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1. Solomon S, Balakrishnan P, Vignesh R, Waldrop G, Solomon SS, Murugavel KG, Kumarasamy N, Yepthomi T, Poongulali S, Swathirajan CR, Sreenivasan V, Chandrasekar C, Suriakumar J, Mahilmaran A, Manoharan G, Moore DA: A rapid and low-cost microscopic observation drug susceptibility assay for detecting TB and MDR-TB among individuals infected by HIV in South India. Indian J Med Microbiol; 2013 Apr-Jun;31(2):130-7
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  • [Title] A rapid and low-cost microscopic observation drug susceptibility assay for detecting TB and MDR-TB among individuals infected by HIV in South India.
  • OBJECTIVE: The purpose of this present study was to evaluate the feasibility of implementing the microscopic observation drug susceptibility (MODS) assay, a novel assay for the diagnosis of TB and multi-drug-resistant tuberculosis (MDR-TB) directly from sputum specimens, in the Indian setting.
  • MATERIALS AND METHODS: This study involved a cross-sectional, blinded assessment of the MODS assay on 1036 suspected cases of pulmonary TB in HIV-positive and HIV-negative patients against the radiometric method, BD-BACTEC TB 460 system.
  • RESULTS: Overall, the sensitivity, specificity, positive predictive value, and negative predictive value of the MODS assay in detecting MTB among TB suspected patients were 89.1%, 99.1%, 94.2%, 95.8%, respectively.
  • In addition, in the diagnosis of drug-resistant TB, the MODS assay was 84.2% sensitive for those specimens reporting MDR, 87% sensitivity for those specimens reporting INH mono-resistance, and 100% sensitive for specimens reporting RIF mono-resistance.
  • The median time to detection of TB in the MODS assay versus BACTEC was 9 versus 21 days (P<0.001).
  • CONCLUSION: Costing 5 to 10 times lesser than the automated culture methods, the MODS assay has the potential clinical utility as a simple and rapid method.
  • [MeSH-minor] Adult. Costs and Cost Analysis. Humans. India. Male. Microbial Sensitivity Tests / economics. Microbial Sensitivity Tests / methods. Predictive Value of Tests. Sensitivity and Specificity. Sputum / microbiology

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  • (PMID = 23867668.001).
  • [ISSN] 1998-3646
  • [Journal-full-title] Indian journal of medical microbiology
  • [ISO-abbreviation] Indian J Med Microbiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antitubercular Agents
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2. Halpern HJ, Jaffe DR, Nguyen TD, Haraf DJ, Spencer DP, Bowman MK, Weichselbaum RR, Diamond AM: Measurement of bioreduction rates of cells with distinct responses to ionizing radiation and cisplatin. Biochim Biophys Acta; 1991 Jul 10;1093(2-3):121-4
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  • Low frequency EPR allows measurements and imaging of living tissue and may be of value as a predictive assay of human tumor response to chemotherapy.

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  • (PMID = 1650577.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01CA42596; United States / NCI NIH HHS / CA / R29CA50679
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Free Radicals; 2896-70-0 / Triacetoneamine-N-Oxyl; Q20Q21Q62J / Cisplatin
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3. Lu Z, Harper MK, Pond CD, Barrows LR, Ireland CM, Van Wagoner RM: Thiazoline peptides and a tris-phenethyl urea from Didemnum molle with anti-HIV activity. J Nat Prod; 2012 Aug 24;75(8):1436-40
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  • The three compounds were evaluated for anti-HIV activity in both an HIV integrase inhibition assay and a cytoprotective cell-based assay.
  • Compound 2 was active in both assays with IC(50) values of 39 and 78 μM, respectively.
  • Compound 3 was active only in the cytoprotective cell-based assay, with an IC(50) value of 60 μM.

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  • [Cites] J Nat Prod. 2000 Feb;63(2):279-82 [10691729.001]
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  • (PMID = 22845329.001).
  • [ISSN] 1520-6025
  • [Journal-full-title] Journal of natural products
  • [ISO-abbreviation] J. Nat. Prod.
  • [Language] ENG
  • [Grant] United States / FIC NIH HHS / TW / U01 TW006671; United States / PHS HHS / / 5U01T006671; United States / NCRR NIH HHS / RR / RR06262
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIV Integrase Inhibitors; 0 / Peptides, Cyclic; 0 / Phenylurea Compounds; 0 / Thiazolidines; 0 / mollamide E; 0 / mollamide F; 0 / molleurea A
  • [Other-IDs] NLM/ NIHMS397617; NLM/ PMC4176947
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4. Sowemimo A, Venables L, Odedeji M, Koekemoer T, van de Venter M, Hongbing L: Antiproliferative mechanism of the methanolic extract of Enterolobium cyclocarpum (Jacq.) Griseb. (Fabaceae). J Ethnopharmacol; 2015 Jan 15;159:257-61
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  • MATERIALS AND METHODS: To explore the ethnopharmacological claims against cancer, the cytotoxicity of the methanolic extract of the leaves, was investigated using the brine shrimp lethality assay, MTT assay using cervical (HeLa) and breast (MCF7) cancer cell lines, cell cycle analysis and Annexin V-FITC/PI assay.
  • RESULTS: In the brine shrimp lethality assay, the extract showed cytotoxic activity with LC50 value of 31.63 µg/mL.
  • Significant growth inhibition was observed in both cell lines with IC50 values of 2.07 ± 1.30 µg/mL and 11.84 ± 1.18 µg/mL for HeLa and MCF7, respectively.
  • The Annexin V-FITC/PI assay revealed phosphatidylserine translocation in both cell lines and thus apoptosis induction upon treatment with the extract.

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  • [Copyright] Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 25460593.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Plant Extracts; 0 / Solvents; Y4S76JWI15 / Methanol
  • [Keywords] NOTNLM ; Apoptosis / Cancer / Cell cycle analysis / Enterolobium cyclocarpum
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5. Nielsen H, Dahlstrøm G, Feldt-Rassmussen U, Seerup K, Kemp E, Svehag SE: Circulating immune complexes and crisis of rejection in renal transplantation. Scand J Urol Nephrol Suppl; 1980;54:141-4
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  • The present study was conducted to assess whether immune complex (IC) activity, measured by a complement consumption assay (CC) could be used to indicate a forthcoming rejection crisis in the early phase after renal transplantation.
  • It is concluded that circulating IC occurred in a rather high percentage of patients with glomerulonephritis or pyelonephritis and that IC determination by the CC assay had no value in the prediction or diagnosis of rejection episodes following renal allotransplantation.

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  • (PMID = 7013033.001).
  • [ISSN] 0300-8886
  • [Journal-full-title] Scandinavian journal of urology and nephrology. Supplementum
  • [ISO-abbreviation] Scand J Urol Nephrol Suppl
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] SWEDEN
  • [Chemical-registry-number] 0 / Antigen-Antibody Complex; 0 / Histocompatibility Antigens
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6. Tsai WS: Use of sonar in diagnosis and management of invasive gestational trophoblastic tumors. Int J Fertil; 1974;19(4):227-32
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  • Intrauterine masses were demonstrated sonographically in all 4 cases, As well as H.C.G. assay and chest X-ray, sonographic follow-up also seems to be of value in evaluating the effectiveness of the chemotherapy.

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  • (PMID = 4376540.001).
  • [ISSN] 0020-725X
  • [Journal-full-title] International journal of fertility
  • [ISO-abbreviation] Int. J. Fertil.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] SWEDEN
  • [Chemical-registry-number] YL5FZ2Y5U1 / Methotrexate
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7. Seong MW, Lee SJ, Cho SI, Ko K, Kim MN, Sung H, Kim JS, Ahn JS, Yu BS, Kim TS, Kim EC, Park SS: External Quality Assessment of MERS-CoV Molecular Diagnostics During the 2015 Korean Outbreak. Ann Lab Med; 2016 May;36(3):230-4
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  • BACKGROUND: The largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection outside Middle East Asia in 2015 has necessitated the rapid expansion of laboratories that conduct MERS-CoV molecular testing in Korea, together with external quality assessment (EQA) to evaluate the assays used.
  • RESULTS: The first EQA phase results for 46 participants showed a linear relationship between the threshold cycle (C(T)) values of RNA materials and the logarithmic concentrations for both upE and ORF1a gene targets (R²=0.73 and 0.75, respectively).
  • The mean C(T) value for each concentration was different depending on which commercial kit was used for the assay.
  • Among the three commonly used kits, PowerChek MERS Real-Time PCR kit (KogeneBiotech, Korea) showed the lowest C(T) values at all concentrations of upE and most concentrations of ORF1a.
  • However, careful establishment and validation of a cut-off value are recommended to ensure good analytical sensitivity.

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  • [Cites] Euro Surveill. 2012;17(39). pii: 20285 [23041020.001]
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  • (PMID = 26915611.001).
  • [ISSN] 2234-3814
  • [Journal-full-title] Annals of laboratory medicine
  • [ISO-abbreviation] Ann Lab Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / RNA, Viral
  • [Other-IDs] NLM/ PMC4773263
  • [Keywords] NOTNLM ; External quality assessment / MERS-CoV / Molecular diagnostics / ORF1a / Real-time PCR / upE
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8. Burke CJ, Waddell S: Remembering nutrient quality of sugar in Drosophila. Curr Biol; 2011 May 10;21(9):746-50
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  • However, sweet taste can be an unreliable predictor of nutrient value because some sugars cannot be metabolized.
  • Here we used an appetitive memory assay in Drosophila [9-11] to investigate the contribution of palatability and relative nutritional value of sugars to memory formation.
  • We show that palatability and nutrient value both contribute to reinforcement of appetitive memory.
  • [MeSH-minor] Animals. Carbohydrates / chemistry. Nutritive Value. Survival Analysis. Taste / physiology

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  • [Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.
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  • (PMID = 21514159.001).
  • [ISSN] 1879-0445
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] eng
  • [Grant] United States / NIMH NIH HHS / MH / MH081982; United States / NIMH NIH HHS / MH / R01 MH081982; United States / NIMH NIH HHS / MH / R01 MH069883-07; United States / NIMH NIH HHS / MH / R01 MH081982-04; United States / NIMH NIH HHS / MH / MH09883; United Kingdom / Wellcome Trust / / 090309; United States / NIMH NIH HHS / MH / R01 MH069883
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbohydrates
  • [Other-IDs] NLM/ NIHMS283270; NLM/ PMC3094154
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9. Jakubowski M, Roberts JL: Multiplex solution hybridization-ribonuclease protection assay for quantitation of different ribonucleic Acid transcripts from snap-frozen neuroendocrine tissues of individual animals. J Neuroendocrinol; 1992 Feb;4(1):79-89
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  • [Title] Multiplex solution hybridization-ribonuclease protection assay for quantitation of different ribonucleic Acid transcripts from snap-frozen neuroendocrine tissues of individual animals.
  • Specific RNA transcripts were analyzed using a quantitative solution hybridization-ribonuclease protection assay coupled with polyacrylamide gel electrophoresis.
  • The value of this highly sensitive assay has been expanded by including several molecular probes against a variety of neuroendocrine mRNA sequences simultaneously (e.g. progonadotropin-releasing hormone, proopiomelanocortin, tyrosine hydroxylase, dopamine D2 receptor, prolactin), thus increasing the amount of information obtained from each sample in one assay.
  • Furthermore, each sample was routinely co-assayed for cyclophilin mRNA, an abundant, generally non-regulated mRNA whose levels reflected the individual variability in sample processing, thus serving as an internal reference.
  • Once stored in hybridization solution, as many as 100 samples could be analyzed simultaneously for several different RNA transcripts in one assay.

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  • (PMID = 21554581.001).
  • [ISSN] 0953-8194
  • [Journal-full-title] Journal of neuroendocrinology
  • [ISO-abbreviation] J. Neuroendocrinol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Siller-Matula JM, Christ G, Lang IM, Delle-Karth G, Huber K, Jilma B: Multiple electrode aggregometry predicts stent thrombosis better than the vasodilator-stimulated phosphoprotein phosphorylation assay. J Thromb Haemost; 2010 Feb;8(2):351-9
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  • [Title] Multiple electrode aggregometry predicts stent thrombosis better than the vasodilator-stimulated phosphoprotein phosphorylation assay.
  • BACKGROUND AND AIM: The prognostic value of the vasodilator-stimulated phosphoprotein (VASP) phosphorylation assay and multiple electrode aggregometry (MEA) for thrombotic adverse events has been shown in independent studies.
  • As no direct comparison between the two methods has been made so far, we investigated which laboratory approach has a better predictive value for stent thrombosis.
  • METHODS: The VASP phosphorylation assay and MEA were performed in 416 patients with coronary artery disease undergoing percutaneous coronary intervention.
  • Receiver operating characteristic (ROC) analysis demonstrated that MEA distinguishes between patients with or without subsequent stent thrombosis better than the VASP phosphorylation assay: the area under the ROC curve was higher for MEA (0.92; P=0.012) than for the VASP phosphorylation assay (0.60; P=0.55).
  • At equal levels of sensitivity (100%), the specificity was greater for MEA than for the VASP phosphorylation assay (86% vs. 37%).
  • Stent thrombosis occurred in 9% of patients with platelet hyperreactivity in MEA, who were simultaneously clopidogrel non-responders in the VASP phosphorylation assay.
  • Interestingly, clopidogrel non-responders in the VASP phosphorylation assay without platelet hyperreactivity in MEA did not suffer from stent thrombosis.
  • CONCLUSIONS: Platelet hyperreactivity in MEA might be a better risk predictor for stent thrombosis than the assessment of the specific clopidogrel effect with the VASP phosphorylation assay.
  • [MeSH-minor] Aged. Aspirin / therapeutic use. Biomarkers / blood. Drug Therapy, Combination. Female. Humans. Logistic Models. Male. Middle Aged. Phosphorylation. Platelet Aggregation Inhibitors / therapeutic use. Predictive Value of Tests. Prospective Studies. ROC Curve. Sensitivity and Specificity. Ticlopidine / analogs & derivatives. Ticlopidine / therapeutic use. Time Factors. Treatment Outcome

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  • (PMID = 19943879.001).
  • [ISSN] 1538-7836
  • [Journal-full-title] Journal of thrombosis and haemostasis : JTH
  • [ISO-abbreviation] J. Thromb. Haemost.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cell Adhesion Molecules; 0 / Microfilament Proteins; 0 / Phosphoproteins; 0 / Platelet Aggregation Inhibitors; 0 / vasodilator-stimulated phosphoprotein; A74586SNO7 / clopidogrel; OM90ZUW7M1 / Ticlopidine; R16CO5Y76E / Aspirin
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11. Nawawi A, Ma C, Nakamura N, Hattori M, Kurokawa M, Shiraki K, Kashiwaba N, Ono M: Anti-herpes simplex virus activity of alkaloids isolated from Stephania cepharantha. Biol Pharm Bull; 1999 Mar;22(3):268-74
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  • By screening water and MeOH extracts of 30 Chinese medicinal plants for their anti-herpes simplex virus (HSV)-1 activity, a MeOH extract of the root tubers of Stephania cepharantha HAYATA showed the most potent activity on the plaque reduction assay with an IC50 value of 18.0 microg/ml.
  • Although N-methylcrotsparine was active against HSV-1, as well as HSV-1 thymidine kinase deficient (acyclovir resistant type, HSV-1 TK-) and HSV-2 (IC50 values of 8.3, 7.7 and 6.7 microg/ml, respectively), it was cytotoxic.
  • FK-3000 was found to be the most active against HSV-1, HSV-1 TK- and HSV-2 (IC50 values of 7.8, 9.9 and 8.7 microg/ml) with in vitro therapeutic indices of 90, 71 and 81, respectively.

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  • (PMID = 10220283.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Antiviral Agents; 0 / Drugs, Chinese Herbal; EC 2.7.1.21 / Thymidine Kinase
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12. Daly AK, Redfern CP: Purification and properties of cellular retinoic acid-binding protein from neonatal rat skin. Biochim Biophys Acta; 1988 May 12;965(2-3):118-26
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  • The ability of various retinoids to compete with all-trans-retinoic acid for binding to CRABP was assayed: 4-oxoretinoic acid and two synthetic retinoids were effective competitors, but 13-cis-retinoic acid, 3,4-didehydroretinoic acid and the acid derivative of etretinate competed poorly.
  • The binding protein had a Kd for all-trans-retinoic acid of 8 nM using a dextran-charcoal assay, but a higher value was obtained using high-performance size-exclusion liquid chromatography.

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  • (PMID = 2835110.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Apoproteins; 0 / Carrier Proteins; 0 / Receptors, Retinoic Acid; 5688UTC01R / Tretinoin
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13. Wong JM, Malec PA, Mabrouk OS, Ro J, Dus M, Kennedy RT: Benzoyl chloride derivatization with liquid chromatography-mass spectrometry for targeted metabolomics of neurochemicals in biological samples. J Chromatogr A; 2016 May 13;1446:78-90
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  • Widely targeted metabolomic assays are useful because they provide quantitative data on large groups of related compounds.
  • Limits of detection for most assayed compounds were below 10nM, relative standard deviations were below 10%, and carryover was less than 5% for 70 compounds separated in 20min, with a total analysis time of 33min.
  • The assay will be of value for evaluating normal physiological changes in metabolism in neurochemical systems.
  • The results demonstrate the utility of benzoyl chloride labeling with HPLC-MS/MS for widely targeted metabolomics assays.

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  • [Copyright] Copyright © 2016 Elsevier B.V. All rights reserved.
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  • (PMID = 27083258.001).
  • [ISSN] 1873-3778
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R37 DK046960; United States / NIDDK NIH HHS / DK / R01 DK046960; United States / NIBIB NIH HHS / EB / R01 EB003320; United States / NIBIB NIH HHS / EB / R37 EB003320; United States / NIDDK NIH HHS / DK / R00 DK097141; United States / NIDDK NIH HHS / DK / P30 DK020572; United States / NIA NIH HHS / AG / R01 AG023166; United States / NIA NIH HHS / AG / F31 AG047696
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Benzoates; 0 / Catecholamines; 0 / Neurotransmitter Agents; VTY8706W36 / benzoyl chloride
  • [Other-IDs] NLM/ NIHMS777689 [Available on 05/13/17]; NLM/ PMC4845038 [Available on 05/13/17]
  • [Keywords] NOTNLM ; Brain / Derivatization / Drosophila / HPLC / Mass spectrometry / Neurochemistry
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14. Bonfrer JM, Korse CM, Verstraeten RA, van Kamp GJ, Hart GA, Kenemans P: Clinical evaluation of the Byk LIA-mat CA125 II assay: discussion of a reference value. Clin Chem; 1997 Mar;43(3):491-7
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  • [Title] Clinical evaluation of the Byk LIA-mat CA125 II assay: discussion of a reference value.
  • The Byk LIA-mat CA125 II assay was compared with the Centocor IRMA CA125 II.
  • The CA125 II assay value at the 95th percentile of the total healthy group was 29 kU/L for the LIA-mat and 32 kU/L for the Centocor assay.
  • For the LIA-mat assay the 95th percentile was 31 kU/L (Centocor 36 kU/L) for the group < 45 years and 21 kU/L (Centocor 25 kU/L) for women > 55 years of age.
  • By using ROC curves we found the optimal pretreatment Byk LIA-mat CA125 II value differentiating between benign and malignant ovarian tumors to be 95 kU/L.
  • Pretreatment CA125 values > 1000 kU/L were detected in serum samples of patients with advanced epithelial ovarian cancer.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. False Positive Reactions. Female. Humans. Immunoassay / methods. Middle Aged. Pregnancy. ROC Curve. Reference Values. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 9068593.001).
  • [ISSN] 0009-9147
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / CA-125 Antigen
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15. Sthaneshwar P, Yap SF, Jayaram G: The diagnostic usefulness of tumour markers CEA and CA-125 in pleural effusion. Malays J Pathol; 2002 Jun;24(1):53-8
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  • The cut-off values for differentiating benign from malignant effusions were determined using results obtained from patients with known benign effusions (mean + 2 SD, 95% confidence interval).
  • CEA assay in pleural fluid had an acceptable sensitivity and good specificity of 64% and 98% respectively.
  • We suggest a good clinical strategy may be to begin with CEA measurement (assay specificity 98%); if CEA is below the cut-off value (negative), CA-125 could then be measured to improve the sensitivity of detection of malignant effusions.

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  • (PMID = 16329556.001).
  • [ISSN] 0126-8635
  • [Journal-full-title] The Malaysian journal of pathology
  • [ISO-abbreviation] Malays J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / Carcinoembryonic Antigen
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16. Chen H, Chung NN, Lemieux C, Zelent B, Vanderkooi JM, Gryczynski I, Wilkes BC, Schiller PW: [Aladan3]TIPP: a fluorescent delta-opioid antagonist with high delta-receptor binding affinity and delta selectivity. Biopolymers; 2005;80(2-3):325-31
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  • The most potent analogue, [Ald3]TIPP, showed a K(e) value of 2.03 nM in the mouse vas deferens assay and five times higher delta vs. mu selectivity (K(i)mu/K(i)delta = 7930) than the TIPP parent peptide in the opioid receptor binding assays.

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc
  • (PMID = 15614807.001).
  • [ISSN] 0006-3525
  • [Journal-full-title] Biopolymers
  • [ISO-abbreviation] Biopolymers
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA-04443
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluorescent Dyes; 0 / Oligopeptides; 0 / Receptors, Opioid, delta; 0 / Tetrahydroisoquinolines; 0 / aladan; 146369-65-5 / tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalanine; CKR7XL41N4 / 2-Naphthylamine; OF5P57N2ZX / Alanine
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17. Ho-Yen DO, Carrington D: Alpha-interferon responses in cerebrospinal fluid of patients with suspected meningitis. J Clin Pathol; 1987 Jan;40(1):83-6
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  • This assay had great predictive value in determining those patients with abnormal cerebrospinal fluid who did not have a bacterial cause of meningitis.
  • As the groups with abnormal cerebrospinal fluid and viral meningitis had a similar spread in alpha-interferon values it is likely that both reflect viral infection of the central nervous system.

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  • (PMID = 3818974.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Interferon Type I
  • [Other-IDs] NLM/ PMC1140834
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18. Holland ML, Heebner ET: High-performance liquid chromatographic assay with ultraviolet detection for the determination of etoperidone and two active metabolites, 5-(1-hydroxyethyl) etoperidone and 1-(3-chlorophenyl)piperazine, in plasma. J Chromatogr; 1991 Jul 5;567(2):433-40
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  • [Title] High-performance liquid chromatographic assay with ultraviolet detection for the determination of etoperidone and two active metabolites, 5-(1-hydroxyethyl) etoperidone and 1-(3-chlorophenyl)piperazine, in plasma.
  • A selective and sensitive high-performance liquid chromatographic assay with ultraviolet detection for the determination of the antidepressant drug etoperidone and two active metabolites in plasma is described.
  • The accuracy and precision of the assay, expressed as the percentage deviation of measured values from the true value and the relative standard deviation (inter-run), are less than or equal to 10% at all concentrations except the minimum quantification limit.
  • The assay has been successfully used for the analysis of plasma samples from pharmacokinetic studies in mice, rats, dogs and humans.

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  • (PMID = 1939475.001).
  • [Journal-full-title] Journal of chromatography
  • [ISO-abbreviation] J. Chromatogr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Indicators and Reagents; 0 / Piperazines; 98159-91-2 / 5-(1-hydroxyethyl)etoperidone; KAI6MVO39Z / etoperidone; REY0CNO998 / 1-(3-chlorophenyl)piperazine; YBK48BXK30 / Trazodone
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19. Jortani SA, Poklis A: Emit ETS plus ethyl alcohol assay for the determination of ethanol in human serum and urine. J Anal Toxicol; 1992 Nov-Dec;16(6):368-71
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  • [Title] Emit ETS plus ethyl alcohol assay for the determination of ethanol in human serum and urine.
  • We evaluated the enzymatic Emit ETS Plus Ethyl Alcohol Assay (Emit) intended for the quantitative analysis of ethanol in human urine, serum, and plasma.
  • The assay had been designed for use with the new Syva ETS Plus analyzer.
  • The assay had a linear range up to 6.5 g/L and a low detection limit of 0.1 g/L.
  • Assay within-run precision in serum with ethanol added to 0.25, 0.40, 1.00, 3.00, and 5.00 g/L yielded CVs (n = 32) of 6.1, 5.8, 3.7, 3.5, and 4.5%, respectively.
  • Within-run precision of the assay using with ethanol added to 0.25, 0.40, 1.00, 3.00, and 5.00 g/L yielded CVs (n = 32) of 4.9, 5.0, 4.3, 3.3, and 5.0%, respectively.
  • Between-run precision of aqueous controls yielded 0.41 +/- 0.02 g/L ethanol (target value, 0.40 g/L), CV = 4.5% (n = 31) and 3.05 +/- 0.06 g/L ethanol (target value, 3.00 g/L) CV = 2.1% (n = 31).
  • Absolute recovery of the assay with 0.40 to 6.00 g/L ethanol added to serum and urine yielded mean recovery values of 105.5 and 101.5%, respectively.
  • Results of the analysis of patient serum and urine specimens for ethanol by the Emit assay correlated well with those obtained by other methods.
  • The Emit assay was found to be rapid, precise, and accurate for the determination of ethanol in clinical specimens.
  • The Emit assay's linear range of up to 6.50 g/L ethanol was a major advantage over the ADx and aca assays; these assays were only linear to 3.00 g/L.

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  • (PMID = 1293403.001).
  • [ISSN] 0146-4760
  • [Journal-full-title] Journal of analytical toxicology
  • [ISO-abbreviation] J Anal Toxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 3K9958V90M / Ethanol
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20. Sun RJ, Wang QY, Zhang JB, Guo YF, Zhao XD: [Regulation of proliferation and apoptosis of human vascular endothelial cell by Acheron]. Zhonghua Shao Shang Za Zhi; 2011 Apr;27(2):156-60
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  • The cell proliferation was determined by MTT assay at post transfection hour (PTH) 1, 24, 48, 72, with expression of absorbance value. (2) Total protein of Eahy926 cells were extracted and quantitated by BCA assay, and then they were divided into Achn antibody precipitation group (100 µg protein), CASK antibody precipitation group (100 µg protein), IgG antibody group (100 µg protein), Western blot group (20 µg protein).
  • (1) The cell proliferation in Achn inhibition group was lower than that in psi4.1 group from PTH 24, and the differences were statistically significant at PTH 48, 72 (with t value respectively 10.777, 6.112, P values all below 0.05).
  • The cell proliferation in Achn induction group during PTH 24-72 were higher that in pcDNA3.1 group (with t value respectively 5.367, 6.053, 9.831, P values all below 0.05).
  • The cell proliferation in cotransfection group at PTH 48, 72 were significantly lower than that in Achn induction group (with t value respectively 5.481, 9.517, P values all below 0.05). (2) Achn protein was detected in CASK antibody precipitation group while CASK protein was also detected in Achn antibody precipitation group. (3) Caspase-3 level in Achn transfection group was lower [(15.6 ± 0.5)%] as compared with that in LPS induction group [(32.8 ± 2.6)%, t = 10.083, P < 0.05], and that in cotransfection group showed further inhibition [(7.0 ± 2.0)%, t = 9.827, P < 0.01]. (4) Apoptosis rate in Achn inhibition group [(45.6 ± 10.9)%] was higher than that in blank control group [(13.2 ± 4.3) %, t = 7.043, P < 0.05]; while that in Achn induction group [(5.3 ± 2.9)%] was lower than that in blank control group (t = 6.499, P < 0.05).

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  • (PMID = 21651853.001).
  • [ISSN] 1009-2587
  • [Journal-full-title] Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
  • [ISO-abbreviation] Zhonghua Shao Shang Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Autoantigens; 0 / Ribonucleoproteins; 0 / SS-B antigen; EC 2.7.4.- / CASK kinases; EC 2.7.4.8 / Guanylate Kinase
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21. Stang LJ: D-dimer and fibrinogen/fibrin degradation products. Methods Mol Biol; 2013;992:415-27
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  • Although clinical requests for D-dimer are generally in the minority of assays in the routine clinical laboratory, they are an important aspect-especially if the laboratory supports an active emergency room and hematology service.
  • Throughout the literature, D-dimer assays have been used for many purposes in the research setting; however it is generally the negative predictive value of the assay that is the most common piece of information being utilized from the standpoint of a clinician.
  • Research or clinical needs will dictate the type of assay required-a qualitative, semiquantitative, or quantitative D-dimer assay may be appropriate for a particular purpose.
  • Commonalities and differences between these assay types are outlined here, as well as universal concerns regarding standardization of D-dimer assay results.

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  • (PMID = 23546734.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Fibrinogen Degradation Products; 0 / fibrin fragment D; 9001-31-4 / Fibrin; 9001-32-5 / Fibrinogen
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22. El-Husseini A, Wang K, Edon A, Saxon D, Lima F, Sloan D, Sawaya BP: Value of Intraoperative Parathyroid Hormone Assay during Parathyroidectomy in Dialysis and Renal Transplant Patients with Secondary and Tertiary Hyperparathyroidism. Nephron; 2017 Nov 09;
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  • [Title] Value of Intraoperative Parathyroid Hormone Assay during Parathyroidectomy in Dialysis and Renal Transplant Patients with Secondary and Tertiary Hyperparathyroidism.
  • BACKGROUND: In dialysis and renal transplant patients with secondary and tertiary hyperparathyroidism (HPT), the value of intraoperative parathyroid hormone (ioPTH) during parathyroidectomy (PTX) and its association with long-term PTH levels are unknown.

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  • [Copyright] © 2017 S. Karger AG, Basel.
  • (PMID = 29131092.001).
  • [ISSN] 2235-3186
  • [Journal-full-title] Nephron
  • [ISO-abbreviation] Nephron
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; Parathyroidectomy / Dialysis / End-stage renal disease / Hyperparathyroidism / Intraoperative parathyroid hormone  / Renal transplant
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23. Quinn TC, Kline R, Moss MW, Livingston RA, Hutton N: Acid dissociation of immune complexes improves diagnostic utility of p24 antigen detection in perinatally acquired human immunodeficiency virus infection. J Infect Dis; 1993 May;167(5):1193-6
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  • Since acid treatment of serum is known to disrupt immune complexes, the diagnostic utility of the p24 antigen assay was examined after acid treatment of 345 serum samples from 158 children born to women infected with human immunodeficiency virus (HIV).
  • Although the p24 antigen assay after acid treatment was negative in 9 HIV-1-infected children < 1 week old, antigen was detectable at high levels in all 30 samples obtained from infected children 1-9 months old.
  • In contrast, the sensitivity of the p24 antigen assay without acid dissociation was only 18% (P < .001).
  • These results demonstrate that acid treatment of serum markedly improves the sensitivity and predictive value of the p24 antigen assay for diagnosis of perinatally acquired HIV-1 infection in children 1 month of age or older.
  • [MeSH-minor] Acids / metabolism. Child. Child, Preschool. Enzyme-Linked Immunosorbent Assay / methods. Female. Humans. Hydrogen-Ion Concentration. Infant. Infant, Newborn. Sensitivity and Specificity

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  • (PMID = 8486954.001).
  • [ISSN] 0022-1899
  • [Journal-full-title] The Journal of infectious diseases
  • [ISO-abbreviation] J. Infect. Dis.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-27565; United States / NINR NIH HHS / NR / NR-02069; United States / NCRR NIH HHS / RR / RR-0052
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Acids; 0 / Antigen-Antibody Complex; 0 / HIV Core Protein p24
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24. Baltsen M, Byskov AG: Quantitation of meiosis activating sterols in human follicular fluid using HPLC and photodiode array detection. Biomed Chromatogr; 1999 Oct;13(6):382-8
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  • A chromatographic assay for 4,4-dimethyl-5alpha-cholesta-8,14, 24-triene-3beta-ol (FF-MAS), and its reduced species, 4, 4-dimethyl-5alpha-cholesta-8,24-triene-3beta-ol (T-MAS), has been established for analysis of human follicular fluid (huFF).
  • The assay also quantifies lanosterol, free cholesterol and progesterone.
  • The lower recovery value for progesterone was due to a sub-optimal extraction procedure for this particular analyte, as indicated by re-extraction.
  • FF-MAS was assayed to approximately 1.6 microM.
  • T-MAS and lanosterol was assayed to about half of this value.
  • Less than 10% of cholesterol was underivatized cholesterol, as more than 10 times the amount of free cholesterol could be assayed after extended saponification.

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  • [Copyright] Copyright 1999 John Wiley & Sons, Ltd.
  • (PMID = 10477894.001).
  • [ISSN] 0269-3879
  • [Journal-full-title] Biomedical chromatography : BMC
  • [ISO-abbreviation] Biomed. Chromatogr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Cholestenes; 0 / Sterols; 64284-64-6 / 4,4-dimethylcholesta-8,14,24-trienol
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25. Passamonti S, Battiston L, Sottocasa GL: Bilitranslocase can exist in two metastable forms with different affinities for the substrates--evidence from cysteine and arginine modification. Eur J Biochem; 1998 Apr 1;253(1):84-90
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  • In rat liver plasma membranes, its function is assayed by recording the electrogenic sulfobromophthalein movement.
  • The substrate concentration in the standard transport assay is 39 microM, a value at which the modified low-affinity form operates in the range of half-maximal velocity.

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  • (PMID = 9578464.001).
  • [ISSN] 0014-2956
  • [Journal-full-title] European journal of biochemistry
  • [ISO-abbreviation] Eur. J. Biochem.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hydroxymercuribenzoates; 0 / Membrane Proteins; 0C2P5QKL36 / Sulfobromophthalein; 138-85-2 / 4-hydroxymercuribenzoate; 60-24-2 / Mercaptoethanol; 71211-72-8 / bilitranslocase; 94ZLA3W45F / Arginine; K848JZ4886 / Cysteine; RFM9X3LJ49 / Bilirubin
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26. Buvanendran A, Kroin JS, Della Valle CJ, Moric M, Tuman KJ: Cerebrospinal fluid neurotransmitter changes during the perioperative period in patients undergoing total knee replacement: a randomized trial. Anesth Analg; 2012 Feb;114(2):434-41
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  • CSF samples were assayed for norepinephrine, substance P, calcitonin gene-related peptide (CGRP), and glutamate concentrations.
  • Numerical rating scale (NRS) pain scores and intrathecal analgesic consumption were recorded postsurgery at 4-hour intervals for 32 hours.
  • Compared with presurgery values, norepinephrine levels were lower in the placebo group at the 2- and 4-hour time points (P < 0.005) whereas in the single and multidose groups, the reduction (P < 0.001) continued until 12 and 24 hours, respectively.
  • Substance P CSF levels had an early peak value (at 2 hours) in all 3 groups, and then returned to baseline.
  • Compared with baseline value, the CGRP CSF levels only decreased at the 32-hour time point in the placebo group, but in both pregabalin groups, CGRP levels decreased over the 4- to 32-hour period.
  • In the placebo group only, CSF glutamate decreased over 4 to 32 hours compared with presurgery values.

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  • (PMID = 22156332.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00729690
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics; 33507-63-0 / Substance P; 3KX376GY7L / Glutamic Acid; 55JG375S6M / Pregabalin; 56-12-2 / gamma-Aminobutyric Acid; 83652-28-2 / Calcitonin Gene-Related Peptide; X4W3ENH1CV / Norepinephrine
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27. Bujard A, Sol M, Carrupt PA, Martel S: Predicting both passive intestinal absorption and the dissociation constant toward albumin using the PAMPA technique. Eur J Pharm Sci; 2014 Oct 15;63:36-44
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  • The parallel artificial membrane permeability assay (PAMPA) is a high-throughput screening (HTS) method that is widely used to predict in vivo passive permeability through biological barriers, such as the skin, the blood brain barrier (BBB) and the gastrointestinal tract (GIT).
  • Furthermore, the assay is based on the use of two separate 5-point kinetic experiments, which increases the analysis time.
  • In the present study, we adapted the hexadecane membrane (HDM)-PAMPA assay to both predict passive gastrointestinal absorption via the permeability coefficient logPe value and determine the Kd.
  • Two assays were performed: one in the presence and one in the absence of HSA in the acceptor compartment.
  • In the absence of HSA, logPe values were determined after a 4-h incubation time, as originally described, but the dimethylsulfoxide (DMSO) percentage and pH were altered to be compatible with the protein.
  • In parallel, a second PAMPA assay was performed in the presence of HSA during a 16-h incubation period.
  • The concentration of compound reaching the acceptor compartment in each case was used to determine both parameters (logPe and logKd) using numerical simulations, which highlighted the originality of this method because these calculations required only two endpoint measurements instead of a complete kinetic study.
  • Thirteen compounds with known Kd values were analyzed using this method, and the obtained Kd values were in agreement with those obtained using primarily the gold-standard equilibrium dialysis.
  • This assay utilizes a technique that is currently routinely used in industrial companies to obtain permeability measurements; moreover, this approach is fast (96-well plate format), economical and easy to handle.
  • This assay uses protein freely in solution, which may be more relevant than embedded proteins in chromatographic systems, for example.
  • [MeSH-major] High-Throughput Screening Assays. Intestinal Absorption. Membranes, Artificial. Permeability. Serum Albumin / metabolism

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  • [Copyright] Copyright © 2014 Elsevier B.V. All rights reserved.
  • (PMID = 25008117.001).
  • [ISSN] 1879-0720
  • [Journal-full-title] European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • [ISO-abbreviation] Eur J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Alkanes; 0 / Membranes, Artificial; 0 / Serum Albumin; F8Z00SHP6Q / n-hexadecane
  • [Keywords] NOTNLM ; Constant of dissociation / Human serum albumin / PAMPA / Passive permeability / Permeation coefficient
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28. Hruby VJ, Bartosz-Bechowski H, Davis P, Slaninova J, Zalewska T, Stropova D, Porreca F, Yamamura HI: Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors. J Med Chem; 1997 Nov 21;40(24):3957-62
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  • In the binding assays the most selective and most potent compound is the p-bromophenyl-alanine-4 analogue (IC50 value = 0.19 nM, selectivity ratio = 21,000 for delta vs mu).
  • In the MVD assay it has an exceptionally low IC50 value of 0.016 nM and a delta vs mu selectivity ratio of 45,000.
  • [MeSH-minor] Amino Acid Sequence. Animals. Guinea Pigs. Kinetics. Male. Radioligand Assay. Rats. Rats, Sprague-Dawley. Substrate Specificity

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  • (PMID = 9397176.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA06284
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Analgesics; 0 / Enkephalins; 0 / Peptides, Cyclic; 0 / Receptors, Opioid, delta
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29. Virk RK, Abro S, de Ubago JMM, Pambuccian SE, Quek ML, Wojcik EM, Mehrotra S, Chatt GU, Barkan GA: The value of the UroVysion® FISH assay in the risk-stratification of patients with "atypical urothelial cells" in urinary cytology specimens. Diagn Cytopathol; 2017 Jun;45(6):481-500
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  • [Title] The value of the UroVysion® FISH assay in the risk-stratification of patients with "atypical urothelial cells" in urinary cytology specimens.
  • METHODS: Using a histologic diagnosis of UC and respectively of high grade UC (HGUC) within 12 months of the index UTCy as a reference standard, we determined the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of U-FISH for patients with AUC diagnosed 2008 to 2014.

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  • [Copyright] © 2017 Wiley Periodicals, Inc.
  • (PMID = 28397365.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; FISH / STARD / UroVysion® / sensitivity / specificity / urine cytology / urothelial carcinoma
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30. van Deventer AJ, van Vliet HJ, Hop WC, Goessens WH: Diagnostic value of anti-Candida enolase antibodies. J Clin Microbiol; 1994 Jan;32(1):17-23
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  • [Title] Diagnostic value of anti-Candida enolase antibodies.
  • An immunodominant antigen with enolase enzyme activity was purified and used for the development of an assay to detect antibodies directed against this antigen in sera from patients with either invasive candidiasis or Candida colonization.
  • The Au enzyme-linked immunosorbent assay established with the Candida enolase antigen was able to discriminate significantly between invasive candidiasis and colonization in both immunocompetent and immunodeficient groups of patients.
  • Antibody levels determined by a counterimmunoelectrophoresis assay with the same set of sera resulted in a better sensitivity for sera from the immunocompetent patient group but a lower specificity, i.e., 80 and 29%, respectively.
  • The counterimmunoelectrophoresis assay of sera from the immunodeficient patient group was not able to discriminate significantly between invasive candidiasis and colonization.
  • With the use of more serum from each patient, the sensitivity of the antibody detection assays increased, while the specificity was maintained.
  • Combining the results of the antibody assays with antigen titers obtained by the Cand-Tec assay did not improve the predictive value with respect to invasive candidiasis, as determined by multivariance regression analysis.
  • [MeSH-minor] Antigens, Viral / immunology. Antigens, Viral / isolation & purification. Enzyme-Linked Immunosorbent Assay. Humans. Immunocompetence. Immunocompromised Host. Immunodominant Epitopes / immunology. Immunodominant Epitopes / isolation & purification. Immunoelectrophoresis, Two-Dimensional. Sensitivity and Specificity

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  • (PMID = 8126174.001).
  • [ISSN] 0095-1137
  • [Journal-full-title] Journal of clinical microbiology
  • [ISO-abbreviation] J. Clin. Microbiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / Antigens, Viral; 0 / Immunodominant Epitopes; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Other-IDs] NLM/ PMC262962
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31. Stoitchkov K, Letellier S, Garnier JP, Bousquet B, Tsankov N, Morel P, Ghanem G, Le Bricon T: Melanoma progression and serum L-dopa/L-tyrosine ratio: a comparison with S100B. Melanoma Res; 2002 Jun;12(3):255-62
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  • Serum L-dopa and L-tyrosine were measured by high performance liquid chromatography (HPLC) (normal value for ratio < 16 x 10(-5)) and S100B using the LIA-mat Sangtec 100 assay (normal value < 0.10 microg/l).
  • Both markers were higher in patients with evolutive disease (n = 23) than in stable patients (n = 24), with values of 20.8 x 10(-5) versus 13.1 x 10(-5) for the ratio (P < 0.05) and 0.89 microg/l versus 0.16 microg/l for S100B (P < 0.001); for the ratio, this difference was more pronounced in stage III than in stage IV patients.
  • In conclusion, the serum L-dopa/L-tyrosine ratio correlates with melanoma progression and has predictive value, especially in stage III patients.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bulgaria / epidemiology. Chromatography, High Pressure Liquid. Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Nerve Growth Factors. Predictive Value of Tests. Prognosis. S100 Calcium Binding Protein beta Subunit

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  • (PMID = 12140382.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Nerve Growth Factors; 0 / S100 Calcium Binding Protein beta Subunit; 0 / S100 Proteins; 0 / S100B protein, human; 42HK56048U / Tyrosine; 46627O600J / Levodopa
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32. Yang Q, Catalano CE, Maluf NK: Kinetic analysis of the genome packaging reaction in bacteriophage lambda. Biochemistry; 2009 Nov 17;48(45):10705-15
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  • Even though DNA packaging has been studied extensively, currently no bulk assays are available that have been optimized to report directly on DNA translocation.
  • Rather, these assays are sensitive to assembly steps reflecting formation of the active, DNA packaging machine.
  • In this work, we have modified the DNase protection assay commonly used to study DNA packaging in several bacteriophage systems, such that it reports directly on the kinetics of the DNA packaging reaction.
  • The magnitude of this value indicates that our assay is most likely sensitive to both mechanical steps associated with DNA insertion as well as occasional slow steps that are repeated every >410 bp.

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  • (PMID = 19788336.001).
  • [ISSN] 1520-4995
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 61D2G4IYVH / Adenosine Diphosphate; 8L70Q75FXE / Adenosine Triphosphate
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33. Lin CT, Tseng CJ, Lai CH, Hsueh S, Huang HJ, Law KS: High-risk HPV DNA detection by Hybrid Capture II. An adjunctive test for mildly abnormal cytologic smears in women &gt; or = 50 years of age. J Reprod Med; 2000 Apr;45(4):345-50
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  • The sensitivity of HPV assay for detection of lesions more severe than CIN 2 was 100%, specificity 64.8%, positive predictive value 66.7% and negative predictive value 100%.
  • CONCLUSION: The addition of a high-risk HPV DNA assay to cytologic examination appears to provide excellent sensitivity and negative predictive value for early detection of high grade CIN or cancer in older women with minimally abnormal Pap smears.
  • [MeSH-minor] Age Factors. Aged. False Negative Reactions. Female. Humans. Mass Screening. Middle Aged. Papanicolaou Test. Predictive Value of Tests. Risk Factors. Sensitivity and Specificity. Vaginal Smears

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  • (PMID = 10804494.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / DNA Probes, HPV; 0 / DNA, Viral
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34. Lai CC, Hsu HL, Lee LN, Hsueh PR: Assessment of Platelia Aspergillus enzyme immunoassay for the diagnosis of invasive aspergillosis. J Microbiol Immunol Infect; 2007 Apr;40(2):148-53
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  • BACKGROUND AND PURPOSE: This study investigated the diagnostic value of Platelia Aspergillus enzyme immunoassay (EIA) for galactomannan (GM) antigen in patients at risk of invasive aspergillosis (IA), and its association with clinical course and outcome.
  • The overall sensitivity, specificity, and positive and negative predictive values for this assay, using a 1.5 index cut-off value, were 78.6%, 93.9%, 55.0%, and 97.9%, respectively.
  • With the 0.5 index cut-off value, the sensitivity would increase to 100%.
  • [MeSH-minor] Adult. Aged. Child. Female. Humans. Kinetics. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity. Time Factors

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  • (PMID = 17446963.001).
  • [ISSN] 1684-1182
  • [Journal-full-title] Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
  • [ISO-abbreviation] J Microbiol Immunol Infect
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Fungal; 0 / Mannans; 11078-30-1 / galactomannan
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35. Sibbing D, Braun S, Morath T, Mehilli J, Vogt W, Schömig A, Kastrati A, von Beckerath N: Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol; 2009 Mar 10;53(10):849-56
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  • A point-of-care assay with similar predictive power would be of great value.

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  • [CommentIn] J Am Coll Cardiol. 2009 Aug 11;54(7):666-7; author reply 667-8 [19660707.001]
  • [CommentIn] J Am Coll Cardiol. 2009 Mar 10;53(10):857-9 [19264242.001]
  • (PMID = 19264241.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platelet Aggregation Inhibitors; A74586SNO7 / clopidogrel; OM90ZUW7M1 / Ticlopidine
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36. Whyte G, George K, Shave R, Dawson E, Stephenson C, Edwards B, Gaze D, Oxborough D, Forster J, Simspon R: Impact of marathon running on cardiac structure and function in recreational runners. Clin Sci (Lond); 2005 Jan;108(1):73-80
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  • Thirty-two runners presented with cTnT values above the lower limit of detection for the assay (0.01 microg/l), and 20 runners presented post-marathon with cTnT values above the acute myocardial infarction cut-off value (0.05 microg/l).

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  • (PMID = 15377277.001).
  • [ISSN] 0143-5221
  • [Journal-full-title] Clinical science (London, England : 1979)
  • [ISO-abbreviation] Clin. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Antioxidants; 0 / Chromans; 0 / Troponin T; 29343-52-0 / 4-hydroxy-2-nonenal; 4Y8F71G49Q / Malondialdehyde; S18UL9710X / 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
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37. Chain B, McCafferty I, Wallace G, Askenase PW: Improvement of the in vitro T cell proliferation assay by a modified method that separates the antigen recognition and IL-2-dependent steps. J Immunol Methods; 1987 May 20;99(2):221-8
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  • [Title] Improvement of the in vitro T cell proliferation assay by a modified method that separates the antigen recognition and IL-2-dependent steps.
  • T cell activation is commonly assayed in vitro by measuring the proliferative response of primed cells to an antigenic stimulus.
  • We have modified the conventional form of this assay by dividing up the response into two stages.
  • This modified form of proliferation assay significantly increased the signal to noise ratio which can be attained, and is of particular value when looking at the T cell response to weak (e.g., cross-reactive) antigens, or low concentrations of antigen.

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  • (PMID = 3108408.001).
  • [ISSN] 0022-1759
  • [Journal-full-title] Journal of immunological methods
  • [ISO-abbreviation] J. Immunol. Methods
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI-12211; United States / NCI NIH HHS / CA / CA-29606
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Antigens; 0 / Insulin; 0 / Interleukin-2; 0 / Receptors, Antigen, T-Cell; 0 / Receptors, Immunologic; 0 / Receptors, Interleukin-2
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38. Fruchart JC: Insulin-resistance and lipoprotein abnormalities. Diabete Metab; 1991 May;17(1 Pt 2):244-8
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  • Using enzyme-linked differential antibody immunosorbent assay and differential electroimmunoassay, we have discovered that the determination of lipoprotein particle profiles is essential for further clarification of the diagnostic value of measuring apo B and apo A-I.

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  • (PMID = 1936484.001).
  • [ISSN] 0338-1684
  • [Journal-full-title] Diabète & métabolisme
  • [ISO-abbreviation] Diabete Metab
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] FRANCE
  • [Chemical-registry-number] 0 / Apolipoproteins; 0 / Blood Glucose; 0 / Lipoproteins
  • [Number-of-references] 46
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39. Jin R, Lu HY, Luo YY, Xu YX, Hu YH, Chen XQ: [Evaluation of the level of urinary cysteinyl leukotriene E4 in diagnosis of bronchopulmonary dysplasia in premature infants]. Zhonghua Er Ke Za Zhi; 2016 Sep;54(9):703-7
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  • METHOD: One hundred and fifty-eight newborn infants were consecutively admitted to the neonatal intensive care units of First Affiliated Hospital of Nanjing Medical University from November 2014 to October 2015.The infants were divided into 3 groups according to the diagnosis on discharge.Sixty-one term infants were classified as having no pulmonary diseases, 52 premature infants were classified as without BPD, and 45 premature infants with BPD were diagnosed at 28 d after birth.Urinary CysLTE4 levels of newborns within 3 days after birth were measured in a blinded way by enzyme- linked immunosorbent assay and were compared among 3 groups, and were evaluated for the diagnostic value and the correlation of gestational age and birth weight.Statistical analysis was performed using correlation analysis, one-way analysis of variance and χ(2) test etc.

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  • (PMID = 27596087.001).
  • [ISSN] 0578-1310
  • [Journal-full-title] Zhonghua er ke za zhi = Chinese journal of pediatrics
  • [ISO-abbreviation] Zhonghua Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers; 75715-89-8 / Leukotriene E4
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40. Farrell S, Hayes T, Shaw M: A negative SimpliRED D-dimer assay result does not exclude the diagnosis of deep vein thrombosis or pulmonary embolus in emergency department patients. Ann Emerg Med; 2000 Feb;35(2):121-5
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  • [Title] A negative SimpliRED D-dimer assay result does not exclude the diagnosis of deep vein thrombosis or pulmonary embolus in emergency department patients.
  • STUDY OBJECTIVE: To determine whether a negative SimpliRED D-dimer assay result excludes the diagnosis of deep vein thrombosis (DVT) or pulmonary embolus (PE) in emergency department patients.
  • Initial ED evaluation included the SimpliRED D-dimer assay (American Diagnostica Inc, Greenwich, CT).
  • Physicians were blinded to assay results.
  • The SimpliRED assay had a sensitivity of 65% and a negative predictive value of 81% for detection of VTE.
  • In patients evaluated for DVT alone, the sensitivity was 56% and the negative predictive value was 77%.
  • For patients with suspected PE, the sensitivity and negative predictive value were 68% and 83%, respectively.
  • CONCLUSION: In contrast to earlier reports on the SimpliRED D-dimer assay, a negative result failed to exclude the diagnosis of VTE in our ED population.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiography. Diagnosis, Differential. Emergency Service, Hospital. Female. Hemagglutination Tests. Humans. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Pulmonary Artery / radiography. Sensitivity and Specificity. Ventilation-Perfusion Ratio

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  • [CommentIn] ACP J Club. 2000 Sep-Oct;133(2):67
  • [CommentIn] Ann Emerg Med. 2000 Feb;35(2):181-7 [10650236.001]
  • [CommentIn] Ann Emerg Med. 2001 May;37(5):549-50 [11326194.001]
  • (PMID = 10650228.001).
  • [ISSN] 0196-0644
  • [Journal-full-title] Annals of emergency medicine
  • [ISO-abbreviation] Ann Emerg Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Fibrin Fibrinogen Degradation Products
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41. Ihara H, Watanabe T, Hashizume N, Totani M, Kamioka K, Onda K, Sunahara S, Suzuki T, Itabashi M, Aoki Y, Ishibashi M, Ito S, Ohashi K, Enomoto T, Saito K, Saeki K, Nagamura Y, Nobori T, Hirota K, Fujishiro K, Maekawa M, Miura M, Ohta Y: Commutability of National Institute of Standards and Technology standard reference material 1955 homocysteine and folate in frozen human serum for total folate with automated assays. Ann Clin Biochem; 2010 Nov;47(Pt 6):541-8
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  • [Title] Commutability of National Institute of Standards and Technology standard reference material 1955 homocysteine and folate in frozen human serum for total folate with automated assays.
  • METHODS: Using a microbiological assay related to the 'information value' of SRM 1955 as a comparison method, we investigated the possibility of standardization for the assay values of serum folate as measured by the automated methods (Access, Centaur and Elecsys).
  • In the assay of 50 patient sera by these automated methods, we corrected observed values by the SRM 1955 and compared with comparison values.
  • RESULTS: The observed values of SRM 1955 Levels I, II and III were within or outside (but near) a 95% prediction interval obtained from patient sera by the automated methods.
  • [MeSH-minor] Government Agencies. High-Throughput Screening Assays / standards. Humans. Linear Models. Reference Standards. United States

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  • (PMID = 20926465.001).
  • [ISSN] 1758-1001
  • [Journal-full-title] Annals of clinical biochemistry
  • [ISO-abbreviation] Ann. Clin. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0LVT1QZ0BA / Homocysteine; 935E97BOY8 / Folic Acid
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42. Eissa S, Seada LS: Quantitation of bcl-2 protein in bladder cancer tissue by enzyme immunoassay: comparison with Western blot and immunohistochemistry. Clin Chem; 1998 Jul;44(7):1423-9
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  • The range of detection of the assay was 5-400 kilounits/L with inter- and intraassay CVs of 5.5-9.2% and 5.0-8.8%, respectively.
  • The detection of substantial amounts of bcl-2 in invasive tumors (compared with nondiseased tissues) suggests that the assay should be a useful tool for investigating the prognostic value of bcl-2 in bladder tumors and for selecting patients for future anti-bcl-2 therapy.

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  • (PMID = 9665419.001).
  • [ISSN] 0009-9147
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Proto-Oncogene Proteins c-bcl-2
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43. Dohmen AJ, Swartz JE, Van Den Brekel MW, Willems SM, Spijker R, Neefjes J, Zuur CL: Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review. Cancers (Basel); 2015;7(3):1716-42
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  • [Title] Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review.
  • This review discusses the feasibility and success rate of existing primary head and neck tumor culturing techniques and their corresponding chemo- and radiosensitivity assays.
  • A comprehensive literature search was performed and success factors for culturing in vitro are debated, together with the actual value of these models as preclinical prediction assay for individual patients.

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  • (PMID = 26343729.001).
  • [ISSN] 2072-6694
  • [Journal-full-title] Cancers
  • [ISO-abbreviation] Cancers (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC4586791
  • [Keywords] NOTNLM ; chemosensitivity / head neck cancer / personalized therapy / primary cell cultures / radiosensitivity
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44. Trudinger B, Wang J, Athayde N, Beutler L, Wang X: Association of umbilical placental vascular disease with fetal acute inflammatory cytokine responses. J Soc Gynecol Investig; 2002 May-Jun;9(3):152-7
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  • Blood was collected from the umbilical vein at delivery, and serum was stored at -70C until assayed using chemiluminescent and enzyme-linked immunosorbent assay methods.
  • RESULTS: In the presence of umbilical placental vascular disease there were significantly higher levels of IL-6 (median 5.3 pg/mL, P <.05) and IL-8 (median 26.5 pg/mL, P <.01) compared with normal pregnancies (median value of IL-6 and IL-8 were below assay threshold).
  • [MeSH-minor] Adult. Birth Weight. Delivery, Obstetric. Female. Fetal Blood / chemistry. Fetal Blood / immunology. Gestational Age. Humans. Infant, Newborn. Interleukin-6 / blood. Maternal Age. Pregnancy. Reference Values. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 12009389.001).
  • [ISSN] 1071-5576
  • [Journal-full-title] Journal of the Society for Gynecologic Investigation
  • [ISO-abbreviation] J. Soc. Gynecol. Investig.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-6; 0 / Tumor Necrosis Factor-alpha
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45. Andersen MB, Tesauro C, Gonzalez M, Kristoffersen EL, Alonso C, Rubiales G, Coletta A, Frøhlich R, Stougaard M, Ho YP, Palacios F, Knudsen BR: Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study. Nanoscale; 2017 Feb 02;9(5):1886-1895
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  • By analysing human topoisomerase I catalysis on the biosensor in the absence or presence of added drug complemented with a few traditional assays, we demonstrate that the investigated member of the indeno-1,5-naphthyridine family inhibited human topoisomerase I activity by blocking enzyme-DNA dissociation.
  • The elucidation of a completely new and rather surprising drug mechanism-of-action using an optical real time sensor highlights the value of this assay system in the search for new topoisomerase I targeting small molecule drugs.

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  • (PMID = 28094391.001).
  • [ISSN] 2040-3372
  • [Journal-full-title] Nanoscale
  • [ISO-abbreviation] Nanoscale
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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46. Waise A, Plebani M: Which surrogate marker can be used to assess the effectiveness of the laboratory and its contribution to clinical outcome? Ann Clin Biochem; 2001 Nov;38(Pt 6):589-95
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  • Such markers could include incident reporting, the appropriateness of assay repertoire, adding value to reports, the quality of comments made, provision of information on the effect of analytical and biological variation on results, cascading requests to help making diagnoses and unearthing such diagnoses.

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  • (PMID = 11732642.001).
  • [ISSN] 0004-5632
  • [Journal-full-title] Annals of clinical biochemistry
  • [ISO-abbreviation] Ann. Clin. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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47. Shinjo K, Takeshita A, Ohnishi K, Ohno R: Expression of granulocyte colony-stimulating factor receptor increases with differentiation in myeloid cells by a newly-devised quantitative flow-cytometric assay. Br J Haematol; 1995 Dec;91(4):783-94
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  • [Title] Expression of granulocyte colony-stimulating factor receptor increases with differentiation in myeloid cells by a newly-devised quantitative flow-cytometric assay.
  • In order to develop a non-isotopic quantitative assay of granulocyte colony-stimulating factor (G-CSF) receptors on human or murine cells, we devised a flow-cytometric assay using cells stained with biotin-labelled G-CSF (b-G-CSF) and a streptavidin-RED670 conjugate.
  • For quantification, we applied the Kolmogorov-Smirnov test and calculated the D value.
  • The D value was evaluated from the degree of shift in two fluorescence profiles according to the increase of fluorescence intensity due to the specific binding of b-G-CSF to G-CSF receptors.
  • A good correlation was observed between the number of G-CSF receptors obtained by the radioisotopic binding assay and the number calculated from the D value by the flow-cytometric assay.
  • [MeSH-minor] Acute Disease. Cell Differentiation / physiology. Cell Separation. Flow Cytometry. Granulocyte Colony-Stimulating Factor / metabolism. Granulocytes / chemistry. Granulocytes / immunology. Humans. Protein Binding. Radioligand Assay. Statistics, Nonparametric

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  • (PMID = 8547119.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Receptors, Granulocyte Colony-Stimulating Factor; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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48. Schülein R, Zühlke K, Oksche A, Hermosilla R, Furkert J, Rosenthal W: The role of conserved extracellular cysteine residues in vasopressin V2 receptor function and properties of two naturally occurring mutant receptors with additional extracellular cysteine residues. FEBS Lett; 2000 Jan 21;466(1):101-6
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  • Only in the case of the mutant receptor R202C, the more sensitive adenylyl cyclase activity assay revealed vasopressin-stimulated cAMP formation with a 35-fold increased EC(50) value and with a reduced EC(max), indicating that ligand binding is not completely abolished.

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  • [ErratumIn] FEBS Lett 2000 May 4;473(1):124
  • (PMID = 10648821.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Disulfides; 0 / Ligands; 0 / Receptors, Vasopressin; 0 / Recombinant Proteins; K848JZ4886 / Cysteine
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49. Whitlatch NL, Perry SL, Ortel TL: Anti-heparin/platelet factor 4 antibody optical density values and the confirmatory procedure in the diagnosis of heparin-induced thrombocytopenia. Thromb Haemost; 2008 Oct;100(4):678-84
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  • [Title] Anti-heparin/platelet factor 4 antibody optical density values and the confirmatory procedure in the diagnosis of heparin-induced thrombocytopenia.
  • The aim was firstly to evaluate the clinical utility of the PF4 ELISA confirmatory assay, secondly to examine the relationship between ELISA optical density (OD) value and clinical diagnosis of HIT, and thirdly to assess current practice at a tertiary care medical centre regarding patients with anti-heparin/PF4 antibodies.
  • Patients who were HIT+/confirm+ had higher ELISA OD values than patients who were HIT?
  • ; all had high ELISA OD values.
  • Although confirm+ status correlated with clinical HIT, the confirmatory procedure misclassified some patients by yielding a confirm- result despite clinical HIT with high ELISA OD values.
  • Future studies should compare higher ELISA OD values with the confirmatory procedure as strategies to improve ELISA diagnostic specificity for HIT.

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  • [CommentIn] Thromb Haemost. 2008 Oct;100(4):523-4 [18841271.001]
  • (PMID = 18841292.001).
  • [ISSN] 0340-6245
  • [Journal-full-title] Thrombosis and haemostasis
  • [ISO-abbreviation] Thromb. Haemost.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / T32 HL007057; United States / NHLBI NIH HHS / HL / U01 HL072289; United States / NHLBI NIH HHS / HL / T32 HL007057-32; United States / NCBDD CDC HHS / DD / U01 DD000014; United States / NHLBI NIH HHS / HL / U01 HL072289-05; United States / NCBDD CDC HHS / DD / U01 DD 000014; United States / NHLBI NIH HHS / HL / U01 HL 072289; United States / NHLBI NIH HHS / HL / U54 HL 077878; United States / NHLBI NIH HHS / HL / K23 HL 084233; United States / NHLBI NIH HHS / HL / K23 HL084233; United States / NHLBI NIH HHS / HL / T32 HL 007057; United States / NCBDD CDC HHS / DD / U18 DD000014; United States / NHLBI NIH HHS / HL / HL072289-05; United States / NHLBI NIH HHS / HL / K23 HL084233-02; United States / NHLBI NIH HHS / HL / HL084233-02; United States / NHLBI NIH HHS / HL / U54 HL077878; United States / NHLBI NIH HHS / HL / U54 HL077878-05; United States / NHLBI NIH HHS / HL / HL077878-05; United States / NHLBI NIH HHS / HL / HL007057-32
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Autoantibodies; 0 / Epitopes; 37270-94-3 / Platelet Factor 4; 9005-49-6 / Heparin
  • [Other-IDs] NLM/ NIHMS59926; NLM/ PMC2575642
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50. Kavlie A, Wiiger MT, Husbyn M, Stormorken H, Prydz H: A novel gene mutation in the 60s loop of human coagulation factor VII - inhibition of interdomain crosstalk. Thromb Haemost; 2004 Jan;91(1):28-37
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  • A synthetic peptide sequence comprising amino acids 177-206 blocked binding of FVIIa to the TF-chip, and the subsequent factor X activation with an IC(50) value of 0.5 micro M in a chromogenic factor Xa assay.

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  • (PMID = 14691565.001).
  • [ISSN] 0340-6245
  • [Journal-full-title] Thrombosis and haemostasis
  • [ISO-abbreviation] Thromb. Haemost.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Cysteine Proteinase Inhibitors; 0 / Enzyme Precursors; 0 / Peptides; 0 / Protein Synthesis Inhibitors; 0 / Recombinant Proteins; 133343-34-7 / lactacystin; 20350-15-6 / Brefeldin A; 9001-25-6 / Factor VII; 9001-29-0 / Factor X; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.6 / Factor Xa; WYQ7N0BPYC / Acetylcysteine
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51. van der Velden KJ, Sintnicolaas K, Löwenberg B: The value of a 51Cr platelet lysis assay as crossmatch test in patients with leukaemia on platelet transfusion therapy. Br J Haematol; 1986 Apr;62(4):635-40
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  • [Title] The value of a 51Cr platelet lysis assay as crossmatch test in patients with leukaemia on platelet transfusion therapy.
  • A 51Cr platelet lysis assay was used for the detection of platelet alloantibodies.
  • We determined the predictive value of this assay as crossmatch procedure on 28 occasions in 14 patients who received random single donor platelet transfusions.
  • The test values were retrospectively compared with the clinical transfusion response, determined as the 1 h post-transfusion platelet recovery.
  • These data indicate that the 51Cr platelet lysis assay adds a useful dimension to the solution of the problem of selecting compatible platelet donors.

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  • (PMID = 3964557.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Chromium Radioisotopes
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52. Burns J, Paterson CR: The value of serum 25-hydroxyvitamin D measurements in hypoparathyroid and pseudohypoparathyroid patients treated with calciferol. Clin Biochem; 1986 Feb;19(1):49-51
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  • [Title] The value of serum 25-hydroxyvitamin D measurements in hypoparathyroid and pseudohypoparathyroid patients treated with calciferol.
  • In 23 patients with hypoparathyroidism or pseudohypoparathyroidism treated with vitamin D, and in whom the dosage was adjusted downward or upward in response to hypercalcemia or hypocalcemia respectively, assays of serum 25-hydroxyvitamin D (25-OHD) were carried out in addition to the usual serum calcium assays.
  • In 120 assays there was a significant correlation between serum 25-OHD levels and serum calcium levels (corrected for serum albumin).
  • The 25-OHD assay was found to be useful only in checking compliance.
  • We conclude that the assay of serum 25-OHD is of no more value than serum calcium alone in the management of compliant patients.

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  • (PMID = 3485479.001).
  • [ISSN] 0009-9120
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] CANADA
  • [Chemical-registry-number] 0 / Ergocalciferols; 21343-40-8 / 25-Hydroxyvitamin D 2; SY7Q814VUP / Calcium
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53. Shinohara K, Oeda E, Nomiyama J, Inoue H, Kamei S, Tajiri M, Ichikawa T, Kuwaki T, Tachibana K: The levels of granulocyte colony-stimulating factor in the plasma of the bone marrow aspirate in various hematological disorders. Stem Cells; 1995 Jul;13(4):421-7
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  • We developed a sensitive method of measurement of granulocyte colony-stimulating factor (G-CSF) by an enzyme-linked immunosorbent assay, which we applied in the plasma of the bone marrow aspirate in 70 patients with various hematological disorders.
  • The level in acute lymphoblastic leukemia was not different from the normal value, as was that in refractory anemia with an excess of blasts, and that in chronic lymphocytic leukemia.
  • The level in polycythemia vera was not significantly different from the normal value.
  • [MeSH-minor] Agranulocytosis / blood. Anemia, Aplastic / blood. Anemia, Refractory / blood. Enzyme-Linked Immunosorbent Assay / methods. Enzyme-Linked Immunosorbent Assay / statistics & numerical data. Hematopoiesis. Humans. Leukemia / blood. Lymphoma, Non-Hodgkin / blood. Multiple Myeloma / blood. Polycythemia Vera / blood. Sensitivity and Specificity

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  • [CommentIn] Stem Cells. 1996 May;14(3):363-5 [8724702.001]
  • (PMID = 7549901.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor
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54. Mayo DR, Brennan T, Cormier DP, Hadler J, Lamb P: Evaluation of a commercial measles virus immunoglobulin M enzyme immunoassay. J Clin Microbiol; 1991 Dec;29(12):2865-7
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  • Paired serum samples from 93 patients suspected of having measles were assayed for measles virus-specific immunoglobulin M (IgM) antibodies by an enzyme immunoassay (EIA), and the results were compared with results from a complement fixation assay and an EIA for measles virus IgG.
  • By using significant serologic rises as the standard for comparison, the IgM EIA assay had a sensitivity of 85.7%, a specificity of 81.3%, a positive predictive value of 95.7%, and a negative predictive value of 54.2%.
  • This assay can be expected to perform well in outbreak situations.

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  • [Cites] Diagn Microbiol Infect Dis. 1986 Apr;4(4):285-90 [3516550.001]
  • [Cites] Ann Intern Med. 1981 Apr;94(4 Pt 2):557-92 [6452080.001]
  • [Cites] JAMA. 1990 May 9;263(18):2467-71 [2278542.001]
  • [Cites] J Clin Microbiol. 1986 Sep;24(3):391-4 [3760134.001]
  • (PMID = 1757560.001).
  • [ISSN] 0095-1137
  • [Journal-full-title] Journal of clinical microbiology
  • [ISO-abbreviation] J. Clin. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Immunoglobulin G; 0 / Immunoglobulin M; 0 / Reagent Kits, Diagnostic
  • [Other-IDs] NLM/ PMC270448
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55. Wilmot H, Hockley J, Rigsby P, Gray E: Establishment of the World Health Organization 2&lt;sup&gt;nd&lt;/sup&gt; International Standard for Factor XI, Plasma, Human. Front Med (Lausanne); 2017;4:28
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  • In addition to the functional activity value, assignment of an antigen value to the 2<sup>nd</sup> IS would allow harmonization of antigen assay methods and differentiation of patients who have low functional activity but normal antigen FXI levels from patients who have both low functional and antigen FXI levels.
  • Assignment of the functional activity (FXI:C) value in International Units (IUs) was performed by one-stage clotting assay by 29 laboratories, relative to the 1<sup>st</sup> IS.
  • The antigen value assignment was performed by 11 laboratories and was calculated relative to normal plasma pools, as is customary with new coagulation factor analytes.
  • The overall GM for the antigen assays was 0.78 IU/amp with an inter-laboratory variation of 10%.
  • The candidate (National Institute for Biological Standards and Control code, 15/180) was established by the World Health Organization (WHO) Expert Committee on Biological Standardization in 2016 as the WHO 2<sup>nd</sup> IS for blood coagulation FXI, plasma, with a functional activity value (FXI:C) of 0.71 IU/amp and an antigen value (FXI:Ag) of 0.78 IU/amp.

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  • [Cites] Haemophilia. 2008 Nov;14(6):1183-9 [18312365.001]
  • [Cites] J Biol Stand. 1974 Oct;2(4):259-67 [4459395.001]
  • (PMID = 28373973.001).
  • [ISSN] 2296-858X
  • [Journal-full-title] Frontiers in medicine
  • [ISO-abbreviation] Front Med (Lausanne)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; International Standard for factor XI / factor XI antigen / factor XI functional activity / measurement of factor XI / multicentre study
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56. Jiang M, Jiang X, Rong L, Xu Y, Chen L, Qiu Z, Mo Y: Serum galactose-deficient IgA1 levels in children with IgA nephropathy. Int J Clin Exp Med; 2015;8(5):7861-6
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  • We used vicia villosa lectin binding enzyme-linked immunosorbent assay to measure the serum levels of galactose-deficient IgA1 in all groups and controls.
  • The values of the area under the curve for galactose-deficient IgA1 levels were 0.976 (95% CI, 0.953-1.000).
  • The cutoff point for galactose-deficient IgA1 levels was 0.125, with a sensitivity of 87.5% and a specificity of 83.3%, with a positive predictive value of 92.6% and a negative predictive value of 73.5% (P < 0.01).
  • Detection of serum galactose-deficient IgA1 levels by vicia villosa lectin binding enzyme-linked immunosorbent assay has a certain clinical value in diagnosis of children with IgAN.

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  • (PMID = 26221341.001).
  • [ISSN] 1940-5901
  • [Journal-full-title] International journal of clinical and experimental medicine
  • [ISO-abbreviation] Int J Clin Exp Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4509286
  • [Keywords] NOTNLM ; Glomerulonephritis / IgA / Vicia villosa Lectin / galactose-deficient IgA1
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57. Averna MR, Genova G, Montalto G, Labisi M, Mazza G, Migneco G, Tripi S, Notarbartolo A: [Serum monoamine oxidase (MAO) in the differential diagnosis of chronic liver disease. I]. Boll Soc Ital Biol Sper; 1984 Sep 30;60(9):1671-7
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  • Aim of this study was to evaluate the diagnostic value of serum MAO activity (sMAO) in chronic liver disease. sMAO has been assayed by benzylamine colorimetric method.
  • No statistically significant differences of sMAO values have been found between controls and acute viral hepatitis or various diseases patients.
  • Differences instead between controls and patients sMAO values (chronic persistent hepatitis, chronic active hepatitis and liver cirrhosis) were statistically significant (p less than 0.005).

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  • (PMID = 6525286.001).
  • [ISSN] 0037-8771
  • [Journal-full-title] Bollettino della Società italiana di biologia sperimentale
  • [ISO-abbreviation] Boll. Soc. Ital. Biol. Sper.
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] ITALY
  • [Chemical-registry-number] EC 1.4.3.4 / Monoamine Oxidase
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58. Thompson RD, Carlson M, Thompson RD, Carlson M: Liquid chromatographic determination of dehydroepiandrosterone (DHEA) in dietary supplement products. J AOAC Int; 2000 Jul-Aug;83(4):847-57
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  • Assay values varied from 0 to 109.5% of the declared amount with an overall mean value of 91.1%.

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  • (PMID = 10995111.001).
  • [ISSN] 1060-3271
  • [Journal-full-title] Journal of AOAC International
  • [ISO-abbreviation] J AOAC Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Acetonitriles; 0 / Buffers; 0 / Indicators and Reagents; 0 / Pharmaceutical Preparations; 0 / Phosphates; 459AG36T1B / Dehydroepiandrosterone; Y4S76JWI15 / Methanol; Z072SB282N / acetonitrile
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59. Kang YA, Lee HW, Hwang SS, Um SW, Han SK, Shim YS, Yim JJ: Usefulness of whole-blood interferon-gamma assay and interferon-gamma enzyme-linked immunospot assay in the diagnosis of active pulmonary tuberculosis. Chest; 2007 Sep;132(3):959-65
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  • [Title] Usefulness of whole-blood interferon-gamma assay and interferon-gamma enzyme-linked immunospot assay in the diagnosis of active pulmonary tuberculosis.
  • PURPOSES: The aim of this study was to evaluate the usefulness of the whole-blood interferon-gamma assay (enzyme-linked immunosorbent assay [ELISA]) and interferon-gamma enzyme-linked immunospot assay (ELISPOT) based on early secretory antigenic target 6 and culture filtrate protein 10 in the diagnosis of active pulmonary tuberculosis (TB) in routine clinical practice.
  • METHOD: We conducted a prospective study enrolling 144 participants with suspected pulmonary TB in a tertiary referral hospital in Seoul, South Korea, to investigate the diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of these tests.
  • Clinical assessment, tuberculin skin test (TST), whole-blood interferon-gamma ELISA (QuantiFERON-TB Gold [QFT-G]; Cellestis Ltd; Victoria, Australia), and an ELISPOT assay (T SPOT.TB; Oxford Immunotec; Oxford, UK) were performed.
  • [MeSH-major] Enzyme-Linked Immunosorbent Assay / methods. Interferon-gamma / blood. Tuberculosis, Pulmonary / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, Bacterial. Bacterial Proteins. Female. Humans. Korea. Male. Middle Aged. Predictive Value of Tests. Reagent Kits, Diagnostic. Reproducibility of Results

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  • (PMID = 17505029.001).
  • [ISSN] 0012-3692
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Comparative Study; Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / Bacterial Proteins; 0 / CFP-10 protein, Mycobacterium tuberculosis; 0 / ESAT-6 protein, Mycobacterium tuberculosis; 0 / Reagent Kits, Diagnostic; 82115-62-6 / Interferon-gamma
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60. Stahl TJ: Radioimmunoassay and the hormones of thyroid function. Semin Nucl Med; 1975 Jul;5(3):221-46
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  • There is new appreciation of the value of assaying serum T3 and TSH concentrations in the clinical management of patients with disturbed function of the thyroid, pituitary, or hypothalamus.

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  • (PMID = 807972.001).
  • [ISSN] 0001-2998
  • [Journal-full-title] Seminars in nuclear medicine
  • [ISO-abbreviation] Semin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Thyroxine-Binding Proteins; 06LU7C9H1V / Triiodothyronine; 51110-01-1 / Somatostatin; 5Y5F15120W / Thyrotropin-Releasing Hormone; 9002-62-4 / Prolactin; 9002-71-5 / Thyrotropin; 9002-72-6 / Growth Hormone; 9007-12-9 / Calcitonin; 9034-48-4 / Long-Acting Thyroid Stimulator; Q51BO43MG4 / Thyroxine
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61. Tripodi A, Di Santo C, Mannucci PM: A chromogenic assay of prothrombin compared with coagulation tests during anticoagulant therapy and liver disease. Ric Clin Lab; 1981 Jul-Sep;11(3):215-22
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  • [Title] A chromogenic assay of prothrombin compared with coagulation tests during anticoagulant therapy and liver disease.
  • A standardized chromogenic assay of prothrombin (factor II, FII) was compared with a conventional coagulation assay and global tests (Quick prothrombin time, Hepatoquick) in patients on oral anticoagulant therapy.
  • There was a highly significant positive correlation between chromogenic and coagulation assays, whereas correlation with global coagulation tests was much lower, particularly when normal plasmas were tested.
  • In patients with liver disease, FII assay gave reduced values and appeared at least as sensitive as global coagulation tests in showing the synthetic defect occurring in liver disease.
  • These findings suggest that the chromogenic assay can be employed in the clinical laboratory, even though prospective studies are warranted to establish its predictive value.

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  • (PMID = 7291868.001).
  • [ISSN] 0390-5748
  • [Journal-full-title] La Ricerca in clinica e in laboratorio
  • [ISO-abbreviation] Ric Clin Lab
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] ITALY
  • [Chemical-registry-number] 0 / Anilides; 0 / Anticoagulants; 0 / Chromogenic Compounds; 0 / Oligopeptides; 61876-61-7 / chromozym TH; 9001-26-7 / Prothrombin
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62. Russell CA, Wulf HC, Sørensen PB, Vindeløv LL: Evaluation of X-radiation and UV-B radiation for elimination of 3H-thymidine incorporation into responder cells in the IL-2 producing helper T lymphocyte precursor assay. J Immunol Methods; 1998 Nov 1;220(1-2):161-8
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  • [Title] Evaluation of X-radiation and UV-B radiation for elimination of 3H-thymidine incorporation into responder cells in the IL-2 producing helper T lymphocyte precursor assay.
  • The helper T lymphocyte precursor (HTLp) assay is of value for predicting graft-vs.-host disease after allogeneic bone marrow transplantation.
  • The assay is based on limiting dilution analysis and requires detection of the amount of interleukin 2 (IL-2) produced by one activated T cell.
  • Detection of IL-2 in the whole culture volume of the wells in the microtiter plates increases sensitivity, but requires elimination of 3H-TdR incorporation into the responder cells in the HTLp assay.
  • Neither X-irradiation nor UV-B irradiation of the cultures affected IL-2 produced in the assay or human recombinant IL-2 measured by 3H-TdR incorporation into the IL-2 dependent cell line, CTLL-2.
  • [MeSH-minor] Biological Assay. Bone Marrow Transplantation / adverse effects. Cell Line. Cells, Cultured. Dose-Response Relationship, Drug. Graft vs Host Disease / immunology. Graft vs Host Disease / prevention & control. Humans. Male. Recombinant Proteins / pharmacology. Tritium / analysis. Ultraviolet Rays. X-Rays

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  • (PMID = 9839937.001).
  • [ISSN] 0022-1759
  • [Journal-full-title] Journal of immunological methods
  • [ISO-abbreviation] J. Immunol. Methods
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Interleukin-2; 0 / Recombinant Proteins; 10028-17-8 / Tritium; VC2W18DGKR / Thymidine
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63. Ishiwata K, Watanabe N: Nippostrongylus brasiliensis: reversibility of reduced-energy status associated with the course of expulsion from the small intestine in rats. Exp Parasitol; 2007 Sep;117(1):80-6
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  • In this study we employed CellTiter-Glo Luminescent Cell Viability Assay to measure the ATP value of individual adult Nippostrongylus brasiliensis during the course of immune-mediated expulsion from the small intestine in rats.
  • The ATP values of adult worms taken from the lumen of the distal small intestine were lower than worms collected from the lumen of the proximal small intestine.
  • Moreover, values from worms in the lumen of the proximal small intestine were lower than those from worms in the mucosa, the preferred site of adult N. brasiliensis.
  • The reduction of ATP values in worms from each region was observed not only at expulsion phase, but also at established phases of the infection suggesting that energy metabolism of the parasites is independent of host immune response.
  • When adult worms with low ATP values on day 12 post-infection were implanted surgically into the small intestine of naïve rats, the worms re-established in recipients and completely restored the ATP values.
  • Short in vitro culture of adult worms under low oxygen tension resulted in low ATP value in the worms.

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  • (PMID = 17482164.001).
  • [ISSN] 0014-4894
  • [Journal-full-title] Experimental parasitology
  • [ISO-abbreviation] Exp. Parasitol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 8L70Q75FXE / Adenosine Triphosphate
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64. Gärtner C, Waldstein EA, Hagen U: Mechanism of the ATP effect in the DNA repair synthesis of gamma-irradiated Escherichia coli cells. Biochim Biophys Acta; 1980 Apr 30;607(2):247-55
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  • The V values of the DNA repair synthesis rise with increasing dose (0-50 Gy); nonirradiated cells showed a negligible nucleotide incorporation.
  • The apparent Michaelis constant KM for dNTP in the assay was 83-143 microM and the value was much higher than for a DNA polymerase reaction in vitro.
  • ATP stimulated the DNA synthesis with concomitant decrease of KM yet unchanged V values.

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  • (PMID = 6989403.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 3FPU23BG52 / Toluene; 8L70Q75FXE / Adenosine Triphosphate
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65. Svetaz L, Zuljan F, Derita M, Petenatti E, Tamayo G, Cáceres A, Cechinel Filho V, Giménez A, Pinzón R, Zacchino SA, Gupta M: Value of the ethnomedical information for the discovery of plants with antifungal properties. A survey among seven Latin American countries. J Ethnopharmacol; 2010 Jan 8;127(1):137-58
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  • [Title] Value of the ethnomedical information for the discovery of plants with antifungal properties. A survey among seven Latin American countries.
  • AIM OF THE STUDY: (a) The main aim of this study was to investigate whether the probability of detecting antifungal plants is higher when plants have reports of ethnopharmacological uses related to fungal infections (PAU group) than when they are selected at random (PNAU group). (b) The second objective was to determine, within the PAU group, whether the probability of obtaining a positive result will be higher when the plants are tested against dermatophytes, than against yeasts or Aspergillus spp. (c) The third goal was to investigate, within all MICs<or=1000 microg/mL, if the MICs displayed by the PAU group are comparatively lower than MIC values of the PNAU group; that is to say, if they can be expected more potent antifungal plants within the group of plants that have a history of traditional use related to fungal infections than when they do not have one.
  • For the antifungal evaluation, the microbroth dilution assay recommended by the Clinical and Laboratory Standards Institute (CLSI, formerly NCCLS) was used against a panel of eleven human opportunistic and pathogenic fungi.
  • [MeSH-minor] Arthrodermataceae / drug effects. Aspergillus / drug effects. Data Collection. Drug Evaluation, Preclinical / methods. Latin America. Medicine, Traditional. Microbial Sensitivity Tests / statistics & numerical data. Phytotherapy. Plant Extracts / isolation & purification. Plant Extracts / pharmacology. Species Specificity. Statistics as Topic. Terminology as Topic. Yeasts / drug effects

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19782744.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Plant Extracts
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66. Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S: Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. Nat Biotechnol; 2013 Jul;31(7):630-7
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  • Here we exploit this observation and assay small-molecule binding to kinases in living cells, using chaperones as 'thermodynamic sensors'.
  • Demonstrating the value of the assay, we identify ETV6-NTRK3 as a target of the FDA-approved drug crizotinib (Xalkori).
  • Finally, we show that our approach is applicable to other chaperone and target classes by assaying HSP70/steroid hormone receptor and CDC37/kinase interactions, suggesting that chaperone interactions will have broad application in detecting drug-target interactions in vivo.

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  • (PMID = 23811600.001).
  • [ISSN] 1546-1696
  • [Journal-full-title] Nature biotechnology
  • [ISO-abbreviation] Nat. Biotechnol.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / UL1-DE019585; United States / NCI NIH HHS / CA / P30 CA014051; United States / NIDCR NIH HHS / DE / UL1 DE019585; United States / NIGMS NIH HHS / GM / RL1-GM084437; United States / Howard Hughes Medical Institute / / ; United States / NCI NIH HHS / CA / RL1-CA133834; United States / NIGMS NIH HHS / GM / RL1 GM084437; United States / NHGRI NIH HHS / HG / RL1-HG004671; United States / NHGRI NIH HHS / HG / RL1 HG004671; United States / NCI NIH HHS / CA / RL1 CA133834
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / ETS translocation variant 6 protein; 0 / HSP90 Heat-Shock Proteins; 0 / Molecular Chaperones; 0 / Protein Kinase Inhibitors; 0 / Proto-Oncogene Proteins c-ets; 0 / Pyrazoles; 0 / Pyridines; 0 / Repressor Proteins; 53AH36668S / crizotinib; EC 2.7.- / Phosphotransferases; EC 2.7.10.1 / Receptor, trkC
  • [Other-IDs] NLM/ NIHMS484224; NLM/ PMC3774174
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67. Du Plessis DH, Van Wyngaardt W, Gerdes GH, Opperman E: Laboratory confirmation of African horsesickness in the western Cape: application of a F(ab')2-based indirect ELISA. Onderstepoort J Vet Res; 1991 Mar;58(1):1-3
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  • Spleen samples from these animals were subjected to analysis by an enzyme-linked immunosorbent assay (ELISA) which uses F(ab')2 fragments of immunoglobulins to detect African horse sickness virus (AHSV) antigens.
  • Subsequently, when the cell culture was assayed by F(ab')2-ELISA, a much higher absorbance value than that obtained with the original spleen sample resulted, thus confirming the presence of AHSV in the initial specimen.
  • [MeSH-minor] Animals. Enzyme-Linked Immunosorbent Assay / veterinary. Horses

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  • (PMID = 2052314.001).
  • [ISSN] 0030-2465
  • [Journal-full-title] The Onderstepoort journal of veterinary research
  • [ISO-abbreviation] Onderstepoort J. Vet. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] SOUTH AFRICA
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / Immunoglobulin Fab Fragments
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68. Huang TS, Huang WK, Lee SS, Tu HZ, Chang SH, Liu YC: Rapid detection of pulmonary tuberculosis using the BDProbeTEC ET Mycobacterium tuberculosis Complex Direct Detection Assay (DTB). Diagn Microbiol Infect Dis; 2003 May;46(1):29-33
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  • [Title] Rapid detection of pulmonary tuberculosis using the BDProbeTEC ET Mycobacterium tuberculosis Complex Direct Detection Assay (DTB).
  • The ability to rapidly detect tubercle bacilli in respiratory secretions was determined for the BDProbeTEC ET Mycobacterium tuberculosis Complex Direct Detection Assay in comparison with the acid-fast smear (AFS).
  • The DTB assay was positive in 70 of 78 culture positive specimens (89.7%) and 12 of 177 culture negative specimens (6.8%).
  • The sensitivity, specificity, positive predictive value, and negative predictive value of DTB assay were 89.7%, 93.7%, 85.4%, and 95.7%, respectively.
  • The greater cost of the DTB assay compared to the AFS was compensated by its valuable information for the diagnosis and control of tuberculosis.
  • These results demonstrated the clinical usefulness of the DTB assay for the rapid diagnosis of tuberculosis in respiratory specimens.

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  • (PMID = 12742316.001).
  • [ISSN] 0732-8893
  • [Journal-full-title] Diagnostic microbiology and infectious disease
  • [ISO-abbreviation] Diagn. Microbiol. Infect. Dis.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Probes; 0 / Reagent Kits, Diagnostic
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69. Blok MJ, Goossens VJ, Vanherle SJ, Top B, Tacken N, Middeldorp JM, Christiaans MH, van Hooff JP, Bruggeman CA: Diagnostic value of monitoring human cytomegalovirus late pp67 mRNA expression in renal-allograft recipients by nucleic acid sequence-based amplification. J Clin Microbiol; 1998 May;36(5):1341-6
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  • [Title] Diagnostic value of monitoring human cytomegalovirus late pp67 mRNA expression in renal-allograft recipients by nucleic acid sequence-based amplification.
  • The diagnostic value of monitoring human cytomegalovirus (HCMV) late pp67 mRNA expression by nucleic acid sequence-based amplification (NASBA) after renal-allograft transplantation was evaluated.
  • NASBA results were compared to results from the pp65 antigenemia assay, virus isolation by cell culture, and serology.
  • The sensitivity value for NASBA proved to be higher than that for the antigenemia assay (50 versus 35%) for the detection of HCMV infection, while the sensitivity values of cell culture and NASBA were comparable (54 and 50%, respectively).
  • NASBA detected the onset of HCMV infection simultaneously with cell culture and the antigenemia assay.
  • Both the antigenemia assay and NASBA are very specific (100%) and highly predictive (100%) for the onset of HCMV infection.
  • Antiviral therapy with ganciclovir resulted in negative results for cell culture, the antigenemia assay, and NASBA.
  • In conclusion, monitoring HCMV pp67 mRNA expression by NASBA is a highly specific method for the detection of HCMV infection in renal-allograft recipients and is more sensitive than the antigenemia assay.

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  • (PMID = 9574702.001).
  • [ISSN] 0095-1137
  • [Journal-full-title] Journal of clinical microbiology
  • [ISO-abbreviation] J. Clin. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Viral; 0 / RNA-Binding Proteins; 0 / Viral Proteins
  • [Other-IDs] NLM/ PMC104825
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70. Bosserman L, Rogers K, Willis C, Davidson D, Whitworth P, Karimi M, Upadhyaya G, Rutledge J, Hallquist A, Perree M, Presant CA: Application of a drug-induced apoptosis assay to identify treatment strategies in recurrent or metastatic breast cancer. PLoS One; 2015;10(5):e0122609
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  • [Title] Application of a drug-induced apoptosis assay to identify treatment strategies in recurrent or metastatic breast cancer.
  • BACKGROUND: A drug-induced apoptosis assay has been developed to determine which chemotherapy drugs or regimens can produce higher cell killing in vitro.
  • This study was done to determine if this assay could be performed in patients with recurrent or metastatic breast cancer patients, to characterize the patterns of drug-induced apoptosis, and to evaluate the clinical utility of the assay.
  • A secondary goal was to correlate assay use with clinical outcomes.
  • METHODS: In a prospective, non-blinded, multi institutional controlled trial, 30 evaluable patients with recurrent or metastatic breast cancer who were treated with chemotherapy had tumor samples submitted for the MiCK drug-induced apoptosis assay.
  • RESULTS: The assay was able to characterize drug-induced apoptosis in tumor specimens from breast cancer patients and identified which drugs or combinations gave highest levels of apoptosis.
  • Physician frequently (73%) used the assay to help select chemotherapy treatments in patients, Patients whose physicians were users had a higher response (CR+PR) rate compared to non-users (38.1% vs 0%, p = 0.04) and a higher disease control (CR+PR+Stable) rate (81% vs 25%, p<0.01).
  • CONCLUSIONS: The MiCK assay can be performed in breast cancer specimens, and results are often used by physicians in breast cancer patients with recurrent or metastatic disease.
  • These results from a good laboratory phase II study can be the basis for a future larger prospective multicenter study to more definitively establish the value of the assay.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Biological Assay / methods. Breast Neoplasms / diagnosis. Breast Neoplasms / drug therapy


71. Srimuang S, Roongruangchai K, Lawtiantong T, Chusattayanond AD, Warrasak S, Sahaphong S, Tanphaichitra D: Immunobiological diagnosis of tropical ocular diseases: Toxocara, Pythium insidiosum, Pseudomonas (Burkholderia) pseudomallei, Mycobacterium chelonei and Toxoplasma gondii. Int J Tissue React; 1996;18(1):23-5
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  • We demonstrated the value of the direct immunofluorescent assay (DIFA) on vitreous specimens from 7 cases of Toxoplasma retinitis.
  • [MeSH-minor] Adolescent. Adult. Animals. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Mycobacterium chelonae. Pythium. Tropical Medicine

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  • (PMID = 8880376.001).
  • [ISSN] 0250-0868
  • [Journal-full-title] International journal of tissue reactions
  • [ISO-abbreviation] Int J Tissue React
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] SWITZERLAND
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72. Lee SK, Cheng N, Hull-Ryde E, Potempa M, Schiffer CA, Janzen W, Swanstrom R: A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid. Biochemistry; 2013 Jul 23;52(29):4929-40
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  • [Title] A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid.
  • In the study presented here, a sensitive assay based on fluorescence polarization that can monitor cleavage at the MA/CA site in the context of the folded protein substrate is described.
  • By limiting the size of CA and increasing the size of MA (with an N-terminal GST fusion), we were able to measure significant differences in polarization values as a function of HIV-1 protease cleavage.
  • The sensitivity of the assay was tested in the presence of increasing amounts of an HIV-1 protease inhibitor, which resulted in a gradual decrease in the fluorescence polarization values demonstrating that the assay is sensitive in discerning changes in protease processing.
  • The high-throughput screening assay validation in 384-well plates showed that the assay is reproducible and robust with an average Z' value of 0.79 and average coefficient of variation values of <3%.
  • The robustness and reproducibility of the assay were further validated using the LOPAC(1280) compound library, demonstrating that the assay provides a sensitive high-throughput screening platform that can be used with large compound libraries for identifying novel maturation inhibitors targeting the MA/CA site of the HIV-1 Gag polyprotein.

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  • (PMID = 23763575.001).
  • [ISSN] 1520-4995
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / P01-GM066524; United States / NIGMS NIH HHS / GM / R01GM65347; United States / NIAID NIH HHS / AI / T32 AI007001; United States / NINDS NIH HHS / NS / R21 NS073052; United States / NCI NIH HHS / CA / P30 CA016086; United States / NIAID NIH HHS / AI / P30-AI50410; United States / NCI NIH HHS / CA / P30 CA16086; United States / NIGMS NIH HHS / GM / P01 GM066524; United States / NIGMS NIH HHS / GM / R01 GM064347; United States / NIAID NIH HHS / AI / P30 AI050410
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.23.- / HIV Protease; TPY09G7XIR / Fluorescein
  • [Other-IDs] NLM/ NIHMS505262; NLM/ PMC3855639
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73. Domthong U, Parikh CR, Kimmel PL, Chinchilli VM, Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury Consortium: Assessing the agreement of biomarker data in the presence of left-censoring. BMC Nephrol; 2014 Sep 03;15:144
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  • However, measurement of a specific biomarker typically cannot provide accurate numerical values below the lower limit of detection (LLD) of the assay, which results in left-censored data.
  • Most researchers discard the data below the LLD or apply simple data imputation methods in the presence of left-censored data, such as replacing values below the LLD with a fixed number less than or equal to the LLD.
  • In all of the simulated scenarios, the ML method yields the smallest relative bias and the highest percentage of the 95% confidence intervals that include the true value of the CCC.
  • CONCLUSIONS: When estimating the CCC from paired biomarker data in the presence of left-censored values, the ML method works better than data deletion and simple data imputation methods.

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  • (PMID = 25186769.001).
  • [ISSN] 1471-2369
  • [Journal-full-title] BMC nephrology
  • [ISO-abbreviation] BMC Nephrol
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / U01 DK082183; United States / NIDDK NIH HHS / DK / K24DK090203; United States / NIDDK NIH HHS / DK / U01DK082183; United States / NIDDK NIH HHS / DK / U01DK082185
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers
  • [Other-IDs] NLM/ PMC4236661
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74. Adlercreutz H, Lehtinen T, Kairento AL: Prediction of ovulation by urinary estrogen assays. J Steroid Biochem; 1980 Jan;12:395-401
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  • [Title] Prediction of ovulation by urinary estrogen assays.
  • 22 women (mean age, 30; range 20 to 40 years) were studied to investigate the predictive value of various individual metabolites.
  • Lengths of menstrual cycles (n=29) ranged from 23 to 37 days )mean 27.6 days) and all were ovulatory as judged from urinary luteinizing hormone (LH), pregnanediol 3-glucuronide (P-3G) and plasma progesterone assays.
  • Mean value for all estrogen metabolites assayed was constant over days -10 to -6 of the follicular phase of the menstrual cycle.
  • Mathematical analyses of about 16,000 hormone assays showed that the increase in excretion starting from day -6 was best fitted by a linear regression function.
  • The E2, E1-3G and E1 assays were the best methods based on the use of 6 different mathematical procedures.
  • Urinary collections during the night and assay of estrone and/or estradiol conjugates in urine are practical methods for predicting ovulation time.

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  • (PMID = 7421224.001).
  • [ISSN] 0022-4731
  • [Journal-full-title] Journal of steroid biochemistry
  • [ISO-abbreviation] J. Steroid Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Estrogens; 0 / Glucuronates; 2DI9HA706A / Estrone; 4TI98Z838E / Estradiol; FB33469R8E / Estriol
  • [Other-IDs] PIP/ 803437; POP/ 00083086
  • [Keywords] PIP ; Clinical Research (major topic) / Estrogens (major topic) / Menstrual Cycle (major topic) / Ovulation Detection (major topic) / Biology / Endocrine System / Estriol / Estrone / Examinations And Diagnoses / Hormones / Laboratory Examinations And Diagnoses / Laboratory Procedures / Menstruation / Ovulation / Physiology / Reproduction / Research Methodology
  • [General-notes] PIP/ TJ: JOURNAL OF STEROID BIOCHEMISTRY.
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75. Karimzadegan E, Clifford AJ, Hill FW: A rat bioassay for measuring the comparative availability of carbohydrates and its application to legume foods, pure carbohydrates and polyols. J Nutr; 1979 Dec;109(12):2247-59
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  • An assay was developed to evaluate the bioavailability of dietary carbohydrate by slope-ratio analysis of weight gain and plasma ketones of rats fed a carbohydrate-free diet supplemented with glucose as a standard and selected food items, pure carbohydrates and polyols.
  • Under these experimental conditions, additional glucose or additional protein were growth stimulating and casein had approximately 50% of the value of an equal weight of glucose, which was consistent with its content of glucogenic amino acids.
  • The specific carbohydrate value of a food was estimated in the assay by subtracting the calculated glucogenic value of its digestible protein from the total response.
  • [MeSH-minor] Amino Acids / analysis. Animals. Biological Assay. Biological Availability. Caseins / administration & dosage. Dietary Fats / administration & dosage. Fructose / metabolism. Glucose / metabolism. Inulin / metabolism. Male. Rats. Soybeans. Starch / metabolism

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  • (PMID = 574537.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Caseins; 0 / Dietary Carbohydrates; 0 / Dietary Fats; 0 / Sugar Alcohols; 30237-26-4 / Fructose; 9005-25-8 / Starch; 9005-80-5 / Inulin; IY9XDZ35W2 / Glucose
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76. He S, Hang JP, Zhang L, Wang F, Zhang DC, Gong FH: A systematic review and meta-analysis of diagnostic accuracy of serum 1,3-β-D-glucan for invasive fungal infection: Focus on cutoff levels. J Microbiol Immunol Infect; 2015 Aug;48(4):351-61
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  • To assess the diagnostic accuracy of 1,3-β-D-glucan (BDG) assay for diagnosing invasive fungal infections (IFI), we searched the Medline and Embase databases, and studies reporting the performance of BDG assays for the diagnosis of IFI were identified.
  • Subgroup analyses indicated that in cohort studies, the cutoff value of BDG at 80 pg/mL had the best diagnostic accuracy, whereas in case-control studies the cutoff value of 20 pg/mL had the best diagnostic accuracy; moreover, the AUC-SROC in cohort studies was lower than that in case-control studies.
  • The cutoff value of 60 pg/mL has the best diagnostic accuracy with the European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria as a reference standard.
  • The 60 pg/mL cutoff value has the best diagnostic accuracy with the Fungitell assay compared to the BDG detection assay.
  • The cutoff value of 20 pg/mL has the best diagnostic accuracy with the Fungitec G-test assay, and the cutoff value of 11 pg/mL has the best diagnostic accuracy with the Wako assay.
  • As such, 60 pg/mL of BDG level can be used as the best cutoff value to distinguish patients with IFIs from patients without IFI (mainly due to Candida and Aspergillus).

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  • [Copyright] Copyright © 2014. Published by Elsevier B.V.
  • (PMID = 25081986.001).
  • [ISSN] 1995-9133
  • [Journal-full-title] Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
  • [ISO-abbreviation] J Microbiol Immunol Infect
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / beta-1,3-D-glucan; 0 / beta-Glucans
  • [Keywords] NOTNLM ; 1,3-β-d-Glucan (BDG) / diagnosis / invasive fungal infection (IFI) / meta-analysis / systematic review
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77. Roemer E, Zenzen V, Conroy LL, Luedemann K, Dempsey R, Schunck C, Sticken ET: Automation of the in vitro micronucleus and chromosome aberration assay for the assessment of the genotoxicity of the particulate and gas-vapor phase of cigarette smoke. Toxicol Mech Methods; 2015;25(4):320-33
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  • [Title] Automation of the in vitro micronucleus and chromosome aberration assay for the assessment of the genotoxicity of the particulate and gas-vapor phase of cigarette smoke.
  • Total particulate matter (TPM) and the gas-vapor phase (GVP) of mainstream smoke from the Reference Cigarette 3R4F were assayed in the cytokinesis-block in vitro micronucleus (MN) assay and the in vitro chromosome aberration (CA) assay, both using V79-4 Chinese hamster lung fibroblasts exposed for up to 24 h.
  • The Metafer image analysis platform was adapted resulting in a fully automated evaluation system of the MN assay for the detection, identification and reporting of cells with micronuclei together with the determination of the cytokinesis-block proliferation index (CBPI) to quantify the treatment-related cytotoxicity.
  • In the CA assay, the same platform was used to identify, map and retrieve metaphases for a subsequent CA evaluation by a trained evaluator.
  • In both the assays, TPM and GVP provoked a significant genotoxic effect: up to 6-fold more micronucleated target cells than in the negative control and up to 10-fold increases in aberrant metaphases.
  • Data variability was lower in the automated version of the MN assay than in the non-automated.
  • It can be estimated that two test substances that differ in their genotoxicity by approximately 30% can statistically be distinguished in the automated MN and CA assays.
  • Time savings, based on man hours, due to the automation were approximately 70% in the MN and 25% in the CA assays.
  • Although only cigarette smoke-derived test material has been applied, the technical improvements should be of value for other test substances.

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  • (PMID = 25986082.001).
  • [ISSN] 1537-6524
  • [Journal-full-title] Toxicology mechanisms and methods
  • [ISO-abbreviation] Toxicol. Mech. Methods
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Gases; 0 / Mutagens; 0 / Particulate Matter; 0 / Smoke
  • [Keywords] NOTNLM ; Automation / chromosome aberration assay / cigarette smoke / cytokinesis-block proliferation index / cytotoxicity / genotoxicity / micronucleus assay
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78. George SE, Bungay PJ, Naylor LH: Functional coupling of endogenous serotonin (5-HT1B) and calcitonin (C1a) receptors in CHO cells to a cyclic AMP-responsive luciferase reporter gene. J Neurochem; 1997 Sep;69(3):1278-85
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  • This reporter gene assay gave the expected pharmacological profile for these receptors when compared with cyclic AMP accumulation assays, confirming its value as a functional assay for G protein-coupled receptors linked to adenylyl cyclase.

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  • (PMID = 9282953.001).
  • [ISSN] 0022-3042
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Receptor, Serotonin, 5-HT1B; 0 / Receptors, Calcitonin; 0 / Receptors, Serotonin; 0 / Recombinant Fusion Proteins; 0 / Serotonin Receptor Agonists; 1F7A44V6OU / Colforsin; 333DO1RDJY / Serotonin; 51110-01-1 / Somatostatin; 9007-12-9 / Calcitonin; BJ4HF6IU1D / Pindolol; E0399OZS9N / Cyclic AMP; EC 1.13.12.- / Luciferases; VTD58H1Z2X / Dopamine
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79. Ambrosi B, Bochicchio D, Peverelli S, Ferrario R, Faglia G: Value of serum dehydroepiandrosterone sulfate assay in the evaluation of pituitary-adrenal insufficiency after pituitary adenomectomy. J Endocrinol Invest; 1992 Dec;15(11):827-33
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  • [Title] Value of serum dehydroepiandrosterone sulfate assay in the evaluation of pituitary-adrenal insufficiency after pituitary adenomectomy.
  • The value of dehydroepiandrosterone sulfate (DHEA-S), a specific marker of adrenal androgen production, in the assessment of clinical states of hypercortisolism and hypocortisolism has been suggested.
  • Before surgery in all pts mean DHEA-S and F basal values were 3.57 +/- 0.42 mumol/L and 391.8 +/- 29.0 nmol/L, respectively.

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  • (PMID = 1337907.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 459AG36T1B / Dehydroepiandrosterone; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
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80. Harrington B, Nickerson B, Guo MX, Barber M, Giamalva D, Lee C, Scrivens G: Sample preparation composite and replicate strategy for assay of solid oral drug products. Anal Chem; 2014 Dec 16;86(24):11930-6
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  • [Title] Sample preparation composite and replicate strategy for assay of solid oral drug products.
  • In pharmaceutical analysis, the results of drug product assay testing are used to make decisions regarding the quality, efficacy, and stability of the drug product.
  • In order to make sound risk-based decisions concerning drug product potency, an understanding of the uncertainty of the reportable assay value is required.
  • Utilizing the most restrictive criteria in current regulatory documentation, a maximum variability attributed to method repeatability is defined for a drug product potency assay.
  • A sampling strategy that reduces the repeatability component of the assay variability below this predefined maximum is demonstrated.
  • The variability, as measured by the standard error (SE), of a potency assay consists of several sources such as sample preparation and dosage unit variability.
  • A sampling scheme that increases the number of sample preparations (r) and/or number of dosage units (k) per sample preparation will reduce the assay variability and thus decrease the uncertainty around decisions made concerning the potency of the drug product.
  • A maximum allowable repeatability component of the standard error (SE) for the potency assay is derived using material in current regulatory documents.
  • [MeSH-minor] Administration, Oral. Biological Assay. Capsules / chemistry. Quality Control

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  • (PMID = 25389711.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Capsules
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81. Yousefi S, Escobar MR, Gouldin CW: A practical cytopathic effect/dye-uptake interferon assay for routine use in the clinical laboratory. Am J Clin Pathol; 1985 Jun;83(6):735-40
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  • [Title] A practical cytopathic effect/dye-uptake interferon assay for routine use in the clinical laboratory.
  • The clinical value of interferon (IFN) level determinations has been demonstrated, but a practical assay procedure for routine use in the diagnostic laboratory has not been available.
  • [MeSH-major] Biological Assay / methods. Cytopathogenic Effect, Viral. Interferon Type I / analysis. Interferon-gamma / analysis

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  • (PMID = 2988328.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Interferon Type I; 82115-62-6 / Interferon-gamma
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82. Singh G, Sharma A, Kaur H, Ishar MP: Chromanyl-isoxazolidines as Antibacterial agents: Synthesis, Biological Evaluation, Quantitative Structure Activity Relationship, and Molecular Docking Studies. Chem Biol Drug Des; 2016 Feb;87(2):213-23
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  • All the synthesized compounds were assayed for their in vitro antibacterial activity and display significant inhibitory potential; in particular, compound 32 exhibited good inhibitory activity against Salmonella typhymurium-1 & Salmonella typhymurium-2 with minimum inhibitory concentration value of 1.56 μg/mL and also showed good potential against methicillin-resistant Staphylococcus aureus with minimum inhibitory concentration 3.12 μg/mL.

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  • [Copyright] © 2015 John Wiley & Sons A/S.
  • (PMID = 26301627.001).
  • [ISSN] 1747-0285
  • [Journal-full-title] Chemical biology & drug design
  • [ISO-abbreviation] Chem Biol Drug Des
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Chromones; 0 / Oxazoles; EC 5.99.1.3 / DNA Topoisomerases, Type II
  • [Keywords] NOTNLM ; 1,3-dipolar cycloaddition / 3-chromanyl-isoxazolidines / ADME properties / antibacterial activity / quantitative structure activity relationship
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83. Phillips LE, Martin RF, Luper WE, Rogers TE: Assays of serum aminoglycoside levels by BACTEC 460 in the presence of cefamandole and cefoxitin. Antimicrob Agents Chemother; 1981 Apr;19(4):567-70
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  • [Title] Assays of serum aminoglycoside levels by BACTEC 460 in the presence of cefamandole and cefoxitin.
  • The effects of cefamandole and cefoxitin on the assays of serum containing gentamicin, tobramycin, or amikacin by the BACTEC 460 (Johnston Laboratories, Cockeysville, Md.) were studied.
  • The results were analyzed to determine whether the presence of the test substances, cefamandole or cefoxitin, caused a statistically different mean value of aminoglycoside or increase in variance as compared with serum assayed in their absence.

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  • [Cites] Clin Chem. 1974 Jul;20(7):825-33 [4835236.001]
  • [Cites] Antimicrob Agents Chemother. 1979 Oct;16(4):463-7 [518075.001]
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  • (PMID = 7247379.001).
  • [ISSN] 0066-4804
  • [Journal-full-title] Antimicrobial agents and chemotherapy
  • [ISO-abbreviation] Antimicrob. Agents Chemother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Aminoglycosides; 0 / Anti-Bacterial Agents; 0 / Cephalosporins; 0 / Gentamicins; 5CKP8C2LLI / Cefamandole; 6OEV9DX57Y / Cefoxitin; 84319SGC3C / Amikacin; VZ8RRZ51VK / Tobramycin
  • [Other-IDs] NLM/ PMC181478
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84. Cooney MJ: Kinetic Measurements for Enzyme Immobilization. Methods Mol Biol; 2017;1504:215-232
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  • The study of an enzyme's kinetics considers the various stages of activity, reveals the catalytic mechanism of this enzyme, correlates its value to assay conditions, and describes how a drug or a poison might inhibit the enzyme.
  • That being said, the estimated value of the Michaelis-Menten coefficients (e.g., V max, K M) can be used to evaluate effects of immobilization on enzyme activity in the immobilized state when applied in a controlled manner.

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  • (PMID = 27770425.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] ENG
  • [Publication-type] JOURNAL ARTICLE
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Enzyme activity / Enzyme kinetics / Immobilization / Michaelis–Menten
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85. Cooney MJ: Kinetic measurements for enzyme immobilization. Methods Mol Biol; 2011;679:207-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The study of an enzyme's kinetics considers the various stages of activity, reveals the catalytic mechanism of the enzyme, correlates its value to assay conditions, and describes how a drug or a poison might inhibit the enzyme.
  • That being said, the estimated value of the Michaelis-Menten coefficients (e.g., V(max), K(M)) can be used to evaluate effects of immobilization on enzyme activity in the immobilized state when applied in a controlled manner.

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  • (PMID = 20865399.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzymes; 0 / Enzymes, Immobilized
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86. Pernod G, Wu H, de Maistre E, Lazarchick J, Kassis J, Aguilar C, Vera PM, Palareti G, D'Angelo A, DiET Study Group (Jeffrey Caterino, Fabienne Dutrillaux, Gary Headden, Colin Kaide, Maxime Maignan, Raphaël Marlu, Anais Richard, Cindy Tissier): Validation of STA-Liatest D-Di assay for exclusion of pulmonary embolism according to the latest Clinical and Laboratory Standard Institute/Food and Drug Administration guideline. Results of a multicenter management study. Blood Coagul Fibrinolysis; 2017 Apr;28(3):254-260
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  • [Title] Validation of STA-Liatest D-Di assay for exclusion of pulmonary embolism according to the latest Clinical and Laboratory Standard Institute/Food and Drug Administration guideline. Results of a multicenter management study.
  • : Combined clinical pretest probability (PTP) and D-dimer testing have great diagnostic value for pulmonary embolism exclusion.
  • To harmonize performance levels of D-dimer assays available on the market, the Clinical and Laboratory Standard Institute (CLSI) has published a guideline, endorsed by the US Food and Drug Administration (FDA).
  • Such guideline specifies the ideal D-dimer assay characteristic and target population.
  • This study was conducted following the CLSI guideline to upgrade the assay-intended use and obtain FDA clearance of STA-Liatest D-Di assay for pulmonary embolism exclusion in patient with low/moderate PTP.
  • D-dimer assay was performed in consecutive, ambulatory outpatients suspected of pulmonary embolism, with low/moderate PTP, and without medical conditions or in clinical settings known to alter default D-dimer values regardless of the presence of thrombosis using a threshold of 0.5 μg/ml (fibrinogen equivalent units) for venous thromboembolism exclusion.
  • STA-Liatest D-Di assay performance has exceeded the CLSI/FDA guidance requirements, with a sensitivity of 97.6% (95% confidence interval: 91.7-99.7%) and a negative predictive value of 99.7% (95% confidence interval: 99.0-100%).
  • STA-Liatest D-Di assay has an excellent performance when used in combination with a PTP score in relevant patients and has the potential to minimize the economic healthcare burden avoiding unnecessary and expensive imaging tests.
  • [MeSH-major] Biological Assay / methods. Fibrin Fibrinogen Degradation Products / metabolism. Pulmonary Embolism / diagnosis

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  • (PMID = 27428016.001).
  • [ISSN] 1473-5733
  • [Journal-full-title] Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
  • [ISO-abbreviation] Blood Coagul. Fibrinolysis
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Fibrin Fibrinogen Degradation Products; 0 / fibrin fragment D
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87. Abadie JM, Blassingame CL, Bankson DD: Albumin cobalt binding assay to rule out acute coronary syndrome. Ann Clin Lab Sci; 2005;35(1):66-72
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  • [Title] Albumin cobalt binding assay to rule out acute coronary syndrome.
  • The purpose of this study was to validate the Albumin Cobalt Binding (ACB) assay at the Seattle Veterans Affairs (VA) Hospital to determine if it would provide an earlier rule-out of acute coronary syndrome (ACS) in patients, compared to current use of cardiac injury markers.
  • This study compares the distribution of ischemia modified albumin (IMA) values of our patient population to those provided by the kit manufacturer.
  • IMA values were determined photometrically on a Roche Modular Analytical System on 200 subjects: 69 subjects not experiencing chest pain (normals), 78 subjects presenting to the emergency room (ER) with chest pain whose initial and subsequent troponin results were negative (non-converters), and 53 subjects presenting to the ER with chest pain whose initial troponin result was negative but subsequent troponin results were positive (converters).
  • Based on the relationships between IMA values in the initial samples from the non-converters and converters, we constructed a ROC curve to identify an optimum IMA rule-out value.
  • The IMA values (mean+/-SD) for the normals, non-converters, and converters were 89+/-7.1, 100+/-13.9, and 126+/-14.1 U/ml, respectively, and each mean was statistically different from the means of the other groups.
  • In conclusion, the ACB assay has a strong negative predictive value and sensitivity in our population for predicting the troponin results at 6 to 24 hr post-presentation.
  • The ACB assay, when used in conjunction with cardiac injury markers and assessment of unstable angina, holds promise in reducing inappropriate low-risk hospital admissions and improving the clinical management of patients with chest pain.
  • [MeSH-minor] Acute Disease. Aged. Angina, Unstable / blood. Angina, Unstable / diagnosis. Biomarkers. Emergencies. False Positive Reactions. Humans. Middle Aged. Reference Values. Reproducibility of Results

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  • (PMID = 15830711.001).
  • [ISSN] 0091-7370
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Serum Albumin; 3G0H8C9362 / Cobalt
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88. Yao Y, Bian YP, Xia DD, Pan B, Niu MS, Zhao K, Zeng LY, Xu KL: [Effect of AZD8330 on proliferation and apoptosis of multiple myeloma cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2014 Oct;22(5):1311-5
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  • The CCK-8 assay was used to detect cell viability and the IC50 value at 48 h.
  • The results showed that AZD8330 could significantly inhibit the cell viability of IM9 and NCI-H929 cell lines in a time-and dose-dependent manner, the IC50 value (48 h) of IM9 and NCI-H929 were 19.88 ± 2.7 nmol/L and 29.3 ± 2.03 nmol/L respectively, these two cell lines were arrested on G1 phase of cell cycle, the apoptosis cells increased along with enhancement of AZD8330 concentration, and the expression level of cleaved caspase-3 protein was up-regulated.


89. John R, Evans PE, Scanlon MF, Hall R: Clinical value of immunoradiometric assay of thyrotropin for patients with nonthyroidal illness and taking various drugs. Clin Chem; 1987 Apr;33(4):566-9
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  • [Title] Clinical value of immunoradiometric assay of thyrotropin for patients with nonthyroidal illness and taking various drugs.
  • Using a two-site immunoradiometric assay, we measured concentrations of thyrotropin (TSH) in serum of 134 clinically euthyroid subjects, 93 patients with nonthyroidal illness, and 80 patients who were being treated with various drugs.
  • We conclude that, for most patients without thyroid disease, a basal (i.e., unstimulated) measurement of their TSH concentration in serum will indicate their thyroid status more reliably than will assay of free thyroxin or free triiodothyronine.

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  • (PMID = 3829391.001).
  • [ISSN] 0009-9147
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 06LU7C9H1V / Triiodothyronine; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
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90. Smith IF, Taiwo O, Payne-Robinson HM: Plasma somatomedin-C in Nigerian malnourished children fed a vegetable protein rehabilitation diet. Eur J Clin Nutr; 1989 Oct;43(10):705-13
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  • By our assay the value for 39 normal children (age range 6-36 months) was 0.315 +/- 0.035 U/ml.
  • The values were higher (P less than 0.05) in the 7 marasmic children (0.26 +/- 0.1) than in the 11 with oedema (0.15 +/- 0.02).

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  • (PMID = 2612459.001).
  • [ISSN] 0954-3007
  • [Journal-full-title] European journal of clinical nutrition
  • [ISO-abbreviation] Eur J Clin Nutr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Somatomedins; 0 / Vegetable Proteins; 67763-96-6 / Insulin-Like Growth Factor I
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91. Brzozowska K, Pinkawa M, Eble MJ, Müller WU, Wojcik A, Kriehuber R, Schmitz S: In vivo versus in vitro individual radiosensitivity analysed in healthy donors and in prostate cancer patients with and without severe side effects after radiotherapy. Int J Radiat Biol; 2012 May;88(5):405-13
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  • The initial level of double-strand breaks (dsb) and repair kinetics measured by phosphorylation of histone H2A (γ-H2AX-assay), apoptosis (Annexin V-assay) and the induction of chromatid aberrations after irradiation in the G2-phase of the cell cycle (G2-assay) were analysed.
  • CONCLUSIONS: There is no obvious correlation between clinical and cellular radiosensitivity in lymphocytes of prostate cancer patients when all chosen in vitro assays are considered.
  • Although 25% of the patients showed both severe side effects and increased radiation-induced chromosomal sensitivity, predictive value of G2-assay is doubtful.

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  • (PMID = 22348555.001).
  • [ISSN] 1362-3095
  • [Journal-full-title] International journal of radiation biology
  • [ISO-abbreviation] Int. J. Radiat. Biol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / H2AFX protein, human; 0 / Histones
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92. Paddle JJ: Evaluation of the Haemoglobin Colour Scale and comparison with the HemoCue haemoglobin assay. Bull World Health Organ; 2002;80(10):813-6
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  • [Title] Evaluation of the Haemoglobin Colour Scale and comparison with the HemoCue haemoglobin assay.
  • OBJECTIVE: To evaluate the Haemoglobin Colour Scale developed by WHO for estimating haemoglobin concentration and to compare the results obtained using it and the HemoCue assay with those determined using a reference method, the Technicon H3 analyser.
  • METHODS: The Colour Scale and HemoCue assay were used to test 408 blood samples.
  • FINDINGS: The mean difference between the Haemoglobin Colour Scale and the reference method was 0.19 g/dl (95% confidence interval: 3.50 g/dl below to 3.11 g/dl above); the corresponding value for the HemoCue assay was 0.50 g/dl (1.16 g/dl below to 0.16 g/dl above).

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  • [CommentIn] Bull World Health Organ. 2002;80(10):839 [12471407.001]
  • (PMID = 12471402.001).
  • [ISSN] 0042-9686
  • [Journal-full-title] Bulletin of the World Health Organization
  • [ISO-abbreviation] Bull. World Health Organ.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Hemoglobins
  • [Other-IDs] NLM/ PMC2567662
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93. Røysland R, Masson S, Omland T, Milani V, Bjerre M, Flyvbjerg A, Di Tano G, Misuraca G, Maggioni AP, Tognoni G, Tavazzi L, Latini R, GISSI-HF Investigators: Prognostic value of osteoprotegerin in chronic heart failure: The GISSI-HF trial. Am Heart J; 2010 Aug;160(2):286-93
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  • [Title] Prognostic value of osteoprotegerin in chronic heart failure: The GISSI-HF trial.
  • Osteoprotegerin was analyzed by enzyme-linked immunosorbent assay.
  • [MeSH-minor] Aged. Female. Fluorobenzenes / therapeutic use. Fluoroimmunoassay. Hospitalization / statistics & numerical data. Humans. Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use. Italy. Male. Middle Aged. Osteoprotegerin. Prognosis. Proportional Hazards Models. Pyrimidines / therapeutic use. Rosuvastatin Calcium. Sulfonamides / therapeutic use

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20691834.001).
  • [ISSN] 1097-6744
  • [Journal-full-title] American heart journal
  • [ISO-abbreviation] Am. Heart J.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluorobenzenes; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0 / Osteoprotegerin; 0 / Pyrimidines; 0 / Sulfonamides; 83MVU38M7Q / Rosuvastatin Calcium
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94. Ruhland GJ, Hellwig M, Wanner G, Fiedler F: Cell-surface location of Listeria-specific protein p60--detection of Listeria cells by indirect immunofluorescence. J Gen Microbiol; 1993 Mar;139(3):609-16
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  • The value of the anti-p60 antiserum in developing a diagnostic assay for Listeria cells in environmental samples and foods is discussed.

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  • (PMID = 8473866.001).
  • [ISSN] 0022-1287
  • [Journal-full-title] Journal of general microbiology
  • [ISO-abbreviation] J. Gen. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Bacterial Proteins
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95. Huh HJ, Jang MA, Seo JY, Kim JY, Ki CS, Kim JW, Lee NY: Evaluation of the iNtRON VRE vanA/vanB real-time PCR assay for detection of vancomycin-resistant enterococci. Ann Lab Med; 2015 Jan;35(1):76-81
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  • [Title] Evaluation of the iNtRON VRE vanA/vanB real-time PCR assay for detection of vancomycin-resistant enterococci.
  • BACKGROUND: Recently, the iNtRON VRE vanA/vanB real-time PCR (iNtRON; iNtRON Biotechnology, Korea) assay, a multiplex real-time PCR method, was introduced.
  • In this prospective study, we compared the iNtRON assay with the Seeplex VRE ACE detection kit (Seeplex; Seegene, Korea), a conventional multiplex PCR assay.
  • A total of 304 consecutive rectal swab specimens were tested for VRE by culture and by iNtRON and Seeplex PCR assays.
  • For the PCR assays, specimens were enriched for 16-24 hr before PCR.
  • The clinical sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the iNtRON assay were 100% (95% confidence interval: 89.8%-100%), 99.2% (96.9%-99.9%), 95.6% (83.6%-99.2%), and 100% (98.2%-100%), respectively, while those of the Seeplex assay were 97.7% (86.2%-99.9%), 99.6% (97.5%-99.9%), 97.7% (86.2%-99.9%), and 99.6% (97.5%-99.9%), respectively.
  • The iNtRON assay had a detection limit of 3,159 copies/µL and 13,702 copies/µL for the vanA and vanB genes, respectively.
  • CONCLUSIONS: The overall performance of the iNtRON assay was comparable to that of a chromogenic agar-based culture method for prompt identification of VRE-colonized patients in hospitals.
  • This assay could be an alternative or supportive method for the effective control of nosocomial VRE infection.

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  • (PMID = 25553284.001).
  • [ISSN] 2234-3814
  • [Journal-full-title] Annals of laboratory medicine
  • [ISO-abbreviation] Ann Lab Med
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA, Bacterial; 0 / Reagent Kits, Diagnostic; 0 / VanA ligase, Bacteria; 0 / VanB protein, Enterococcus; EC 6.1.- / Carbon-Oxygen Ligases
  • [Other-IDs] NLM/ PMC4272969
  • [Keywords] NOTNLM ; Performance / Real-time PCR / Vancomycin-resistant enterococci / vanA / vanB
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96. Morel E, Raimond F, Goulon-Goëau C, Berrih S, Vernet-Der-Garabedian B, Harb J, Bach JF: [Assay of acetylcholine receptor antibodies in myasthenia gravis. A study of 329 sera (author's transl)]. Nouv Presse Med; 1982 May 22;11(24):1849-54
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  • [Title] [Assay of acetylcholine receptor antibodies in myasthenia gravis. A study of 329 sera (author's transl)].
  • In addition to its diagnostic value, the assay of antibodies to acetylcholine receptors proved useful in the follow-up of myasthenic patients (notably neonates) treated by thymectomy, immunodepressants and plasmapheresis.

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  • (PMID = 7110933.001).
  • [ISSN] 0301-1518
  • [Journal-full-title] La Nouvelle presse médicale
  • [ISO-abbreviation] Nouv Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] FRANCE
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Receptors, Cholinergic
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97. Jones CA, Uhl CB, Mattox VR, Kinsey JH, Cortese DA, Lieber MM: Use of a soft-agar colony-forming assay to determine the photosensitizing effects of several components of hematoporphyrin derivative. J Surg Oncol; 1984 May;26(1):9-13
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  • [Title] Use of a soft-agar colony-forming assay to determine the photosensitizing effects of several components of hematoporphyrin derivative.
  • The photosensitizing/cytotoxic effects of four porphyrin compounds derived from hematoporphyrin were compared using two human tumor cell lines with a soft-agar colony-forming assay.
  • Two fractions derived from hematoporphyrin derivative (HPD) were found to be better photosensitizers than HPD itself, indicating the potential value of this in vitro assay for detecting the most active component from a heterogeneous mixture.
  • [MeSH-major] Colony-Forming Units Assay. Hematoporphyrins / pharmacology. Light. Radiation-Sensitizing Agents / pharmacology

  • Hazardous Substances Data Bank. AGAR-AGAR .
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  • (PMID = 6233458.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Hematoporphyrins; 0 / Radiation-Sensitizing Agents; 68335-15-9 / Hematoporphyrin Derivative; 9002-18-0 / Agar
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98. Gautschi O, Huegli B, Ziegler A, Gugger M, Heighway J, Ratschiller D, Mack PC, Gumerlock PH, Kung HJ, Stahel RA, Gandara DR, Betticher DC: Origin and prognostic value of circulating KRAS mutations in lung cancer patients. Cancer Lett; 2007 Sep 8;254(2):265-73
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  • [Title] Origin and prognostic value of circulating KRAS mutations in lung cancer patients.
  • Because of the current controversy on the origin and clinical value of circulating KRAS codon 12 mutations in lung cancer, we screened 180 patients using a combined restriction fragment-length polymorphism and polymerase chain reaction (RFLP-PCR) assay.

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  • (PMID = 17449174.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / ras Proteins
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99. Belikova YO, Burov VI, Vinogradov AD: Isolation and properties of oxaloacetate keto-enol-tautomerases from bovine heart mitochondria. Biochim Biophys Acta; 1988 Oct 26;936(1):10-9
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  • When assayed in the enol----ketone direction at 25 degrees C (pH 9.0), the enzyme obeys a simple substrate saturation kinetics with Km and Vmax values of 45 microM and 74 units per mg of protein, respectively; the latter value corresponds to the turnover number of 2700 min-1.
  • The kinetic parameters of the enzyme as assayed in the enol----ketone direction at 25 degrees C (pH 9.0) are: Km = 220 microM and Vmax = 20 units per mg of protein; the latter corresponds to the turnover number of 1600 min-1.

  • Hazardous Substances Data Bank. MALEIC ACID .
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  • (PMID = 3179281.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Maleates; 0 / Oxalates; 0 / Oxaloacetates; 0 / Phosphates; 91XW058U2C / maleic acid; 9E7R5L6H31 / Oxalic Acid; EC 5.- / Isomerases; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.2.2 / oxaloacetate tautomerase; SU46BAM238 / Ammonium Sulfate; T8ID5YZU6Y / Dithiothreitol
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100. Zhang AB, Zheng SS, Jia CK, Wang Y: Effect of 1,25-dihydroxyvitamin D3 on preventing allograft from acute rejection following rat orthotopic liver transplantation. World J Gastroenterol; 2003 May;9(5):1067-71
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  • After treatment with 1,25-(OH)2 D3, mean value of all the assay tested on each experimental time was compared, liver function in group IV was significantly improved (AST 127+/-41 U/L-360+/-104 U/L, BIL 13+/-5 mmol/l-38+/-11 mmol/l; vs Group II, P<0.05; vs Group III, P>0.05.

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  • (PMID = 12717858.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / RNA, Messenger; 130068-27-8 / Interleukin-10; 82115-62-6 / Interferon-gamma; FXC9231JVH / Calcitriol; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC4611374
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