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1. Lewis H, Adamson J, Atherton K, Bailey D, Birtwistle J, Bosanquet K, Clare E, Delgadillo J, Ekers D, Foster D, Gabe R, Gascoyne S, Haley L, Hargate R, Hewitt C, Holmes J, Keding A, Lilley-Kelly A, Maya J, McMillan D, Meer S, Meredith J, Mitchell N, Nutbrown S, Overend K, Pasterfield M, Richards D, Spilsbury K, Torgerson D, Traviss-Turner G, Trépel D, Woodhouse R, Ziegler F, Gilbody S: CollAborative care and active surveillance for Screen-Positive EldeRs with subthreshold depression (CASPER): a multicentred randomised controlled trial of clinical effectiveness and cost-effectiveness. Health Technol Assess; 2017 Feb;21(8):1-196
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  • [Title] CollAborative care and active surveillance for Screen-Positive EldeRs with subthreshold depression (CASPER): a multicentred randomised controlled trial of clinical effectiveness and cost-effectiveness.
  • Less attention has been paid to those with mild disorders/subthreshold depression, but these patients also suffer significant impairments in their quality of life and level of functioning.
  • There is currently no clear evidence-based guidance regarding treatment for this patient group.
  • OBJECTIVES: To establish the clinical effectiveness and cost-effectiveness of a low-intensity intervention of collaborative care for primary care older adults who screened positive for subthreshold depression.
  • INTERVENTIONS: Participants in the intervention group received a low-intensity intervention of collaborative care, which included behavioural activation delivered by a case manager for an average of six sessions over 7-8 weeks, alongside usual GP care.
  • Control-arm participants received only usual GP care.
  • MAIN OUTCOME MEASURES: The primary outcome measure was a self-reported measure of depression severity, the Patient Health Questionnaire-9 items PHQ-9 score at 4 months post randomisation.
  • Secondary outcome measures included the European Quality of Life-5 Dimensions, Short Form questionnaire-12 items, Patient Health Questionnaire-15 items, Generalised Anxiety Disorder seven-item scale, Connor-Davidson Resilience Scale two-item version, a medication questionnaire and objective data.
  • RESULTS: In total, 705 participants were randomised (collaborative care <i>n</i> = 344, usual care <i>n</i> = 361), with 586 participants (83%; collaborative care 76%, usual care 90%) followed up at 4 months and 519 participants (74%; collaborative care 68%, usual care 79%) followed up at 12 months.
  • Attrition was markedly greater in the collaborative care arm.
  • Model estimates at the primary end point of 4 months revealed a statistically significant effect in favour of collaborative care compared with usual care [mean difference 1.31 score points, 95% confidence interval (CI) 0.67 to 1.95 score points; <i>p</i> < 0.001].
  • On average, participants allocated to collaborative care displayed significantly higher QALYs than those allocated to the control group (annual difference in adjusted QALYs of 0.044, 95% bias-corrected CI 0.015 to 0.072; <i>p</i> = 0.003).
  • CONCLUSIONS: Collaborative care has been shown to be clinically effective and cost-effective for older adults with subthreshold depression and to reduce the proportion of people who go on to develop case-level depression at 12 months.
  • Important future work would include investigating the longer-term effect of collaborative care on the CASPER population, which could be conducted by introducing an extension to follow-up, and investigating the impact of collaborative care on managing multimorbidities in people with subthreshold depression.

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  • (PMID = 28248154.001).
  • [ISSN] 2046-4924
  • [Journal-full-title] Health technology assessment (Winchester, England)
  • [ISO-abbreviation] Health Technol Assess
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Dugas M, Trottier MÈ, Chipenda Dansokho S, Vaisson G, Provencher T, Colquhoun H, Dogba MJ, Dupéré S, Fagerlin A, Giguere AM, Haslett L, Hoffman AS, Ivers NM, Légaré F, Légaré J, Levin CA, Menear M, Renaud JS, Stacey D, Volk RJ, Witteman HO: Involving members of vulnerable populations in the development of patient decision aids: a mixed methods sequential explanatory study. BMC Med Inform Decis Mak; 2017 Jan 19;17(1):12
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  • [Title] Involving members of vulnerable populations in the development of patient decision aids: a mixed methods sequential explanatory study.
  • BACKGROUND: Patient decision aids aim to present evidence relevant to a health decision in understandable ways to support patients through the process of making evidence-informed, values-congruent health decisions.
  • METHODS: To describe and compare the development practices of research teams that did and did not specifically involve members of vulnerable populations in the development of patient decision aids, we conducted a secondary analysis of data from a systematic review about the development processes of patient decision aids.
  • CONCLUSIONS: There are a small number of key differences in the development processes for patient decision aids in which members of vulnerable populations were or were not specifically involved.

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  • (PMID = 28103862.001).
  • [ISSN] 1472-6947
  • [Journal-full-title] BMC medical informatics and decision making
  • [ISO-abbreviation] BMC Med Inform Decis Mak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Decision aids / Marginalized populations / Patient engagement / Shared decision making / Vulnerable populations
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3. Powell JT, Sweeting MJ, Ulug P, Blankensteijn JD, Lederle FA, Becquemin JP, Greenhalgh RM, EVAR-1, DREAM, OVER and ACE Trialists: Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. Br J Surg; 2017 Feb;104(3):166-178
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  • [Title] Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
  • METHODS: An individual-patient data meta-analysis of four multicentre randomized trials of EVAR versus open repair was conducted to a prespecified analysis plan, reporting on mortality, aneurysm-related mortality and reintervention.
  • RESULTS: The analysis included 2783 patients, with 14 245 person-years of follow-up (median 5·5 years).
  • Patients with moderate renal dysfunction or previous coronary artery disease had no early survival advantage under EVAR.
  • Over 5 years, patients of marginal fitness had no early survival advantage from EVAR compared with open repair.
  • Aneurysm-related mortality and patients with low ankle : brachial pressure index contributed to the erosion of the early survival advantage for the EVAR group.
  • Trial registration numbers: EVAR-1, ISRCTN55703451; DREAM (Dutch Randomized Endovascular Aneurysm Management), NCT00421330; ACE (Anévrysme de l'aorte abdominale, Chirurgie versus Endoprothèse), NCT00224718; OVER (Open Versus Endovascular Repair Trial for Abdominal Aortic Aneurysms), NCT00094575.

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  • [Copyright] © 2017 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.
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  • (PMID = 28160528.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Investigator] Greenhalgh RM; Beard JD; Buxton MJ; Brown LC; Harris PL; Powell JT; Rose JD; Russell IT; Sculpher MJ; Thompson SG; Lilford RJ; Bell PR; Greenhalgh RM; Whitaker SC; Poole-Wilson TL; Ruckley CV; Campbell WB; Dean MR; Ruttley MS; Coles EC; Powell JT; Halliday A; Gibbs SJ; Brown LC; Epstein D; Sculpher MJ; Thompson SG; Hannon RJ; Johnston L; Bradbury AW; Henderson MJ; Parvin SD; Shepherd DF; Greenhalgh RM; Mitchell AW; Edwards PR; Abbott GT; Higman DJ; Vohra A; Ashley S; Robottom C; Wyatt MG; Rose JD; Byrne D; Edwards R; Leiberman DP; McCarter DH; Taylor PR; Reidy JF; Wilkinson AR; Ettles DF; Clason AE; Leen GL; Wilson NV; Downes M; Walker SR; Lavelle JM; Gough MJ; McPherson S; Scott DJ; Kessell DO; Naylor R; Sayers R; Fishwick NG; Harris PL; Gould DA; Walker MG; Chalmers NC; Garnham A; Collins MA; Beard JD; Gaines PA; Ashour MY; Uberoi R; Braithwaite B; Whitaker SC; Davies JN; Travis S; Hamilton G; Platts A; Shandall A; Sullivan BA; Sobeh M; Matson M; Fox AD; Orme R; Yusef W; Doyle T; Horrocks M; Hardman J; Blair PH; Ellis PK; Morris G; Odurny A; Vohra R; Duddy M; Thompson M; Loosemore TM; Belli AM; Morgan R; Adiseshiah M; Brookes JA; McCollum CN; Ashleigh R; Aukett M; Baker S; Barbe E; Batson N; Bell J; Blundell J; Boardley D; Boyes S; Brown O; Bryce J; Carmichael M; Chance T; Coleman J; Cosgrove C; Curran G; Dennison T; Devine C; Dewhirst N; Errington B; Farrell H; Fisher C; Fulford P; Gough M; Graham C; Hooper R; Horne G; Horrocks L; Hughes B; Hutchings T; Ireland M; Judge C; Kelly L; Kemp J; Kite A; Kivela M; Lapworth M; Lee C; Linekar L; Mahmood A; March L; Martin J; Matharu N; McGuigen K; Morris-Vincent P; Murray S; Murtagh A; Owen G; Ramoutar V; Rippin C; Rowley J; Sinclair J; Spencer S; Taylor V; Tomlinson C; Ward S; Wealleans V; West J; White K; Williams J; Wilson L; Grobbee DE; Blankensteijn JD; Bak AA; Buth J; Pattynama PM; Verhoeven EL; van Voorthuisen AE; Blankensteijn JD; Balm R; Buth J; Cuypers PW; Grobbee DE; Prinssen M; van Sambeek MR; Verhoeven EL; Baas AF; Hunink MG; van Engelshoven JM; Jacobs MJ; de Mol BA; van Bockel JH; Balm R; Reekers J; Tielbeek X; Verhoeven EL; Wisselink W; Boekema N; Heuveling LM; Sikking I; Prinssen M; Balm R; Blankensteijn JD; Buth J; Cuypers PW; van Sambeek MR; Verhoeven EL; de Bruin JL; Baas AF; Blankensteijn JD; Prinssen M; Buth J; Tielbeek AV; Blankensteijn JD; Balm R; Reekers JA; van Sambeek MR; Pattynama P; Verhoeven EL; Prins T; van der Ham AC; van der Velden JJ; van Sterkenburg SM; Ten Haken GB; Bruijninckx CM; van Overhagen H; Tutein Nolthenius RP; Hendriksz TR; Teijink JA; Odink HF; de Smet AA; Vroegindeweij D; van Loenhout RM; Rutten MJ; Hamming JF; Lampmann LE; Bender MH; Pasmans H; Vahl AC; de Vries C; Mackaay AJ; van Dortmont LM; van der Vliet AJ; Schultze Kool LJ; Boomsma JH; van Dop HR; de Mol van Otterloo JC; de Rooij TP; Smits TM; Yilmaz EN; Wisselink W; van den Berg FG; Visser MJ; van der Linden E; Schurink GW; de Haan M; Smeets HJ; Stabel P; van Elst F; Poniewierski J; Vermassen FE; Lederle FA; Freischlag JA; Kohler TR; Latts E; Matsumura J; Padberg FT Jr; Kyriakides TC; Swanson KM; Guarino P; Peduzzi P; Antonelli M; Cushing C; Davis E; Durant L; Joyner S; Kossack TL; Kyriakides TC; LeGwin M; McBride V; O'Connor T; Poulton J; Stratton TL; Zellner S; Snodgrass AJ; Thornton J; Swanson KM; Haakenson CM; Stroupe KT; Jonk Y; Hallett JW; Hertzer N; Towne J; Katz DA; Karrison T; Matts JP; Marottoli R; Kasl S; Mehta R; Feldman R; Farrell W; Allore H; Perry E; Niederman J; Randall F; Zeman M; Beckwith TL; O'Leary TJ; Huang GD; Latts E; Bader M; Ketteler ER; Kingsley DD; Marek JM; Massen RJ; Matteson BD; Pitcher JD; Langsfeld M; Corson JD; Goff JM Jr; Kasirajan K; Paap C; Robertson DC; Salam A; Veeraswamy R; Milner R; Kasirajan K; Guidot J; Lal BK; Busuttil SJ; Lilly MP; Braganza M; Ellis K; Patterson MA; Jordan WD; Whitley D; Taylor S; Passman M; Kerns D; Inman C; Poirier J; Ebaugh J; Raffetto J; Chew D; Lathi S; Owens C; Hickson K; Dosluoglu HH; Eschberger K; Kibbe MR; Baraniewski HM; Matsumura J; Endo M; Busman A; Meadows W; Evans M; Giglia JS; El Sayed H; Reed AB; Ruf M; Ross S; Jean-Claude JM; Pinault G; Kang P; White N; Eiseman M; Jones TL; Timaran CH; Modrall JG; Welborn MB 3rd; Lopez J; Nguyen T; Chacko JK; Granke K; Vouyouka AG; Olgren E; Chand P; Allende B; Ranella M; Yales C; Whitehill TA; Krupski TL; Nehler MR; Johnson SP; Jones DN; Strecker P; Bhola MA; Shortell CK; Gray JL; Lawson JH; McCann R; Sebastian MW; Kistler Tetterton J; Blackwell C; Prinzo PA; Lee N; Padberg FT Jr; Cerveira JJ; Lal BK; Zickler RW; Hauck KA; Berceli SA; Lee WA; Ozaki CK; Nelson PR; Irwin AS; Baum R; Aulivola B; Rodriguez H; Littooy FN; Greisler H; O'Sullivan MT; Kougias P; Lin PH; Bush RL; Guinn G; Bechara C; Cagiannos C; Pisimisis G; Barshes N; Pillack S; Guillory B; Cikrit D; Lalka SG; Lemmon G; Nachreiner R; Rusomaroff M; O'Brien E; Cullen JJ; Hoballah J; Sharp WJ; McCandless JL; Beach V; Minion D; Schwarcz TH; Kimbrough J; Ashe L; Rockich A; Warner-Carpenter J; Moursi M; Eidt JF; Brock S; Bianchi C; Bishop V; Gordon IL; Fujitani R; Kubaska SM 3rd; Behdad M; Azadegan R; Ma Agas C; Zalecki K; Hoch JR; Carr SC; Acher C; Schwarze M; Tefera G; Mell M; Dunlap B; Rieder J; Stuart JM; Weiman DS; Abul-Khoudoud O; Garrett HE; Walsh SM; Wilson KL; Seabrook GR; Cambria RA; Brown KR; Lewis BD; Framberg S; Kallio C; Barke RA; Santilli SM; d'Audiffret AC; Oberle N; Proebstle C; Johnson LL; Jacobowitz GR; Cayne N; Rockman C; Adelman M; Gagne P; Nalbandian M; Caropolo LJ; Pipinos II; Johanning J; Lynch T; DeSpiegelaere H; Purviance G; Zhou W; Dalman R; Lee JT; Safadi B; Coogan SM; Wren SM; Bahmani DD; Maples D; Thunen S; Golden MA; Mitchell ME; Fairman R; Reinhardt S; Wilson MA; Tzeng E; Muluk S; Peterson NM; Foster M; Edwards J; Moneta GL; Landry G; Taylor L; Yeager R; Cannady E; Treiman G; Hatton-Ward S; Salabsky TL; Kansal N; Owens E; Estes M; Forbes BA; Sobotta C; Rapp JH; Reilly LM; Perez SL; Yan K; Sarkar R; Dwyer SS; Perez S; Chong K; Kohler TR; Hatsukami TS; Glickerman DG; 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Meaulle PY; Chaix D; Juliae P; Fabiani JN; Chevalier P; Combes M; Seguin A; Belhomme D; Sapoval M; Baque J; Pellerin O; Favre JP; Barral X; Veyret C; Watelet J; Peillon C; Plissonier D; Thomas P; Clavier E; Lermusiaux P; Martinez R; Bleuet F; C D; Verhoye JP; Langanay T; Heautot JF; Koussa M; Haulon S; Halna P; Destrieux L; Lions C; Wiloteaux S; Beregi JP; Bergeron P; Pinot JJ; Patra P; Costargent A; Chaillou P; D'Alicourt A; Goueffic Y; Cheysson E; Parrot A; Garance P; Demon A; Tyazi A; Pillet JC; Lescalie F; Tilly G; Steinmetz E; Favier C; Brenot R; Krause D; Cercueil JP; Vahdat O; Sauer M; Soula P; Querian A; Garcia O; Levade M; Colombier D; Cardon JM; Joyeux A; Borrelly P; Dogas G; Magnan PÉ; Branchereau A; Bartoli JM; Hassen-Khodja R; Batt M; Planchard PF; Bouillanne PJ; Haudebourg P; Bayne J; Gouny P; Badra A; Braesco J; Nonent M; Lucas A; Cardon A; Kerdiles Y; Rolland Y; Kassab M; Brillu C; Goubault F; Tailboux L; Darrieux H; Briand O; Maillard JC; Varty K; Cousins C
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4. van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, Bäumer V, Engelborghs S, De Bleecker J, Baets J, Gelpi E, Rojas-García R, Clarimón J, Lleó A, Diehl-Schmid J, Alexopoulos P, Perneczky R, Synofzik M, Just J, Schöls L, Graff C, Thonberg H, Borroni B, Padovani A, Jordanova A, Sarafov S, Tournev I, de Mendonça A, Miltenberger-Miltényi G, Simões do Couto F, Ramirez A, Jessen F, Heneka MT, Gómez-Tortosa E, Danek A, Cras P, Vandenberghe R, De Jonghe P, De Deyn PP, Sleegers K, Cruts M, Van Broeckhoven C, Goeman J, Nuytten D, Smets K, Robberecht W, Damme PV, Bleecker J, Santens P, Dermaut B, Versijpt J, Michotte A, Ivanoiu A, Deryck O, Bergmans B, Delbeck J, Bruyland M, Willems C, Salmon E, Pastor P, Ortega-Cubero S, Benussi L, Ghidoni R, Binetti G, Hernández I, Boada M, Ruiz A, Sorbi S, Nacmias B, Bagnoli S, Sorbi S, Sanchez-Valle R, Llado A, Santana I, Rosário Almeida M, Frisoni GB, Maetzler W, Matej R, Fraidakis MJ, Kovacs GG, Fabrizi GM, Testi S: TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Hum Mutat; 2017 Mar;38(3):297-309
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  • [Title] TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
  • : We investigated the mutation spectrum of the TANK-Binding Kinase 1 (TBK1) gene and its associated phenotypic spectrum by exonic resequencing of TBK1 in a cohort of 2,538 patients with frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), or FTD plus ALS, ascertained within the European Early-Onset Dementia Consortium.
  • Although missense mutations were also present in controls, over three times more mutations affecting TBK1 functioning were found in the mutation fraction observed in patients only, suggesting high-risk alleles (P = 0.03).

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  • [Copyright] © 2016 The Authors. **Human Mutation published by Wiley Periodicals, Inc.
  • (PMID = 28008748.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; ALS / FTD / NFκB luciferase reporter assay / TANK-Binding Kinase 1 / TBK1 / amyotrophic lateral sclerosis / frontotemporal dementia / mutations
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5. Gilbody S, Lewis H, Adamson J, Atherton K, Bailey D, Birtwistle J, Bosanquet K, Clare E, Delgadillo J, Ekers D, Foster D, Gabe R, Gascoyne S, Haley L, Hamilton J, Hargate R, Hewitt C, Holmes J, Keding A, Lilley-Kelly A, Meer S, Mitchell N, Overend K, Pasterfield M, Pervin J, Richards DA, Spilsbury K, Traviss-Turner G, Trépel D, Woodhouse R, Ziegler F, McMillan D: Effect of Collaborative Care vs Usual Care on Depressive Symptoms in Older Adults With Subthreshold Depression: The CASPER Randomized Clinical Trial. JAMA; 2017 02 21;317(7):728-737
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  • [Title] Effect of Collaborative Care vs Usual Care on Depressive Symptoms in Older Adults With Subthreshold Depression: The CASPER Randomized Clinical Trial.
  • Objective: To evaluate whether a collaborative care intervention can reduce depressive symptoms and prevent more severe depression in older people.
  • Design, Setting, and Participants: Randomized clinical trial conducted from May 24, 2011, to November 14, 2014, in 32 primary care centers in the United Kingdom among 705 participants aged 65 years or older with Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) subthreshold depression; participants were followed up for 12 months.
  • Interventions: Collaborative care (n=344) was coordinated by a case manager who assessed functional impairments relating to mood symptoms.
  • The control group received usual primary care (n=361).
  • Main Outcomes and Measures: The primary outcome was self-reported depression severity at 4-month follow-up on the 9-item Patient Health Questionnaire (PHQ-9; score range, 0-27).
  • Four-month retention was 83%, with higher loss to follow-up in collaborative care (82/344 [24%]) vs usual care (37/361 [10%]).
  • Collaborative care resulted in lower PHQ-9 scores vs usual care at 4-month follow-up (mean score with collaborative care, 5.36 vs with usual care, 6.67; mean difference, -1.31; 95% CI, -1.95 to -0.67; P < .001).
  • Treatment differences remained at 12 months (mean PHQ-9 score with collaborative care, 5.93 vs with usual care, 7.25; mean difference, -1.33; 95% CI, -2.10 to -0.55).
  • Conclusions and Relevance: Among older adults with subthreshold depression, collaborative care compared with usual care resulted in a statistically significant difference in depressive symptoms at 4-month follow-up, of uncertain clinical importance.
  • [MeSH-minor] Aged. Antidepressive Agents / therapeutic use. Comorbidity. Female. Follow-Up Studies. Humans. Male. Patient Care Team. Patient Dropouts / statistics & numerical data. Primary Health Care. Psychiatry. Quality of Life. Sample Size. Self Report. Time Factors. United Kingdom

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  • [CommentIn] JAMA. 2017 Feb 21;317(7):702-704 [28241337.001]
  • (PMID = 28241357.001).
  • [ISSN] 1538-3598
  • [Journal-full-title] JAMA
  • [ISO-abbreviation] JAMA
  • [Language] eng
  • [Databank-accession-numbers] ISRCTN/ ISRCTN02202951
  • [Publication-type] Journal Article; Multicenter Study; Pragmatic Clinical Trial; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antidepressive Agents
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6. Schober A, Sterz F, Herkner H, Wallmueller C, Weiser C, Hubner P, Testori C: Emergency extracorporeal life support and ongoing resuscitation: a retrospective comparison for refractory out-of-hospital cardiac arrest. Emerg Med J; 2017 Feb 17;
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  • Extracorporeal cardiopulmonary resuscitation (ECPR) is an option for certain patients with cardiac arrest.
  • The aim of this study was to evaluate characteristics of patients selected for ECPR.
  • METHODS: Anonymised data of adult patients suffering refractory cardiac arrest, transported with ongoing CPR to an ED of a tertiary care centre between 2002 and 2012 were analysed.
  • RESULTS: Overall, 239 patients fulfilled the inclusion criteria.
  • ECPR was initiated in seven patients.
  • Patients treated with ECPR were younger (46 vs 60 years; p=0.04), had shorter intervals before CPR was started (0 vs 1 min; p=0.013), faster admissions at the ED (38 vs 56 min; p=0.31) and lower blood glucose levels on admission (14 vs 21 mmol/L; p=0.018).
  • Survival to discharge in good neurological condition was achieved in 14 (6%) of all patients.
  • One patient in the ECPR group survived in excellent neurological condition.
  • CONCLUSIONS: Emergency extracorporeal life support was used for a highly selected group of patients in refractory cardiac arrest.
  • The patient selection resulting in a survival of one patient out of seven treated seems reasonable.

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  • [Copyright] © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
  • (PMID = 28213587.001).
  • [ISSN] 1472-0213
  • [Journal-full-title] Emergency medicine journal : EMJ
  • [ISO-abbreviation] Emerg Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Cardiac arrest / ECLS / ECPR / Extracorporeal life support / Resuscitation / Ventricular fibrillation
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7. Funk M, Fennie KP, Stephens KE, May JL, Winkler CG, Drew BJ, PULSE Site Investigators: Association of Implementation of Practice Standards for Electrocardiographic Monitoring With Nurses' Knowledge, Quality of Care, and Patient Outcomes: Findings From the Practical Use of the Latest Standards of Electrocardiography (PULSE) Trial. Circ Cardiovasc Qual Outcomes; 2017 Feb;10(2)
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  • [Title] Association of Implementation of Practice Standards for Electrocardiographic Monitoring With Nurses' Knowledge, Quality of Care, and Patient Outcomes: Findings From the Practical Use of the Latest Standards of Electrocardiography (PULSE) Trial.
  • We evaluated implementation of American Heart Association practice standards for ECG monitoring on nurses' knowledge, quality of care, and patient outcomes.
  • Nurses' knowledge (N=3013 nurses) was measured by a validated 20-item online test, quality of care related to ECG monitoring (N=4587 patients) by on-site observation, and patient outcomes (mortality, in-hospital myocardial infarction, and not surviving a cardiac arrest; N=95 884 hospital admissions) by review of administrative, laboratory, and medical record data.
  • For most measures of quality of care (accurate electrode placement, accurate rhythm interpretation, appropriate monitoring, and ST-segment monitoring when indicated), the intervention was associated with significant improvement, which was sustained 15 months later.
  • Of the 3 patient outcomes, only in-hospital myocardial infarction declined significantly after the intervention and was sustained.
  • CONCLUSIONS: Online ECG monitoring education and strategies to change practice can lead to improved nurses' knowledge, quality of care, and patient outcomes.

  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
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  • [Copyright] © 2017 American Heart Association, Inc.
  • (PMID = 28174175.001).
  • [ISSN] 1941-7705
  • [Journal-full-title] Circulation. Cardiovascular quality and outcomes
  • [ISO-abbreviation] Circ Cardiovasc Qual Outcomes
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT01269736
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL081642
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; electrocardiography / nursing / outcome assessment (health care) / quality of health care / randomized controlled trial
  • [Investigator] Borman B; Calcasola S; Carey M; Currie L; Davis L; Fitzpatrick E; Fleischman R; Hawkins D; Hazlewood E; Henry R; Honess C; Kalowes P; Ann Kearns S; Leeper B; Liggett J; Lusardi P; Lynn C; Man M; McCauley K; Hing M; Pang A; Parkosewich J; Phillips J; Robinson A; Salazar N; Sandau K; Piper Sandoval C; Sangkachand P; Shaffer R; Sherrard H; Smith M; Stamm R; Strang V; Tee N; Wells K; White P
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8. Califf RM, Robb MA, Bindman AB, Briggs JP, Collins FS, Conway PH, Coster TS, Cunningham FE, De Lew N, DeSalvo KB, Dymek C, Dzau VJ, Fleurence RL, Frank RG, Gaziano JM, Kaufmann P, Lauer M, Marks PW, McGinnis JM, Richards C, Selby JV, Shulkin DJ, Shuren J, Slavitt AM, Smith SR, Washington BV, White PJ, Woodcock J, Woodson J, Sherman RE: Transforming Evidence Generation to Support Health and Health Care Decisions. N Engl J Med; 2016 Dec 15;375(24):2395-2400
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  • [Title] Transforming Evidence Generation to Support Health and Health Care Decisions.
  • [MeSH-major] Delivery of Health Care / organization & administration. Evidence-Based Medicine. Health Policy. Translational Medical Research

  • MedlinePlus Health Information. consumer health - Choosing a Doctor or Health Care Service.
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  • (PMID = 27974039.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Mehta S, Burns KE, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS: Gender Parity in Critical Care Medicine. Am J Respir Crit Care Med; 2017 Feb 27;
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  • [Title] Gender Parity in Critical Care Medicine.
  • Clinical practice guidelines are systematically developed statements to assist practitioner and patient decisions about appropriate healthcare for specific clinical circumstances.
  • These documents inform and shape patient care around the world.
  • In this perspective we discuss the importance of diversity on guideline panels, the disproportionately low representation of women on critical care guideline panels, and existing initiatives to increase the representation of women in corporations, universities and government.
  • We propose five strategies to ensure gender parity within critical care medicine.

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  • (PMID = 28240961.001).
  • [ISSN] 1535-4970
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; diversity, gender, critical care, interprofessional
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10. Temel JS, Greer JA, El-Jawahri A, Pirl WF, Park ER, Jackson VA, Back AL, Kamdar M, Jacobsen J, Chittenden EH, Rinaldi SP, Gallagher ER, Eusebio JR, Li Z, Muzikansky A, Ryan DP: Effects of Early Integrated Palliative Care in Patients With Lung and GI Cancer: A Randomized Clinical Trial. J Clin Oncol; 2016 Dec 28;:JCO2016705046
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of Early Integrated Palliative Care in Patients With Lung and GI Cancer: A Randomized Clinical Trial.
  • : Purpose We evaluated the impact of early integrated palliative care (PC) in patients with newly diagnosed lung and GI cancer.
  • Patients and Methods We randomly assigned patients with newly diagnosed incurable lung or noncolorectal GI cancer to receive either early integrated PC and oncology care (n = 175) or usual care (n = 175) between May 2011 and July 2015.
  • Patients who were assigned to the intervention met with a PC clinician at least once per month until death, whereas those who received usual care consulted a PC clinician upon request.
  • Secondary end points included change in QOL from baseline to week 24, change in depression per the Patient Health Questionnaire-9, and differences in end-of-life communication.
  • Results Intervention patients ( v usual care) reported greater improvement in QOL from baseline to week 24 (1.59 v -3.40; P = .010) but not week 12 (0.39 v -1.13; P = .339).
  • Intervention patients also reported lower depression at week 24, controlling for baseline scores (adjusted mean difference, -1.17; 95% CI, -2.33 to -0.01; P = .048).
  • Intervention effects varied by cancer type, such that intervention patients with lung cancer reported improvements in QOL and depression at 12 and 24 weeks, whereas usual care patients with lung cancer reported deterioration.
  • Patients with GI cancers in both study groups reported improvements in QOL and mood by week 12.
  • Intervention patients versus usual care patients were more likely to discuss their wishes with their oncologist if they were dying (30.2% v 14.5%; P = .004).
  • Conclusion For patients with newly diagnosed incurable cancers, early integrated PC improved QOL and other salient outcomes, with differential effects by cancer type.
  • Early integrated PC may be most effective if targeted to the specific needs of each patient population.

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  • (PMID = 28029308.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Fordyce CB, Al-Khalidi HR, Jollis JG, Roettig ML, Gu J, Bagai A, Berger PB, Corbett CC, Dauerman HL, Fox K, Garvey JL, Henry TD, Rokos IC, Sherwood MW, Wilson BH, Granger CB, STEMI Systems Accelerator Project: Association of Rapid Care Process Implementation on Reperfusion Times Across Multiple ST-Segment-Elevation Myocardial Infarction Networks. Circ Cardiovasc Interv; 2017 Jan;10(1)
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of Rapid Care Process Implementation on Reperfusion Times Across Multiple ST-Segment-Elevation Myocardial Infarction Networks.
  • BACKGROUND: The Mission: Lifeline STEMI Systems Accelerator program, implemented in 16 US metropolitan regions, resulted in more patients receiving timely reperfusion.
  • We assessed whether implementing key care processes was associated with system performance improvement.
  • METHODS AND RESULTS: Hospitals (n=167 with 23 498 ST-segment-elevation myocardial infarction patients) were surveyed before (March 2012) and after (July 2014) program intervention.
  • Data were merged with patient-level clinical data over the same period.
  • For reperfusion, hospitals were grouped by whether a specific process of care was implemented, preexisting, or never implemented.
  • Uptake of 4 key care processes increased after intervention: prehospital catheterization laboratory activation (62%-91%; P<0.001), single call transfer protocol from an outside facility (45%-70%; P<0.001), and emergency department bypass for emergency medical services direct presenters (48%-59%; P=0.002) and transfers (56%-79%; P=0.001).
  • Similarly, patients treated at hospitals implementing single call transfer protocols had shorter median first medical contact-to-device times (112 versus 128 versus 152 minutes; P<0.001).
  • CONCLUSIONS: The Accelerator program increased uptake of key care processes, which were associated with improved system performance.

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  • [Copyright] © 2017 American Heart Association, Inc.
  • (PMID = 28082714.001).
  • [ISSN] 1941-7632
  • [Journal-full-title] Circulation. Cardiovascular interventions
  • [ISO-abbreviation] Circ Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; ST-segment–elevation myocardial infarction / percutaneous coronary intervention / quality improvement / reperfusion times / systems of care
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12. Zingg W, Hopkins S, Gayet-Ageron A, Holmes A, Sharland M, Suetens C, ECDC PPS study group: Health-care-associated infections in neonates, children, and adolescents: an analysis of paediatric data from the European Centre for Disease Prevention and Control point-prevalence survey. Lancet Infect Dis; 2017 Jan 13;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Health-care-associated infections in neonates, children, and adolescents: an analysis of paediatric data from the European Centre for Disease Prevention and Control point-prevalence survey.
  • BACKGROUND: In 2011-12, the European Centre for Disease Prevention and Control (ECDC) held the first Europe-wide point-prevalence survey of health-care-associated infections in acute care hospitals.
  • We analysed paediatric data from this survey, aiming to calculate the prevalence and type of health-care-associated infections in children and adolescents in Europe and to determine risk factors for infection in this population.
  • Patients present on the ward at 0800 h on the day of the survey and who were not discharged at the time of the survey were included.
  • Data were collected by locally trained health-care workers according to patient-based or unit-based protocols.
  • We extracted data from the ECDC database for all paediatric patients (age 0-18 years).
  • We report adjusted prevalence for health-care-associated infections by clustering at the hospital and country level.
  • We also calculated risk factors for development of health-care-associated infections with use of a generalised linear mixed-effects model.
  • 770 health-care-associated infections were reported in 726 children and adolescents, corresponding to a prevalence of 4·2% (95% CI 3·7-4·8).
  • The prevalence of infections was highest in paediatric intensive care units (15·5%, 95% CI 11·6-20·3) and neonatal intensive care units (10·7%, 9·0-12·7).
  • 392 microorganisms were reported for 342 health-care-associated infections, with Enterobacteriaceae being the most frequently found (113 [15%]).

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  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 28089444.001).
  • [ISSN] 1474-4457
  • [Journal-full-title] The Lancet. Infectious diseases
  • [ISO-abbreviation] Lancet Infect Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Investigator] Almeida M; Asembergiene J; Borg MA; Budimir A; Cairns S; Cunney R; Deptula A; Berciano PG; Gudlaugsson O; Hadjiloucas A; Hammami N; Harrison W; Heisbourg E; Kolman J; Kontopidou F; Kristensen B; Lyytikäinen O; Märtin P; McIlvenny G; Moro ML; Piening B; Presterl E; Serban R; Smid E; Sorknes NK; Stefkovicova M; Sviestina I; Szabo R; Tkadlecova H; Vatcheva-Dobrevska R; VerjatTrannoy D
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13. Dobrolecki LE, Airhart SD, Alferez DG, Aparicio S, Behbod F, Bentires-Alj M, Brisken C, Bult CJ, Cai S, Clarke RB, Dowst H, Ellis MJ, Gonzalez-Suarez E, Iggo RD, Kabos P, Li S, Lindeman GJ, Marangoni E, McCoy A, Meric-Bernstam F, Piwnica-Worms H, Poupon MF, Reis-Filho J, Sartorius CA, Scabia V, Sflomos G, Tu Y, Vaillant F, Visvader JE, Welm A, Wicha MS, Lewis MT: Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Cancer Metastasis Rev; 2016 Dec;35(4):547-573
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patient-derived xenograft (PDX) models in basic and translational breast cancer research.
  • : Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research.
  • Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics.
  • This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research.

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  • (PMID = 28025748.001).
  • [ISSN] 1573-7233
  • [Journal-full-title] Cancer metastasis reviews
  • [ISO-abbreviation] Cancer Metastasis Rev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA112305; United States / NCI NIH HHS / CA / R01 CA140985; United States / NCI NIH HHS / CA / P30 CA125123; United States / NCI NIH HHS / CA / R01 CA166422; United States / NCI NIH HHS / CA / P50 CA058183; United States / NCI NIH HHS / CA / U01 CA214172; United States / NCI NIH HHS / CA / U54 CA149196
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Breast cancer / Immunocompromised/immunodeficient mice / PDX consortium / Patient-derived xenograft / Translational research
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14. Breitenstein C, Grewe T, Flöel A, Ziegler W, Springer L, Martus P, Huber W, Willmes K, Ringelstein EB, Haeusler KG, Abel S, Glindemann R, Domahs F, Regenbrecht F, Schlenck KJ, Thomas M, Obrig H, de Langen E, Rocker R, Wigbers F, Rühmkorf C, Hempen I, List J, Baumgaertner A, FCET2EC study group: Intensive speech and language therapy in patients with chronic aphasia after stroke: a randomised, open-label, blinded-endpoint, controlled trial in a health-care setting. Lancet; 2017 Mar 01;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intensive speech and language therapy in patients with chronic aphasia after stroke: a randomised, open-label, blinded-endpoint, controlled trial in a health-care setting.
  • METHODS: In this multicentre, parallel group, superiority, open-label, blinded-endpoint, randomised controlled trial, patients aged 70 years or younger with aphasia after stroke lasting for 6 months or more were recruited from 19 inpatient or outpatient rehabilitation centres in Germany.
  • RESULTS: We randomly assigned 158 patients between April 1, 2012, and May 31, 2014.
  • The modified intention-to-treat population comprised 156 patients (78 per group).
  • Eight patients had adverse events during therapy or treatment deferral (one car accident [in the control group], two common cold [one patient per group], three gastrointestinal or cardiac symptoms [all intervention group], two recurrent stroke [one in intervention group before initiation of treatment, and one before group assignment had occurred]); all were unrelated to study participation.

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  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 28256356.001).
  • [ISSN] 1474-547X
  • [Journal-full-title] Lancet (London, England)
  • [ISO-abbreviation] Lancet
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Investigator] Villringer A; Bley M; Jöbges M; Halm K; Schulz J; Werner C; Goldenberg G; Klingenberg G; König E; Müller F; Gröne B; Knecht S; Baake R; Knauss J; Miethe S; Steller U; Sudhoff R; Schillikowski E; Pfeiffer G; Billo K; Hoffmann H; Ferneding FJ; Keck T; Middeldorf V; Krüger S; Wilde B; Krakow K; Berghoff C; Reinhuber F; Maser I; Hofmann W; Sous-Kulke C; Schupp W; Oertel A; Bätz D; Hamzei F; Schulz K; Meyer A; Kartmann A; Som O; Schipke SB; Bamborschke S
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15. Krupchanka D, Khalifeh H, Abdulmalik J, Ardila-Gómez S, Armiya'u AY, Banjac V, Baranov A, Bezborodovs N, Brecic P, Čavajda Z, de Girolamo G, Denisenko M, Dickens HA, Dujmovic J, Ergovic Novotny D, Fedotov I, Fernández MA, Frankova I, Gasparovic M, Giurgi-Oncu C, Grahovac T, James BO, Jomli R, Kekin I, Knez R, Lanfredi M, Lassman F, Mehta N, Nacef F, Nawka A, Nemirovsky M, Ola BA, Oshodi YO, Ouali U, Peharda T, Razic Pavicic A, Rojnic Kuzman M, Roventa C, Shamenov R, Smirnova D, Smoljanic D, Spikina A, Thornicroft A, Tomicevic M, Vidovic D, Williams P, Yakovleva Y, Zhabenko O, Zhilyaeva T, Zivkovic M, Thornicroft G, Sartorius N: Satisfaction with psychiatric in-patient care as rated by patients at discharge from hospitals in 11 countries. Soc Psychiatry Psychiatr Epidemiol; 2017 Mar 11;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Satisfaction with psychiatric in-patient care as rated by patients at discharge from hospitals in 11 countries.
  • PURPOSE: There is disregard in the scientific literature for the evaluation of psychiatric in-patient care as rated directly by patients.
  • In this context, we aimed to explore satisfaction of people treated in mental health in-patient facilities.
  • The research team at each study site approached a consecutive target sample of 30 discharged patients to measure their satisfaction using the five-item study-specific questionnaire.
  • After taking clustering into account, the only independent correlates of low satisfaction were schizophrenia diagnosis and low psychiatrist to patient ratio.
  • CONCLUSION: Further studies on patients' satisfaction should additionally pay attention to treatment expectations formed by the previous experience of treatment, service-related knowledge, stigma and patients' disempowerment, and power imbalance.

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  • (PMID = 28285452.001).
  • [ISSN] 1433-9285
  • [Journal-full-title] Social psychiatry and psychiatric epidemiology
  • [ISO-abbreviation] Soc Psychiatry Psychiatr Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; Inpatient care / Patients satisfaction / Psychiatry / Service evaluation
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16. Yang K, Downey C, Suter N, Gott L, Naughton L, Aufiero K, Day S, McGovern N, Brock J, Andreou K, Strasser J, Koprowski C, Raben A, Chen H, Mourtada F: SU-F-J-35: Moving Towards Isocentric Prone Breast Setup with Contralateral Leveling Tattoo and Couch Move Assistant (CMA). Med Phys; 2016 Jun;43(6):3413-3414
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Large setup variability has been observed for prone breast patients due to rotation error.
  • METHODS: Daily CBCT is used to evaluate the prone breast patient positioning uncertainty of proposed isocentric technique against our routine manual clinical setup.
  • While the proposed isocentric prone breast method features an additional contralateral leveling tattoo positioned at mid-level of torso during CT simulation to determine correct patient obliqueness, and an automatic couch shift using Elekta CMA to correct both known distance from 2PT to the iso and daily setup uncertainty.
  • Summary statistics were calculated for a cohort of prone breast patients from our clinic (n=5), and will be updated as more patients get administrated.
  • CONCLUSION: Contralateral leveling tattoo is essential to determine correct patient obliqueness.
  • More consistent and accurate isocentric prone breast patient positioning is achievable on Elekta linac with CMA and CBCT.

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  • [Copyright] © 2016 American Association of Physicists in Medicine.
  • (PMID = 28047378.001).
  • [ISSN] 2473-4209
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Cone beam computed tomography / Linear accelerators / Medical imaging
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17. Ferguson S, Ahmad S, Chen Y, Ferreira C, Islam M, Keeling V, Lau A, Jin H: SU-F-T-143: Implementation of a Correction-Based Output Model for a Compact Passively Scattered Proton Therapy System. Med Phys; 2016 Jun;43(6):3494-3495
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A previously published output prediction model (Sahoo et al, Med Phys, 35, 5088-5097, 2008) was commissioned for our Mevion S250 proton therapy system.
  • To minimize fluence perturbation, scattered dose from range compensator and patient was not considered.
  • However, great care should be taken when the field-size is less than 5×5 cm<sup>2</sup> where a direct output measurement is required due to substantial output change by irregular block shape.

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  • [Copyright] © 2016 American Association of Physicists in Medicine.
  • (PMID = 28047467.001).
  • [ISSN] 2473-4209
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Computer modeling / Interpolation / Proton therapy
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18. Erb S, Letang E, Glass TR, Natamatungiro A, Mnzava D, Mapesi H, Haschke M, Duthaler U, Berger B, Muri L, Bader J, Marzolini C, Elzi L, Klimkait T, Langewitz W, Battegay M, Kilombero Ulanga Antiretroviral Cohort (KIULARCO) study group: Health care provider communication training in rural Tanzania empowers HIV-infected patients on antiretroviral therapy to discuss adherence problems. HIV Med; 2017 Mar 13;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Health care provider communication training in rural Tanzania empowers HIV-infected patients on antiretroviral therapy to discuss adherence problems.
  • OBJECTIVES: Self-reported adherence assessment in HIV-infected patients on antiretroviral therapy (ART) is challenging and may overestimate adherence.
  • The aim of this study was to improve the ability of health care providers to elicit patients' reports of nonadherence using a "patient-centred" approach in a rural sub-Saharan African setting.
  • METHODS: A prospective interventional cohort study of HIV-infected patients on ART for ≥ 6 months attending an HIV clinic in rural Tanzania was carried out.
  • The intervention consisted of a 2-day workshop for health care providers on patient-centred communication and the provision of an adherence assessment checklist for use in the consultations.
  • Patients' self-reports of nonadherence (≥ 1 missed ART dose/4 weeks), subtherapeutic plasma ART concentrations (< 2.5th percentile of published population-based pharmacokinetic models), and virological and immunological failure according to the World Health Organization definition were assessed before and after (1-3 and 6-9 months after) the intervention.
  • RESULTS: Before the intervention, only 3.3% of 299 patients included in the study reported nonadherence.
  • Subtherapeutic plasma ART drug concentrations and virological and immunological failure were recorded in 6.5%, 7.7% and 14.5% of the patients, respectively.
  • Two months after the intervention, health care providers detected significantly more patients reporting nonadherence compared with baseline (10.7 vs. 3.3%, respectively; P < 0.001), decreasing to 5.7% after 6-9 months.
  • CONCLUSIONS: Patient-centred communication can successfully be implemented with a simple intervention in rural Africa.
  • It increases the likelihood of HIV-infected patients reporting problems with adherence to ART; however, sustainability remains a challenge.

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  • [Copyright] © 2017 The Authors HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.
  • (PMID = 28296019.001).
  • [ISSN] 1468-1293
  • [Journal-full-title] HIV medicine
  • [ISO-abbreviation] HIV Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; HIV / antiretroviral therapy / patient-centred communication / self-reported adherence / sub-Saharan Africa / therapeutic drug monitoring
  • [Investigator] Asantiel A; Chale A; Faini D; Felger I; Francis G; Furrer H; Gamell A; Glass T; Hatz C; Hatz S; Kasuga B; Kalinjuma AV; Kimera N; Kisunga Y; Luhombero A; Luwanda LB; Mbwile L; Mkulila M; Mkumbo J; Mkusa M; Mossad G; Mpundunga D; Msami D; Mtandanguo A; Mwamelo KD; Myeya S; Nahota S; Ndaki R; Ngulukila A; Ntamatungiro AJ; Samson L; Sikalengo G; Tanner M; Vanobberghen F
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19. Sauser Zachrison K, Levine DA, Fonarow GC, Bhatt DL, Cox M, Schulte P, Smith EE, Suter RE, Xian Y, Schwamm LH: Timely Reperfusion in Stroke and Myocardial Infarction Is Not Correlated: An Opportunity for Better Coordination of Acute Care. Circ Cardiovasc Qual Outcomes; 2017 Mar;10(3)
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Timely Reperfusion in Stroke and Myocardial Infarction Is Not Correlated: An Opportunity for Better Coordination of Acute Care.
  • The degree to which hospital performance is correlated on emergent STEMI and AIS care is unknown.
  • Primary objective of this study was to determine whether there was a positive correlation between hospital performance on door-to-balloon (D2B) time for STEMI and door-to-needle (DTN) time for AIS, with and without controlling for patient and hospital differences.
  • METHODS AND RESULTS: Prospective study of all hospitals in both Get With The Guidelines-Stroke and Get With The Guidelines-Coronary Artery Disease from 2006 to 2009 and treating ≥10 patients.
  • There were 43 hospitals with 1976 AIS and 59 823 STEMI patients.
  • There was no correlation between hospitals' proportion of eligible patients treated within target time windows for AIS and STEMI (median DTN time <60 minutes: 21% [interquartile range, 11-30]; median D2B time <90 minutes: 68% [interquartile range, 62-79]; ρ=-0.14; <i>P</i>=0.36).
  • Opportunities exist to improve hospitals' performance of time-critical care processes for AIS and STEMI in a coordinated approach.

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  • [Copyright] © 2017 American Heart Association, Inc.
  • (PMID = 28283469.001).
  • [ISSN] 1941-7705
  • [Journal-full-title] Circulation. Cardiovascular quality and outcomes
  • [ISO-abbreviation] Circ Cardiovasc Qual Outcomes
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; American Heart Association / fibrinolysis / myocardial infarction / stroke / tissue-type plasminogen activator
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20. Scott CB, Gonzalez ML, Einhorn J, Yan H, Sullivan M, Srinivas S, Zhong F, Crump B, Paz-Querubin ER, McPherson M, DeMarco C, Kasimis B: Patient-reported outcomes for determining prognostic groups in veterans with stage IV solid tumors starting systemic therapy. J Clin Oncol; 2014 Nov;32(31_suppl):48
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patient-reported outcomes for determining prognostic groups in veterans with stage IV solid tumors starting systemic therapy.
  • : 48 Background: A Recursive Partitioning Analysis (RPA) prognostic algorithm based on quality of life and symptoms predicted 4 groups with distinct median survivals in patients with metastatic solid tumors receiving chemotherapy (ASCO 2013, Abst 9567).
  • We analyzed records of patients with stage IV metastatic solid tumors enrolled through June 2013, and determined survival as of June 15, 2014.
  • RESULTS: There were 97 patients(pts).
  • The patient in group 1 had uterine sarcoma.
  • CONCLUSIONS: These preliminary findings suggest that this algorithm is capable of dividing patients with metastatic solid tumor who are starting systemic therapy into prognostic groups.

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  • (PMID = 28142847.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Caruana M, Apers S, Kovacs AH, Luyckx K, Thomet C, Budts W, Sluman M, Eriksen K, Dellborg M, Berghammer M, Johansson B, Soufi A, Callus E, Moons P, Grech V, APPROACH-IS consortium and the International Society for Adult Congenital Heart Disease (ISACHD): Red Flags for Maltese Adults with Congenital Heart Disease: Poorer Dental Care and Less Sports Participation Compared to Other European Patients-An APPROACH-IS Substudy. Pediatr Cardiol; 2017 Mar 24;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Red Flags for Maltese Adults with Congenital Heart Disease: Poorer Dental Care and Less Sports Participation Compared to Other European Patients-An APPROACH-IS Substudy.
  • Studies in recent years have explored lifestyle habits and health-risk behaviours in adult congenital heart disease (ACHD) patients when compared to controls.
  • The aim of this study was to investigate differences in lifestyle habits between Maltese and other European ACHD patients.
  • Data on alcohol consumption, cigarette smoking, substance misuse, dental care and physical activity collected in 2013-2015 during "Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart disease-International Study" (APPROACH-IS) were analysed.
  • Significantly fewer Maltese patients with simple (Maltese 84.1% vs.
  • Maltese patients with simple (Maltese 31.8% vs. European 56.1%, p = 0.002) and moderately complex lesions (Maltese 30.0% vs.
  • Comparison by country showed Maltese patients to have significantly poorer tooth brushing and sports participation than patients from any other participating country.
  • Alcohol consumption, cigarette smoking and substance misuse were not significantly different.
  • This study highlights lifestyle aspects that Maltese ACHD patients need to improve on, which might not be evident upon comparing patients to non-CHD controls.
  • These findings should also caution researchers against considering behaviours among patients in one country as necessarily representative of patients on the larger scale.

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  • (PMID = 28341902.001).
  • [ISSN] 1432-1971
  • [Journal-full-title] Pediatric cardiology
  • [ISO-abbreviation] Pediatr Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Congenital heart disease / Health behaviour / Lifestyle / Risk factors
  • [Investigator] Alday L; Maisuls H; Vega B; Menahem S; Eaton S; Larion R; Wang QF; Budts W; Van Deyk K; Apers S; Goossens E; Rassart J; Luyckx K; Moons P; Rempel G; Mackie A; Ballantyne R; Rankin K; Norris C; Taylor D; Vondermuhll I; Windram J; Heggie P; Lasiuk G; Khairy P; Proietti A; Dore A; Mercier LA; Mongeon FP; Marcotte F; Ibrahim R; Mondésert B; Côté MC; Kovacs A; Oechslin E; Bandyopadhyay M; Soufi A; Filippo SD; Sassolas F; Bozio A; Chidambarathanu S; Farzana F; Lakshmi N; Callus E; Quadri E; Chessa M; Campioni G; Giamberti A; Enomoto J; Mizuno Y; Caruana M; Grech V; Vella S; Mifsud A; Borg N; Chircop D; Mercieca Balbi M; Vella Critien R; Farrugia J; Gatt Y; Muscat D; Eriksen K; Estensen ME; Dellborg M; Berghammer M; Mattson E; Strandberg A; Karlström-Hallberg P; Johansson B; Kronhamn AK; Schwerzmann M; Thomet C; Huber M; Wang JK; Lu CW; Yang HL; Hua YC; Mulder B; Sluman M; Post M; Pieper E; Peels K; Waskowsky M; Veldtman G; Faust M; Lozier C; Reed C; Hilfer J; Daniels C; Jackson J; Kutty S; Chamberlain C; Cook S; Hindes M; Cedars A; White K; Rompfh A; Fernandes S; MacMillen K
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22. Neyt M, Baeyens H, Pouppez C, Slegers P, Hulstaert F, Stordeur S, Vinck I: Introduction of high-risk medical devices: national measures that can be taken under the current European legislation to put the patient interest central. Expert Rev Med Devices; 2017 Mar;14(3):181-188
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Introduction of high-risk medical devices: national measures that can be taken under the current European legislation to put the patient interest central.
  • INTRODUCTION: High-risk medical devices may not always provide a therapeutic added value to patients.
  • In conclusion, within the framework of the (revised) European legislation, measures at national level can be taken to temporarily restrict and follow up the use of high-risk medical devices with a greater focus on the therapeutic added value for the patients.

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  • (PMID = 28128008.001).
  • [ISSN] 1745-2422
  • [Journal-full-title] Expert review of medical devices
  • [ISO-abbreviation] Expert Rev Med Devices
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Device approval / European union / equipement and supplies / government regulation / treatment outcome
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23. Van Fleet H, Dunn DK, McNinch NL, Volsko TA: Evaluation of Functional Characteristics of 4 Oscillatory Positive Pressure Devices in a Simulated Cystic Fibrosis Model. Respir Care; 2017 Apr;62(4):451-458
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  • METHODS: The ASL 5000 was scripted to simulate pulmonary mechanics of a pediatric cystic fibrosis patient with moderate to severe lung disease.

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  • [Copyright] Copyright © 2017 by Daedalus Enterprises.
  • (PMID = 28292973.001).
  • [ISSN] 1943-3654
  • [Journal-full-title] Respiratory care
  • [ISO-abbreviation] Respir Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; OPEP / airway clearance / simulated model
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24. Petkovic J, Barton JL, Flurey C, Goel N, Bartels CM, Barnabe C, de Wit MP, Lyddiatt A, Lacaille D, Welch V, Boonen A, Shea B, Christensen R, Maxwell LJ, Campbell W, Jull J, Toupin-April K, Singh JA, Goldsmith CH, Sreih AG, Pohl C, Hofstetter C, Beaton DE, Buchbinder R, Guillemin F, Tugwell PS: Health Equity Considerations for Developing and Reporting Patient-reported Outcomes in Clinical Trials: A Report from the OMERACT Equity Special Interest Group. J Rheumatol; 2017 Feb 15;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Health Equity Considerations for Developing and Reporting Patient-reported Outcomes in Clinical Trials: A Report from the OMERACT Equity Special Interest Group.
  • OBJECTIVE: Despite advances integrating patient-centered outcomes into rheumatologic studies, concerns remain regarding their representativeness across diverse patient groups and how this affects equity.
  • METHODS: We surveyed current and previous OMERACT meeting attendees and members of the Campbell and Cochrane Equity Group regarding whether to address equity issues within the OMERACT Filter 2.0 Core Outcome Sets and how to assess the appropriateness of domains, instruments, and measurement properties among diverse patients.
  • RESULTS: We proposed 6 moments for which an equity lens could be added to the development, selection, or testing of patient-reported outcome measures (PROM):.
  • CONCLUSION: There is a need to (1) conduct a systematic review to assess how equity and population characteristics have been considered in PROM development and whether these differences influence the ranking of importance of outcome domains or a patient's response to questionnaire items, and (2) conduct the same survey described above with patients representing groups experiencing health inequities.

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  • (PMID = 28202740.001).
  • [ISSN] 0315-162X
  • [Journal-full-title] The Journal of rheumatology
  • [ISO-abbreviation] J. Rheumatol.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / K23 AR064372
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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25. Ro J, Andre F, Loi S, Verma S, Iwata H, Harbeck N, Loibl S, Bartlett CH, Zhang K, Giorgetti C, Randolph S, Koehler M, Cristofanilli M: PALOMA3: A double-blind, phase III trial of fulvestrant with or without palbociclib in pre- and post-menopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer that progressed on prior endocrine therapy. J Clin Oncol; 2015 Jun 20;33(18_suppl):LBA502
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Resistance to endocrine treatment remains a major clinical problem for patients with hormone receptor positive breast cancer.
  • METHODS: In this double-blind phase 3 study women with HR positive/HER2 negative advanced metastatic BC whose cancer had relapsed or progressed on prior endocrine therapy, were randomized 2:1 to palbociclib (Palbo, 125 mg/d orally for 3 wk followed by 1 wk off) and fulvestrant (F, 500 mg per standard of care) or placebo (PLB) and F.
  • Secondary endpoints included overall survival (OS), response assessment, patient-reported outcomes, and safety and tolerability.
  • CONCLUSIONS: Palbociclib combined with fulvestrant improved progression free survival in hormone receptor positive advanced breast cancer that had progressed on prior endocrine therapy, and can be considered as a treatment option for these patients.

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  • (PMID = 28147719.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Guo F, Svenningsen S, Kirby M, Capaldi DP, Sheikh K, Fenster A, Parraga G, Canadian Respiratory Research Network: Thoracic CT-MRI Co-Registration for Regional Pulmonary Structure-Function Measurements of Obstructive Lung Disease. Med Phys; 2017 Feb 16;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Recent pulmonary imaging research has revealed that in patients with chronic obstructive pulmonary disease (COPD) and asthma, structural and functional abnormalities are spatially heterogeneous.
  • This novel information may help optimize treatment in individual patients, monitor interventional efficacy and develop new treatments.
  • Moreover, by automating the measurement of regional biomarkers for the 19 different anatomical lung segments, there is an opportunity to embed imaging biomarkers into clinically-acceptable clinical workflows and improve lung disease clinical care.
  • METHODS: Thirty-five patients including 15 severe, poorly-controlled asthmatics and 20 COPD patients (classified according to the Global Initiative for chronic Obstructive Lung Disease (GOLD) criteria) provided written informed consent to a study protocol approved by Health Canada and underwent pulmonary function tests, MRI and CT during a single 2-hour visit.
  • Using this diverse patient dataset, we developed and evaluated a joint deformable registration approach to simultaneously co-register CT with both <sup>1</sup> H and <sup>3</sup> He MRI by enforcing the similarity of the deformation fields from the two individual registrations.
  • To estimate fiducial localization reproducibility, a single observer manually identified 109 pairs of CT and <sup>3</sup> He MRI fiducials for 35 patient images on five separate occasions and determined the fiducial localization error (FLE).
  • RESULTS: In 35 patients including 15 with severe asthma and 20 with COPD, mean forced expiratory volume in 1 second (FEV<sub>1</sub> ) was 63±24%<sub>pred</sub> and FEV<sub>1</sub> /forced vital capacity (FVC) was 54±17%.
  • CONCLUSIONS: For a diverse group of patients with COPD and asthma, whole-lung and segmental VDP was measured using an automated lung image analysis pipeline which provides a way to incorporate lung functional biomarkers into clinical research and patient care.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • [Copyright] This article is protected by copyright. All rights reserved.
  • (PMID = 28206676.001).
  • [ISSN] 2473-4209
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; CT / MRI / convex-optimization / deformable-registration / lung
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27. Nguyen KT, Olgin JE, Pletcher MJ, Ng M, Kaye L, Moturu S, Gladstone RA, Malladi C, Fann AH, Maguire C, Bettencourt L, Christensen MA, Marcus GM: Smartphone-Based Geofencing to Ascertain Hospitalizations. Circ Cardiovasc Qual Outcomes; 2017 Mar;10(3)
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Ascertainment of hospitalizations is critical to assess quality of care and the effectiveness and adverse effects of various therapies.
  • An in-person study included consecutive consenting patients scheduled for electrophysiology and cardiac catheterization procedures.
  • Of 22 eligible in-person patients, 17 hospitalizations were detected (sensitivity 77%; 95% confidence interval, 55%-92%).
  • This first proof of concept may ultimately be applicable to geofencing other types of prespecified locations to facilitate healthcare research and patient care.

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  • [Copyright] © 2017 American Heart Association, Inc.
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  • (PMID = 28325751.001).
  • [ISSN] 1941-7705
  • [Journal-full-title] Circulation. Cardiovascular quality and outcomes
  • [ISO-abbreviation] Circ Cardiovasc Qual Outcomes
  • [Language] eng
  • [Grant] United States / NIBIB NIH HHS / EB / U2C EB021881
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; fast food / hospitalization / internet / pharmacies / smartphone
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28. Tang LH, Kikkenborg Berg S, Christensen J, Lawaetz J, Doherty P, Taylor RS, Langberg H, Zwisler AD: Patients' preference for exercise setting and its influence on the health benefits gained from exercise-based cardiac rehabilitation. Int J Cardiol; 2017 Apr 01;232:33-39
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  • [Title] Patients' preference for exercise setting and its influence on the health benefits gained from exercise-based cardiac rehabilitation.
  • OBJECTIVE: To assess patient preference for exercise setting and examine if choice of setting influences the long-term health benefit of exercise-based cardiac rehabilitation.
  • METHODS: Patients participating in a randomised controlled trial following either heart valve surgery, or radiofrequency ablation for atrial fibrillation were given the choice to perform a 12-week exercise programme in either a supervised centre-based, or a self-management home-based setting.
  • RESULTS: Across the 158 included patients, an equivalent proportion preferred to undertake exercise rehabilitation in a centre-based setting (55%, 95% CI: 45% to 63%) compared to a home-based setting (45%, 95% CI: 37% to 53%, p=0.233).
  • CONCLUSION: The preference of patients to participate in home-based and centre-based exercise programmes appears to be equivalent and provides similar health benefits.
  • Whilst these findings support that patients should be given the choice between exercise-settings when initiating cardiac rehabilitation, further confirmatory evidence is needed.

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  • [Copyright] Copyright © 2017. Published by Elsevier B.V.
  • (PMID = 28159358.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Atrial fibrillation / Cardiac rehabilitation / Exercise setting / Exercise training / Heart valve diseases / Patient preference
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29. Sheedy SP, Bruining DH, Dozois EJ, Faubion WA, Fletcher JG: MR Imaging of Perianal Crohn Disease. Radiology; 2017 Mar;282(3):628-645
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  • Perianal fistulas are a leading cause of patient morbidity because closure often requires multimodality treatments over a prolonged period of time.
  • Different treatment modalities are selected based on fistula anatomy, patient factors, and management goals (closure versus sepsis control).
  • Radiologists can help maximize patient care by being familiar with MR imaging features of perianal Crohn disease and knowledgeable about what features may influence therapy decisions.

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  • (PMID = 28218881.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Korteland NM, Ahmed Y, Koolbergen DR, Brouwer M, de Heer F, Kluin J, Bruggemans EF, Klautz RJ, Stiggelbout AM, Bucx JJ, Roos-Hesselink JW, Polak P, Markou T, van den Broek I, Ligthart R, Bogers AJ, Takkenberg JJ: Does the Use of a Decision Aid Improve Decision Making in Prosthetic Heart Valve Selection? A Multicenter Randomized Trial. Circ Cardiovasc Qual Outcomes; 2017 Feb;10(2)
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: A Dutch online patient decision aid to support prosthetic heart valve selection was recently developed.
  • A multicenter randomized controlled trial was conducted to assess whether use of the patient decision aid results in optimization of shared decision making in prosthetic heart valve selection.
  • METHODS AND RESULTS: In a 5-center randomized controlled trial, patients were allocated to receive either standard preoperative care (control group) or additional access to the patient decision aid (intervention group).
  • Legally capable adult patients accepted for elective isolated or combined aortic and mitral valve replacement were included.
  • Primary outcome was preoperative decisional conflict (Decisional Conflict Scale); secondary outcomes included patient knowledge, involvement in valve selection, anxiety and depression, (valve-specific) quality of life, and regret.
  • Out of 306 eligible patients, 155 were randomized (78 control and 77 intervention).
  • Intervention patients felt better informed (median Decisional Conflict Scale informed subscore: 8 versus 17; <i>P</i>=0.046) and had a better knowledge of prosthetic valves (85% versus 68%; <i>P</i>=0.004).
  • Intervention patients experienced less anxiety and depression (median Hospital Anxiety and Depression Scale score: 6 versus 9; <i>P</i>=0.015) and better mental well-being (mean Short Form Health Survey score: 54 versus 50; <i>P</i>=0.032).
  • CONCLUSIONS: A patient decision aid to support shared decision making in prosthetic heart valve selection does not lower decisional conflict.
  • It does result in more knowledgeable, better informed, and less anxious and depressed patients, with a better mental well-being.

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  • [Copyright] © 2017 American Heart Association, Inc.
  • (PMID = 28228452.001).
  • [ISSN] 1941-7705
  • [Journal-full-title] Circulation. Cardiovascular quality and outcomes
  • [ISO-abbreviation] Circ Cardiovasc Qual Outcomes
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; anxiety / cardiovascular diseases / decision making / heart valves / randomized controlled trial
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31. Vesterhus M, Holm A, Hov JR, Nygård S, Schrumpf E, Melum E, Thorbjørnsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJ, Vatn M, Schaap FG, Jansen PL, Ueland T, Røsjø H, Moum B, Ponsioen CY, Boberg KM, Färkkilä M, Karlsen TH, Lund-Johansen F: Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. J Hepatol; 2017 Feb 02;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND & AIMS: Prognostic biomarkers are lacking in primary sclerosing cholangitis, hampering patient care and the development of therapy.
  • RESULTS: In the bile derivation panel, the levels of 14 proteins were different between PSC patients and controls (p<0.05); all were confirmed in the validation panel.
  • Twenty-four proteins in the bile derivation panel were significantly (p<0.05) different between PSC patients with mild compared to severe cholangiographic changes (modified Amsterdam criteria); this was replicated for 18 proteins in the validation panel.
  • Stratifying PSC patients according to tertiles of serum IL-8, but not MMP9/LCN2 and S100A12, provided excellent discrimination for transplant-free survival both in the serum derivation and validation cohort.
  • LAY SUMMARY: Prognostic biomarkers are lacking in primary sclerosing cholangitis, hampering patient care and the development of therapy.
  • We have identified inflammatory proteins including calprotectin and IL-8 as important indicators of disease severity and prognosis in bile and serum from patients with primary sclerosing cholangitis.

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  • [Copyright] Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
  • (PMID = 28161472.001).
  • [ISSN] 1600-0641
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Biomarker / Calprotectin / IL-8 / PSC / Prognosis
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32. Iskandar H, Gray DM 2nd, Vu H, Mirza F, Rude MK, Regan K, Abdalla A, Gaddam S, Almaskeen S, Mello M, Marquez E, Meyer C, Bolkhir A, Kanuri N, Sayuk G, Gyawali CP: Coeliac disease screening is suboptimal in a tertiary gastroenterology setting. Postgrad Med J; 2017 Jan 09;
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  • BACKGROUND AND AIMS: Coeliac disease (CD) is widely prevalent in North America, but case-finding techniques currently used may not be adequate for patient identification.
  • RESULTS: 616 consecutive patients (49±0.6 years, range 16-87 years, 58.5% females, 94% Caucasian) fulfilled inclusion criteria.
  • Of 145 patients screened, 4 patients (2.4%) had serology consistent with CD, of which 2 were proven by duodenal biopsy.
  • Using this proportion, an additional 5 patients might have been diagnosed in 191 untested patients with indications for CD screening.
  • CONCLUSIONS: More than 50% of patients in a tertiary GI clinic have indications for CD screening, but <50% of indicated cases are screened.
  • Case-finding techniques therefore are suboptimal, constituting a gap in patient care and an important target for future quality improvement initiatives.

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  • [Copyright] Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
  • (PMID = 28069744.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / T32 DK007130
  • [Publication-type] Journal Article
  • [Publication-country] England
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33. Tursi A, Di Mario F, Franceschi M, De Bastiani R, Elisei W, Baldassarre G, Ferronato A, Grillo S, Landi S, Zamparella M, De Polo M, Boscariolo L, Picchio M: New bismuth-containing quadruple therapy in patients infected with Helicobacter pylori: A first Italian experience in clinical practice. Helicobacter; 2017 Jan 26;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New bismuth-containing quadruple therapy in patients infected with Helicobacter pylori: A first Italian experience in clinical practice.
  • AIMS: To test the efficacy and safety of the new bismuth-containing quadruple therapy in patients infected with Helicobacter pylori.
  • MATERIAL AND METHODS: Consecutive H. pylori-positive dyspeptic patients were enrolled, either naïve or with previous failure treatment.
  • Patients were treated with Pylera<sup>®</sup> (three-in-one capsules containing bismuth subcitrate potassium 140 mg, metronidazole 125 mg, and tetracycline 125 mg) three capsules q.i.d. plus omeprazole 20 mg or esomeprazole 40 mg b.i.d. for 10 days.
  • RESULTS: One hundred and thirty-one patients were included in the study: 42% of patients were naïve, and 58%, with previous failure treatment. H. pylori eradication was achieved in 124 patients (94.7%, 95% confidence intervals (CIs) 89.3-97.8) in ITT population.
  • No difference in eradication rate was found either between naïve and previously treated patients (92.7% vs 96.0%, P=.383), or smoking and nonsmoking ones, or in patients taking omeprazole or esomeprazole.
  • Treatment-emergent adverse events occurred in 35 patients (26.7%, 95% CIs 19.9-34.9).
  • They were mild in all cases except in four, who discontinued the study due to diarrhea (three patients) and diffuse urticarial rush (one patient).

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  • [Copyright] © 2017 John Wiley & Sons Ltd.
  • (PMID = 28125857.001).
  • [ISSN] 1523-5378
  • [Journal-full-title] Helicobacter
  • [ISO-abbreviation] Helicobacter
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Helicobacter pylori / antibiotics / bismuth-containing therapy / treatment
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34. Erek E, Aydın S, Suzan D, Yıldız O, Altın F, Kırat B, Demir IH, Ödemiş E: Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest in children after cardiac surgery. Anatol J Cardiol; 2016 Mar 03;
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  • Medical records of all the patients who experienced cardiac arrest and ECPR in an early postoperative period (n=25; 4%) were analyzed.
  • Sixteen patients had palliative procedures.
  • In 88% of the patients, cardiac arrest episodes occurred in the first 24 h after operation.
  • RESULTS: The CPR duration until commencing mechanical support was <20 min in two patients, 20-40 min in 11 patients, and >40 min in 12 patients.
  • Eleven patients (44%) were weaned successfully from ECMO and survived more than 7 days.
  • While four patients were observed to have normal neuromotor development, one patient died of cerebral bleeding 6 months after discharge.

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  • (PMID = 28045013.001).
  • [ISSN] 2149-2271
  • [Journal-full-title] Anatolian journal of cardiology
  • [ISO-abbreviation] Anatol J Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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35. Holt TA, Dalton A, Marshall T, Fay M, Qureshi N, Kirkpatrick S, Hislop J, Lasserson D, Kearley K, Mollison J, Yu LM, Hobbs FD, Fitzmaurice D: Automated Software System to Promote Anticoagulation and Reduce Stroke Risk: Cluster-Randomized Controlled Trial. Stroke; 2017 Mar;48(3):787-790
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We investigated the effectiveness of a software tool (AURAS-AF [Automated Risk Assessment for Stroke in Atrial Fibrillation]) designed to identify such individuals during routine care through a cluster-randomized trial.
  • METHODS: Screen reminders appeared each time the electronic health records of an eligible patient was accessed until a decision had been taken over OAC treatment.
  • Control practices continued usual care.
  • Incidence of recorded transient ischemic attack was higher in the intervention practices (median 10.0 versus 2.3 per 1000 patients with atrial fibrillation; <i>P</i>=0.027), but at 12 months, we found a lower incidence of both all cause stroke (<i>P</i>=0.06) and hemorrhage (<i>P</i>=0.054).

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  • [Copyright] © 2017 American Heart Association, Inc.
  • [Cites] Trials. 2013 Nov 13;14:385 [24220602.001]
  • [Cites] Br J Gen Pract. 2012 Oct;62(603):e710-7 [23265231.001]
  • [Cites] Lancet. 2014 Mar 15;383(9921):955-62 [24315724.001]
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  • (PMID = 28119433.001).
  • [ISSN] 1524-4628
  • [Journal-full-title] Stroke
  • [ISO-abbreviation] Stroke
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; anticoagulants / atrial fibrillation / electronic health records / reminder systems / stroke
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36. Ataide R, Ashley EA, Powell R, Chan JA, Malloy MJ, O'Flaherty K, Takashima E, Langer C, Tsuboi T, Dondorp AM, Day NP, Dhorda M, Fairhurst RM, Lim P, Amaratunga C, Pukrittayakamee S, Hien TT, Htut Y, Mayxay M, Faiz MA, Beeson JG, Nosten F, Simpson JA, White NJ, Fowkes FJ: Host immunity to &lt;i&gt;Plasmodium falciparum&lt;/i&gt; and the assessment of emerging artemisinin resistance in a multinational cohort. Proc Natl Acad Sci U S A; 2017 Mar 13;
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  • Antibodies specific to 12 <i>Plasmodium falciparum</i> sporozoite and blood-stage antigens were determined in 959 patients (from 11 sites in Southeast Asia) participating in a multinational cohort study assessing parasite clearance half-life (PCt<sub>1/2</sub>) after artesunate treatment and <i>kelch13</i> mutations.
  • Linear mixed-effects modeling of pooled individual patient data assessed the association between antibody responses and PCt<sub>1/2.
  • Naturally acquired immunity accelerates the clearance of artemisinin-resistant parasites in patients with falciparum malaria and may confound the current working definition of artemisinin resistance.

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  • (PMID = 28289193.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; artemisinin / drug resistance / immunity / malaria / serology
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37. Udy AA, Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Paul SK, Lipman J, BLING-II Investigators, ANZICS Clinical Trials Group: Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial. Int J Antimicrob Agents; 2017 Mar 09;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial.
  • This substudy of the BLING-II trial aimed to explore the association between ARC and patient outcomes in a large randomised clinical trial.
  • Patients receiving any form of renal replacement therapy were excluded.
  • A total of 254 patients were included, among which 45 (17.7%) manifested ARC [median (IQR) CL<sub>Cr</sub> 165 (144-198) mL/min].
  • ARC patients were younger (P <0.001), more commonly male (P = 0.04) and had less organ dysfunction (P <0.001).
  • There were no statistically significant differences in clinical outcomes in ARC patients according to the dosing strategy employed.

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  • [Copyright] Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
  • (PMID = 28286115.001).
  • [ISSN] 1872-7913
  • [Journal-full-title] International journal of antimicrobial agents
  • [ISO-abbreviation] Int. J. Antimicrob. Agents
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Augmented renal clearance / Critical illness / Sepsis / β-Lactams
  • [Investigator] Bellomo R; Eastwood G; Peck L; Young H; Boschert C; Fletcher J; Smith J; Nand K; Sara T; Shirwadkar C; Harney A; Rodgers H; Van Haren F; Clarke S; Durham D; Hannan C; Matheson E; Schwartz K; Thomas K; Bone A; Cattigan C; Elderkin T; Salerno T; Cameron R; Ellis K; Hatter S; Davis J; Sanap M; Soar N; Wood J; Chan K; Heffernan A; Lai NA; Moss C; Sheehy K; Duroux M; Ratcliffe M; Shone S; Warhurst T; Dulhunty J; Dunlop R; Lipman J; Paterson D; Roberts J; Starr T; Stuart J; Udy A; Cooper D; McAllister R; Webb S; Cheng A; Inskip D; Miller J; Myburgh J; Knowles S; Reynolds C; Rudham S; Baker S; Hepburn K; Roberts B; Woods P; Chatterjee I; Smith J; Cullen M; Kong J; Nayyar V; Whitehead C; Gomersall C; Leung P; Gilder E; McCarthy L; McGuiness S; Parke R; Benefield K; Chen Y; McArthur C; Newby L; Henderson S; Mehrtens J; Noble S; Chadwick L; Freebain R; Hogan C; Kazemi A; Rust L; Song R; Tilsley A; Williams A; Durning J; Frengley R; La Pine M; McCracken G; Sharma SB; Andrews L; Dinsdale R; Hunt A; Hurford S; Mackle D; Ongley J; Young P; Lipman J; Bellomo R; Davis J; Dulhunty J; Eastwood G; Gomersall C; Myburgh J; Paterson D; Roberts J; Shirwadkar C; Starr T; Webb S; Kollef M; Turnidge J; Paul S
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38. Weiss CR, Akinwande O, Paudel K, Cheskin LJ, Holly B, Hong K, Fischman AM, Patel RS, Shin EJ, Steele KE, Moran TH, Kaiser K, Park A, Shade DM, Kraitchman DL, Arepally A: Clinical Safety of Bariatric Arterial Embolization: Preliminary Results of the BEAT Obesity Trial. Radiology; 2017 Feb 14;:160914
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  • Purpose To conduct a pilot prospective clinical trial to evaluate the feasibility, safety, and short-term efficacy of bariatric embolization, a recently developed endovascular procedure for the treatment of obesity, in patients with severe obesity.
  • Five severely obese patients (four women, one man) who were 31-49 years of age and who had a mean body mass index of 43.8 kg/m<sup>2</sup> ± 2.9 with no clinically important comorbidities were enrolled in this study.
  • Results The left gastric artery, with or without the gastroepiploic artery, was embolized in five patients, with a technical success rate of 100%.
  • A hospital stay of less than 48 hours for routine supportive care was provided for three patients.
  • Conclusion Bariatric embolization is feasible and appears to be well tolerated in severely obese patients.
  • In this small patient cohort, it appears to induce appetite suppression and may induce weight loss.

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  • (PMID = 28195823.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Dreber H, Reynisdottir S, Angelin B, Tynelius P, Rasmussen F, Hemmingsson E: Mental distress in treatment seeking young adults (18-25 years) with severe obesity compared with population controls of different body mass index levels: cohort study. Clin Obes; 2017 Feb;7(1):1-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : Young adults (18-25) with severe obesity constitute a challenging patient group, and there is limited evidence about their mental health status compared to population controls.

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  • [Copyright] © 2017 World Obesity Federation.
  • (PMID = 28058812.001).
  • [ISSN] 1758-8111
  • [Journal-full-title] Clinical obesity
  • [ISO-abbreviation] Clin Obes
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Clinical care / mental distress / severe obesity / young adult
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40. Gramatzki D, Kickingereder P, Hentschel B, Felsberg J, Herrlinger U, Schackert G, Tonn JC, Westphal M, Sabel M, Schlegel U, Wick W, Pietsch T, Reifenberger G, Loeffler M, Bendszus M, Weller M: Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma. Neurology; 2017 Mar 15;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To explore an association with survival of modifying the current standard of care for patients with newly diagnosed glioblastoma of surgery followed by radiotherapy plus concurrent and 6 cycles of maintenance temozolomide chemotherapy (TMZ/RT → TMZ) by extending TMZ beyond 6 cycles.
  • METHODS: The German Glioma Network cohort was screened for patients with newly diagnosed glioblastoma who received TMZ/RT → TMZ and completed ≥6 cycles of maintenance chemotherapy without progression.
  • Associations of clinical patient characteristics, molecular markers, and residual tumor determined by magnetic resonance imaging after 6 cycles of TMZ with progression-free survival (PFS) and overall survival (OS) were analyzed with the log-rank test.
  • RESULTS: Sixty-one of 142 identified patients received at least 7 maintenance TMZ cycles (median 11, range 7-20).
  • Patients with extended maintenance TMZ treatment had better PFS (20.5 months, 95% confidence interval [CI] 17.7-23.3, vs 17.2 months, 95% CI 10.2-24.2, <i>p</i> = 0.035) but not OS (32.6 months, 95% CI 28.9-36.4, vs 33.2 months, 95% CI 25.3-41.0, <i>p</i> = 0.126).
  • CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that in patients with newly diagnosed glioblastoma, prolonged TMZ chemotherapy does not significantly increase PFS or OS.

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  • [Copyright] © 2017 American Academy of Neurology.
  • (PMID = 28298550.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Nesbitt M, Kennerley K, Lacoursiere L, Frechette C, Flaherty S, Catalano PJ, Fuller F, Thiele J, Gilchrist H, Kostka J, Buswell LA: Standardizing chemotherapy education for quality improvement. J Clin Oncol; 2013 Nov;31(31_suppl):136
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 136 Background: Variation of chemotherapy teaching at three affiliated regional oncology centers was associated with a low patient satisfaction PS; Press Ganey Survey for Adult Oncology score of 83.7% in understanding what to expect during chemotherapy treatment and 72.9% in how to manage chemotherapy side effects.
  • Nursing staff collaborated to standardize content to improve PS and quality of care.
  • 1) A standardized teaching checklist, 2) electronic patient calendars, 3) 3 weeks later a patient education assessment survey (EAS).
  • 2) calendars listing (clinic appointments, symptoms requiring MD/NP notification, how to contact providers); and 3) ES assessed patient's level of comprehension.
  • Staff reported high satisfaction, highlighting its benefit to patients.

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  • (PMID = 28136415.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Demeyer H, Louvaris Z, Frei A, Rabinovich RA, de Jong C, Gimeno-Santos E, Loeckx M, Buttery SC, Rubio N, Van der Molen T, Hopkinson NS, Vogiatzis I, Puhan MA, Garcia-Aymerich J, Polkey MI, Troosters T, Mr Papp PROactive study group and the PROactive consortium: Physical activity is increased by a 12-week semiautomated telecoaching programme in patients with COPD: a multicentre randomised controlled trial. Thorax; 2017 Jan 30;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Physical activity is increased by a 12-week semiautomated telecoaching programme in patients with COPD: a multicentre randomised controlled trial.
  • RATIONALE: Reduced physical activity (PA) in patients with COPD is associated with a poor prognosis.
  • Increasing PA is a key therapeutic target, but thus far few strategies have been found effective in this patient group.
  • OBJECTIVES: To investigate the effectiveness of a 12-week semiautomated telecoaching intervention on PA in patients with COPD in a multicentre European randomised controlled trial.
  • METHODS: 343 patients from six centres, encompassing a wide spectrum of disease severity, were randomly allocated to either a usual care group (UCG) or a telecoaching intervention group (IG) between June and December 2014.
  • In IG patients, an improvement could be observed in the functional state domain of the clinical COPD questionnaire (p=0.03) compared with UCG.
  • CONCLUSIONS: The amount and intensity of PA can be significantly increased in patients with COPD using a 12-week semiautomated telecoaching intervention including a step counter and an application installed on a smartphone.

  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
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  • [Copyright] Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
  • (PMID = 28137918.001).
  • [ISSN] 1468-3296
  • [Journal-full-title] Thorax
  • [ISO-abbreviation] Thorax
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT02158065
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Exercise / Pulmonary Rehabilitation
  • [Investigator] Janssens W; Van den Brande P; Spruyt M; Hornikx M; Tanner R; Raste Y; Yerramasu C; Oosterom H; Buesching G; Strassman A; Frey M; Turk A; Keusch S; Zürcher A; Serra I; Ivanoff N; Karlsson N; Corriol-Rohou S; Jarrod I; Erzen D; Scuri M; McBride P; Kamel N; Tabberer M; Dobbels F; de Boer P; Nikai E; MacNee B
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43. Strandberg AY, Khanfir H, Mäkimattila S, Saukkonen T, Strandberg TE, Hoti F: Insulins NPH, Glargine, and Detemir, and Risk of Severe Hypoglycaemia among Working-Age Adults. Ann Med; 2016 Dec 31;:1-23
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  • Risk of severe hypoglycaemia requiring hospital care was compared between insulin types.
  • RESULTS: 16,985 persons initiated basal insulin treatment (5,586, 7,499, and 3,900 patients started NPH, glargine, and detemir, respectively) during follow-up.
  • Absolute rate (per 1000 patient-years) was 20.6 (95% CI 17.9, 23.8), 17.8 (15.6, 20.3), and 12.4 (9.9, 15.5) for NPH, glargine, and detemir initiators, respectively.

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  • (PMID = 28042719.001).
  • [ISSN] 1365-2060
  • [Journal-full-title] Annals of medicine
  • [ISO-abbreviation] Ann. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Basal insulin therapy / Hypoglycaemia / Insulin detemir / Insulin glargine / NPH insulin / Working-age population
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44. Turhal NS, Kilickap S, Yalcin S, Sezgin C, Yamac D, Akbulut H, Ozyilkan O, Ozdemir F, Cabuk D, Sevinc A, Turkish Oncology Group: The association between sociodemographic parameters and the use of complementary interventions in patients with cancer in Turkey: A Turkish Oncology Group study. J Clin Oncol; 2011 May 20;29(15_suppl):e19598
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The association between sociodemographic parameters and the use of complementary interventions in patients with cancer in Turkey: A Turkish Oncology Group study.
  • METHODS: A questionnaire consisting of 32 questions was completed by 872 patients in ten different medical institutions, which included over 90% of the oncological care given in Turkey, were represented.
  • To allay patients' concerns that their answers could influence their treatment, the questionnaire was given to each patient by support people and not by the attending physician.
  • RESULTS: For the sample of 872 patients, 44% were male and 55% were female.
  • The median age of the patients was 55 ± 13 (range 16-89).
  • The average age of the male patients was significantly greater than that of females (57 versus 53; p< 0.001).
  • Of all patients, 165 (18.9%) used some form of complementary interventions during their illnesses.We found no evidence that the use of complementary treatments was associated with any of the remaining demographic variables.
  • Frequency of patients who used complementary interventions varied significantly (p<0.002) among medical institutions.
  • However, complementary interventions were used most frequently by patients with prostate cancer (33%), head and neck cancer (27%), and lung cancer (22%).
  • The patients who were least likely to use complementary interventions were the patients with soft tissue tumors.
  • Forty-one percent of the patients who used complementary interventions were using some sort of it during the time that they filled out the questionnaire.
  • Sources of information regarding complementary interventions included relatives (37%), television (26%), other patients with cancer (22%), and the internet (21%).
  • Fifty-five percent of patients thought that they benefited from these methods.
  • CONCLUSIONS: Approximately 20% of cancer patients in Turkey used complementary interventions and this frequency was lower than expected.

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  • (PMID = 28022293.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Bruns BR, Morris DS, Zielinski M, Mowery NT, Miller PR, Arnold K, Phelan HA, Murry J, Turay D, Fam J, Oh JS, Gunter OL, Enniss T, Love JD, Skarupa D, Benns M, Fathalizadeh A, Leung PS, Carrick MM, Jewett B, Sakran J, O'Meara L, Herrera AV, Chen H, Scalea TM, Diaz JJ: Stapled versus hand-sewn: A prospective emergency surgery study. An American Association for the Surgery of Trauma multi-institutional study. J Trauma Acute Care Surg; 2017 Mar;82(3):435-443
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Data from the trauma patient population suggests handsewn (HS) anastomoses are superior to stapled (ST).
  • A recent retrospective study in emergency general surgery (EGS) patients had similar findings.
  • The aim of the current study was to evaluate HS and ST anastomoses in EGS patients undergoing urgent/emergent operations.
  • Patients undergoing urgent/emergent bowel resection for EGS pathology were prospectively enrolled from July 22, 2013 to December 31, 2015.
  • Patients were grouped by HS/ST anastomoses, and variables were collected.
  • RESULTS: Fifteen institutions enrolled a total of 595 patients with 649 anastomoses (253 HS and 396 ST).
  • Hospital and intensive care unit days, as well as mortality, were greater in the HS group.
  • On multivariate regression, the presence of contamination at initial resection (odds ratio, 1.965; 95% confidence interval, 1.183-3.264) and the patient being managed with open abdomen (odds ratio, 2.529; 95% confidence interval, 1.492-4.286) were independently associated with anastomotic failure, while the type of anastomosis was not.
  • CONCLUSION: EGS patients requiring bowel resection and anastomosis are at high risk for anastomotic failure.
  • The current study illustrates an apparent bias among acute care surgeons to perform HS techniques in higher-risk patients.
  • Despite the individualized application of technique for differing patient populations, the risk of anastomotic failure was equivalent when comparing HS and ST anastomoses.

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  • (PMID = 28030492.001).
  • [ISSN] 2163-0763
  • [Journal-full-title] The journal of trauma and acute care surgery
  • [ISO-abbreviation] J Trauma Acute Care Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Williams MC, Hunter A, Shah A, Assi V, Lewis S, Mangion K, Berry C, Boon NA, Clark E, Flather M, Forbes J, McLean S, Roditi G, van Beek EJ, Timmis AD, Newby DE, Scottish COmputed Tomography of the HEART (SCOT-HEART) Trial Investigators: Symptoms and quality of life in patients with suspected angina undergoing CT coronary angiography: a randomised controlled trial. Heart; 2017 Feb 28;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Symptoms and quality of life in patients with suspected angina undergoing CT coronary angiography: a randomised controlled trial.
  • BACKGROUND: In patients with suspected angina pectoris, CT coronary angiography (CTCA) clarifies the diagnosis, directs appropriate investigations and therapies, and reduces clinical events.
  • The effect on patient symptoms is currently unknown.
  • METHODS: In a prospective open-label parallel group multicentre randomised controlled trial, 4146 patients with suspected angina due to coronary heart disease were randomised 1:1 to receive standard care or standard care plus CTCA.
  • Compared with standard care alone, CTCA was associated with less marked improvements in physical limitation (difference -1.74 (95% CIs, -3.34 to -0.14), p=0.0329), angina frequency (difference -1.55 (-2.85 to -0.25), p=0.0198) and quality of life (difference -3.48 (-4.95 to -2.01), p<0.0001) at 6 months.
  • For patients undergoing CTCA, improvements in symptoms were greatest in those diagnosed with normal coronary arteries or who had their preventative therapy discontinued, and least in those with moderate non-obstructive disease or had a new prescription of preventative therapy (p<0.001 for all).

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  • [Copyright] Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
  • (PMID = 28246175.001).
  • [ISSN] 1468-201X
  • [Journal-full-title] Heart (British Cardiac Society)
  • [ISO-abbreviation] Heart
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Investigator] Williams M; Pawade T; Flapan A; Hargreaves A; Leslie S; McKillop G; Reid J; Spratt J; Uren N; Craig P; Barlow T; McCormack C; Shepherd S; Bucukoglu M; Parker R; Krishan A; Wee F; Wackett A; Walker A; Milne L; Oatey K; Neary P; Donaldson G; Fairbairn T; Fotheringham M; Hall F; Glen S; Perkins S; Taylor F; Cram L; Beveridge C; Cairns A; Dougherty F; Eteiba H; Rae A; Robb K; Crawford W; Clarkin P; Lennon E; Houston G; Pringle S; Prasad GR; Sudarshan T; Fogarty Y; Barrie D; Bissett K; Dawson A; Dundas S; Letham D; O'Neill L; Ritchie V; Weir-McCall J; Dougall H; Ahmed F; Cormack A; Findlay I; Hood S; Murphy C; Peat E; McCabe L; McCubbin M; Allen B; Behan M; Bertram D; Brian D; Cowan A; Cruden N; Denvir M; Dweck M; Flint L; Fyfe S; Grubb N; Keanie C; Lang C; MacGillivray T; MacLachlan D; MacLeod M; Mirsadraee S; Morrison A; Mills N; Northridge D; Phillips A; Queripel L; Weir N; Jacob A; Bett F; Divers F; Fairley K; Keegan E; White T; Fowler J; Gemmill J; McGowan J; Henry M; Francis M; Sandeman D; Dinnel L; Bloomfield P; Denvir M; Henriksen P; MacLeod D; Morrison A; Mordi I; Tzemos N; Connolly E; Boylan H; Brown A; Farrell L; Frood A; Glover C; Johnstone J; Lanaghan K; McGlynn D; McGregor L; McLennan E; Murdoch L; Paterson V; Teyhan F; Teenan M; Woodward R; Steedman T
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47. Taqui A, Cerejo R, Itrat A, Briggs FB, Reimer AP, Winners S, Organek N, Buletko AB, Sheikhi L, Cho SM, Buttrick M, Donohue MM, Khawaja Z, Wisco D, Frontera JA, Russman AN, Hustey FM, Kralovic DM, Rasmussen P, Uchino K, Hussain MS, Cleveland Pre-Hospital Acute Stroke Treatment (PHAST) Group: Reduction in time to treatment in prehospital telemedicine evaluation and thrombolysis. Neurology; 2017 Mar 08;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To compare the times to evaluation and thrombolytic treatment of patients treated with a telemedicine-enabled mobile stroke treatment unit (MSTU) vs those among patients brought to the emergency department (ED) via a traditional ambulance.
  • A vascular neurologist evaluated each patient via telemedicine and a neuroradiologist and vascular neurologist remotely assessed images obtained by the MSTU CT.
  • The evaluation and treatment of the first 100 MSTU patients (July 18, 2014-November 1, 2014) was compared to a control group of 53 patients brought to the ED via a traditional ambulance in 2014.
  • RESULTS: Patient and stroke severity characteristics were similar between 100 MSTU and 53 ED control patients (initial NIH Stroke Scale score 6 vs 7, <i>p</i> = 0.679).
  • Sixteen patients evaluated on MSTU received thrombolysis, 25% of whom received it within 60 minutes of symptom onset.

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  • [Copyright] © 2017 American Academy of Neurology.
  • (PMID = 28275084.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Joseph B, Orouji Jokar T, Hassan A, Azim A, Mohler MJ, Kulvatunyou N, Siddiqi S, Phelan H, Fain M, Rhee P: Redefining the association between old age and poor outcomes after trauma: The impact of frailty syndrome. J Trauma Acute Care Surg; 2017 Mar;82(3):575-581
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Frailty syndrome (FS) is a well-established predictor of outcomes in geriatric patients.
  • The aim of this study was to quantify the prevalence of FS in geriatric trauma patients and to determine its association with trauma readmissions, repeat falls, and mortality at 6 months.
  • METHODS: we performed a 2-year (2012-2013) prospective cohort analysis of all consecutive geriatric (age, ≥ 65 years) trauma patients.
  • Patients were stratified into: nonfrail, TSFI ≤ 0.12; prefrail, TSFI = 0.1 to 0.27; and frail, TSFI > 0.27.
  • Patient follow-up occurred at 6 months to assess outcomes.
  • RESULTS: Three hundred fifty patients were enrolled.
  • Frail patients were more likely to develop in-hospital complications (nonfrail, 12%; prefrail, 17.4%; and frail, 33.4%; p = 0.02) and an adverse discharge disposition compared with nonfrail and prefrail (nonfrail, 8%; prefrail,18%; and frail, 47%; p = 0.001).
  • Six-month follow-up was recorded in 80% of the patients.
  • Compared with nonfrail patients, frail patients were more likely to have had a trauma-related readmission (odds ratio [OR], 1.4; 95% confidence interval [CI], 1.2-3.6) and/or repeated falls (OR, 1.6; 95%CI, 1.1-2.5) over the 6-month period.
  • Overall 6-month mortality was 2.8% (n = 10), and frail elderly patients were more likely to have died (OR, 1.1; 95% CI, 1.04-4.7) compared with nonfrail patients.
  • CONCLUSION: Over a third of geriatric trauma patients had FS.
  • TSFI provides a practical and accurate assessment tool for identifying elderly trauma patients who are at increased risk of both short-term and long-term outcomes.
  • Early focused intervention in frail geriatric patients is warranted to improve long-term outcomes.

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  • (PMID = 28225741.001).
  • [ISSN] 2163-0763
  • [Journal-full-title] The journal of trauma and acute care surgery
  • [ISO-abbreviation] J Trauma Acute Care Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Wagenaar BH, Gimbel S, Hoek R, Pfeiffer J, Michel C, Cuembelo F, Quembo T, Afonso P, Gloyd S, Lambdin BH, Micek MA, Porthé V, Sherr K: Wait and consult times for primary healthcare services in central Mozambique: a time-motion study. Glob Health Action; 2016 Jan;9(1):31980
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Design We observed 8,102 patient arrivals and departures from clinical service areas across 12 public-sector clinics in Sofala and Manica Provinces between January and April 2011.
  • Over 70% (884/1,248) of patients arrived at the clinic to begin queuing for general reception prior to 10:30 am.

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  • (PMID = 28157004.001).
  • [ISSN] 1654-9880
  • [Journal-full-title] Global health action
  • [ISO-abbreviation] Glob Health Action
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; health professionals / health services research / healthcare allocation / maternal and child health / maternity services / primary health care / priority setting
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50. Silverman P, Colella F, McQuigg B, Hines H, Ciarallo S, Whittington L, Belcher S: Elective chemotherapy admission pilot and work-flow improvements to reduce excess days. J Clin Oncol; 2012 Dec;30(34_suppl):101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 101 Background: The Inpatient (Inpt) Oncology Service at University Hospitals Seidman Cancer Center, a large urban academic NCI Comprehensive Cancer Center was charged with identifying opportunities to link patient (pt) quality improvement and decreased length of stay (LOS) in pts admitted for elective chemotherapy (EC).
  • METHODS: A 2-month pilot was conducted, using an intervention group (IG) and control (C) group representing usual care (UC).
  • Census was taken above cap to accommodate IG patients.

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  • (PMID = 28146956.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Atri M, Zhang Z, Dehdashti F, Lee SI, Marques H, Ali S, Koh WJ, Mannel RS, DiSilvestro P, King SA, Pearl M, Zhou X, Plante M, Moxley KM, Gold M: Utility of PET/CT to Evaluate Retroperitoneal Lymph Node Metastasis in High-Risk Endometrial Cancer: Results of ACRIN 6671/GOG 0233 Trial. Radiology; 2017 Jan 03;:160200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients underwent PET/CT and pelvic and abdominal lymphadenectomy.
  • Two hundred seven of 215 enrolled patients had PET/CT and pathologic examination results for the abdomen and pelvis.
  • Mean patient age was 62.7 years ± 9.6 (standard deviation).
  • Data in all 23 patients with a positive abdominal examination and in 26 randomly selected patients with a negative abdominal examination were used for this central reader study.

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  • (PMID = 28051912.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. McCord J, Cabrera R, Lindahl B, Giannitsis E, Evans K, Nowak R, Frisoli T, Body R, Christ M, deFilippi CR, Christenson RH, Jacobsen G, Alquezar A, Panteghini M, Melki D, Plebani M, Verschuren F, French J, Bendig G, Weiser S, Mueller C, TRAPID-AMI Investigators: Prognostic Utility of a Modified HEART Score in Chest Pain Patients in the Emergency Department. Circ Cardiovasc Qual Outcomes; 2017 Feb;10(2)
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic Utility of a Modified HEART Score in Chest Pain Patients in the Emergency Department.
  • METHODS AND RESULTS: Twelve centers evaluated 1282 patients in the emergency department for possible AMI from 2011 to 2013.
  • Low-risk patients had an m-HS≤3 and had either hs-cTnT<14 ng/L over serial testing or had AMI excluded by the 1-hour protocol.
  • By the 1-hour protocol, 777 (60%) patients had an AMI excluded.
  • Of those 777 patients, 515 (66.3%) patients had an m-HS≤3, with 1 (0.2%) patient having a MACE, and 262 (33.7%) patients had an m-HS≥4, with 6 (2.3%) patients having MACEs (P=0.007).
  • Over 4 to 14 hours, 661 patients had a hs-cTnT<14 ng/L.
  • Of those 661 patients, 413 (62.5%) patients had an m-HS≤3, with 1 (0.2%) patient having a MACE, and 248 (37.5%) patients had an m-HS≥4, with 5 (2.0%) patients having MACEs (P=0.03).

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  • [Copyright] © 2017 American Heart Association, Inc.
  • (PMID = 28167641.001).
  • [ISSN] 1941-7705
  • [Journal-full-title] Circulation. Cardiovascular quality and outcomes
  • [ISO-abbreviation] Circ Cardiovasc Qual Outcomes
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; mortality / myocardial i / nfarction / patient discharge / prognosis / troponin-T
  • [Investigator] Twerenbold R; Katus HA; Popp S; Ordóñez-Llanos J; Santalo-Bel M; Horner D; Dolci A; Jernberg T; Zaninotto M; Manara A; Dinkel C; Menassanch-Volker S; Jarausch J; Zaugg C
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53. Damelin M, Bankovich A, Bernstein J, Lucas J, Chen L, Williams S, Park A, Aguilar J, Ernstoff E, Charati M, Dushin R, Aujay M, Lee C, Ramoth H, Milton M, Hampl J, Lazetic S, Pulito V, Rosfjord E, Sun Y, King L, Barletta F, Betts A, Guffroy M, Falahatpisheh H, O'Donnell CJ, Stull R, Pysz M, Escarpe P, Liu D, Foord O, Gerber HP, Sapra P, Dylla SJ: A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. Sci Transl Med; 2017 Jan 11;9(372)
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Therapies that target tumor-initiating cells (TICs) should improve patient survival by eliminating the cells that can drive tumor recurrence and metastasis.
  • We demonstrate that protein tyrosine kinase 7 (PTK7), a highly conserved but catalytically inactive receptor tyrosine kinase in the Wnt signaling pathway, is enriched on TICs in low-passage TNBC, OVCA, and NSCLC patient-derived xenografts (PDXs).
  • The PTK7-targeted ADC induced sustained tumor regressions and outperformed standard-of-care chemotherapy.
  • Together, these preclinical data demonstrate the potential for the PTK7-targeted ADC to improve the long-term survival of cancer patients.

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  • [Copyright] Copyright © 2017, American Association for the Advancement of Science.
  • (PMID = 28077676.001).
  • [ISSN] 1946-6242
  • [Journal-full-title] Science translational medicine
  • [ISO-abbreviation] Sci Transl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Fogel MA, Li C, Elci OU, Pawlowski T, Schwab PJ, Wilson F, Nicolson SC, Montenegro LM, Diaz L, Spray TL, Gaynor JW, Fuller S, Mascio C, Keller MS, Harris MA, Whitehead KK, Bethel J, Vossough A, Licht DJ: Neurological Injury and Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction. Circulation; 2017 Feb 14;135(7):671-682
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Patients with a single ventricle experience a high rate of brain injury and adverse neurodevelopmental outcome; however, the incidence of brain abnormalities throughout surgical reconstruction and their relationship with cerebral blood flow, oxygen delivery, and carbon dioxide reactivity remain unknown.
  • METHODS: Patients with a single ventricle were studied with magnetic resonance imaging scans immediately prior to bidirectional Glenn (pre-BDG), before Fontan (BDG), and then 3 to 9 months after Fontan reconstruction.
  • Nonacute ischemic white matter changes on T2-weighted imaging, focal tissue loss, and ventriculomegaly were all more commonly detected in BDG and Fontan compared with pre-BDG patients (<i>P</i><0.05).
  • BDG patients had significantly higher cerebral blood flow than did Fontan patients.
  • The odds of discovering brain injury with adjustment for surgical stage as well as ≥2 coexisting lesions within a patient decreased (63%-75% and 44%, respectively) with increasing amount of cerebral blood flow (<i>P</i><0.05).
  • In general, there was no association of oxygen delivery (except for ventriculomegaly in the BDG group) or carbon dioxide reactivity with neurological injury.
  • CONCLUSIONS: Significant brain abnormalities are commonly present in patients with a single ventricle, and detection of these lesions increases as children progress through staged surgical reconstruction, with multiple coexisting lesions more common earlier than later.
  • In addition, this study demonstrated that BDG patients had greater cerebral blood flow than did Fontan patients and that an inverse association exists of various indexes of cerebral blood flow with these brain lesions.
  • However, CO<sub>2</sub> reactivity and oxygen delivery (with 1 exception) were not associated with brain lesion development.

  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
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  • [Copyright] © 2016 American Heart Association, Inc.
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  • (PMID = 28031423.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT02135081
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL090615; United States / NINDS NIH HHS / NS / R01 NS060653; United States / NINDS NIH HHS / NS / R01 NS072338; United States / NICHD NIH HHS / HD / U01 HD087180
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Fontan procedure / cerebral infarction / cerebrovascular circulation / heart ventricles / magnetic resonance imaging
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55. Duma A, Pal S, Johnston J, Helwani MA, Bhat A, Gill B, Rosenkvist J, Cartmill C, Brown F, Miller JP, Scott MG, Sanchez-Conde F, Jarvis M, Farber NB, Zorumski CF, Conway C, Nagele P: High-sensitivity Cardiac Troponin Elevation after Electroconvulsive Therapy: A Prospective, Observational Cohort Study. Anesthesiology; 2017 Apr;126(4):643-652
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: This was a prospective cohort study in adult patients undergoing electroconvulsive therapy in a single academic center (up to three electroconvulsive therapy treatments per patient).
  • Twelve-lead electrocardiogram and high-sensitivity cardiac troponin I values were obtained before and 15 to 30 min after electroconvulsive therapy; in a subset of patients, an additional 2-h high-sensitivity cardiac troponin I value was obtained.
  • RESULTS: The final study population was 100 patients and a total of 245 electroconvulsive therapy treatment sessions.
  • Eight patients (8 of 100; 8%) experienced new high-sensitivity cardiac troponin I elevation after electroconvulsive therapy with a cumulative incidence of 3.7% (9 of 245 treatments; one patient had two high-sensitivity cardiac troponin I elevations), two of whom had a non-ST-elevation myocardial infarction (incidence 2 of 245; 0.8%).
  • CONCLUSIONS: Electroconvulsive therapy appears safe from a cardiac standpoint in a large majority of patients.
  • A small subset of patients with preexisting cardiovascular risk factors, however, may develop new cardiac troponin elevation after electroconvulsive therapy, the clinical relevance of which is unclear in the absence of signs of myocardial ischemia.

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  • (PMID = 28166110.001).
  • [ISSN] 1528-1175
  • [Journal-full-title] Anesthesiology
  • [ISO-abbreviation] Anesthesiology
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL126892; United States / NIMH NIH HHS / MH / R21 MH108901; United States / NCRR NIH HHS / RR / UL1 RR024992
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Bosnic-Anticevich S, Callan C, Chrystyn H, Lavorini F, Nikolaou V, Kritikos V, Dekhuijzen PN, Roche N, Bjermer L, Rand C, Zwar N, Price DB: Inhaler technique mastery and maintenance in healthcare professionals trained on different devices. J Asthma; 2017 Mar 23;:0
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Healthcare professionals (HCPs) are required to assess and train patients in the correct use of inhalers but are often unable to demonstrate correct technique themselves.
  • METHODS: We conducted a randomised, un-blinded, cross-over study in undergraduate HCPs who undertook a six-step training procedure (intuitive use, patient information leaflet, instructional video, individual tuition from expert, then two repeats of individual tuition) for the use of Turbuhaler® (an established device) and Spiromax® (a newer device, reportedly easier to use).
  • The implications on clinical practice, device education delivery and patient outcomes require further evaluation.

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  • (PMID = 28332886.001).
  • [ISSN] 1532-4303
  • [Journal-full-title] The Journal of asthma : official journal of the Association for the Care of Asthma
  • [ISO-abbreviation] J Asthma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; asthma / clinical trial / device mastery / device mastery maintenance / dry powder inhaler / handling errors
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57. Khan A, Coffey M, Litterer KP, Baird JD, Furtak SL, Garcia BM, Ashland MA, Calaman S, Kuzma NC, O'Toole JK, Patel A, Rosenbluth G, Destino LA, Everhart JL, Good BP, Hepps JH, Dalal AK, Lipsitz SR, Yoon CS, Zigmont KR, Srivastava R, Starmer AJ, Sectish TC, Spector ND, West DC, Landrigan CP, and the Patient and Family Centered I-PASS Study Group, Allair BK, Alminde C, Alvarado-Little W, Atsatt M, Aylor ME, Bale JF Jr, Balmer D, Barton KT, Beck C, Bismilla Z, Blankenberg RL, Chandler D, Choudhary A, Christensen E, Coghlan-McDonald S, Cole FS, Corless E, Cray S, Da Silva R, Dahale D, Dreyer B, Growdon AS, Gubler L, Guiot A, Harris R, Haskell H, Kocolas I, Kruvand E, Lane MM, Langrish K, Ledford CJ, Lewis K, Lopreiato JO, Maloney CG, Mangan A, Markle P, Mendoza F, Micalizzi DA, Mittal V, Obermeyer M, O'Donnell KA, Ottolini M, Patel SJ, Pickler R, Rogers JE, Sanders LM, Sauder K, Shah SS, Sharma M, Simpkin A, Subramony A, Thompson ED Jr, Trueman L, Trujillo T, Turmelle MP, Warnick C, Welch C, White AJ, Wien MF, Winn AS, Wintch S, Wolf M, Yin HS, Yu CE: Families as Partners in Hospital Error and Adverse Event Surveillance. JAMA Pediatr; 2017 Feb 27;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • While clinician reports are the foundation of operational hospital safety surveillance and a key component of multifaceted research surveillance, patient and family reports are not routinely gathered.
  • Design, Setting, and Participants: We conducted a prospective cohort study including the parents/caregivers of 989 hospitalized patients 17 years and younger (total 3902 patient-days) and their clinicians from December 2014 to July 2015 in 4 US pediatric centers.
  • Rates were generated using Poisson regression estimated via generalized estimating equations to account for repeated measures on the same patient.
  • Error rates with family reporting (45.9 per 1000 patient-days) were 1.2-fold (95% CI, 1.1-1.2) higher than rates without family reporting (39.7 per 1000 patient-days).
  • Adverse event rates with family reporting (28.7 per 1000 patient-days) were 1.1-fold (95% CI, 1.0-1.2; P = .006) higher than rates without (26.1 per 1000 patient-days).
  • Families and clinicians reported similar rates of errors (10.0 vs 12.8 per 1000 patient-days; relative rate, 0.8; 95% CI, .5-1.2) and AEs (8.5 vs 6.2 per 1000 patient-days; relative rate, 1.4; 95% CI, 0.8-2.2).

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  • (PMID = 28241211.001).
  • [ISSN] 2168-6211
  • [Journal-full-title] JAMA pediatrics
  • [ISO-abbreviation] JAMA Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Grubbs SS, Go RS, Berger MZ, Gonzalez M, Thompson MA, Enos R, St Germain DC, Denicoff A, Servididio C, Bearden JD, Zaren H, Wilkinson K, Krasna M, McCaskill-Stevens W, Bell M, Freeman RK, Miesfeldt S, Ravikumar TS, Nair SG, Bashey A: Early success in narrowing age, gender, and racial disparities in clinical trial accrual: Targeted screening efforts through the National Cancer Institute Community Cancer Centers Program (NCCCP). J Clin Oncol; 2011 May 20;29(15_suppl):6110
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The data included patient demographics, trial eligibility, trial enrollment, and reasons for non-enrollment.
  • This abstract addresses patient demographics.
  • RESULTS: Of the 1,589 patients screened during this period, 359 were enrolled, for an overall accrual rate of 23%.
  • No disparity based on gender, ethnicity, or race between Whites and African Americans (P value for the latter comparison 0.59) was found and the disparity gap between the young and elderly appears narrowed when compared to historical data (3-fold difference; Murthy VH, et al JAMA 2004).

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  • (PMID = 28022513.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Jaruseviciene L, Orozco M, Ibarra M, Cordova Ossio F, Vega B, Auquilla N, Medina J, Gorter AC, Decat P, De Meyer S, Temmerman M, Edmonds AB, Valius L, Lazarus JV: Primary healthcare providers' views on improving sexual and reproductive healthcare for adolescents in Bolivia, Ecuador, and Nicaragua. Glob Health Action; 2013 Jan;6(1):20444
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : Objectives To elicit the views of primary healthcare providers from Bolivia, Ecuador, and Nicaragua on how adolescent sexual and reproductive health (ASRH) care in their communities can be improved.
  • Results Study participants emphasized managerial issues such as the prioritization of adolescents as a patient group and increased healthcare providers' awareness about adolescent-friendly approaches.

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  • (PMID = 28140871.001).
  • [ISSN] 1654-9880
  • [Journal-full-title] Global health action
  • [ISO-abbreviation] Glob Health Action
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Latin America / adolescents / healthcare personnel / primary healthcare / reproductive health services
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60. Cox H, Dickson-Hall L, Ndjeka N, Van't Hoog A, Grant A, Cobelens F, Stevens W, Nicol M: Delays and loss to follow-up before treatment of drug-resistant tuberculosis following implementation of Xpert MTB/RIF in South Africa: A retrospective cohort study. PLoS Med; 2017 Feb;14(2):e1002238
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: South Africa has a large burden of rifampicin-resistant tuberculosis (RR-TB), with 18,734 patients diagnosed in 2014.
  • The number of diagnosed patients has increased substantially with the introduction of the Xpert MTB/RIF test, used for tuberculosis (TB) diagnosis for all patients with presumptive TB.
  • Routine aggregate data suggest a large treatment gap (pre-treatment loss to follow-up) between the numbers of patients with laboratory-confirmed RR-TB and those reported to have started second-line treatment.
  • METHODS AND FINDINGS: A nationwide retrospective cohort study was conducted to assess second-line treatment initiation and treatment delay among laboratory-diagnosed RR-TB patients.
  • Cohorts, including approximately 300 sequentially diagnosed RR-TB patients per South African province, were drawn from the years 2011 and 2013, i.e., before and after Xpert implementation.
  • Patients with prior laboratory RR-TB diagnoses within 6 mo and currently treated patients were excluded.
  • Treatment initiation was determined through data linkage with national and local treatment registers, medical record review, interviews with health care staff, and direct contact with patients or household members.
  • National estimates of the percentage of patients who initiated treatment and time to treatment were weighted to account for the sampling design.
  • There were 2,508 and 2,528 eligible patients in the 2011 and 2013 cohorts, respectively; 92% were newly diagnosed with RR-TB (no prior RR-TB diagnoses).
  • Nationally, among the 2,340 and 2,311 new RR-TB patients in the 2011 and 2013 cohorts, 55% (95% CI 53%-57%) and 63% (95% CI 61%-65%), respectively, started treatment within 6 mo of laboratory receipt of their diagnostic specimen (p < 0.001).
  • However, in 2013, there was no difference in the percentage of patients who initiated treatment at 6 mo between the 1,368 new RR-TB patients diagnosed by Xpert (62%, 95% CI 59%-65%) and the 943 diagnosed by other methods (64%, 95% CI 61%-67%) (p = 0.39).
  • In 2013, across the nine provinces, there were substantial variations in both treatment initiation (range 51%-73% by 6 mo) and median time to treatment (range 15-36 d, n = 1,450), and only 53% of the 1,448 new RR-TB patients who received treatment were recorded in the national RR-TB register.
  • Other limitations include the use of names and dates of birth to locate patient-level data, potentially resulting in missed treatment initiation among some patients.
  • However, given improved case detection with Xpert, a larger proportion of RR-TB patients overall have received treatment, with reduced delays.
  • Nonetheless, strategies to further improve linkage to treatment for all diagnosed RR-TB patients are urgently required.

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  • (PMID = 28222095.001).
  • [ISSN] 1549-1676
  • [Journal-full-title] PLoS medicine
  • [ISO-abbreviation] PLoS Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Kadokura M, Ishida Y, Tatsumi A, Takahashi E, Shindo H, Amemiya F, Takano S, Fukasawa M, Sato T, Enomoto N: Performance status and neutrophil-lymphocyte ratio are important prognostic factors in elderly patients with unresectable pancreatic cancer. J Gastrointest Oncol; 2016 Dec;7(6):982-988
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  • [Title] Performance status and neutrophil-lymphocyte ratio are important prognostic factors in elderly patients with unresectable pancreatic cancer.
  • BACKGROUND: The usefulness of various prognostic factors for pancreatic cancer (PC) has been reported, but the number of elderly patients in these studies is disproportionately fewer compared with those in everyday practice.
  • The purpose of this study was to investigate the prognostic factors for unresectable PC in elderly patients.
  • METHODS: We retrospectively analyzed 67 elderly (age ≥75 years) patients with unresectable PC who underwent chemotherapy between January 2006 and December 2014 at our hospital.
  • CONCLUSIONS: The two prognostic factors identified herein are useful in the identification of patients with a poor prognosis and subsequent administration of supportive care alone, which may help avoid the unnecessary adverse effects and complications of systemic chemotherapy.

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  • (PMID = 28078122.001).
  • [ISSN] 2078-6891
  • [Journal-full-title] Journal of gastrointestinal oncology
  • [ISO-abbreviation] J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Keywords] NOTNLM ; Pancreatic cancer (PC) / elderly patient / neutrophil-lymphocyte ratio (NLR) / prognostic factor
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62. Bailly S, Leroy O, Azoulay E, Montravers P, Constantin JM, Dupont H, Guillemot D, Lortholary O, Mira JP, Perrigault PF, Gangneux JP, Timsit JF, AmarCAND2 Study Group: Impact of echinocandin on prognosis of proven invasive candidiasis in ICU: A post-hoc causal inference model using the AmarCAND2 study. J Infect; 2017 Jan 16;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: guidelines recommend first-line systemic antifungal therapy (SAT) with echinocandins in invasive candidiasis (IC), especially in critically ill patients.
  • This study aimed at assessing the impact of echinocandins compared to azoles as initial SAT on the 28-day prognosis in adult ICU patients.
  • METHODS: From the prospective multicenter AmarCAND2 cohort (835 patients), we selected those with documented IC and treated with echinocandins (ECH) or azoles (AZO).
  • RESULTS: 397 patients were selected, treated with echinocandins (242 patients, 61%) or azoles (155 patients, 39%); septic shock: 179 patients (45%).
  • However, echinocandin tended to benefit patients with septic shock (HR: 0.46 [0.19; 1.07]; p = 0.07).
  • CONCLUSION: Patients who received echinocandins were more severely ill.
  • Echinocandin use was associated with a non-significant 7% decrease of 28-day mortality and a trend to a beneficial effect for patient with septic shock.

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [Copyright] Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 28104387.001).
  • [ISSN] 1532-2742
  • [Journal-full-title] The Journal of infection
  • [ISO-abbreviation] J. Infect.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Echinocandin / Fluconazole / IPTW estimator / Invasive candidiasis / Patient prognosis
  • [Investigator] Aait H; Adda; Allaouchiche; Ammenouche; Angel; Argaud; Badetti; Baldesi; Barthet; Bastien; Baudin; Bellec; Blasco; Bollaert; Bonadona; Bretonnière; Brocas; Brua; Bruder; Brunin; Cabaret; Carpentier; Cartier; Cerf; Chabanne; Charles; Cheval; Cinotti; Cohen; Constantin; Cousson; Delpierre; Demory; Diconne; Du Cheyron; Dubost; Dumenil; Durand; Duroy; Forel; Foucher-Lezla; Fratea; Gally; Gaudard; Geffe; Gergaud; Gette; Girault; Goubaux; Gouin; Grenot; Grossmith; Guelon; Guerin-Robardey; Guervilly; Hayl-Slayman; Hilbert; Houissa; Hraiech; Ichai; Jung; Kaidomar; Karoubi; Kherchache; Lambiotte; Lamhaut; Launoy; Lebreton; Lefrant; Lemaire; Lepape; Lepoivre; Leroy; Lesieur; Levy; Luyt; Mahe; Mahul; Mateu; Megarbane; Merle; Mira; Montcriol; Mootien; Navellou; Ouattara; Page; Perrigault; Petitpas; Plantefeve; Quinart; Quintard; Ragonnet; Roquilly; Ruiz; Saliba; Samba; Schmitt; Seguin; Sejourne; Tellier; Thevenot; Tonnelier; Van Grunderbeek; Vincent; Wiramus; Zogheib
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63. Blecha S, Harth M, Schlachetzki F, Zeman F, Blecha C, Flora P, Burger M, Denzinger S, Graf BM, Helbig H, Pawlik MT: Changes in intraocular pressure and optic nerve sheath diameter in patients undergoing robotic-assisted laparoscopic prostatectomy in steep 45° Trendelenburg position. BMC Anesthesiol; 2017 Mar 11;17(1):40
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  • [Title] Changes in intraocular pressure and optic nerve sheath diameter in patients undergoing robotic-assisted laparoscopic prostatectomy in steep 45° Trendelenburg position.
  • BACKGROUND: To evaluate changes in intraocular pressure (IOP) and intracerebral pressure (ICP) reflected by the optic nerve sheath diameter (ONSD) in patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) in permanent 45° steep Trendelenburg position (STP).
  • METHODS: Fifty-one patients undergoing RALP under a standardised anaesthesia.
  • IOP was perioperatively measured in awake patients (T0) and IOP and ONSD 20 min after induction of anaesthesia (T1), after insufflation of the abdomen in supine position (T2), after 30 min in STP (T3), when controlling Santorini's plexus in STP (T4) and before awakening while supine (T5).
  • We investigated the influence of respiratory and circulatory parameters as well as patient-specific and time-dependent factors on IOP and ONSD.
  • Patients aged <63 years showed a 0.21 mm wider ONSD on average (p = 0.017) and greater variations in diameter than older patients.
  • Differences in the ONSD were age-related, showing higher output values as well as better autoregulation and compliance in STP for patients aged <63 years.

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  • (PMID = 28284189.001).
  • [ISSN] 1471-2253
  • [Journal-full-title] BMC anesthesiology
  • [ISO-abbreviation] BMC Anesthesiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Intraocular pressure / Optic nerve sheath diameter / Robotic-assisted laparoscopic prostatectomy / steep Trendelenburg position
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64. Escudier B, Sharma P, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, Castellano D, Gurney H, Donskov F, Peltola K, Wagstaff J, Gauler TC, Ueda T, Zhao H, Waxman IM, Motzer RJ, CheckMate 025 investigators: CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma. Eur Urol; 2017 Mar 02;
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  • The benefit with nivolumab versus everolimus was noteworthy for patients with poor MSKCC risk (hazard ratio 0.48, 95% confidence interval 0.32-0.70).
  • CONCLUSION: The trend for OS and ORR benefit with nivolumab for multiple subgroups, without notable safety concerns, may help to guide treatment decisions, and further supports nivolumab as the standard of care in previously treated patients with aRCC.
  • PATIENT SUMMARY: We investigated the impact of demographic and pretreatment features on survival benefit and tumor response with nivolumab versus everolimus in advanced renal cell carcinoma (aRCC).
  • Survival benefit and response were observed for multiple subgroups, supporting the use of nivolumab as a new standard of care across a broad range of patients with previously treated aRCC.

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  • [Copyright] Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.
  • (PMID = 28262413.001).
  • [ISSN] 1873-7560
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; Everolimus / Immune checkpoint inhibitor / Nivolumab / Phase 3 / Renal cell carcinoma
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65. Buntrock C, Berking M, Smit F, Lehr D, Nobis S, Riper H, Cuijpers P, Ebert D: Preventing Depression in Adults With Subthreshold Depression: Health-Economic Evaluation Alongside a Pragmatic Randomized Controlled Trial of a Web-Based Intervention. J Med Internet Res; 2017 Jan 04;19(1):e5
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  • Participants were randomized to a Web-based guided self-help intervention (ie, cognitive-behavioral therapy and problem-solving therapy assisted by supervised graduate students or health care professionals) in addition to usual care or to usual care supplemented with Web-based psycho-education (enhanced usual care).
  • Costs measured from a societal and health care perspective were related to DFYs and quality-adjusted life years (QALYs).
  • Taking the health care perspective and assuming a willingness-to-pay of €20,000 (£17,000), the intervention's likelihood of being cost-effective was 99% for gaining a DFY and 64% or 99% for gaining an EQ-5D or a SF-6D QALY.
  • Offering the intervention has an acceptable likelihood of being more cost-effective than enhanced usual care and could therefore reach community members on a wider scale.
  • TRIAL REGISTRATION: German Clinical Trials Register: DRKS00004709; http://www.drks.de/DRKS00004709 (Archived by WebCite at http://www.webcitation.org/6kAZVUxy9).

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  • (PMID = 28052841.001).
  • [ISSN] 1438-8871
  • [Journal-full-title] Journal of medical Internet research
  • [ISO-abbreviation] J. Med. Internet Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Internet / cost effectiveness / early intervention / major depressive disorders / prevention
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66. Chersich MF, Takkinen J, Charlier C, Leclercq A, Adams PE, Godbole G, Altmeyer U, Friesema IH, Labbé Sandelin L, Jenkin L, Fontana L, Aldigeri R, Venter F, Luchters SM, Lecuit M, Cimino L: Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review. Ocul Immunol Inflamm; 2017 Feb 01;:1-10
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  • PURPOSE: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis.
  • Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed.
  • Median days from entering care to diagnosis was 8 (IQR = 5-17).
  • Older patients had poorer outcomes.


67. Tan D, Xu J, Shao S, Fu Y, Sun F, Zhang Y, Hu Y, Walline J, Zhu H, Yu X: Comparison of different inspiratory triggering settings in automated ventilators during cardiopulmonary resuscitation in a porcine model. PLoS One; 2017;12(2):e0171869
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  • A turned-off patient triggering or a pressure-triggering of 20 cmH2O is preferred for ventilation when an ordinary inpatient hospital ventilator is used during resuscitation.

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  • (PMID = 28187154.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Pericàs JM, Messina JA, Garcia-de-la-Mària C, Park L, Sharma-Kuinkel BK, Marco F, Wray D, Kanafani ZA, Carugati M, Durante-Mangoni E, Tattevin P, Chu VH, Moreno A, Fowler VG Jr, Miró JM, International Collaboration on Endocarditis Microbiology Investigators: Influence of vancomycin minimum inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus left-sided infective endocarditis treated with antistaphylococcal β-lactam antibiotics: a prospective cohort study by the International Collaboration on Endocarditis. Clin Microbiol Infect; 2017 Feb 01;
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  • METHODS: All patients with left-sided MSSA infective endocarditis treated with antistaphylococcal β-lactam antibiotics between 2000 and 2006 with available isolates were included.
  • No significant differences in patient demographic data or characteristics of infection were observed between patients with infective endocarditis due to high and low vancomycin MIC isolates.
  • CONCLUSIONS: In this international cohort of patients with left-sided MSSA endocarditis treated with antistaphylococcal β-lactams, vancomycin MIC phenotype was not associated with patient demographics, clinical outcome or virulence gene repertoire.

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [Copyright] Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 28159672.001).
  • [ISSN] 1469-0691
  • [Journal-full-title] Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • [ISO-abbreviation] Clin. Microbiol. Infect.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Endocarditis / Genotype / Phenotype / Staphylococcus aureus / Vancomycin MIC
  • [Investigator] Athan E; Harris O; Korman TM; Kotsanas D; Jones P; Reinbott P; Ryan S; Fortes CQ; Garcia P; Jones SB; Barsic B; Bukovski S; Selton-Suty C; Aissa N; Doco-Lecompte T; Delahaye F; Vandenesch F; Tattevin P; Hoen B; Plesiat P; Giamarellou H; Giannitsioti E; Tarpatzi E; Durante-Mangoni E; Iossa D; Orlando S; Ursi MP; Pafundi PC; D' Amico F; Bernardo M; Cuccurullo S; Dialetto G; Covino FE; Manduca S; Della Corte A; De Feo M; Tripodi MF; Baban T; Kanafani Z; Kanj SS; Sfeir J; Yasmine M; Morris A; Murdoch DR; Premru MM; Lejko-Zupanc T; Almela M; Ambrosioni J; Azqueta M; Brunet M; Cervera C; De Lazzari E; Falces C; Fuster D; Garcia-de-la-Maria C; Garcia-Gonzalez J; Gatell JM; Marco F; Miró JM; Moreno A; Ortiz J; Ninot S; Paré JC; Pericas JM; Quintana E; Ramirez J; Sandoval E; Sitges M; Tolosana JM; Vidal B; Vila J; Bouza E; Rodríguez-Créixems M; Ramallo V; Bradley S; Wray D; Steed L; Cantey R; Peterson G; Stancoven A; Woods C; Corey GR; Reller LB; Fowler VG Jr; Chu VH; Baloch K; Chu VH; Corey GR; Dixon CC; Fowler VG Jr; Harding T; Jones-Richmond M; Pappas P; Park LP; Redick T; Stafford J; Anstrom K; Athan E; Bayer AS; Cabell CH; Chu VH; Corey GR; Fowler VG Jr; Hoen B; Karchmer AW; Miró JM; Murdoch DR; Sexton DJ; Wang A; Bayer AS; Cabell CH; Chu V; Corey GR; Durack DT; Eykyn S; Fowler VG Jr; Hoen B; Miró JM; Moreillon P; Olaison L; Raoult D; Rubinstein E; Sexton DJ
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69. Hirose T, Kimbara F, Shinozaki M, Mizushima Y, Yamamoto H, Kishi M, Kiguchi T, Shiono S, Noborio M, Fuke A, Akimoto H, Kimura T, Kaga S, Horiuchi T, Shimazu T: Screening for hereditary angioedema (HAE) at 13 emergency centers in Osaka, Japan: A prospective observational study. Medicine (Baltimore); 2017 Feb;96(6):e6109
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  • The objective is to study the incidence of HAE among patients who visit the emergency department.This was a 3-year prospective observational screening study involving 13 urban tertiary emergency centers in Osaka prefecture, Japan.
  • Patients were included if they met the following criteria: unexplained edema of the body, upper airway obstruction accompanied by edema, anaphylaxis, acute abdomen with intestinal edema (including ileus and acute pancreatitis), or asthma attack.
  • C1-INH activity and C4 level were measured at the time of emergency department admission during the period between July 2011 and June 2014.This study comprised 66 patients with a median age of 54.0 (IQR: 37.5-68.3) years.
  • Three patients were newly diagnosed as having HAE, and 1 patient had already been diagnosed as having HAE.
  • C1-INH activity levels of the patients with HAE were below the detection limit (<25%), whereas those of non-HAE patients (n = 62) were 106% (IQR: 85.5%-127.0%) (normal range, 70%-130%).
  • The median level of C4 was significantly lower in the patients with HAE compared with those without HAE (1.2 [IQR: 1-3] mg/dL vs 22 [IQR: 16.5-29.5] mg/dL, P < 0.01) (normal range, 17-45 mg/dL).Three patients with undiagnosed HAE were diagnosed as having HAE in the emergency department during the 3-year period.
  • If patients have signs and symptoms suspicious of HAE, the levels of C1-INH activity and C4 should be measured.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Complement C1 Inhibitor Protein / analysis. Complement C4 / analysis. Female. Humans. Japan. Male. Middle Aged. Prospective Studies. Tertiary Care Centers

  • Genetic Alliance. consumer health - Hereditary angioedema.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 28178173.001).
  • [ISSN] 1536-5964
  • [Journal-full-title] Medicine
  • [ISO-abbreviation] Medicine (Baltimore)
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Observational Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Complement C1 Inhibitor Protein; 0 / Complement C4
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70. Robinson D, Humbert M, Buhl R, Cruz AA, Inoue H, Korom S, Hanania NA, Nair P: Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy; 2017 Feb;47(2):161-175
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  • : Asthma is a complex respiratory disorder characterized by marked heterogeneity in individual patient disease triggers and response to therapy.
  • Endotypes further describe the functional or pathophysiologic mechanisms underlying the patient's disease. type 2-driven asthma is an emerging nomenclature for a common subtype of asthma and is characterized by the release of signature cytokines IL-4, IL-5 and IL-13 from cells of both the innate and adaptive immune systems.
  • These type 2 cytokines are targets for pharmaceutical intervention, and a number of therapeutic options are under clinical investigation for the management of patients with uncontrolled severe asthma.
  • Anticipating and understanding the heterogeneity of asthma and subsequent improved characterization of different phenotypes and endotypes must guide the selection of treatment to meet individual patients' needs.

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  • [Copyright] © 2017 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd.
  • (PMID = 28036144.001).
  • [ISSN] 1365-2222
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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71. Goodship TH, Cook HT, Fakhouri F, Fervenza FC, Frémeaux-Bacchi V, Kavanagh D, Nester CM, Noris M, Pickering MC, Rodríguez de Córdoba S, Roumenina LT, Sethi S, Smith RJ, Conference Participants: Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference. Kidney Int; 2017 Mar;91(3):539-551
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  • In order to help guide clinicians who are caring for such patients, recommendations for best treatment strategies were discussed at length, providing the evidence base underpinning current treatment options.

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  • [Copyright] Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
  • (PMID = 27989322.001).
  • [ISSN] 1523-1755
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; C3 glomerulopathy / anti-complement therapies / atypical hemolytic uremic syndrome / complement / glomerulonephritis / kidney disease
  • [Investigator] Alpers CE; Appel GB; Ardissino G; Ariceta G; Arici M; Bagga A; Bajema IM; Blasco M; Burke L; Cairns TD; Carratala M; D'Agati VD; Daha MR; De Vriese AS; Dragon-Durey MA; Fogo AB; Galbusera M; Gale DP; Haller H; Johnson S; Józsi M; Karpman D; Lanning L; Le Quintrec M; Licht C; Loirat C; Monfort F; Morgan BP; Noël LH; O'Shaughnessy MM; Rabant M; Rondeau E; Ruggenenti P; Sheerin NS; Smith J; Spoleti F; Thurman JM; van de Kar NC; Vivarelli M; Zipfel PF
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72. Bonsang-Kitzis H, Mouttet-Boizat D, Guillot E, Feron JG, Fourchotte V, Alran S, Pierga JY, Cottu P, Lerebours F, Stevens D, Vincent-Salomon A, Sigal-Zafrani B, Campana F, Rouzier R, Reyal F: Medico-economic impact of MSKCC non-sentinel node prediction nomogram for ER-positive HER2-negative breast cancers. PLoS One; 2017;12(2):e0169962
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  • PURPOSE: The aim of this study is to simulate the medico-economic impact of the routine use of the MSKCC non-sentinel node (NSN) prediction nomogram for ER+ HER2- breast cancer patients.
  • METHODS: We studied 1036 ER+ HER2- breast cancer patients with a metastatic SNB.
  • For each patient, we calculated the probability of the NSN positivity using the MSKCC nomogram.
  • After validation of this nomogram in the population, we described how the patients' characteristics spread as the threshold value changed.
  • Then, we performed an economic simulation study to estimate the total cost of caring for patients treated according to the MSKCC predictive nomogram results.
  • RESULTS: A 0.3 threshold discriminate the type of sentinel node (SN) metastases: 98.8% of patients with pN0(i+) and 91.6% of patients with pN1(mic) had a MSKCC score under 0.3 (false negative rate = 6.4%).
  • If we use the 0.3 threshold for economic simulation, 43% of ALND could be avoided, reducing the costs of caring by 1 051 980 EUROS among the 1036 patients.
  • CONCLUSION: We demonstrated the cost-effectiveness of using the MSKCC NSN prediction nomogram by avoiding ALND for the pN0(i+) or pN1(mic) ER+ HER2- breast cancer patients with a MSKCC score of less than or equal to 0.3.

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  • (PMID = 28241044.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Biegstraaten M, Cox TM, Belmatoug N, Berger MG, Collin-Histed T, Vom Dahl S, Di Rocco M, Fraga C, Giona F, Giraldo P, Hasanhodzic M, Hughes DA, Iversen PO, Kiewiet AI, Lukina E, Machaczka M, Marinakis T, Mengel E, Pastores GM, Plöckinger U, Rosenbaum H, Serratrice C, Symeonidis A, Szer J, Timmerman J, Tylki-Szymańska A, Weisz Hubshman M, Zafeiriou DI, Zimran A, Hollak CE: Management goals for type 1 Gaucher disease: An expert consensus document from the European working group on Gaucher disease. Blood Cells Mol Dis; 2016 Oct 24;
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  • Therapy improves the principal manifestations of the condition and, as a consequence, many patients show a modified phenotype which reflects manifestations of their disease that are refractory to treatment.
  • More generally, it is increasingly recognised that information as to how a patient feels and functions [obtained by patient- reported outcome measurements (PROMs)] is critical to any comprehensive evaluation of treatment.
  • Based on a literature review and with input from patients, 65 potential goals were formulated as statements.
  • When applying this set of goals in medical practice, the clinical status of the individual patient should be taken into account.

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  • [Copyright] Copyright © 2016. Published by Elsevier Inc.
  • (PMID = 28274788.001).
  • [ISSN] 1096-0961
  • [Journal-full-title] Blood cells, molecules & diseases
  • [ISO-abbreviation] Blood Cells Mol. Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Delphi study / Gaucher disease / Management goals / PROMs / Therapy
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74. Ng WF, Miller A, Bowman SJ, Price EJ, Kitas GD, Pease C, Emery P, Lanyon P, Hunter J, Gupta M, Giles I, Isenberg D, McLaren J, Regan M, Cooper A, Young-Min SA, McHugh N, Vadivelu S, Moots RJ, Coady D, MacKay K, Dasgupta B, Sutcliffe N, Bombardieri M, Pitzalis C, Griffiths B, Mitchell S, Miyamoto ST, Trenell M, UK Primary Sjögren’s Syndrome Registry: Physical activity but not sedentary activity is reduced in primary Sjögren's syndrome. Rheumatol Int; 2017 Apr;37(4):623-631
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  • To this cross-sectional study, self-reported levels of physical activity from 273 PSS patients were measured using the International Physical Activity Questionnaire-short form (IPAQ-SF) and were compared with healthy controls matched for age, sex and body mass index.
  • Clinical care teams should explore the clinical utility of targeting low levels of physical activity in PSS.

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  • (PMID = 28013357.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; Fatigue / Patient registry / Patient-reported outcomes / Physical activity / Primary Sjögren’s syndrome
  • [Investigator] Hall F; Bacabac EC; Moots R; Chakravarty K; Lamabadusuriya S; Bombardieri M; Pitzalis C; Sutcliffe N; Gendi N; Adeniba R; Hamburger J; Richards A; Rauz S; Brailsford S; Logan J; Mulherin D; Andrews J; Emery P; McManus A; Pease C; Booth A; Regan M; Dimitroulas T; Kadiki L; Kaur D; Kitas G; Lloyd M; Moore L; Gordon E; Lawson C; Gupta M; Hunter J; Stirton L; Ortiz G; Price E; Clunie G; Rose G; Cuckow S; Knight S; Symmons D; Jones B; Al-Ali S; Carr A; Collins K; Corbett I; Downie C; Edgar S; Carrozzo M; Figuereido F; Foggo H; James K; Lendrem D; Macleod I; Mawson P; Mitchell S; Natasari A; Stocks P; Tarn J; Jones A; Lanyon P; Muir A; White P; Young-Min S; Pugmire S; Vadivelu S; Cooper A; Watkins M; Field A; Kaye S; Mewar D; Medcalf P; Tomlinson P; Whiteside D; McHugh N; Pauling J; James J; Olaitan N; Akil M; McDermott J; Godia O; Coady D; Kidd E; Palmer L; Dasgupta B; Katsande V; Long P; Li C; Chandra U; MacKay K; Fedele S; Ferenkeh-Koroma A; Giles I; Isenberg D; Maconnell H; Porter S; Allcoat P; McLaren J
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75. Beckmann S, Nikolic N, Denhaerynck K, Binet I, Koller M, Boely E, De Geest S, Psychosocial Interest Group, Swiss Transplant Cohort Study: Evolution of body weight parameters up to 3 years after solid organ transplantation: The prospective Swiss Transplant Cohort Study. Clin Transplant; 2016 Dec 23;
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  • After 3 years, based on their BMI categories at 6 months, normal weight and obese liver Tx patients, as well as underweight kidney, lung and heart Tx patients had the highest weight gains.
  • Judged against international Tx patient data, the majority of our Swiss Tx recipients' experienced lower post-Tx weight gain.

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  • [Copyright] © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
  • (PMID = 28008650.001).
  • [ISSN] 1399-0012
  • [Journal-full-title] Clinical transplantation
  • [ISO-abbreviation] Clin Transplant
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Keywords] NOTNLM ; body mass index / obesity / organ transplantation / prospective study / underweight / weight gain
  • [Investigator] Berben L; Burkhalter H; Claes V; Helmy R; Kirsch M; Leppla L; Mauthner O; Struker M; Boehler A; Gerull S; Huynh-Do U; Catana E; Simcox A; Seiler A; Klaghofer R; Künzler-Heule P; Achermann R; Amico P; Aubert JD; Banz V; Beldi G; Benden C; Berger C; Bochud PY; Bucher H; Bühler L; Carell T; Chalandon Y; de Rougemont O; Dickenmann M; Duchosal M; Elkrief L; Fehr T; Ferrari-Lacraz S; Garzoni C; Soccal PG; Gaudet C; Giostra E; Golshayan D; Hadaya K; Halter J; Heim D; Hess C; Hillinger S; Hirsch HH; Hofbauer G; Immer F; Laesser B; Lehmann R; Lovis C; Manuel O; Marti HP; Martin PY; Meylan P; Mohacsi P; Morel P; Mueller U; Mueller NJ; Mueller-McKenna H; Müller A; Müller T; Müllhaupt B; Nadal D; Pascual M; Passweg J; Rick J; Roosnek E; Rosselet A; Rothlin S; Ruschitzka F; Schanz U; Schaub S; Schnyder A; Seiler C; Stampf S; Steiger J; Stirnimann G; Toso C; Van Delden C; Venetz JP; Villard J; Wick M; Wilhelm M; Yerly P
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76. Goobie SM, Cladis FP, Glover CD, Huang H, Reddy SK, Fernandez AM, Zurakowski D, Stricker PA, the Pediatric Craniofacial Collaborative Group: Safety of antifibrinolytics in cranial vault reconstructive surgery: a report from the pediatric craniofacial collaborative group. Paediatr Anaesth; 2017 Mar;27(3):271-281
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  • No significant difference was detected in the incidence of postoperative seizures between patients receiving tranexamic acid and those receiving aminocaproic acid [the odds ratio for seizures being 0.34 (95% confidence interval: 0.07-1.85) controlling for American Society of Anesthesia (ASA) physical class] nor in patients receiving antifibrinolytics compared to those not administered antifibrinolytics (the odds ratio for seizures being 1.02 (confidence interval 0.29-3.63) controlling for ASA physical class).
  • One complicated patient in the antifibrinolytic group with a femoral venous catheter had a postoperative deep venous thrombosis.
  • There was no significant difference in postoperative seizures or seizure-like events in those patients who received the tranexamic acid or aminocaproic acid vs those that did not.
  • Caution should prevail however in using antifibrinolytic in high-risk patients.

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  • [Copyright] © 2017 John Wiley & Sons Ltd.
  • (PMID = 28211198.001).
  • [ISSN] 1460-9592
  • [Journal-full-title] Paediatric anaesthesia
  • [ISO-abbreviation] Paediatr Anaesth
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Keywords] NOTNLM ; aminocaproic acid / antifibrinolytics / craniofacial surgery / craniosynostosis / safety / tranexamic acid
  • [Investigator] Fiadjoe J; Soneru C; Falcon R; Petersen T; Kowalczyk-Derderian C; Dalesio N; Budac S; Groenewald N; Rubens D; Thompson D; Watts R; Gentry K; Ivanova I; Hetmaniuk M; Hsieh V; Collins M; Wong K; Binstock W; Reid R; Poteet-Schwartz K; Gries H; Hall R; Koh J; Colpitts K; Scott L; Bannister C; Sung W; Jain R; Chaudhry R; Tuite GF; Ruas E; Drozhinin O; Tetreault L; Muldowney B; Ricketts K; Fernandez P; Sohn L; Hajduk J; Taicher B; Burkhart J; Wright A; Kugler J; Barajas-DeLoa L; Gangadharan M; Busso V; Stallworth K; Staudt S; Labovsky K; Glover C; Karlberg-Hippard H; Capehart S; Streckfus C; Nguyen KP; Manyang P; Martinez JL; Hansen J; Mitzel H; Brzenski A; Chiao F; Ingelmo P; Mujallid R; Bosenberg A
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77. Tzoran I, Papadakis M, Brenner B, Fidalgo Á, Rivas A, Wells PS, Gavín O, Adarraga MD, Moustafa F, Monreal M, Registro Informatizado de Enfermedad TromboEmbólica Investigators: Outcome of Patients with Venous Thromboembolism and Factor V Leiden or Prothrombin 20210 Carrier Mutations During the Course of Anticoagulation. Am J Med; 2017 Apr;130(4):482.e1-482.e9
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  • [Title] Outcome of Patients with Venous Thromboembolism and Factor V Leiden or Prothrombin 20210 Carrier Mutations During the Course of Anticoagulation.
  • However, the influence of these polymorphisms on patient outcome during anticoagulant therapy has not been consistently explored.
  • METHODS: We used the Registro Informatizado de Enfermedad TromboEmbólica database to compare rates of venous thromboembolism recurrence and bleeding events occurring during the anticoagulation course in factor V Leiden carriers, prothrombin mutation carriers, and noncarriers.
  • RESULTS: Between March 2001 and December 2015, 10,139 patients underwent thrombophilia testing.
  • During the anticoagulation course, 160 patients developed recurrent deep vein thrombosis and 94 patients developed pulmonary embolism (16 died); 154 patients had major bleeding (10 died), and 291 patients had nonmajor bleeding.

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  • [Copyright] Copyright © 2017. Published by Elsevier Inc.
  • (PMID = 27986523.001).
  • [ISSN] 1555-7162
  • [Journal-full-title] The American journal of medicine
  • [ISO-abbreviation] Am. J. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Anticoagulant therapy / Bleeding / Thrombophilia / Venous thromboembolism
  • [Investigator] Decousus H; Prandoni P; Brenner B; Barba R; Di Micco P; Bertoletti L; Tzoran I; Reis A; Bosevski M; Bounameaux H; Malý R; Wells P; Papadakis M; Adarraga MD; Aibar MA; Alfonso M; Arcelus JI; Barba R; Barrón M; Barrón-Andrés B; Bascuñana J; Blanco-Molina A; Bueso T; Cañada G; Cañas I; Chic N; Del Pozo R; Del Toro J; Díaz-Pedroche MC; Díaz-Peromingo JA; Falgá C; Fernández-Capitán C; Fidalgo MA; Font C; Font L; Gallego P; García A; García MA; García-Bragado F; García-Brotons P; Gavín O; Gómez C; Gómez V; González J; González-Marcano D; Grau E; Grimón A; Guijarro R; Gutiérrez J; Hernández-Comes G; Hernández-Blasco L; Hermosa-Los Arcos MJ; Jara-Palomares L; Jaras MJ; Jiménez D; Joya MD; Llamas P; Lecumberri R; Lobo JL; López P; López-Jiménez L; López-Reyes R; López-Sáez JB; Lorente MA; Lorenzo A; Maestre A; Marchena PJ; Martín-Martos F; Monreal M; Nieto JA; Nieto S; Núñez A; Núñez MJ; Odriozola M; Otero R; Pedrajas JM; Pérez G; Pérez-Ductor C; Peris ML; Porras JA; Reig O; Riera-Mestre A; Riesco D; Rivas A; Rodríguez C; Rodríguez-Dávila MA; Rosa V; Ruiz-Giménez N; Sahuquillo JC; Sala-Sainz MC; Sampériz A; Sánchez-Martínez R; Sánchez Simón-Talero R; Sanz O; Soler S; Suriñach JM; Torres MI; Trujillo-Santos J; Uresandi F; Valero B; Valle R; Vela J; Vicente MP; Villalobos A; Vanassche T; Verhamme P; Wells P; Hirmerova J; Malý R; Tomko T; Del Pozo G; Salgado E; Sánchez GT; Bertoletti L; Bura-Riviere A; Mahé I; Merah A; Moustafa F; Papadakis M; Braester A; Brenner B; Tzoran I; Antonucci G; Barillari G; Bilora F; Bortoluzzi C; Cattabiani C; Ciammaichella M; Di Biase J; Di Micco P; Duce R; Ferrazzi P; Giorgi-Pierfranceschi M; Grandone E; Imbalzano E; Lodigiani C; Maida R; Mastroiacovo D; Pace F; Pesavento R; Pinelli M; Poggio R; Prandoni P; Rota L; Tiraferri E; Tonello D; Tufano A; Visonà A; Zalunardo B; Gibietis V; Skride A; Vitola B; Monteiro P; Ribeiro JL; Sousa MS; Bosevski M; Zdraveska M; Bounameaux H; Calanca L; Erdmann A; Mazzolai L
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78. Mintegi S, Azkunaga B, Prego J, Qureshi N, Dalziel SR, Arana-Arri E, Acedo Y, Martinez-Indart L, Urkaregi A, Salmon N, Benito J, Kuppermann N, Pediatric Emergency Research Networks (PERN) Poisoning Working Group: International Epidemiological Differences in Acute Poisonings in Pediatric Emergency Departments. Pediatr Emerg Care; 2017 01 24;
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  • No patient died.

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  • (PMID = 28121975.001).
  • [ISSN] 1535-1815
  • [Journal-full-title] Pediatric emergency care
  • [ISO-abbreviation] Pediatr Emerg Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Investigator] Kuppermann N; Benito J; Waisman Y; Osmond M; Johnson D; Chamberlain J; Macias CG; Kharbanda A; Babl FE; Dalziel S; Sutter M; Cohen D; Lloyd J; Duffy E; Mahajan P; Wang GS; Bradin SA; Ramirez J; Stephenson S; Carison A; Babl FE; Craig S; Graudins A; Cheek J; Dalziel SR; Bonish M; Van de Voorde P; Hachimi-Idrissi S; Petrovska A; Mercier JC; Morin L; Cheron G; Szabo E; Nagy R; Bognar Z; Simon G; Balla G; Juhász E; Martin C; Koshy R; Mc Namara R; Waisman Y; Amir L; Da Dalt L; Moretti C; Norbedo S; Salvatore R; Debbia C; Arrighini A; Botarelli P; Pisani M; Ponticiello E; Tipo E; Moll H; Bilhota X; Garrido A; Gata L; Mação P; Costa Lima S; Araújo e Sá G; Almeida S; Gafencu M; Babeu A; Moldovan D; Mitrofan DM; Humayor Yanez FJ; Andrés Andrés AG; del Campo Muñoz T; Mendivil R; Olomi IB; Fábrega i Sabaté J; Iturralde-Orive I; Roca A; Fernández R; Jorda-Lope A; Canduela V; Mesa S; García-Vao Bel C; Bar A; Herrero L; Campos Calleja C; Molina JC; Herrero MAG; Canduela C; Bello-Gutiérrez P; Velasco R; Martínez Sánchez L; Martínez Mengual L; Rodríguez Suárez J; Mintegi S; Salmon N; Muñoz-Bernal JA; López-Ávila J; Vázquez López P; May E; Cozar-Olmo J; López-Corominas V; Tallón-García M; Crespo-Rupérez E; Pérez Sáez A; Sancosmed Ron M; Velasco-Puyó P; Mesa J; Pociello N; Galán-Mercado M; Seiler M; Rey-Bellet Gasser C; Pittet A; Gervaix A; Manzano S; Ulas Saz E; Yurtseven A; Anil M; Oguz S; Tekin D; Kurt F; Ryan M; Hoyle A; Lyttle MD; Potter S; Babakhanlou R; Cagnasia S; Berzel H; Cargnel E; Gordillo E; Gait N; Méndez MM; Has AI; Quevedo MG; Parot Varela MM; Regnando M; Bonifacio Rino P; Torres-Cerino V; Tobares H; Bruno F; Godoy L; Pavlicich V; Casella W; Giachetto-Larraz GA; Ferreira MI; Pedemoti A; Antúnez E; Dall’Orso P; Más M; Torello P; Parodi V; Pandolfo S; Prego J; García-Gariglio L; Arreseigor E; Gugliemone H; Yemini L; Qureshi N; Fayyaz J
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79. Evangelidis N, Tong A, Manns B, Hemmelgarn B, Wheeler DC, Tugwell P, Crowe S, Harris T, Van Biesen W, Winkelmayer WC, Sautenet B, O'Donoghue D, Tam-Tham H, Youssouf S, Mandayam S, Ju A, Hawley C, Pollock C, Harris DC, Johnson DW, Rifkin DE, Tentori F, Agar J, Polkinghorne KR, Gallagher M, Kerr PG, McDonald SP, Howard K, Howell M, Craig JC, Standardized Outcomes in Nephrology–Hemodialysis (SONG-HD) Initiative: Developing a Set of Core Outcomes for Trials in Hemodialysis: An International Delphi Survey. Am J Kidney Dis; 2017 Feb 23;
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  • BACKGROUND: Survival and quality of life for patients on hemodialysis therapy remain poor despite substantial research efforts.
  • Existing trials often report surrogate outcomes that may not be relevant to patients and clinicians.
  • SETTING & PARTICIPANTS: 1,181 participants (202 [17%] patients/caregivers, 979 health professionals) from 73 countries completed round 1, with 838 (71%) completing round 3.
  • OUTCOMES & MEASUREMENTS: Outcomes included in the potential core outcome set met the following criteria for both patients/caregivers and health professionals: median score ≥ 8, mean score ≥ 7.5, proportion rating the outcome as critically important ≥ 75%, and median score in the forced ranking question < 10.
  • RESULTS: Patients/caregivers rated 4 outcomes higher than health professionals: ability to travel, dialysis-free time, dialysis adequacy, and washed out after dialysis (mean differences of 0.9, 0.5, 0.3, and 0.2, respectively).
  • CONCLUSIONS: Patients/caregivers gave higher priority to lifestyle-related outcomes than health professionals.

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  • [Copyright] Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 28238554.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Delphi survey / Hemodialysis (HD) / Standardized Outcomes in Nephrology-Hemodialysis (SONG-HD) / biochemical end point / cardiovascular disease (CVD) / core outcome set / dialysis adequacy / lifestyle-related outcomes / mortality / outcome domains / outcomes / patient-centered care / quality of life / research priorities / surrogate end points / trials / vascular access problems / well-being
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80. Chen TH, Yen AM, Fann JC, Gordon P, Chen SL, Chiu SY, Hsu CY, Chang KJ, Lee WC, Yeoh KG, Saito H, Promthet S, Hamashima C, Maidin A, Robinson F, Zhao LZ: Clarifying the debate on population-based screening for breast cancer with mammography: A systematic review of randomized controlled trials on mammography with Bayesian meta-analysis and causal model. Medicine (Baltimore); 2017 Jan;96(3):e5684
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Humans. Medical Overuse. Patient Acceptance of Health Care. Randomized Controlled Trials as Topic. Sensitivity and Specificity

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  • (PMID = 28099330.001).
  • [ISSN] 1536-5964
  • [Journal-full-title] Medicine
  • [ISO-abbreviation] Medicine (Baltimore)
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] United States
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81. Higginson IJ, Simon ST, Benalia H, Downing J, Daveson BA, Harding R, Bausewein C, PRISMA: Which questions of two commonly used multidimensional palliative care patient reported outcome measures are most useful? Results from the European and African PRISMA survey. BMJ Support Palliat Care; 2012 Mar;2(1):36-42
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  • [Title] Which questions of two commonly used multidimensional palliative care patient reported outcome measures are most useful? Results from the European and African PRISMA survey.
  • AIM: To evaluate the views of clinicians and researchers on their use of outcome measures and which questions are most important in palliative and end-of-life care.
  • METHODS: Online survey of professionals working in clinical care, clinical audit and research in palliative care across Europe and Africa identified through national and international associations and databases.
  • Questions focused on measures used, reasons and which questions were important in two commonly used multidimensional measures, the Palliative care Outcome Scale (POS) and the Support Team Assessment Schedule (STAS).
  • The main uses were similar: assessing patients' symptoms/needs (88% and 85% of POS and STAS users, respectively), monitoring changes (62%, 58%), evaluating care (61%, 48%) and assessing family needs (59%, 60%).
  • CONCLUSIONS: In palliative care, outcome measures often used in clinical practice are also often used in research.
  • Questions relating to pain, symptoms, emotional needs and family concerns are consistently considered the most useful and important in palliative patient reported outcome measures (PROMs).
  • [MeSH-major] Attitude of Health Personnel. Cross-Cultural Comparison. Outcome Assessment (Health Care). Palliative Care. Surveys and Questionnaires

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  • (PMID = 24653497.001).
  • [ISSN] 2045-4368
  • [Journal-full-title] BMJ supportive & palliative care
  • [ISO-abbreviation] BMJ Support Palliat Care
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Investigator] Albers G; Antunes B; Bennett E; Barros Pinto A; Bausewein C; Bechinger-English D; Benalia H; Bradley L; Ceulemans L; Daveson BA; Deliens L; Derycke N; de Vlieger M; Dillen L; Downing J; Echteld M; Evans N; Faksvåg Haugen D; Gikaara N; Gomes B; Gysels M; Hall S; Harding R; Higginson IJ; Kaasa S; Koffman J; Ferreira PL; Menten J; Monteiro Calanzani N; Murtagh F; Onwuteaka-Philipsen B; Pasman R; Pettenati F; Pool R; Powell T; Ribbe M; Sigurdardottir K; Simon S; Toscani F; van den Eynden B; van der Steen J; Vanden Berghe P; van Iersel T
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82. Opekun AR, Gotschall AB, Abdalla N, Agent C, Torres E, Sutton FM, Graham DY, Tsuchiya K: Improved infrared spectrophotometer for point-of-care patient 13C-urea breath testing in the primary care setting. Clin Biochem; 2005 Aug;38(8):731-4
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  • [Title] Improved infrared spectrophotometer for point-of-care patient 13C-urea breath testing in the primary care setting.
  • The 13C-urea breath test provides non-invasive testing for Helicobacter pylori infection with the possibility of analysis at the point of care.
  • Point of care tests require accurate and efficient desktop instrumentation.
  • [MeSH-major] Breath Tests / instrumentation. Point-of-Care Systems. Spectrophotometry, Infrared / instrumentation. Urea
  • [MeSH-minor] Adolescent. Adult. Aged. Carbon Isotopes. Female. Helicobacter Infections / diagnosis. Helicobacter pylori. Humans. Male. Middle Aged. Primary Health Care. Prospective Studies

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  • (PMID = 15963485.001).
  • [ISSN] 0009-9120
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK56338
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbon Isotopes; 8W8T17847W / Urea
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83. Koroloff N, Boots R, Lipman J, Thomas P, Rickard C, Coyer F: A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient. Intensive Care Med; 2004 Jun;30(6):1122-6
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  • [Title] A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient.
  • OBJECTIVE: To compare the efficacy of two forms of eye care (hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.
  • PATIENTS AND PARTICIPANTS: One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection.
  • INTERVENTIONS: All patients received standard eye cleansing every 2 h.
  • No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group.
  • CONCLUSIONS: Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
  • [MeSH-minor] Australia / epidemiology. Chlorobutanol / therapeutic use. Drug Combinations. Female. Humans. Hypromellose Derivatives. Intensive Care Units. Lanolin / therapeutic use. Male. Methylcellulose / analogs & derivatives. Methylcellulose / therapeutic use. Middle Aged. Mineral Oil / therapeutic use. Petrolatum / therapeutic use. Polyethylene. Statistics, Nonparametric

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  • [CommentIn] Intensive Care Med. 2005 Feb;31(2):313 [15565358.001]
  • (PMID = 15014864.001).
  • [ISSN] 0342-4642
  • [Journal-full-title] Intensive care medicine
  • [ISO-abbreviation] Intensive Care Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Ophthalmic Solutions; 3NXW29V3WO / Hypromellose Derivatives; 78200-24-5 / lacri-lube; 8006-54-0 / Lanolin; 8009-03-8 / Petrolatum; 8020-83-5 / Mineral Oil; 9002-88-4 / Polyethylene; 9004-67-5 / Methylcellulose; HM4YQM8WRC / Chlorobutanol
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84. Nusbaum MR, Frasier PY, Rojas F, Trotter K, Tudor G: Sexual orientation and sexual health care needs: a comparison of women beneficiaries in outpatient military health care settings. J Homosex; 2008;54(3):259-76
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  • [Title] Sexual orientation and sexual health care needs: a comparison of women beneficiaries in outpatient military health care settings.
  • A survey was mailed to women patients from two military outpatient settings, with 1,196 women responding.
  • Larger primary care patient-based studies of sexual health care needs of sexual minorities are needed.
  • [MeSH-major] Ambulatory Care. Health Services Needs and Demand. Heterosexuality. Homosexuality, Female. Hospitals, Military. Military Personnel
  • [MeSH-minor] Adult. Demography. Female. Humans. Middle Aged. Physician-Patient Relations. United States

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  • (PMID = 18825863.001).
  • [ISSN] 0091-8369
  • [Journal-full-title] Journal of homosexuality
  • [ISO-abbreviation] J Homosex
  • [Language] eng
  • [Grant] United States / PHS HHS / / 5-D12-HP00055
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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85. Vinicor F, Cohen SJ, Mazzuca SA, Moorman N, Wheeler M, Kuebler T, Swanson S, Ours P, Fineberg SE, Gordon EE, et al: DIABEDS: a randomized trial of the effects of physician and/or patient education on diabetes patient outcomes. J Chronic Dis; 1987;40(4):345-56
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  • [Title] DIABEDS: a randomized trial of the effects of physician and/or patient education on diabetes patient outcomes.
  • To examine the effects of intensive patient and/or physician diabetes education on patient health outcomes, a controlled trial was conducted in which internal medicine residents and their 532 diabetic patients were randomly assigned to: routine care; patient education; physician education; or both patient and physician education.
  • Patient outcome data were analyzed either by analysis of covariance on post intervention values (2-hour post-prandial plasma glucose [PPG]; body weight [BW]; blood pressure [BP]; or analysis of variance conducted on change values (fasting plasma glucose [FPG] and glycosylated hemoglobin [A1Hgb]).
  • After patient education, significant improvements were observed in FPG, A1Hgb, BW, and systolic and diastolic BP.
  • The combination of patient plus physician education resulted in the greatest improvements in patients' health outcomes including FPG, A1Hgb, PPG, BW and diastolic BP.
  • Thus, achieving optimal patient outcomes for a chronic disease like diabetes mellitus may require a greater or more effective use of resources than currently estimated.
  • [MeSH-major] Diabetes Mellitus. Internal Medicine / education. Internship and Residency. Patient Education as Topic
  • [MeSH-minor] Clinical Trials as Topic. Female. Humans. Male. Middle Aged. Outcome and Process Assessment (Health Care). Random Allocation

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  • (PMID = 3549757.001).
  • [ISSN] 0021-9681
  • [Journal-full-title] Journal of chronic diseases
  • [ISO-abbreviation] J Chronic Dis
  • [Language] eng
  • [Grant] United States / NIADDK NIH HHS / AM / P60 AM20542
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] ENGLAND
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86. Ramamurthy S, Bhatti P, Munir F, Ng T, Applegate K, Tridandapani S: A novel technology for automatically obtaining digital facial photographs near-simultaneously with portable radiographs. J Digit Imaging; 2015 Jun;28(3):259-63
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  • Our objective is to design, implement, and phantom-test a device to automatically obtain point-of-care patient photographs along with portable radiographs.
  • Such photographs could help with detection of wrong-patient errors.

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  • [Cites] Acad Radiol. 2005 Jan;12(1):97-103 [15691730.001]
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  • (PMID = 25447418.001).
  • [ISSN] 1618-727X
  • [Journal-full-title] Journal of digital imaging
  • [ISO-abbreviation] J Digit Imaging
  • [Language] ENG
  • [Grant] United States / NCATS NIH HHS / TR / KL TR000455; United States / NCATS NIH HHS / TR / KL2 TR000455; United States / NCATS NIH HHS / TR / UL1TR000454; United States / NCRR NIH HHS / RR / UL1RR025008; United States / NCRR NIH HHS / RR / KL2 RR025009; United States / NIBIB NIH HHS / EB / K23EB013221; United States / NCATS NIH HHS / TR / UL1 TR000454; United States / PHS HHS / / KL2 RF025009; United States / NCRR NIH HHS / RR / UL1 RR025008; United States / NIBIB NIH HHS / EB / K23 EB013221
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4441700
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87. Devine EB, Alfonso-Cristancho R, Devlin A, Edwards TC, Farrokhi ET, Kessler L, Lavallee DC, Patrick DL, Sullivan SD, Tarczy-Hornoch P, Yanez ND, Flum DR, CERTAIN Collaborative: A model for incorporating patient and stakeholder voices in a learning health care network: Washington State's Comparative Effectiveness Research Translation Network. J Clin Epidemiol; 2013 Aug;66(8 Suppl):S122-9
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  • [Title] A model for incorporating patient and stakeholder voices in a learning health care network: Washington State's Comparative Effectiveness Research Translation Network.
  • OBJECTIVE: To describe the inaugural comparative effectiveness research (CER) cohort study of Washington State's Comparative Effectiveness Research Translation Network (CERTAIN), which compares invasive with noninvasive treatments for peripheral artery disease, and to focus on the patient centeredness of this cohort study by describing it within the context of a newly published conceptual framework for patient-centered outcomes research (PCOR).
  • STUDY DESIGN AND SETTING: The peripheral artery disease study was selected because of clinician-identified uncertainty in treatment selection and differences in desired outcomes between patients and clinicians.
  • Patient centeredness is achieved through the "Patient Voices Project," a CERTAIN initiative through which patient-reported outcome (PRO) instruments are administered for research and clinical purposes, and a study-specific patient advisory group where patients are meaningfully engaged throughout the life cycle of the study.
  • RESULTS: Primary outcomes are PRO instruments that measure function, health-related quality of life, and symptoms, the latter developed with input from the patients.
  • Input from the patient advisory group led to revised retention procedures, which now focus on short-term (3-6 months) follow-up.
  • The research advisory panel is piloting a point-of-care, patient assessment checklist, thereby returning study results to practice.
  • CONCLUSION: The CERTAIN's inaugural cohort study may serve as a useful model for conducting PCOR and creating a learning health care network.

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  • [Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.
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  • (PMID = 23849146.001).
  • [ISSN] 1878-5921
  • [Journal-full-title] Journal of clinical epidemiology
  • [ISO-abbreviation] J Clin Epidemiol
  • [Language] ENG
  • [Grant] United States / NCATS NIH HHS / TR / UL1TR000423; United States / AHRQ HHS / HS / R01 HS020025; United States / AHRQ HHS / HS / 1 R01 HS 20025-01; United States / NCRR NIH HHS / RR / UL1 RR025014; United States / NCATS NIH HHS / TR / UL1 TR000423
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS540290; NLM/ PMC4097950
  • [Keywords] NOTNLM ; Comparative effectiveness research / Patient-centered outcomes research / Patient-reported outcomes / Peripheral artery disease / Research infrastructure / Stakeholders
  • [Investigator] Clowes A; Alexander F; Meissner M; Van Eaton E; Yetisgen-Yildiz YY; Armstrong C; Berman M; Boland R; Capurro D; Grant R; Hativa M; Johansen M; Johnson S; Klamp W; Lawrence S; Lloyd A; Machinchick E; Mallahan S; Nickel K; Osman R; Pagoaga C; Patel K; Salazar R; Gaston Symons R; Tepper M; Tran T; Yantsides C; Zadworny M; Farrokhi E
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88. Swain MA, Steckel SB: Influencing adherence among hypertensives. Res Nurs Health; 1981 Mar;4(1):213-22
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  • In a 3 x 4 repeated measures analysis of variance design, 115 patients were randomly selected and randomly assigned to one of three treatment modalities (routine clinic care, patient education, and contingency contracting) and were followed over four clinic visits.
  • Patient education was not effective in lowering blood pressures; it produced an untoward outcome, a dropout rate higher than that for patients receiving only routine clinic care.
  • However, contingency contracting was an effective intervention strategy for improving patient knowledge, F (1,59) = 51.32, p less than .0001; adherence to requests for regular medical care, Max L (2) = 25.9, p less than .0001; and decreasing diastolic blood pressures, F (2,49) = 3.39, p less than .05.
  • [MeSH-major] Hypertension / therapy. Patient Compliance
  • [MeSH-minor] Adult. Blood Pressure. Female. Follow-Up Studies. Humans. Male. Outpatient Clinics, Hospital / utilization. Patient Dropouts. Patient Education as Topic. Random Allocation

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  • (PMID = 6908098.001).
  • [ISSN] 0160-6891
  • [Journal-full-title] Research in nursing & health
  • [ISO-abbreviation] Res Nurs Health
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL 17045
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
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89. Davidson KW, Bigger JT, Burg MM, Carney RM, Chaplin WF, Czajkowski S, Dornelas E, Duer-Hefele J, Frasure-Smith N, Freedland KE, Haas DC, Jaffe AS, Ladapo JA, Lespérance F, Medina V, Newman JD, Osorio GA, Parsons F, Schwartz JE, Shaffer JA, Shapiro PA, Sheps DS, Vaccarino V, Whang W, Ye S: Centralized, stepped, patient preference-based treatment for patients with post-acute coronary syndrome depression: CODIACS vanguard randomized controlled trial. JAMA Intern Med; 2013 Jun 10;173(11):997-1004
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  • [Title] Centralized, stepped, patient preference-based treatment for patients with post-acute coronary syndrome depression: CODIACS vanguard randomized controlled trial.
  • OBJECTIVE: To determine the effects of providing post-ACS depression care on depressive symptoms and health care costs.
  • SETTING: Patients were recruited from 2 private and 5 academic ambulatory centers across the United States.
  • PARTICIPANTS: A total of 150 patients with elevated depressive symptoms (Beck Depression Inventory [BDI] score ≥10) 2 to 6 months after an ACS, recruited between March 18, 2010, and January 9, 2012.
  • INTERVENTIONS: Patients were randomized to 6 months of centralized depression care (patient preference for problem-solving treatment given via telephone or the Internet, pharmacotherapy, both, or neither), stepped every 6 to 8 weeks (active treatment group; n = 73), or to locally determined depression care after physician notification about the patient's depressive symptoms (usual care group; n = 77).
  • MAIN OUTCOME MEASURES: Change in depressive symptoms during 6 months and total health care costs.
  • RESULTS: Depressive symptoms decreased significantly more in the active treatment group than in the usual care group (differential change between groups, -3.5 BDI points; 95% CI, -6.1 to -0.7; P = .01).
  • Although mental health care estimated costs were higher for active treatment than for usual care, overall health care estimated costs were not significantly different (difference adjusting for confounding, -$325; 95% CI, -$2639 to $1989; P = .78).
  • CONCLUSIONS: For patients with post-ACS depression, active treatment had a substantial beneficial effect on depressive symptoms.
  • This kind of depression care is feasible, effective, and may be cost-neutral within 6 months; therefore, it should be tested in a large phase 3 pragmatic trial.
  • [MeSH-major] Depression / economics. Depression / therapy. Patient Preference

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  • (PMID = 23471421.001).
  • [ISSN] 2168-6114
  • [Journal-full-title] JAMA internal medicine
  • [ISO-abbreviation] JAMA Intern Med
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT01032018
  • [Grant] United States / NHLBI NIH HHS / HL / HL-088117; United States / NHLBI NIH HHS / HL / 5RC2HL101663; United States / NHLBI NIH HHS / HL / P01 HL088117; United States / NHLBI NIH HHS / HL / RC2 HL101663; United States / NHLBI NIH HHS / HL / K24 HL084034; United States / NHLBI NIH HHS / HL / R01 HL114924; United States / NCATS NIH HHS / TR / UL1TR000040; United States / NHLBI NIH HHS / HL / HL-84034; United States / NCATS NIH HHS / TR / UL1 TR000040
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS463638; NLM/ PMC3681929
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90. Sunaert P, Bastiaens H, Nobels F, Feyen L, Verbeke G, Vermeire E, De Maeseneer J, Willems S, De Sutter A: Effectiveness of the introduction of a Chronic Care Model-based program for type 2 diabetes in Belgium. BMC Health Serv Res; 2010 Jul 14;10:207
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  • [Title] Effectiveness of the introduction of a Chronic Care Model-based program for type 2 diabetes in Belgium.
  • BACKGROUND: During a four-year action research project (2003-2007), a program targeting all type 2 diabetes patients was implemented in a well-defined geographical region in Belgium.
  • The implementation of the program resulted in an increase of the overall Assessment of Chronic Illness Care (ACIC) score from 1.45 in 2003 to 5.5 in 2007.
  • The aim of the follow-up study in 2008 was to assess the effect of the implementation of Chronic Care Model (CCM) elements on the quality of diabetes care in a country where the efforts to adapt primary care to a more chronic care oriented system are still at a starting point.
  • METHODS: A quasi-experimental study design involving a control region with comparable geographical and socio-economic characteristics and health care facilities was used to evaluate the effect of the intervention in the region.
  • RESULTS: In total 4,174 type 2 diabetes patients were selected from the research database; 2,425 patients (52.9% women) with a mean age of 67.5 from the intervention region and 1,749 patients (55.7% women) with a mean age of 67.4 from the control region.
  • In 2006 only 26% of the patients had their urine tested for micro-albuminuria and only 36% had consulted an ophthalmologist.
  • CONCLUSION: Although the overall ACIC score increased from 1.45 to 5.5, the improvement in the quality of diabetes care was moderate.
  • Further improvements are needed in the CCM components delivery system design and clinical information systems.
  • But it is clear that, simultaneously, action is needed on the health system level to realize the installation of an accurate quality monitoring system and the necessary preconditions for chronic care delivery in primary care (patient registration, staff support, IT support).
  • [MeSH-minor] Aged. Belgium. Cohort Studies. Databases, Factual. Female. Follow-Up Studies. Humans. Male. Middle Aged. Quality Indicators, Health Care


91. Pileggi DJ, Fugit A, Romanelli F, Winstead PS, Lawson A, Deep KS, Cook AM: Pharmacy residents' preparedness for the emotional challenges of patient care. Am J Health Syst Pharm; 2015 Sep 1;72(17):1475-80
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  • [Title] Pharmacy residents' preparedness for the emotional challenges of patient care.
  • Both respondent groups provided perspectives on pharmacy residents' frequency of exposure to and preparedness for nine scenarios that could potentially be emotionally unsettling to pharmacy residents (e.g., a patient's death, participation in a response to a cardiorespiratory arrest).
  • Majorities of both RPDs and residents (85.2% and 67.1%, respectively) indicated that residents could be better prepared for the emotional challenges of patient care.
  • CONCLUSION: The majority of RPD and resident respondents indicated that residents could be better prepared for the emotional challenges of patient care.
  • [MeSH-major] Emotions. Patient Care / psychology. Pharmaceutical Services / organization & administration. Pharmacy Residencies / organization & administration

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  • [Copyright] Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.
  • (PMID = 26294241.001).
  • [ISSN] 1535-2900
  • [Journal-full-title] American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • [ISO-abbreviation] Am J Health Syst Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Abernethy AP, Zafar SY, Uronis H, Wheeler JL, Coan A, Rowe K, Shelby RA, Fowler R, Herndon JE 2nd: Validation of the Patient Care Monitor (Version 2.0): a review of system assessment instrument for cancer patients. J Pain Symptom Manage; 2010 Oct;40(4):545-58
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  • [Title] Validation of the Patient Care Monitor (Version 2.0): a review of system assessment instrument for cancer patients.
  • CONTEXT: The Patient Care Monitor (PCM) is a review of systems survey delivered by means of an electronic patient-reported outcomes (ePRO) data capture system that uses wireless tablet computers.
  • METHODS: Two hundred seventy-five individuals participated in three clinical trials enrolling breast (n=65), gastrointestinal (n=113), and lung (n=97) cancer patients.
  • Prior reports demonstrate patient satisfaction with PCM 2.0.
  • CONCLUSION: Within three unique academic oncology populations, PCM 2.0 is a valid ePRO instrument for assessing symptoms with seven patient-centered subscale or index domains.
  • [MeSH-minor] Aged. Data Collection / instrumentation. Data Collection / methods. Fatigue / complications. Fatigue / diagnosis. Fatigue / physiopathology. Fatigue / psychology. Female. Humans. Male. Middle Aged. Patient Satisfaction. Quality of Life / psychology. Regression Analysis

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  • [Copyright] Copyright © 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20579839.001).
  • [ISSN] 1873-6513
  • [Journal-full-title] Journal of pain and symptom management
  • [ISO-abbreviation] J Pain Symptom Manage
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Validation Studies
  • [Publication-country] United States
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93. Kuzma AM, Meli Y, Meldrum C, Jellen P, Butler-Lebair M, Koczen-Doyle D, Rising P, Stavrolakes K, Brogan F: Multidisciplinary care of the patient with chronic obstructive pulmonary disease. Proc Am Thorac Soc; 2008 May 1;5(4):567-71
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  • [Title] Multidisciplinary care of the patient with chronic obstructive pulmonary disease.
  • The National Emphysema Treatment Trial used a multidisciplinary team approach to implement the maximum medical care protocol, including adjustment of medications and outpatient pulmonary rehabilitation for all patients and nutritional and psychological counseling as needed.
  • This article discusses the benefits of such an approach in the care of the patient with chronic obstructive pulmonary disease.
  • Team member roles complement each other and contribute to the goal of providing the highest-quality medical care.
  • The primary focus of the team is to reinforce the medical plan and to provide patient education and support.
  • This article reviews the elements of the initial patient assessment and the functional and nutritional assessment.
  • Patient education focuses on medication use, recognition and management of chronic obstructive pulmonary disease exacerbation symptoms, smoking cessation, advance directives, and travel.

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  • (PMID = 18453373.001).
  • [ISSN] 1546-3222
  • [Journal-full-title] Proceedings of the American Thoracic Society
  • [ISO-abbreviation] Proc Am Thorac Soc
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HR / N01HR76113; United States / NHLBI NIH HHS / HR / N01HR76107; United States / NHLBI NIH HHS / HR / N01HR76102; United States / NHLBI NIH HHS / HR / N01HR76104; United States / NHLBI NIH HHS / HR / N01HR76118; United States / NHLBI NIH HHS / HR / N01HR76115; United States / NHLBI NIH HHS / HR / N01HR76105; United States / NHLBI NIH HHS / HR / N01HR76111; United States / NHLBI NIH HHS / HR / N01HR76114; United States / NHLBI NIH HHS / HR / N01HR76103; United States / NHLBI NIH HHS / HR / N01HR76110; United States / NHLBI NIH HHS / HR / N01HR76119; United States / NHLBI NIH HHS / HR / N01HR76108; United States / NHLBI NIH HHS / HR / N01HR76106; United States / NHLBI NIH HHS / HR / N01HR76109; United States / NHLBI NIH HHS / HR / N01HR76116; United States / NHLBI NIH HHS / HR / N01HR76112; United States / NHLBI NIH HHS / HR / N01HR76101
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Number-of-references] 39
  • [Other-IDs] NLM/ PMC2645337
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94. Buysse DJ, Barzansky B, Dinges D, Hogan E, Hunt CE, Owens J, Rosekind M, Rosen R, Simon F, Veasey S, Wiest F: Sleep, fatigue, and medical training: setting an agenda for optimal learning and patient care. Sleep; 2003 Mar 15;26(2):218-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sleep, fatigue, and medical training: setting an agenda for optimal learning and patient care.
  • The difficult issues surrounding discussions of sleep, fatigue, and medical education stem from an ironic biologic truth: physicians share a common physiology with their patients, a physiology that includes an absolute need for sleep and endogenous circadian rhythms governing alertness and performance.
  • We cannot ignore the fact that patients become ill and require medical care at all times of the day and night, but we also cannot escape the fact that providing such care requires that medical professionals, including medical trainees, be awake and functioning at times that are in conflict with their endogenous sleep and circadian physiology.
  • Empiric research addressing the effects of sleep loss on patient safety, education outcomes, and resident health is urgently needed: equally important are the development and assessment of innovative countermeasures to maximize performance and learning.
  • By working together to address the problems of sleep and fatigue in its own trainees, the medical field can provide a valuable legacy to patients and to future generations of healthcare providers--a legacy or optimal medical education, healthy doctors, and healthy patients.
  • [MeSH-major] Education, Medical. Fatigue / complications. Learning. Patient Care. Sleep Wake Disorders / etiology. Teaching / methods

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  • (PMID = 12683483.001).
  • [ISSN] 0161-8105
  • [Journal-full-title] Sleep
  • [ISO-abbreviation] Sleep
  • [Language] eng
  • [Publication-type] Congresses; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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95. Amouretti M, Czernichow P, Kerjean A, Hochain P, Nousbaum JB, Rudelli A, Zerbib F, Dupas JL, Gouérou H, Herman H, Colin R: [Management of upper digestive hemorrhage occurring in the community: patterns of patient care in 4 French administrative areas]. Gastroenterol Clin Biol; 2000 Nov;24(11):1003-11
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  • [Title] [Management of upper digestive hemorrhage occurring in the community: patterns of patient care in 4 French administrative areas].
  • [Transliterated title] Prise en charge des hémorragies digestives hautes communautaires. Trajectoires des malades dans 4 départements français.
  • AIMS: To describe patterns of health care management in patients with upper gastrointestinal hemorrhage and to identify factors linked to the different patterns.
  • PATIENTS AND METHODS: We conducted a prospective study of patients over 18 with upper gastrointestinal hemorrhage (inpatients excluded) among all public hospitals and private practice gastroenterologists in 4 French administrative areas (3 in Northern France and one in the South West).
  • RESULTS: One thousand six hundred and two patients were included over a six-month period (1996).
  • An endoscopic procedure was performed in 1532 patients in public (70%) or private (20.5%) hospitals, or at private office (9.5%).
  • Hospitalization was necessary in 78.8% of the patients in university, non university public or private hospitals (38.9, 45.5 and 15.6%, respectively) with a median duration of 6.5 days.
  • Endoscopic hemostasis was performed in 21.4% of the patients, more often in university and no university public hospitals.
  • Surgery was necessary in 4% of the patients.
  • Patients' characteristics did not differ between the 4 areas.
  • On the other hand, health care supply provided in the management of upper gastrointestinal hemorrhage was different in the four French geographical areas.
  • CONCLUSION: a) An initial endoscopic procedure is nearly always performed in patients with an upper gastrointestinal hemorrhage in France; in 1 patient out of 10, endoscopy was performed in a private gastroenterologist office;.
  • c) the geographical variations observed in referral patterns depend in part on health care supply;.
  • d) upper gastrointestinal haemorrhage status could be used as an indicator of the quality of health care organizations.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Blood Transfusion. Data Collection. Data Interpretation, Statistical. Delivery of Health Care. Endoscopy, Digestive System. France. Health Services Accessibility. Humans. Length of Stay. Middle Aged. Patient Care. Prospective Studies. Quality of Health Care. Time Factors

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  • (PMID = 11139667.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] FRANCE
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96. Hadji P, Klein S, Häussler B, Kless T, Linder R, Rowinski-Jablokow M, Verheyen F, Gothe H: The bone evaluation study (BEST): patient care and persistence to treatment of osteoporosis in Germany. Int J Clin Pharmacol Ther; 2013 Nov;51(11):868-72
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  • [Title] The bone evaluation study (BEST): patient care and persistence to treatment of osteoporosis in Germany.
  • OBJECTIVE: Data on fracture frequency and medical care of patients with osteoporosis are still insufficient.
  • We assessed fractures, frequencies, and the number of multiple fractures per patient as well as time to follow-up fracture and drug persistence using Kaplan-Meier analysis.
  • RESULTS: Within the observation period, 27% of the osteoporosis patients sustained fractures; of those with fractures, 69% had multiple fractures.
  • For patients with multiple fractures, re-fracture rate after 360 days was between 69% for patients who received parathyroid hormone and 85% for patients who received no anti-osteoporotic medication 360 days before follow-up fracture.
  • In the patient population, persistence rates after 1 year were between 58% for parathyroid hormone and 2% for other osteoporosis-specific drugs (alfacalcidol, fluorides, nandrolone, calcitonin).
  • CONCLUSIONS: In Germany, the number of patients with osteoporosis-attributable fractures is high.
  • Low persistence lead to a relatively high proportion of patients with follow-up fractures.
  • [MeSH-minor] Aged. Female. Germany / epidemiology. Humans. Male. Medication Adherence. Middle Aged. Patient Care. Retrospective Studies

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  • (PMID = 24040854.001).
  • [ISSN] 0946-1965
  • [Journal-full-title] International journal of clinical pharmacology and therapeutics
  • [ISO-abbreviation] Int J Clin Pharmacol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents
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97. Kohi MP, Fidelman N, Behr S, Taylor AG, Kolli K, Conrad M, Hwang G, Weinstein S: Periprocedural Patient Care. Radiographics; 2015 Oct;35(6):1766-78
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Periprocedural Patient Care.
  • Periprocedural care of patients who undergo image-guided interventions is a task of monumental importance.
  • As physicians who perform procedures, radiologists rely on their noninterpretive skills to optimize patient care.
  • At the center of periprocedural care is proper patient identification.
  • It is imperative to perform the indicated procedure for the correct patient.
  • It is also of great importance to discuss with the patient the nature of the procedure.
  • Once the patient agrees to the procedure and grants informed consent, it is imperative to stop and confirm that the correct procedure is being performed on the correct patient.
  • This universal time-out policy helps decrease errors and improves patient care.
  • To optimize our interpretative and procedural skills, it may be necessary to provide the patient with sedation or anesthesia.
  • However, it is important to understand the continuum of sedation and be able to appropriately monitor the patient and manage the sedation in these patients.
  • To minimize the risks of infection, periprocedural care of patients relies on aseptic or, at times, sterile techniques.
  • Before the procedure, it is important to evaluate the patient's coagulation parameters and bleeding risks and correct the coagulopathy, if needed.
  • During the procedure, the patient's blood pressure and at times the patient's glucose levels will also require monitoring and management.
  • After the procedure, patients must be observed in a recovery unit and deemed safe for discharge.
  • The fundamental components of periprocedural care necessary to enhance patient safety, satisfaction, and care are reviewed to familiarize the reader with the important noninterpretive skills necessary to optimize periprocedural care.
  • [MeSH-major] Patient Care. Radiography, Interventional / methods. Radiology / methods
  • [MeSH-minor] Anesthesia / adverse effects. Anesthesia / methods. Blood Glucose / analysis. Clinical Competence. Conscious Sedation / adverse effects. Conscious Sedation / methods. Humans. Infection Control / methods. Infection Control / standards. Informed Consent. Monitoring, Physiologic. Patient Education as Topic. Patient Identification Systems / standards. Patient Safety. Radiology Department, Hospital / organization & administration. Safety Management. Time Out, Healthcare

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  • [Copyright] © RSNA, 2015.
  • (PMID = 26466184.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose
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98. De Georgia MA, Kaffashi F, Jacono FJ, Loparo KA: Information technology in critical care: review of monitoring and data acquisition systems for patient care and research. ScientificWorldJournal; 2015;2015:727694
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Information technology in critical care: review of monitoring and data acquisition systems for patient care and research.
  • There is a broad consensus that 21st century health care will require intensive use of information technology to acquire and analyze data and then manage and disseminate information extracted from the data.
  • No area is more data intensive than the intensive care unit.
  • While there have been major improvements in intensive care monitoring, the medical industry, for the most part, has not incorporated many of the advances in computer science, biomedical engineering, signal processing, and mathematics that many other industries have embraced.
  • Acquiring, synchronizing, integrating, and analyzing patient data remain frustratingly difficult because of incompatibilities among monitoring equipment, proprietary limitations from industry, and the absence of standard data formatting.
  • In this paper, we will review the history of computers in the intensive care unit along with commonly used monitoring and data acquisition systems, both those commercially available and those being developed for research purposes.

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  • (PMID = 25734185.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] ENG
  • [Grant] United States / BLRD VA / BX / I01 BX000873
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4334936
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99. Wood M, Mayo F, Marsland D: A systems approach to patient care, curriculum, and research in family practice. J Med Educ; 1975 Dec;50(12 Pt1):1106-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A systems approach to patient care, curriculum, and research in family practice.
  • The system of data recording and retrieval which defines a family practice population of patients is described.
  • Depending on resources available, it is possible to record demographic and morbidity data from the patient populations of both teaching and nonteaching practices.
  • Data have been collected from a patient population of 88,000 in 26 practicing sites in Virginia, totaling 380,000 diagnostic and follow-up visits.
  • The costs of this recording process in nonteaching practices, the use of such data as an educational resource for the training of primary care physicians, and the evaluations of health care delivered are discussed.
  • [MeSH-major] Curriculum. Family Practice / education. Patient Care Planning. Systems Analysis
  • [MeSH-minor] Delivery of Health Care. Internship and Residency. Primary Health Care. Research Design. Virginia

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  • (PMID = 1195325.001).
  • [ISSN] 0022-2577
  • [Journal-full-title] Journal of medical education
  • [ISO-abbreviation] J Med Educ
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
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100. McMorrow ML, Masanja MI, Kahigwa E, Abdulla SM, Kachur SP: Quality assurance of rapid diagnostic tests for malaria in routine patient care in rural Tanzania. Am J Trop Med Hyg; 2010 Jan;82(1):151-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quality assurance of rapid diagnostic tests for malaria in routine patient care in rural Tanzania.
  • For quality assurance (QA), thick blood smears for reference microscopy were collected for 2 to 3 days per week from patients receiving RDTs; microscopy was not routinely performed at the health facilities.
  • Ten thousand six hundred fifty (10,650) patients were tested with RDTs, and 51.5% (5,488/10,650) had a positive test result.
  • Blood smear results were available for 3,914 patients, of whom 40.1% (1,577/3,914) were positive for P. falciparum malaria.
  • [MeSH-major] Antimalarials / therapeutic use. Malaria / diagnosis. Malaria / drug therapy. Quality Assurance, Health Care. Rural Population

  • Genetic Alliance. consumer health - Malaria.
  • MedlinePlus Health Information. consumer health - Malaria.
  • MedlinePlus Health Information. consumer health - Rural Health Concerns.
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  • (PMID = 20065013.001).
  • [ISSN] 1476-1645
  • [Journal-full-title] The American journal of tropical medicine and hygiene
  • [ISO-abbreviation] Am. J. Trop. Med. Hyg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimalarials
  • [Other-IDs] NLM/ PMC2803527
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