Proteins; 0 / Cytoskeletal Proteins; 0 / DST protein, human; 0 / Membrane Glycoproteins; 0 / Nerve Tissue Proteins; 9242ECW6R0 / mycophenolate mofetil; ADN79D536H / Clobetasol; HU9DX48N0T / Mycophenolic Acid; YL5FZ2Y5U1 / Methotrexate
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70. Delpont PJ, Ruf H, Blanc B, Gamerre M, Adrai J, Conte M, Dupont S, Bellia-Rousseau J: [Value of the radioimmunological assay of HCG and its subunits in the diagnosis and follow-up of gestational trophoblastic disease]. Rev Fr Gynecol Obstet; 1985 Oct;80(10):737-52
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  • [Title] [Value of the radioimmunological assay of HCG and its subunits in the diagnosis and follow-up of gestational trophoblastic disease].
  • The value of the assay of the sub-units of human chorionic gonadotrophin in the diagnosis and follow-up of trophoblastic disease is generally recognised.

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  • (PMID = 2417299.001).
  • [ISSN] 0035-290X
  • [Journal-full-title] Revue française de gynécologie et d'obstétrique
  • [ISO-abbreviation] Rev Fr Gynecol Obstet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] FRANCE
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / Glycoprotein Hormones, alpha Subunit; 0 / Peptide Fragments
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71. Hodgson MI, Pantoja H, Latorre JJ, Vial P, Henríquez A, Wenger J, Peña A, Siri MT, Guiraldes E: Helicobacter pylori-associated gastroduodenal disease in symptomatic Chilean children: diagnostic value of serological assay. J Pediatr Gastroenterol Nutr; 1995 Oct;21(3):263-8
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  • [Title] Helicobacter pylori-associated gastroduodenal disease in symptomatic Chilean children: diagnostic value of serological assay.
  • A newly developed enzyme-linked immunosorbent assay (ELISA) IgG serological assay for the diagnosis of Helicobacter pylori infection was used recently in two epidemiological surveys in Chile.
  • To evaluate the diagnostic efficacy of this assay in a local symptomatic pediatric population, we studied 70 school-age patients referred for upper gastrointestinal endoscopy because of complaints suggestive of gastroduodenal disease.
  • This group had significantly higher mean IgG optical density values when compared with the H. pylori-negative group (1.860 versus 0.669; p < 0.001).
  • The sensitivity and specificity of the assay in detecting antral H. pylori were both 90%; the positive predictive value was 98% and the negative, 60%.
  • Accuracy of the assay was superior in predicting the presence or absence of gastroduodenal lesions with a sensitivity of 96%, a specificity of 92%, a positive predictive value of 98%, and a negative predictive value of 86%.
  • We conclude that the diagnostic efficiency of this assay renders it appropriate both to screen for H. pylori-associated gastroduodenal disease in individual patients and to be used in seroepidemiological surveys.
  • [MeSH-minor] Adolescent. Antibodies, Bacterial / blood. Child. Chile. Duodenal Ulcer / microbiology. Enzyme-Linked Immunosorbent Assay. Female. Gastritis / diagnosis. Humans. Immunoglobulin G / blood. Male

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  • (PMID = 8523209.001).
  • [ISSN] 0277-2116
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Immunoglobulin G
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72. Northam BE, Smith JH, Fitzgerald MG, Nattrass M, Wright AD: Value of serum glucose assay as part of the biochemical profile in screening for diabetes. Ann Clin Biochem; 1982 Nov;19(6):412-5
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  • [Title] Value of serum glucose assay as part of the biochemical profile in screening for diabetes.
  • The value of adding serum glucose assay to the 'biochemical profile' was assessed by a detailed follow-up of all inpatients with serum glucose concentrations of 10 mmol/l or more.

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  • (PMID = 7159009.001).
  • [ISSN] 0004-5632
  • [Journal-full-title] Annals of clinical biochemistry
  • [ISO-abbreviation] Ann. Clin. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Blood Glucose
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73. Echenique-Robba P, Nelo-Bazán MA, Carrodeguas JA: Reducing the standard deviation in multiple-assay experiments where the variation matters but the absolute value does not. PLoS One; 2013;8(10):e78205
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reducing the standard deviation in multiple-assay experiments where the variation matters but the absolute value does not.
  • When the value of a quantity x for a number of systems (cells, molecules, people, chunks of metal, DNA vectors, so on) is measured and the aim is to replicate the whole set again for different trials or assays, despite the efforts for a near-equal design, scientists might often obtain quite different measurements.
  • This work presents a novel correction method of a very low mathematical and numerical complexity that can reduce the standard deviation of such results and increase their statistical significance.
  • Two conditions are to be met: the inter-system variations of x matter while its absolute value does not, and a similar tendency in the values of x must be present in the different assays (or in other words, the results corresponding to different assays must present a high linear correlation).
  • [MeSH-major] Biological Assay / methods

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  • [Cites] J Biol Chem. 1999 Nov 12;274(46):32543-6 [10551805.001]
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  • (PMID = 24205158.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MTCH1 protein, human; 0 / Membrane Proteins; 0 / Mitochondrial Proteins
  • [Other-IDs] NLM/ PMC3813515
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74. Nikolaisen C, Rekvig OP, Nossent HC: Rheumatoid factor by laser nephelometry and Waaler-Rose assay: prognostic value in patients with recent-onset rheumatoid arthritis. Scand J Rheumatol; 2005 Jul-Aug;34(4):269-76
MedlinePlus Health Information. consumer health - Rheumatoid Arthritis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rheumatoid factor by laser nephelometry and Waaler-Rose assay: prognostic value in patients with recent-onset rheumatoid arthritis.
  • OBJECTIVE: To evaluate the prognostic value of rheumatoid factor (RF), detected in the Waaler-Rose agglutination assay and by nephelometry, in patients with recent-onset rheumatoid arthritis (RA).

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  • (PMID = 16195159.001).
  • [ISSN] 0300-9742
  • [Journal-full-title] Scandinavian journal of rheumatology
  • [ISO-abbreviation] Scand. J. Rheumatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Antirheumatic Agents; 0 / Biomarkers; 9009-79-4 / Rheumatoid Factor
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75. Eissa S, Azzazy HM, Matboli M, Shawky SM, Said H, Anous FA: The prognostic value of histidine-rich glycoprotein RNA in breast tissue using unmodified gold nanoparticles assay. Appl Biochem Biotechnol; 2014 Sep;174(2):751-61
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  • [Title] The prognostic value of histidine-rich glycoprotein RNA in breast tissue using unmodified gold nanoparticles assay.
  • The aim of is this study is to explore the role of tissue histidine-rich glycoprotein (HRG) RNA as a promising clinically useful biomarker for breast cancer patients prognosis using nanogold assay.
  • The developed HRG AuNPs assay had a sensitivity and a specificity of 90 %, and a detection limit of 1.5 nmol/l.
  • The concordance rate between the HRG AuNPs assay with RT-PCR after RNA purification using magnetic nanoparticles was 93.3 %.
  • HRG RNA is an independent prognostic marker for breast cancer and can be detected using gold NPs assay, which is rapid, sensitive, specific, inexpensive to extend the value for breast cancer prognosis.

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  • (PMID = 25091325.001).
  • [ISSN] 1559-0291
  • [Journal-full-title] Applied biochemistry and biotechnology
  • [ISO-abbreviation] Appl. Biochem. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Proteins; 0 / histidine-rich proteins; 63231-63-0 / RNA; 7440-57-5 / Gold
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76. Gudjónsson S, Isfoss BL, Hansson K, Domanski AM, Warenholt J, Soller W, Lundberg LM, Liedberg F, Grabe M, Månsson W: The value of the UroVysion assay for surveillance of non-muscle-invasive bladder cancer. Eur Urol; 2008 Aug;54(2):402-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of the UroVysion assay for surveillance of non-muscle-invasive bladder cancer.
  • All patients were investigated by cystoscopy, cytology, and UV assay.
  • The UV assay was evaluated with regards to sensitivity, specificity, and positive predictive value for tumour recurrence.
  • CONCLUSIONS: The UV assay cannot replace cystoscopy for surveillance of patients with non-muscle-invasive bladder cancer, but it may be valuable as a supplement to traditional measures for detecting CIS.

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  • [CommentIn] Eur Urol. 2008 Aug;54(2):407-8 [18082933.001]
  • [CommentIn] Eur Urol. 2009 Feb;55(2):e29 [18692953.001]
  • [CommentIn] Eur Urol. 2008 Aug;54(2):408 [18082932.001]
  • (PMID = 18082934.001).
  • [ISSN] 1873-7560
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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77. Ohnuma K, Hayashi N, Fukuzumi N, Saito A, Tanaka M, Kumagai S, Kawano S: [Evaluation of cut-off value for autoantibodies against double-stranded DNA-complexed nucleosomes based on enzyme linked immunosorbent assay]. Rinsho Byori; 2014 Mar;62(3):223-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Evaluation of cut-off value for autoantibodies against double-stranded DNA-complexed nucleosomes based on enzyme linked immunosorbent assay].
  • The new classification criteria for systemic lupus erythematosus (SLE) by Systemic Lupus International Collaborating Clinics (SLICC) published in 2012 have defined positive level titer of antibody against double stranded (ds) DNA as more than double the reference range if tested by enzyme linked immunosorbent assay (ELISA).
  • The aim of this study was to evaluate optimal cut-off value and diagnostic performance of the anti-dsDNA nucleosome-complexed (anti-dsDNA-NcX) ELISA, which uses salmon testis DNA complexed with purified nucleosomes as antigens, for diagnosis of SLE.
  • Receiver operating characteristic curve analysis showed that the titer of 44 IU/mL calculated as 99 percentile of 323 healthy volunteers is a better cut-off value for anti-dsDNA-NcX than the 100 IU/mL recommended by the manufacturer.
  • By setting the cut-off value at 44 IU/mL, anti-dsDNA-NcX showed the highest sensitivity (75.0%) and specificity (90.5%) of the 3 assays.
  • In conclusion, anti-dsDNA-NcX has a good diagnostic performance for SLE with our proposed cut-off value of 44 IU/mL.
  • [MeSH-major] Antibodies, Antinuclear / blood. DNA / immunology. Enzyme-Linked Immunosorbent Assay / methods. Nucleosomes / metabolism

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  • (PMID = 24800496.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Nucleosomes; 9007-49-2 / DNA
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78. Chen ZX, Wang Q, Zheng L, Bao J: [Clinical value of an improved ischemia-modified albumin assay in the diagnosis of early acute myocardial infarction]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Jul;29(7):1378-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical value of an improved ischemia-modified albumin assay in the diagnosis of early acute myocardial infarction].
  • OBJECTIVE: To assess the value of an improved ischemia modified albumin (IMA) assay in the diagnosis of early acute myocardial infarction (AMI).
  • Receiver operator characteristic curve (ROC curve) was used to evaluate the optimal cut-off value of the assay.
  • The area under the receiver of ROC curve was 0.947, and at the cut-off value of 0.906 ABSU, the sensitivity and specificity of the assay were 93.0% and 82.9%, respectively.
  • CONCLUSION: The improved IMA assay shows good value in early diagnosis of AMI in patients with acute chest pain.

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  • (PMID = 19620058.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Serum Albumin; 0 / Troponin T; 0 / ischemia-modified albumin
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79. Sasaki K, Shintani H, Itoh J, Kamogawa T, Kajihara Y: Effect of calcium in assay medium on D value of Bacillus stearothermophilus ATCC 7953 spores. Appl Environ Microbiol; 2000 Dec;66(12):5509-13
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of calcium in assay medium on D value of Bacillus stearothermophilus ATCC 7953 spores.
  • The D value of commercial biological indicator spore strips using Bacillus stearothermophilus ATCC 7953 was increased by higher calcium concentrations in assay media.
  • The calcium concentration in assay media varied among the manufacturers.
  • The calcium concentration in assay media is an important factor to consider to minimize the variation of D value.

  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
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  • [Cites] Appl Microbiol. 1965 Nov;13(6):851-7 [4956036.001]
  • [Cites] Appl Microbiol. 1965 Nov;13(6):993-9 [5866047.001]
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  • (PMID = 11097939.001).
  • [ISSN] 0099-2240
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Culture Media; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC92493
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80. Azzaraà A, Chimenti M, Carulli G, Rizzuti-Gullaci A, Ambrogi F: An image processing procedure for the assessment of normality curves of motility of human granulocytes in micropore filters. Scand J Clin Lab Invest; 1995 Aug;55(5):399-408

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • With the conventional methods used in current practice, the results of human granulocyte motility assays are expressed by a numerical value that defines the leading front of cells into micropore filters.

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  • (PMID = 8545598.001).
  • [ISSN] 0036-5513
  • [Journal-full-title] Scandinavian journal of clinical and laboratory investigation
  • [ISO-abbreviation] Scand. J. Clin. Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] NORWAY
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81. Zrimsek P, Kosec M, Kunc J, Mrkun J: Determination of the diagnostic value of the resazurin reduction assay for evaluating boar semen by receiver operating characteristic analysis. Asian J Androl; 2006 May;8(3):343-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Determination of the diagnostic value of the resazurin reduction assay for evaluating boar semen by receiver operating characteristic analysis.
  • METHODS: The accuracy of the spectrophotometric application of the resazurin reduction assay was assessed using receiver operating characteristic (ROC) analysis.
  • The assay was less accurate when motile sperm concentration was used as the criterion value, yielding sensitivity of 88.2% and specificity of 87.5%, respectively.
  • CONCLUSION: These results show that the resazurin reduction assay combined with spectrophotometry is an accurate method of assessing the quality of boar semen.

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  • (PMID = 16625285.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Oxazines; 0 / Xanthenes; 1FN9YD6968 / resazurin
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82. Juchet H, Fonquernie L, Ollier S, Oksman F, Arlet P: [Positive predictive value of thrombotic complication from the assay of anticardiolipin antibodies. Apropos of systematic assays in 111 patients]. Rev Med Interne; 1993;14(10):1027
MedlinePlus Health Information. consumer health - Blood Clots.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Positive predictive value of thrombotic complication from the assay of anticardiolipin antibodies. Apropos of systematic assays in 111 patients].

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  • (PMID = 8009023.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antibodies, Anticardiolipin; 0 / Biomarkers
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83. Cauchon N, Leduy A: Effect of dilution on carboxymethylcellulase and xylanase assays. Biotechnol Bioeng; 1984 Aug;26(8):988-91
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of dilution on carboxymethylcellulase and xylanase assays.
  • It has been demonstrated that the dilution of samples prior to the carboxymethylcellulase and xylanase assays causes serious discrepancies in the numerical values obtained for the enzyme activities.
  • Even when the sample is assayed with the identical procedure, one could obtain different numerical values of the enzyme activity U depending on how much this sample has been diluted before the enzyme assay.

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  • (PMID = 18553487.001).
  • [ISSN] 0006-3592
  • [Journal-full-title] Biotechnology and bioengineering
  • [ISO-abbreviation] Biotechnol. Bioeng.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Buera MP, Pilosof AM, Bartholomai GB: [Rapid storage assay for the study of the loss of nutritive value of bean flour (Phaseolus vulgaris) proteins]. Arch Latinoam Nutr; 1984 Jun;34(2):376-83
Hazardous Substances Data Bank. L-Lysine .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Rapid storage assay for the study of the loss of nutritive value of bean flour (Phaseolus vulgaris) proteins].
  • The loss of the nutritive value of bean flour protein was studied through a kinetic assay on the loss of available lysine of the flour at high temperatures (70-110 degrees C) and at different moisture contents.
  • Kinetic parameters at high temperatures were used to predict the retention of available lysine at 34 degrees C; these values were in accordance with those obtained by storing bean flour with different moisture contents, at 34 degrees C.

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  • (PMID = 6443064.001).
  • [ISSN] 0004-0622
  • [Journal-full-title] Archivos latinoamericanos de nutrición
  • [ISO-abbreviation] Arch Latinoam Nutr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] VENEZUELA
  • [Chemical-registry-number] 0 / Vegetable Proteins; K3Z4F929H6 / Lysine
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85. Zhang XY, Zhao SY, Jiang ZF: [Value of serum galactomannan assay in the diagnosis of pediatric invasive pulmonary aspergillosis]. Zhonghua Er Ke Za Zhi; 2009 Feb;47(2):83-6
Genetic Alliance. consumer health - Aspergillosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of serum galactomannan assay in the diagnosis of pediatric invasive pulmonary aspergillosis].
  • Many studies suggest that serum galactomannan assay has an excellent sensitivity and specificity for the early diagnosis of adult invasive aspergillosis (IA).
  • However, there have been few studies on serum galactomannan assay in pediatric patients.
  • Therefore, we evaluate the value of serum galactomannan assay in the diagnosis of pediatric invasive pulmonary aspergillosis in this study.
  • If the cut-off GM ODI was set at 0.5, the sensitivity and specificity of the assay for IPA were 71.4% and 91.9% respectively.

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  • (PMID = 19573449.001).
  • [ISSN] 0578-1310
  • [Journal-full-title] Zhonghua er ke za zhi = Chinese journal of pediatrics
  • [ISO-abbreviation] Zhonghua Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mannans; 11078-30-1 / galactomannan
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86. Berk JE, Ayulo JA, Fridhandler L: Value of pancreatic-type isoamylase assay as an index of pancreatic insufficiency. Dig Dis Sci; 1979 Jan;24(1):6-10
MedlinePlus Health Information. consumer health - Pancreatic Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of pancreatic-type isoamylase assay as an index of pancreatic insufficiency.
  • The study here reported was undertaken to assess the value of assay of the specific isoamylase form arising from the pancreas (P-type) as an index of pancreatic exocrine insufficiency.
  • Abnormally low values for P-type isoamylase in the serum and urine of these patients were infrequent.
  • Conversely, values within the normal ranges for serum P-type isoamylase and Upam/Ucr were common.
  • It is concluded that while subnormal values for P-type isoamylase in the serum and urine may be viewed as supportive evidence for pancreatic insufficiency, failure to find such values does not exclude this condition.
  • [MeSH-minor] Creatinine / urine. Evaluation Studies as Topic. Humans. Reference Values

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  • [Cites] J Lab Clin Med. 1977 Jul;90(1):141-52 [874365.001]
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  • (PMID = 428291.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; AYI8EX34EU / Creatinine; EC 3.2.1.- / Glycoside Hydrolases; EC 3.2.1.68 / Isoamylase
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87. Marinović B, Fabris Z, Lipozencić J, Stulhofer Buzina D, Lakos Jukić I: Comparison of diagnostic value of indirect immunofluorescence assay and desmoglein ELISA in the diagnosis of pemphigus. Acta Dermatovenerol Croat; 2010;18(2):79-83
MedlinePlus Health Information. consumer health - Pemphigus.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of diagnostic value of indirect immunofluorescence assay and desmoglein ELISA in the diagnosis of pemphigus.
  • In the present study, the value of indirect immunofluorescence (IIF) and enzyme linked immunosorbent assay (ELISA) for desmoglein 1 (Dsg 1) and desmoglein 3 (Dsg 3) at baseline visit was compared.
  • [MeSH-major] Enzyme-Linked Immunosorbent Assay. Fluorescent Antibody Technique, Indirect. Pemphigus / diagnosis
  • [MeSH-minor] Cohort Studies. Desmoglein 1 / metabolism. Desmoglein 3 / metabolism. Female. Humans. Male. Predictive Value of Tests. Reproducibility of Results. Retrospective Studies

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  • (PMID = 20624356.001).
  • [ISSN] 1847-6538
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Desmoglein 1; 0 / Desmoglein 3
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88. van Heemst J, Trouw LA, Nogueira L, van Steenbergen HW, van der Helm-van Mil AH, Allaart CF, Serre G, Holmdahl R, Huizinga TW, Toes RE, van der Woude D: An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting. Arthritis Res Ther; 2015;17:276
MedlinePlus Health Information. consumer health - Rheumatoid Arthritis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting.
  • Such assays are designed for exploratory studies.
  • The interpretation of positive antibody reactivities can best be made if the diagnostic and prognostic value of a multiplex array in an early arthritis setting is known and if the multiplex-positive patients who are negative according to three commonly used commercial ACPA assays are characterized.
  • Findings were compared with results primarily of the anti-citrullinated cyclic peptide 2 (anti-CCP-2) assay but also with anti- CCP-3 and anti-mutated citrullinated vimentin (anti-MCV) assays.
  • RESULTS: Thirty-one percent of anti-CCP-2-negative RA patients displayed reactivity toward citrullinated peptides in the multiplex assay.
  • The presence of residual citrulline reactivities detected by this multiplex system in arthritis patients who are negative in commercial ACPA assays needs to be interpreted with caution.
  • [MeSH-minor] Cohort Studies. Early Diagnosis. Enzyme-Linked Immunosorbent Assay / methods. Humans. Prognosis. Reproducibility of Results. Sensitivity and Specificity. Vimentin / immunology

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  • Genetic Alliance. consumer health - Rheumatoid arthritis.
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  • (PMID = 26437716.001).
  • [ISSN] 1478-6362
  • [Journal-full-title] Arthritis research & therapy
  • [ISO-abbreviation] Arthritis Res. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Peptides, Cyclic; 0 / Vimentin; 0 / cyclic citrullinated peptide; 29VT07BGDA / Citrulline
  • [Other-IDs] NLM/ PMC4595184
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89. Yuan K, Liang D, Wu XQ, Yao ZS, Jin DX, Yang ZD, Zhang SC, Ding JY, Jiang XB, Chen JT: Diagnostic value of enzyme-linked immunospot assay using CFP10/ESAT6 fusion protein as antigen in spinal tuberculosis. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2015 Feb;37(1):44-9
Genetic Alliance. consumer health - Tuberculosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of enzyme-linked immunospot assay using CFP10/ESAT6 fusion protein as antigen in spinal tuberculosis.
  • OBJECTIVE: To establish a method of detecting spinal tuberculosis (TB) infection by enzyme-linked immunospot (ELlSPOT) assay and evaluate the value of CFP10/ESAT6 fusion protein for diagnosis of spinal TB.
  • Among the spinal TB patients and non-TB disease patients,the overall sensitivity, specificity, positive predictive value, and negative predictive value of the ELISPOT assay in spinal TB diagnosis were 82.7%,87.2%,89.6%, and 79.1%,respectively; the 4 indexes of the PPD skin test were 61.5%, 46.2%, 60.4%, and 47.4%, respectively;those of the antibody detection were 55.8%, 61.5%, 65.9%, and 51.1%.
  • Moderate agreement was found between pathological examination and the ELISPOT assay (87.2%, Κ=0.498, P=0.001).
  • CONCLUSION: With high sensitivity and specificity, the ELISPOT assay using CFP10/ESAT6 fusion protein as antigen is an effective technique for auxiliary diagnosis of spinal TB.
  • [MeSH-minor] Antigens. Enzyme-Linked Immunospot Assay. Humans. Recombinant Fusion Proteins

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  • (PMID = 25676269.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens; 0 / ESAT-6-CFP10 fusion protein; 0 / Recombinant Fusion Proteins
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90. Chan EC, Wee PY, Ho PC: The value of analytical assays that are stability-indicating. Clin Chim Acta; 1999 Oct;288(1-2):47-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of analytical assays that are stability-indicating.
  • It is essential to validate an assay with regards to its precision, accuracy, reproducibility, selectivity and robustness.
  • In pharmaceutical research, in addition to these requirements, an assay is often required to be proven beyond doubt to be stability-indicating.
  • A stability-indicating assay is one that can accurately and selectively differentiate an intact drug from its potential decomposition products.
  • An assay that fails to meet this requirement would produce stability data that are inaccurate and misleading.
  • In this study, we employed an amperometric HPLC assay developed for the measurements of urinary catecholamines and metanephrines to illustrate the validation process of this assay with regards to its stability-indicating capacity.

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  • (PMID = 10529457.001).
  • [ISSN] 0009-8981
  • [Journal-full-title] Clinica chimica acta; international journal of clinical chemistry
  • [ISO-abbreviation] Clin. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Catecholamines; 5001-33-2 / Metanephrine
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91. Washburn KE, Bissett WT, Waldron DF, Fajt VR: Serologic and bacteriologic culture prevalence of Corynebacterium pseudotuberculosis infection in goats and sheep and use of Bayesian analysis to determine value of assay results for prediction of future infection. J Am Vet Med Assoc; 2013 Apr 1;242(7):997-1002

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serologic and bacteriologic culture prevalence of Corynebacterium pseudotuberculosis infection in goats and sheep and use of Bayesian analysis to determine value of assay results for prediction of future infection.
  • OBJECTIVE: To determine the serologic and bacteriologic culture prevalence of Corynebacterium pseudotuberculosis infection in sheep and goats and the value of such assays for prediction of future development of caseous lymphadenitis (CL).
  • The value of assays for prediction of future development of CL lesions was determined.
  • [MeSH-minor] Animals. Bayes Theorem. Goats. Predictive Value of Tests. Sheep

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  • (PMID = 23517214.001).
  • [ISSN] 1943-569X
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Villena V, López-Encuentra A, Echave-Sustaeta J, Martín-Escribano P, Ortuño-de-Solo B, Estenoz-Alfaro J: Diagnostic value of CA 72-4, carcinoembryonic antigen, CA 15-3, and CA 19-9 assay in pleural fluid. A study of 207 patients. Cancer; 1996 Aug 15;78(4):736-40
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of CA 72-4, carcinoembryonic antigen, CA 15-3, and CA 19-9 assay in pleural fluid. A study of 207 patients.
  • Several tumor markers have been evaluated in pleural fluid, but the value of CA 72-4 assay and of combinations of tumor marker assays has not been firmly established.
  • To find a minimally invasive tool for differentiating between pleural effusions of malignant or benign origin, the authors assessed the diagnostic value of CA 72-4, carcinoembryonic antigen (CEA), CA 15-3, and CA 19-9 assays in pleural fluid individually and in combination.
  • RESULTS: CA 72-4 assay in pleural fluid had an acceptable sensitivity and very good specificity for diagnosing malignant pleural effusion.
  • The combination of CA 72-4 plus CEA plus CA 15-3 yielded the best accuracy, 0.90 (95% confidence interval [CI] 0.85-0.94), with a sensitivity of 0.78 (95% CI, 0.67-0.88), specificity of 0.95 (95% CI, 0.90-0.98), positive predictive value of 0.88 (95% CI, 0.77-0.95), and negative predictive value of 0.91 (range, 0.85-0.94).
  • A good clinical strategy may be to begin with a CEA assay (specificity of I) and then, if it is negative, to add CA 15-3 or even CA 72-4 assays to improve sensitivity.
  • CONCLUSIONS: Assays of CEA, CA 72-4, and CA 15-3 in pleural fluid, or the combination of CEA with CA 15-3 and CA 72-4, was useful in differentiating between pleural effusion of malignant and benign origin.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. CA-19-9 Antigen / analysis. Diagnosis, Differential. Female. Humans. Male. Mesothelioma / chemistry. Mesothelioma / diagnosis. Middle Aged. Mucin-1 / analysis. Neoplasms / chemistry. Neoplasms / diagnosis. Predictive Value of Tests. Prospective Studies. ROC Curve

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  • (PMID = 8756365.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / CA-72-4 antigen; 0 / Carcinoembryonic Antigen; 0 / Mucin-1
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93. Do ultrasensitive assays have clinical value? HIV Hotline; 1998 Mar;8(1):3
MedlinePlus Health Information. consumer health - HIV/AIDS.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Do ultrasensitive assays have clinical value?
  • Three new viral load assays with much higher sensitivities have reached the market.
  • These assays can now detect down to 40 copies/mL of virus.
  • The question of whether these ultrasensitive assays further the management of HIV disease is unanswered.
  • This is the question to be considered when deciding whether the new assays are cost effective in a clinical setting.

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  • (PMID = 11365358.001).
  • [Journal-full-title] HIV hotline
  • [ISO-abbreviation] HIV Hotline
  • [Language] eng
  • [Publication-type] Newspaper Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / DNA, Viral
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94. Tsibul'kin AP, Khaertynova IM, Gerasimova CV, Khaertynov KS: [The diagnostic value of enzyme-linked immunosorbent assay technique in detection of anti-tuberculosis antibodies in groups of patients with HIV-positive and HIV-negative reaction]. Klin Lab Diagn; 2013 Dec;(12):41-4
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  • [Title] [The diagnostic value of enzyme-linked immunosorbent assay technique in detection of anti-tuberculosis antibodies in groups of patients with HIV-positive and HIV-negative reaction].
  • The article analyzes the results of evaluation of diagnostic value of enzyme-linked immunosorbent assay for detection of antituberculosis antibodies with purpose to diagnose tuberculosis of lungs separately in groups of both HIV-positive and HIV-negative persons.
  • A moderate diagnostic value of enzyme-linked immunosorbent assay is established under screening for tuberculosis of lungs in HIV-negative patients.
  • In view of many positive results in detection of anti-tuberculosis antibodies in control group of patients with HIV-infection the data testified the low diagnostic significance of enzyme-linked immunosorbent assay in group of patients with HIV-infection.
  • The drawbacks of enzyme-linked immunosorbent assay technique of diagnostic of tuberculosis of lungs in common group of HIV-infected patients partially compensated by possibility of its application at late stages of development of HIV-infection.
  • [MeSH-minor] Antigens, Bacterial / immunology. Enzyme-Linked Immunosorbent Assay. HIV / isolation & purification. HIV / pathogenicity. HIV Infections / blood. HIV Infections / complications. HIV Infections / immunology. HIV Infections / virology. Humans

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  • (PMID = 24757864.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Bacterial
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95. Hayag JE, Manchanda PP: Predictive Value of the Rapid Whole Blood Agglutination D-Dimer Assay (AGEN SimpliRED) in Community Outpatients with Suspected Deep Venous Thrombosis. Perm J; 2006;10(1):16-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive Value of the Rapid Whole Blood Agglutination D-Dimer Assay (AGEN SimpliRED) in Community Outpatients with Suspected Deep Venous Thrombosis.
  • CONTEXT: D-dimer assay has been used to screen patients with deep venous thrombosis (DVT).
  • Because both the predictive value and sensitivity/specificity of the test vary according to the type of assay, prevalence, and pretest probability of DVT, clinicians must know the local performance of the d-dimer assay.
  • OBJECTIVE: To evaluate the predictive value of the rapid whole blood agglutination d-dimer Assay (AGEN SimpliRED) in community outpatients with suspected DVT in the Kaiser Permanente (KP) Mid-Atlantic Region.
  • A total of 551 electronic medical records were reviewed, and results of d-dimer assay and compression ultrasonography were tabulated.
  • A total of 129 (23.8%) patients had positive d-dimer; the positive predictive value was 20.2% (CI, 13.2% to 27%).
  • A total of 412 (76.1%) patients had negative test results; three of these patients had DVT shown by compression ultra-sonography; negative predictive value was 99.3% (CI, 98.4% to 100%).
  • CONCLUSION: In the outpatient setting, the rapid whole blood agglutination d-dimer assay (AGEN SimpliRED) used in combination with both clinical judgment and compression ultrasonography exhibited a high negative predictive value comparable with previously reported values.

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  • [Cites] Ann Intern Med. 2001 Jul 17;135(2):108-11 [11453710.001]
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  • (PMID = 21519449.001).
  • [ISSN] 1552-5767
  • [Journal-full-title] The Permanente journal
  • [ISO-abbreviation] Perm J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3076977
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96. Brandel JP, Beaudry P, Delasnerie-Lauprêtre N, Laplanche JL: [Creutzfeldt-Jakob disease: diagnostic value of protein 14-3-3 and neuronal specific enolase assay in cerebrospinal fluid]. Rev Neurol (Paris); 1999 Feb;155(2):148-51
MedlinePlus Health Information. consumer health - Creutzfeldt-Jakob Disease.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Creutzfeldt-Jakob disease: diagnostic value of protein 14-3-3 and neuronal specific enolase assay in cerebrospinal fluid].
  • We studied the diagnostic value of detecting protein 14-3-3 and of assaying neuronal specific enolase (NSE) in the cerebrospinal fluid of 150 patients with suspected sporadic Creutzfeldt-Jakob disease registered in an epidemiology research program between 1991 and 1996.
  • This study confirms results reported earlier and authorizes a new definition of Creutzfeldt-Jakob disease which gives protein 14-3-3 the same diagnostic value as EEG recordings for classifying sporadic cases.
  • [MeSH-minor] 14-3-3 Proteins. Electroencephalography. Epilepsies, Myoclonic / diagnosis. Humans. Predictive Value of Tests. Retrospective Studies

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  • (PMID = 10226319.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] FRANCE
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Cerebrospinal Fluid Proteins; 0 / Proteins; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; EC 4.2.1.11 / Phosphopyruvate Hydratase
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97. MacFarlane JK, Thomson DM, Phelan K, Shenouda G, Scanzano R: Predictive value of tube leukocyte adherence inhibition (LAI) assay for breast, colorectal, stomach and pancreatic cancer. Cancer; 1982 Mar 15;49(6):1185-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive value of tube leukocyte adherence inhibition (LAI) assay for breast, colorectal, stomach and pancreatic cancer.
  • The tube LAI assay measures accurately antitumor immunity in patients with early cancer but fails to detect up to 75% of patients with advanced cancer due to excess circulating organ-specific neoantigen (OSN).
  • Substances such as prostaglandin E2 (PGE2) or aminophylline, which increase intracellular nucleotides in leukocytes of patients with advanced cancer reversed this nonreactivity and greatly increased the sensitivity of the assay without any loss of specificity.
  • Antitumor immunity can now be detected in advanced cancer, and a combination of the two assays gives prognostic potential to the assay: a positive test with PGE2 and negative test without indicates the patient has a large tumor burden.
  • The specificity of the assay for each cancer was high and in most instances was greater than or equal to 95%.
  • The PGE2 stimulated assay retained the high specificity.
  • The sensitivity of the regular tube assay was often low, 33-56% because of the many advanced cancer patients tested, whereas the PGE2 stimulated assay showed almost a two-fold increase in sensitivity, 67-93%.
  • The diagnostic value of the assay was estimated by calculating the predictive value for different prevalences of cancer.
  • It was found that at low prevalences of cancer as found in the general population, the assay had a low diagnostic value since few patients with a positive test would have the cancer tested for.
  • With prevalences of cancer of 5% or greater as might be found in a tertiary care clinical setting, the assay would seem to have diagnostic value since one half or more patients with a positive test would have the cancer tested for.
  • Most false positives, but not all, are found in patients who have lesions that are often considered to increase their risk for cancer: severe dysplasia of the breast, colon adenomas, chronic atrophic gastritis and chronic pancreatitis, suggesting that the assay predicts oncogenesis.

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  • (PMID = 7037158.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Prostaglandins E; 27Y3KJK423 / Aminophylline
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98. Stege R, Carlström K, Eriksson A, Gustafsson SA, Henriksson P, Pousette A: Serum prolactin assays have no prognostic value in treatment of prostatic cancer by orchidectomy or estrogens. Urol Int; 1987;42(2):124-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum prolactin assays have no prognostic value in treatment of prostatic cancer by orchidectomy or estrogens.
  • There were no differences in PRL values between responders and nonresponders at any time in any of the two treatment groups.
  • It is concluded that serum PRL assays have no prognostic value in the employed endocrine treatment of CAP.

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  • (PMID = 3617239.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] SWITZERLAND
  • [Chemical-registry-number] 0 / Estradiol Congeners; 9002-62-4 / Prolactin
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99. Zhang TM, Zhang LM, Liu Y, Zhang ZF, Wang CL: [Diagnostic value of (18)F-FDG PET/CT imaging plus serum tumor marker assays for pulmonary lesions and clinical significance of SUVmax]. Zhonghua Yi Xue Za Zhi; 2012 Nov 6;92(41):2901-4
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic value of (18)F-FDG PET/CT imaging plus serum tumor marker assays for pulmonary lesions and clinical significance of SUVmax].
  • OBJECTIVE: To evaluate the diagnostic value of (18)F-FDG positron emission tomography/computed tomography (PET/CT) plus serum tumor marker assay in lung cancer and explore the correlation between standard uptake value (SUVmax) with clinicopathologic factors in lung cancer.

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  • (PMID = 23328236.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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100. Drinka PJ, Siebers M, Voeks SK: Poor positive predictive value of low sensitive thyrotropin assay levels for hyperthyroidism in nursing home residents. South Med J; 1993 Sep;86(9):1004-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Poor positive predictive value of low sensitive thyrotropin assay levels for hyperthyroidism in nursing home residents.
  • We assessed the positive predictive value of a low thyrotropin (TSH) level on sensitive TSH (STSH) assay as an indicator of hyperthyroidism.
  • [MeSH-minor] Aged. Aged, 80 and over. False Positive Reactions. Female. Humans. Male. Middle Aged. Nursing Homes. Predictive Value of Tests

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  • (PMID = 8367743.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin
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