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1. |||||..... 50%  Ballatori N: Pleiotropic functions of the organic solute transporter Ostα-Ostβ. Dig Dis; 2011;29(1):13-7
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  • [Title] Pleiotropic functions of the organic solute transporter Ostα-Ostβ.
  • The heteromeric organic solute transporter alpha-beta (Ostα-Ostβ) is expressed at relatively high levels on the basolateral membrane of enterocytes, where it plays a critical role in the intestinal absorption of bile acids and the enterohepatic circulation.
  • Bile acids activate nuclear receptors such as the farnesoid X receptor (FXR/NR1H4), the pregnane X receptor and the vitamin D receptor, are ligands for a G-protein-coupled bile acid receptor (GPBAR1/TGR5), and can also activate protein kinases A and C as well as mitogen-activated protein kinase pathways.
  • Note that although FXR and TGR5 are thought to function primarily as bile acid receptors, they are modulated by some other sterols and select lipid metabolites, and are also widely expressed in tissues, indicating a complex interplay among diverse regulatory networks that impact critical cell and organ functions.
  • [MeSH-minor] Animals. Bile Acids and Salts / metabolism. Humans. Organ Specificity. Receptors, Cytoplasmic and Nuclear / metabolism. Sterols / metabolism

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
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  • (PMID = 21691099.001).
  • [ISSN] 1421-9875
  • [Journal-full-title] Digestive diseases (Basel, Switzerland)
  • [ISO-abbreviation] Dig Dis
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK067214; United States / NIEHS NIH HHS / ES / ES01247; United States / NIEHS NIH HHS / ES / ES07026
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Membrane Transport Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Sterols
  • [Other-IDs] NLM/ PMC3128137
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2. ||||...... 45%  Poole JA, Romberger DJ: Immunological and inflammatory responses to organic dust in agriculture. Curr Opin Allergy Clin Immunol; 2012 Apr;12(2):126-32
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  • [Title] Immunological and inflammatory responses to organic dust in agriculture.
  • PURPOSE OF REVIEW: Agriculture represents a major industry worldwide, and despite protection against the development of IgE-mediated diseases, chronic exposure to agriculture-related organic dusts is associated with an increased risk of developing respiratory disease.
  • This article will review the literature regarding new knowledge of important etiologic agents in the dusts and focus on the immunologic responses following acute and repetitive organic dust exposures.
  • Pattern recognition receptors including Toll-like receptor 4 (TLR4), TLR2 and intracellular nucleotide oligomerization domain-like receptors are partially responsible for mediating the inflammatory consequences.
  • Repeated organic dust exposures modulate innate and adaptive immune function with a resultant adaptation-like response.
  • SUMMARY: The immunological consequences of organic dust exposure in the farming industry are likely explained by the diversity of microbial motifs in dust that can elicit differing innate immune receptor signaling pathways.
  • [MeSH-minor] Animals. Chronic Disease. Endotoxins / immunology. Female. General Adaptation Syndrome / immunology. Humans. Immunoglobulin E / immunology. Male. Mice. Occupational Exposure / adverse effects. Receptors, Pattern Recognition / immunology

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  • (PMID = 22306554.001).
  • [ISSN] 1473-6322
  • [Journal-full-title] Current opinion in allergy and clinical immunology
  • [ISO-abbreviation] Curr Opin Allergy Clin Immunol
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1 U54 OH010162-01; United States / NIEHS NIH HHS / ES / ES015522-03S1; United States / NIEHS NIH HHS / ES / K08 ES015522-01; United States / NIEHS NIH HHS / ES / K08 ES015522-05; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NIEHS NIH HHS / ES / R01 ES019325-02; United States / NIEHS NIH HHS / ES / R01 ES019325-03; United States / NIOSH CDC HHS / OH / R01 OH008539-01
  • [Publication-type] Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dust; 0 / Endotoxins; 0 / Receptors, Pattern Recognition; 37341-29-0 / Immunoglobulin E
  • [Other-IDs] NLM/ NIHMS355362; NLM/ PMC3292674
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3. ||||...... 44%  Takayama H: [Creation of functional organic compounds and their applications]. Yakugaku Zasshi; 2002 Feb;122(2):127-55
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  • [Title] [Creation of functional organic compounds and their applications].
  • Our studies on creation of functional organic compounds and their applications, have focused on three areas, namely, (A) organic chemical studies on VD (vitamin D) analogues, (B) studies on solitary wasp venoms, and (C) studies on functional building blocks for organic synthesis.
  • In the first area, several novel and important vitamin D analogues were synthesized and biologically evaluated, and their high VDR (vitamin D receptor) binding affinities were discussed on the basis of conformational analysis and docking study by Molecular Mechanics Calculation to the LBD (ligand binding domain) of VDR: These compounds include 24,24-difluoro-1 alpha,25-dihydroxy-VD3 (2) (an antimetabolism agent, the first VD analogue having higher potency than the natural hormone (1)), 2 alpha-methyl-1 alpha,25-dihydroxy-VD3 (42b) (the first A-ring-modified VD analogue exhibiting stronger VDR affinity than 1) and its 20-epimer (43b) (a VD analogue having a highest HL-60 cell differentiation inducing activity with a relatively low calcemic effect), and 2 alpha-(omega-hydroxypropyl)-1 alpha,25-dihydroxy-VD3 (exceptionally high calcemic effect).
  • [MeSH-minor] Animals. Chemistry, Organic. Organic Chemistry Phenomena. Receptors, Calcitriol / metabolism. Structure-Activity Relationship

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  • [ErratumIn] Yakugaku Zasshi. 2003 Jun;123(6):475-6
  • (PMID = 11857955.001).
  • [ISSN] 0031-6903
  • [Journal-full-title] Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • [ISO-abbreviation] Yakugaku Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bicyclo Compounds, Heterocyclic; 0 / Cyclic S-Oxides; 0 / Neurotoxins; 0 / Receptors, Calcitriol; 0 / Wasp Venoms; 1406-16-2 / Vitamin D
  • [Number-of-references] 63
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View summary of articles of this page
7. The present findings that organic and inorganic mercury compounds were deposited in the olfactory system along its whole length, from the receptor cell apices to the brain, support the electrophysiological results presented elsewhere (Baatrup et al., 1990, Ecotoxicol. Environ.

24. Acting by different cell-receptor mechanisms, but nonetheless potent, nonadrenergic stimulators of adenylate cyclase in the ciliary epithelium, such as cholera toxin and organic fluorides, have been studied in experimental animals.

99. The Vgamma9Vdelta2 T cell subset, which represents up to 90% of the circulating gammadelta T cells in humans, was shown to be activated, via the T cell receptor (TcR), by non-peptidic phosphorylated small organic molecules.


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4. ||||...... 41%  Katow H, Yaguchi S, Kyozuka K: Serotonin stimulates [Ca2+]i elevation in ciliary ectodermal cells of echinoplutei through a serotonin receptor cell network in the blastocoel. J Exp Biol; 2007 Feb;210(Pt 3):403-12
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  • [Title] Serotonin stimulates [Ca2+]i elevation in ciliary ectodermal cells of echinoplutei through a serotonin receptor cell network in the blastocoel.
  • A full-length serotonin receptor mRNA from the 5Hthpr gene was sequenced from larvae of the sea urchin, Hemicentrotus pulcherrimus.
  • Immunohistochemistry with anti-5HThpr antibodies indicated that the protein was expressed on blastocoelar cells that comprised the major blastocoelar network (serotonin receptor cell network).
  • The calcium transient propagated as a wave at about 175 microm s(-1), but was not detectable in the serotonin receptor-positive cell network.
  • In larvae treated with p-chlorophenylalanine, a potent and irreversible serotonin synthesis inhibitor, serotonin application did not stimulate [Ca(2+)](i), the serotonin receptor cell network did not develop properly, and the swimming behavior of the larvae was abnormal.
  • These results imply that serotonin secreted from the apical ganglion into the blastocoel stimulates the elevation of [Ca(2+)](i) in the larval ectodermal cells through the serotonin receptor cell network.
  • [MeSH-major] Calcium / metabolism. Ectoderm / drug effects. Receptors, Serotonin / metabolism. Sea Urchins / metabolism. Serotonin / pharmacology
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Cilia / metabolism. Embryo, Nonmammalian / cytology. Embryo, Nonmammalian / drug effects. Embryo, Nonmammalian / metabolism. Fenclonine / pharmacology. Larva / drug effects. Larva / genetics. Larva / metabolism. Molecular Sequence Data. Neurites / drug effects. Neurites / metabolism. Organic Chemicals / analysis. Protein Structure, Tertiary. RNA, Messenger / chemistry. RNA, Messenger / metabolism. Sequence Analysis, DNA. Sequence Analysis, Protein. Serotonin Antagonists / pharmacology. Swimming / physiology

  • HSDB. structure - Fenclonine.
  • HSDB. structure - CALCIUM, ELEMENTAL.
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  • (PMID = 17234609.001).
  • [ISSN] 0022-0949
  • [Journal-full-title] The Journal of experimental biology
  • [ISO-abbreviation] J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oregon Green BAPTA-dextran; 0 / Organic Chemicals; 0 / RNA, Messenger; 0 / Receptors, Serotonin; 0 / Serotonin Antagonists; 333DO1RDJY / Serotonin; R5J7E3L9SP / Fenclonine; SY7Q814VUP / Calcium
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5. ||||...... 37%  Murata Y, Kataoka-Shirasugi N, Amakawa T: Electrophysiological studies of salty taste modification by organic acids in the labellar taste cell of the blowfly. Chem Senses; 2002 Jan;27(1):57-65
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  • [Title] Electrophysiological studies of salty taste modification by organic acids in the labellar taste cell of the blowfly.
  • Using the labellar salt receptor cells of the blowfly, Phormia regina, we electrophysiologically showed that the response to NaCl and KCl aqueous solutions was enhanced and depressed by acetic, succinic and citric acids.
  • The organic acid concentrations at which the most enhanced salt response (MESR) was obtained were found to be different: 0.05-1 mM citric acid, 0.5-2 mM succinic acid and 5-50 mM acetic acid.
  • Another explanation for the enhancement is that the salty taste may also be enhanced by undissociated molecules of the organic acids, because the MESRs were obtained at the pH values lower than the pKa(1) or pKa(2) values of these organic acids.
  • On the other hand, the salty taste could be depressed by both the lower pH range (pH 2.5-2.0) and the dissociated organic anions from organic acid molecules with at least two carboxyl groups.

  • HSDB. structure - POTASSIUM CHLORIDE.
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  • (PMID = 11751469.001).
  • [ISSN] 0379-864X
  • [Journal-full-title] Chemical senses
  • [ISO-abbreviation] Chem. Senses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carboxylic Acids; 660YQ98I10 / Potassium Chloride; 7647-14-5 / Sodium Chloride
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6. ||||...... 37%  Pophof B, Stange G, Abrell L: Volatile organic compounds as signals in a plant-herbivore system: electrophysiological responses in olfactory sensilla of the moth Cactoblastis cactorum. Chem Senses; 2005 Jan;30(1):51-68
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  • [Title] Volatile organic compounds as signals in a plant-herbivore system: electrophysiological responses in olfactory sensilla of the moth Cactoblastis cactorum.
  • The male sensilla trichodea house a receptor cell responding to the putative pheromone component (9Z,12E)-tetradecadienyl acetate.
  • The sensilla trichodea of the females were much shorter than those of the males and contained specialized receptor cells responding to certain terpenoids, the most frequent being the nerolidol-sensitive cell.
  • Eight volatile organic compounds emitted by Opuntia stricta, a host plant of C. cactorum, were identified using gas chromatography-mass spectrometry, beta-caryophyllene being the major compound.
  • Five compounds identified by gas chromatography in the headspace of O. stricta elicited responses in olfactory receptor cells of C. cactorum, nonanal being the most active compound and therefore a candidate attractant of C. cactorum.
  • [MeSH-major] Moths / physiology. Organic Chemicals / analysis. Pheromones / analysis. Pheromones / physiology. Plant Oils / analysis. Receptors, Odorant / metabolism. Sense Organs / physiology

  • HSDB. structure - VEGETABLE OIL.
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  • [ErratumIn] Chem Senses. 2005 Mar;30(3):279
  • (PMID = 15647464.001).
  • [ISSN] 0379-864X
  • [Journal-full-title] Chemical senses
  • [ISO-abbreviation] Chem. Senses
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / Pheromones; 0 / Plant Oils; 0 / Receptors, Odorant
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7. |||||||||. 102%  Baatrup E, Døving KB: Histochemical demonstration of mercury in the olfactory system of salmon (Salmo salar L.) following treatments with dietary methylmercuric chloride and dissolved mercuric chloride. Ecotoxicol Environ Saf; 1990 Dec;20(3):277-89
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  • The deposition of organic and inorganic mercury compounds was studied histochemically in the salmon (Salmo salar L.) olfactory system.
  • The silver grains evoked by methylmercury were localized predominantly in lysosome-like inclusions within the receptor cells, while those produced by HgCl2 exposure were situated mainly along the borders of neighboring cells.
  • The present findings that organic and inorganic mercury compounds were deposited in the olfactory system along its whole length, from the receptor cell apices to the brain, support the electrophysiological results presented elsewhere (Baatrup et al., 1990, Ecotoxicol. Environ.

  • HSDB. structure - Methylmercuric chloride.
  • HSDB. structure - MERCURIC CHLORIDE.
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  • (PMID = 2090443.001).
  • [ISSN] 0147-6513
  • [Journal-full-title] Ecotoxicology and environmental safety
  • [ISO-abbreviation] Ecotoxicol. Environ. Saf.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Mercury Radioisotopes; 0 / Methylmercury Compounds; 53GH7MZT1R / Mercuric Chloride; RWZ4L3O1X0 / methylmercuric chloride
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8. ||||...... 43%  Grung M, Lichtenthaler R, Ahel M, Tollefsen KE, Langford K, Thomas KV: Effects-directed analysis of organic toxicants in wastewater effluent from Zagreb, Croatia. Chemosphere; 2007 Feb;67(1):108-20
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  • [Title] Effects-directed analysis of organic toxicants in wastewater effluent from Zagreb, Croatia.
  • The organic toxicants present in the effluent of the main sewer of the city of Zagreb, Croatia were isolated and identified through the use of effects-directed characterisation techniques.
  • The organic load of the wastewater was isolated by solid phase extraction and toxicity profiles obtained using reverse-phase HPLC.
  • The steroid estrogens 17 beta-estradiol and estriol were identified by LC-MS/MS as estrogen receptor agonists in two of the estrogenic fractions.
  • [MeSH-minor] Animals. Cell Survival / drug effects. Cells, Cultured. Chromatography, High Pressure Liquid. Chromatography, Liquid. Croatia. Cytochrome P-450 CYP1A1 / metabolism. Environmental Monitoring / methods. Gas Chromatography-Mass Spectrometry. Mass Spectrometry. Molecular Structure. Trout / metabolism. Vitellogenins / metabolism

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  • (PMID = 17166550.001).
  • [ISSN] 0045-6535
  • [Journal-full-title] Chemosphere
  • [ISO-abbreviation] Chemosphere
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Sewage; 0 / Vitellogenins; 0 / Water Pollutants, Chemical; EC 1.14.14.1 / Cytochrome P-450 CYP1A1
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9. ||||...... 43%  Liljefors T, Thelin B, Van Der Pers JN: Structure-activity relationships between stimulus molecule and response of a pheromone receptor cell in turnip moth,Agrotis segetum : Modifications of the acetate group. J Chem Ecol; 1984 Dec;10(12):1661-75
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  • [Title] Structure-activity relationships between stimulus molecule and response of a pheromone receptor cell in turnip moth,Agrotis segetum : Modifications of the acetate group.
  • The response of an antennal receptor cell of the turnip moth,Agrotis segetum, was recorded during stimulation with a series of (Z)-7-dodecenyl acetate analogs with structural variations of the acetate group.
  • The investigated receptor cell is known to be highly selective to (Z)-7-dodecenyl acetate.
  • The results indicate very strict requirements on the shape of the polar functional group, as well as on its electron distribution for a successful interaction with the antennal receptor cell.

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  • (PMID = 24318425.001).
  • [ISSN] 0098-0331
  • [Journal-full-title] Journal of chemical ecology
  • [ISO-abbreviation] J. Chem. Ecol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. ||||...... 37%  Anzai N, Jutabha P, Kanai Y, Endou H: Integrated physiology of proximal tubular organic anion transport. Curr Opin Nephrol Hypertens; 2005 Sep;14(5):472-9
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  • [Title] Integrated physiology of proximal tubular organic anion transport.
  • PURPOSE OF REVIEW: Renal organic anion transport proteins play important roles in the reabsorption and the secretion of endogenous and exogenous compounds.
  • RECENT FINDINGS: To date, molecular identification of organic anion transport proteins is still continuing: rodent organic anion transporter 5, organic anion-transporting polypeptide 4C1, voltage-driven organic anion transporter 1, multidrug resistance-associated protein 4, and sodium-coupled monocarboxylate transporter have yielded additional information in this field.
  • Finally, discovery of dicarboxylate receptors in the renal tubular cells raises the possibility that dicarboxylate anions function as intrarenal signaling molecules.
  • This novel aspect of renal organic anion transport, the potential modulation of signaling via dicarboxylate receptors, may be of significant relevance to renovascular hypertension and other renal diseases.
  • SUMMARY: Comprehensive understanding of the multimolecular complex, which is composed of transporters and their related signaling elements and is supported by the scaffold proteins underneath the plasma membrane, may be useful in clarifying complex transport phenomena such as renal apical organic anion handling.
  • [MeSH-minor] Animals. Carrier Proteins / metabolism. Cell Membrane / metabolism. Dicarboxylic Acids / metabolism. Humans. Ion Transport. Models, Biological. Multiprotein Complexes. Organic Anion Transporters / metabolism. Organic Cation Transport Proteins. Receptors, Cytoplasmic and Nuclear / metabolism. Signal Transduction. Sodium-Phosphate Cotransporter Proteins / metabolism

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  • (PMID = 16046907.001).
  • [ISSN] 1062-4821
  • [Journal-full-title] Current opinion in nephrology and hypertension
  • [ISO-abbreviation] Curr. Opin. Nephrol. Hypertens.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Dicarboxylic Acids; 0 / Multiprotein Complexes; 0 / Organic Anion Transporters; 0 / Organic Cation Transport Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 0 / SLC22A12 protein, human; 0 / Sodium-Phosphate Cotransporter Proteins; 0 / diazepam-binding inhibitor receptor
  • [Number-of-references] 57
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11. ||||...... 36%  Balasubramanian S, Lynch JW, Barry PH: The permeation of organic cations through cAMP-gated channels in mammalian olfactory receptor neurons. J Membr Biol; 1995 Jul;146(2):177-91
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  • [Title] The permeation of organic cations through cAMP-gated channels in mammalian olfactory receptor neurons.
  • The permeation of monovalent organic cations through adenosine 3',5'-cyclic monophosphate-(cAMP) activated channels was studied by recording macroscopic currents in excised inside-out membrane patches from the dendritic knobs of isolated mammalian olfactory receptor neurons (ORNs).
  • Current-voltage relations were measured when bathing solution Na+ was replaced by monovalent organic cations.
  • Some of the small organic cations tested included ammonium (NH4+), hydroxylammonium and formamidinium, with relative permeability ratios of 1.41, 2.3 and 1.01 respectively.
  • (ii) the pore dimension must be at least 6.5 x 6.5 A, in order to allow TEA and Tris to permeate and (iii) molecular sieving must be an important mechanism for the permeation of large organic ions through the channels with specific ion binding playing a smaller role than in other structurally similar channels.
  • In addition, the results clearly indicate that cyclic nucleotide-gated (CNG) channels in different cells are not the same, the olfactory CNG channel being different from that of the photoreceptors, particularly with respect to the permeation of large organic cations, which the ORN channels allow to permeate readily.
  • [MeSH-major] Ion Channels / metabolism. Olfactory Receptor Neurons / metabolism
  • [MeSH-minor] Amidines / metabolism. Animals. Arginine / metabolism. Cations. Cell Membrane Permeability. Choline / metabolism. Cyclic AMP / metabolism. Cyclic Nucleotide-Gated Cation Channels. Electric Conductivity. Female. Methylation. Quaternary Ammonium Compounds / metabolism. Rats. Rats, Wistar. Tromethamine / metabolism

  • HSDB. structure - CHOLINE CHLORIDE.
  • HSDB. structure - (L)-ARGININE.
  • HSDB. structure - TROMETHAMINE.
  • HSDB. structure - CHOLINE BITARTRATE.
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  • (PMID = 7473687.001).
  • [ISSN] 0022-2631
  • [Journal-full-title] The Journal of membrane biology
  • [ISO-abbreviation] J. Membr. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Amidines; 0 / Cations; 0 / Cyclic Nucleotide-Gated Cation Channels; 0 / Ion Channels; 0 / Quaternary Ammonium Compounds; 0 / olfactory cyclic-nucleotide-gated channel 2; 023C2WHX2V / Tromethamine; 463-52-5 / formamidine; 94ZLA3W45F / Arginine; E0399OZS9N / Cyclic AMP; N91BDP6H0X / Choline
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12. ||||...... 36%  Tanimoto S, Takahashi D, Toshima K: Chemical methods for degradation of target proteins using designed light-activatable organic molecules. Chem Commun (Camb); 2012 Aug 11;48(62):7659-71
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  • [Title] Chemical methods for degradation of target proteins using designed light-activatable organic molecules.
  • Molecular design, chemical synthesis, and biological evaluation of several designed organic molecules, which target-selectively degrade proteins upon photo-irradiation, are introduced.
  • The designed molecules for protein photo-degradation include 2-phenylquinoline-steroid hormone hybrids and porphyrin derivatives, both of which selectively photo-degrade estrogen receptor-α, and fullerene-sugar and -sulfonic acid hybrids, which selectively photo-degrade HIV-1 protease and amyloid β, respectively.
  • [MeSH-minor] Amyloid beta-Peptides / chemistry. Animals. Cell Line. Estrogen Receptor alpha / chemistry. Fullerenes / chemistry. HIV Protease / chemistry. Humans. Monosaccharides / chemistry. Porphyrins / chemistry. Quinolines / chemistry. Rats. Steroids / chemistry. Sulfonic Acids / chemistry. Ultraviolet Rays

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  • (PMID = 22739361.001).
  • [ISSN] 1364-548X
  • [Journal-full-title] Chemical communications (Cambridge, England)
  • [ISO-abbreviation] Chem. Commun. (Camb.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2-phenylquinoline; 0 / Amyloid beta-Peptides; 0 / Estrogen Receptor alpha; 0 / Fullerenes; 0 / Monosaccharides; 0 / Photosensitizing Agents; 0 / Porphyrins; 0 / Quinolines; 0 / Steroids; 0 / Sulfonic Acids; 0 / estrogen receptor alpha, human; EC 3.4.23.- / HIV Protease; EC 3.4.23.- / p16 protease, Human immunodeficiency virus 1
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13. ||||...... 35%  Aubert L, Motais R: Molecular features of organic anion permeablity in ox red blood cell. J Physiol; 1975 Mar;246(1):159-79
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  • [Title] Molecular features of organic anion permeablity in ox red blood cell.
  • 1. The penetration of organic anions into bovine red blood cells has been studied under experimental conditions where it could be distinguished from the penetration of undissociated acids which proceeds by diffusion through lipid zones of the membrane.
  • 2. Several lines of evidence suggest that the entry of organic anions cannot be ascribed to simple diffusion across aqueous channels limited by positive charges but needs a specific interaction of the penetrating anion with a component of the membrane.
  • Interaction between substrate and receptor requires at least a three point attachment involving three oxygen atoms in the substrate which react with complementary loci on the receptor to form ionic and hydrogen bonds.
  • 4. As suggested by the behaviour of the formate anion, in such a transport system any carboxylic acid could interact transiently with the receptor and therefore interfere with the transport of an organic anion even though such ionic interaction with the receptor were insufficient to produce transport of the acid itself.
  • [MeSH-major] Cell Membrane Permeability. Erythrocytes / metabolism

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  • (PMID = 237121.001).
  • [ISSN] 0022-3751
  • [Journal-full-title] The Journal of physiology
  • [ISO-abbreviation] J. Physiol. (Lond.)
  • [Language] eng
  • [Publication-type] In Vitro; Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Anions; 0 / Carboxylic Acids; 0 / Dicarboxylic Acids; 0 / Sulfonic Acids
  • [Other-IDs] NLM/ PMC1309408
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14. ||||...... 35%  Uehara A, Hume JR: Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J Gen Physiol; 1985 May;85(5):621-47
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  • [Title] Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells.
  • Inhibition of whole-cell calcium currents in enzymatically dispersed frog atrial myocytes by D-600, diltiazem, and nifedipine was studied using a single-micropipette voltage-clamp technique.
  • The objective of these experiments was to test the applicability of a modulated-receptor hypothesis similar to that proposed for local anesthetic interactions with sodium channels to account for the tonic and frequency-dependent interactions of these organic compounds with myocardial calcium channels.
  • Experiments in which the pH was modified, however, reveal some important differences for the interaction of organic calcium antagonists with myocardial calcium channels.
  • It is concluded that two distinct receptor sites may be involved in block of iCa by some of these compounds: a proton-accessible site and a proton-inaccessible site.

  • HSDB. structure - Nifedipine.
  • HSDB. structure - DILTIAZEM.
  • HSDB. structure - CALCIUM, ELEMENTAL.
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  • (PMID = 2582076.001).
  • [ISSN] 0022-1295
  • [Journal-full-title] The Journal of general physiology
  • [ISO-abbreviation] J. Gen. Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL30143
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Calcium Channel Blockers; 0 / Ion Channels; 39WPC8JHR8 / Gallopamil; EE92BBP03H / Diltiazem; I9ZF7L6G2L / Nifedipine; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2215823
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15. ||||...... 35%  Burckhardt G: Drug transport by Organic Anion Transporters (OATs). Pharmacol Ther; 2012 Oct;136(1):106-30
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  • [Title] Drug transport by Organic Anion Transporters (OATs).
  • Common to all so far functionally characterized Organic Anion Transporters (OATs) is their broad substrate specificity and their ability to exchange extracellular against intracellular organic anions.
  • In human kidneys, OAT1, OAT2, and OAT3 are localized in the basolateral membrane, and OAT4, OAT10, and URAT1 in the apical cell membrane of proximal tubule cells, respectively.
  • Several classes of drugs interact with human OAT1-3, including ACE inhibitors, angiotensin II receptor antagonists, diuretics, HMG CoA reductase inhibitors, β-lactam antibiotics, antineoplastic and antiviral drugs, and uricosuric drugs.
  • [MeSH-major] Organic Anion Transporters / physiology. Pharmaceutical Preparations / metabolism

  • MedlinePlus Health Information. consumer health - Medicines.
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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22841915.001).
  • [ISSN] 1879-016X
  • [Journal-full-title] Pharmacology & therapeutics
  • [ISO-abbreviation] Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Anion Transporters; 0 / Pharmaceutical Preparations
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16. ||||...... 35%  Roy R, Shiao TC: Organic chemistry and immunochemical strategies in the design of potent carbohydrate-based vaccines. Chimia (Aarau); 2011;65(1-2):24-9
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  • [Title] Organic chemistry and immunochemical strategies in the design of potent carbohydrate-based vaccines.
  • To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting specific competent immune cell receptors.
  • Amongst several potential vaccine candidates dedicated against diseases, this short report will focused on those most advance and state of the art organic chemistry involved therein.
  • [MeSH-minor] Carbohydrate Sequence. Chemistry, Organic. Drug Design. Immunochemistry. Models, Immunological. Molecular Sequence Data

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  • (PMID = 21469440.001).
  • [ISSN] 0009-4293
  • [Journal-full-title] Chimia
  • [ISO-abbreviation] Chimia (Aarau)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Carbohydrates; 0 / Vaccines
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17. ||||...... 35%  Ma L, Lu L, Zhu M, Wang Q, Gao F, Yuan C, Wu Y, Xing S, Fu X, Mei Y, Gao X: Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases. J Inorg Biochem; 2011 Sep;105(9):1138-47
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  • [Title] Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases.
  • Three dinuclear copper complexes of organic claw ligands (2,2',2″,2'''-(5-R-2-hydroxy-1,3-phenylene)bis(methylene)bis(azanetriyl)tetraacetic acid, R=methyl (H(5)L1), chloro (H(5)L2) and bromo (H(5)L3)): [Cu(2)NaL1(H(2)O)(2)] (1), [Cu(2)HL2(H(2)O)(2)] (2), [Cu(2)NaL3(H(2)O)(2)] (3), have been synthesized and characterized by elemental analyses, infrared spectra, thermo-gravimetric analyses, X-ray diffraction analysis, electrospray ionization mass spectra, pH-potentiometric titration, molar conductivity.
  • Their inhibitory effects against human protein tyrosine phosphatase 1B (PTP1B), T cell protein tyrosine phosphatase (TCPTP), Megakaryocyte protein tyrosinephosphatase 2 (PTP-MEG2), srchomology phosphatase 1 (SHP-1) and srchomology phosphatase 2 (SHP-2) are evaluated in vitro.
  • [MeSH-major] Acids, Heterocyclic / pharmacology. Chelating Agents / pharmacology. Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors. Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors. Protein Tyrosine Phosphatase, Non-Receptor Type 2 / antagonists & inhibitors. Protein Tyrosine Phosphatase, Non-Receptor Type 6 / antagonists & inhibitors. Protein Tyrosine Phosphatases, Non-Receptor / antagonists & inhibitors. Recombinant Proteins / antagonists & inhibitors

  • HSDB. structure - COPPER, ELEMENTAL.
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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 21708098.001).
  • [ISSN] 1873-3344
  • [Journal-full-title] Journal of inorganic biochemistry
  • [ISO-abbreviation] J. Inorg. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acids, Heterocyclic; 0 / Chelating Agents; 0 / Enzyme Inhibitors; 0 / Ligands; 0 / Recombinant Proteins; 789U1901C5 / Copper; EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / PTPN6 protein, human; EC 3.1.3.48 / PTPN9 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 1; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 2; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48 / Protein Tyrosine Phosphatases, Non-Receptor
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18. |||....... 35%  Cheng X, Quintás-Cardama A, Golemovic M, Zingaro R, Gao MZ, Freireich EJ, Andreeff M, Kantarjian HM, Verstovsek S: The organic arsenic derivative GMZ27 induces PML-RARα-independent apoptosis in myeloid leukemia cells. Anticancer Res; 2012 Jul;32(7):2871-80
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  • [Title] The organic arsenic derivative GMZ27 induces PML-RARα-independent apoptosis in myeloid leukemia cells.
  • However, organic arsenic derivatives (OAD) have a more favorable toxicity profile than ATO.
  • GMZ27 had potent antiproliferative activity against human acute myeloid leukemia (AML) cell lines that was higher than that of ATO.
  • In contrast to ATO, GMZ27 only marginally induced maturation of leukemia cells and had no effect on the cell cycle.
  • [MeSH-minor] Animals. Caspase 9 / metabolism. Cell Cycle / drug effects. Cell Growth Processes / drug effects. Cell Line, Tumor. Dose-Response Relationship, Drug. Enzyme Activation / drug effects. Female. HL-60 Cells. Humans. Mice. Oxides / pharmacology. Oxygen / metabolism

  • Genetic Alliance. consumer health - Leukemia, Myeloid.
  • HSDB. structure - ARSENIC COMPOUNDS.
  • HSDB. structure - ARSENIC TRIOXIDE.
  • HSDB. structure - OXYGEN.
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  • (PMID = 22753750.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Arsenicals; 0 / Oncogene Proteins, Fusion; 0 / Oxides; 0 / promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; 1327-53-3 / arsenic trioxide; EC 3.4.22.- / Caspase 9; S88TT14065 / Oxygen
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19. |||....... 35%  Hjelmborg PS, Andreassen TK, Bonefeld-Jørgensen EC: Cellular uptake of lipoproteins and persistent organic compounds--an update and new data. Environ Res; 2008 Oct;108(2):192-8
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  • [Title] Cellular uptake of lipoproteins and persistent organic compounds--an update and new data.
  • This paper will focus on the interactions between lipoproteins and persistent organic pollutants (POPs) and how these particles are taken up by cells.
  • A number of POPs including the pesticide p,p'-dichlorodiphenyltrichloroethane (DDT), and especially its metabolite p,p'-dichlorodiphenyldichloroethene (DDE), interacts with nuclear hormone receptors causing these to malfunction, which in turn results in a range of deleterious health effects in humans.
  • The aim of the present study was to determine the role of lipoprotein receptors in mouse embryonic fibroblast (MEF) cells in conjunction with uptake of DDT-lipoprotein complexes from supplemented media in vitro.
  • Uptake of DDT by MEF cells was investigated using MEF1 cells carrying the receptors low-density lipoprotein receptor-related protein (LRP) and low-density lipoprotein receptor (LDLR) present and MEF4 cells with no LRP and LDLR expression.
  • The receptor function was further evaluated by adding the 40kDa receptor-associated protein (RAP) which blocks receptor activity.
  • There was no strong evidence for a receptor-mediated uptake of the [(14)C]DDT-lipoprotein complex.
  • To conclude, DDT travels in the blood stream and can cross cell membranes while being transported as a DDT-lipoprotein complex.
  • The lipoproteins do not need receptors to cross cell membranes since passive diffusion constitutes a major passageway.
  • [MeSH-major] Environmental Pollutants / pharmacokinetics. Fibroblasts / drug effects. Lipoproteins / metabolism. Organic Chemicals / pharmacokinetics
  • [MeSH-minor] Animals. Biological Transport. Cell Culture Techniques. Cell Line. Mice. Mice, Knockout. Receptors, LDL / genetics. Ultracentrifugation

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  • (PMID = 18762293.001).
  • [ISSN] 1096-0953
  • [Journal-full-title] Environmental research
  • [ISO-abbreviation] Environ. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Environmental Pollutants; 0 / Lipoproteins; 0 / Organic Chemicals; 0 / Receptors, LDL
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20. |||....... 34%  Sriarj W, Aoki K, Ohya K, Takagi Y, Shimokawa H: Bovine dentine organic matrix down-regulates osteoclast activity. J Bone Miner Metab; 2009;27(3):315-23
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  • [Title] Bovine dentine organic matrix down-regulates osteoclast activity.
  • These results could be because of different susceptibilities to acid and the different organic matrices between deciduous and permanent dentine.
  • TRAP positive cell number, TRAP activity, the areas of resorption pits, and mRNA levels of TRAP, v-ATPase, calcitonin receptor, cathepsin K, and MMP-9 were examined.
  • [MeSH-minor] Acid Phosphatase / metabolism. Animals. Bone Resorption / metabolism. Cattle. Cell Count. Cell Differentiation / drug effects. Coculture Techniques. Electrophoresis, Polyacrylamide Gel. Isoenzymes / metabolism. Mice. RNA, Messenger / genetics. RNA, Messenger / metabolism. Tissue Extracts / pharmacology. src-Family Kinases / antagonists & inhibitors

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  • (PMID = 19296049.001).
  • [ISSN] 0914-8779
  • [Journal-full-title] Journal of bone and mineral metabolism
  • [ISO-abbreviation] J. Bone Miner. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / RNA, Messenger; 0 / Tissue Extracts; EC 2.7.10.2 / src-Family Kinases; EC 3.1.3.- / tartrate-resistant acid phosphatase; EC 3.1.3.2 / Acid Phosphatase
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21. |||....... 34%  Huber RD, Gao B, Sidler Pfändler MA, Zhang-Fu W, Leuthold S, Hagenbuch B, Folkers G, Meier PJ, Stieger B: Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am J Physiol Cell Physiol; 2007 Feb;292(2):C795-806
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  • [Title] Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.
  • In the present study we isolated two splice variants of organic anion transporting polypeptide 3A1 (OATP3A1_v1 and OATP3A1_v2) from human brain.
  • Immunolocalization of OATP3A1_v2 included Sertoli cells in testis, apical and/or subapical membranes in choroid plexus epithelial cells, and neurons (cell bodies and axons) of the gray and white matter of human frontal cortex.
  • Transported substrates include prostaglandin (PG)E(1) and PGE(2), thyroxine, and the cyclic oligopeptides BQ-123 (endothelin receptor antagonist) and vasopressin.
  • [MeSH-major] Alternative Splicing. Brain / metabolism. Organic Anion Transporters / physiology
  • [MeSH-minor] Alprostadil / metabolism. Amino Acid Sequence. Animals. CHO Cells. Cricetinae. Cricetulus. Dinoprostone / metabolism. Humans. Molecular Sequence Data. Organ Specificity. Rats. Receptors, Endothelin / antagonists & inhibitors. Vasopressins / metabolism. Xenopus laevis

  • HSDB. structure - VASOPRESSIN.
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  • (PMID = 16971491.001).
  • [ISSN] 0363-6143
  • [Journal-full-title] American journal of physiology. Cell physiology
  • [ISO-abbreviation] Am. J. Physiol., Cell Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organic Anion Transporters; 0 / Receptors, Endothelin; 0 / SLCO3A1 protein, human; 11000-17-2 / Vasopressins; F5TD010360 / Alprostadil; K7Q1JQR04M / Dinoprostone
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22. |||....... 34%  Trdan Lušin T, Stieger B, Marc J, Mrhar A, Trontelj J, Zavratnik A, Ostanek B: Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene. J Transl Med; 2012;10:76
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  • [Title] Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene.
  • BACKGROUND: Raloxifene, a selective estrogen receptor modulator, exhibits quite large and unexplained interindividual variability in pharmacokinetics and pharmacodynamics.
  • The aim of this study was to determine the role of organic-anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants in the pharmacokinetics and pharmacodynamics of raloxifene.
  • [MeSH-major] Genetic Variation. Organic Anion Transporters / physiology. Organic Anion Transporters, Sodium-Independent / physiology. Raloxifene / pharmacology. Selective Estrogen Receptor Modulators / pharmacokinetics

  • HSDB. structure - RALOXIFENE.
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  • (PMID = 22533838.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Anion Transporters; 0 / Organic Anion Transporters, Sodium-Independent; 0 / SLCO1B1 protein, human; 0 / SLCO1B3 protein, human; 0 / Selective Estrogen Receptor Modulators; YX9162EO3I / Raloxifene
  • [Other-IDs] NLM/ PMC3476964
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23. |||....... 33%  Cohen BN, Labarca C, Davidson N, Lester HA: Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations. J Gen Physiol; 1992 Sep;100(3):373-400
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  • [Title] Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations.
  • We measured the permeability ratios (PX/PNa) of 3 wild-type, 1 hybrid, 2 subunit-deficient, and 22 mutant nicotinic receptors expressed in Xenopus oocytes for alkali metal and organic cations using shifts in the bi-ionic reversal potential of the macroscopic current.
  • Mutations at position 2' (alpha Thr244, beta Gly255, gamma Thr253, delta Ser258) near the intracellular end of M2 changed the organic cation permeability ratios as much as twofold and reduced PCs/PNa and PK/PNa by 16-18%.
  • The wild-type mouse receptor displayed a surprising interaction with the primary ammonium cations; relative permeability peaked at a chain length equal to four carbons.
  • Analysis of the organic permeability ratios for the wild-type mouse receptor shows that (a) the diameter of the narrowest part of the pore is 8.4 A;.
  • (b) the mouse receptor departs significantly from size selectivity for monovalent organic cations; and (c) lowering the temperature reduces Pguanidinium/PNa by 38% and Pbutylammonium/PNa more than twofold.
  • The results reinforce present views that positions -1' and 2' are the narrowest part of the pore and suggest that positions 6' and 10' align some permeant organic cations in the pore in an interaction similar to that with channel blocker, QX-222.
  • [MeSH-major] Cations / metabolism. Mutation. Receptors, Nicotinic / metabolism
  • [MeSH-minor] Amino Acid Sequence. Ammonia / metabolism. Ammonia / pharmacokinetics. Animals. Cell Membrane Permeability / physiology. Cesium / metabolism. Cesium / pharmacokinetics. Female. Glycine / analogs & derivatives. Glycine / metabolism. Glycine / pharmacokinetics. Guanidine. Guanidines / metabolism. Guanidines / pharmacokinetics. Lidocaine / analogs & derivatives. Lidocaine / pharmacology. Mice. Molecular Sequence Data. Oocytes / chemistry. Oocytes / physiology. Oocytes / ultrastructure. Sodium / metabolism. Sodium / pharmacokinetics. Temperature. Torpedo. Xenopus

  • HSDB. structure - GUANIDINE.
  • HSDB. structure - LIDOCAINE.
  • HSDB. structure - GLYCINE.
  • HSDB. structure - SODIUM.
  • HSDB. structure - CESIUM, ELEMENTAL.
  • HSDB. structure - AMMONIA.
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  • (PMID = 1431803.001).
  • [ISSN] 0022-1295
  • [Journal-full-title] The Journal of general physiology
  • [ISO-abbreviation] J. Gen. Physiol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS-11756
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Cations; 0 / Guanidines; 0 / Receptors, Nicotinic; 1KSV9V4Y4I / Cesium; 21236-55-5 / QX-222; 459-73-4 / glycine ethyl ester; 616-34-2 / glycine methyl ester; 7664-41-7 / Ammonia; 98PI200987 / Lidocaine; 9NEZ333N27 / Sodium; JU58VJ6Y3B / Guanidine; TE7660XO1C / Glycine
  • [Other-IDs] NLM/ PMC2229089
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24. |||....... 33%  Sears ML: Regulation of aqueous flow by the adenylate cyclase receptor complex in the ciliary epithelium. Am J Ophthalmol; 1985 Jul 15;100(1):194-8
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  • [Title] Regulation of aqueous flow by the adenylate cyclase receptor complex in the ciliary epithelium.
  • The answer to how the beta-adrenergic receptor mediates a fall in intraocular pressure has been elusive.
  • On a molecular basis, stimulation of the beta-adrenergic receptor activates intracellular adenylate cyclase to produce increased cyclic adenosine monophosphate.
  • Acting by different cell-receptor mechanisms, but nonetheless potent, nonadrenergic stimulators of adenylate cyclase in the ciliary epithelium, such as cholera toxin and organic fluorides, have been studied in experimental animals.
  • [MeSH-minor] ADP-Ribosylation Factors. Adenylate Cyclase / physiology. Adult. Aged. Anterior Chamber / metabolism. Cell Membrane Permeability. Colforsin. Cyclic AMP / biosynthesis. Epithelium / metabolism. Humans. Middle Aged. Receptors, Adrenergic, beta / physiology. Timolol / pharmacology

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  • (PMID = 2990214.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY-00237; United States / NEI NIH HHS / EY / EY-00785
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Diterpenes; 0 / Membrane Proteins; 0 / Receptors, Adrenergic, beta; 1F7A44V6OU / Colforsin; 817W3C6175 / Timolol; E0399OZS9N / Cyclic AMP; EC 3.6.5.2 / ADP-Ribosylation Factors; EC 4.6.1.1 / Adenylate Cyclase
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25. |||....... 32%  Poole JA, Alexis NE, Parks C, MacInnes AK, Gentry-Nielsen MJ, Fey PD, Larsson L, Allen-Gipson D, Von Essen SG, Romberger DJ: Repetitive organic dust exposure in vitro impairs macrophage differentiation and function. J Allergy Clin Immunol; 2008 Aug;122(2):375-82, 382.e1-4
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  • [Title] Repetitive organic dust exposure in vitro impairs macrophage differentiation and function.
  • BACKGROUND: Organic dust exposure in the agricultural industry results in significant airway disease and lung function decrease.
  • OBJECTIVE: We sought to investigate the effect of organic dust extract (ODE) from modern swine operations on monocyte-derived macrophage (MDM) phenotype and function.
  • At 1 week, cells were analyzed by means of flow cytometry for cell-surface marker expression (HLA-DR, CD80, CD86, Toll-like receptor 2, Toll-like receptor 4, mCD14, and CD16), phagocytosis (IgG-opsonized zymosan particles), and intracellular killing of Streptococcus pneumoniae.
  • CONCLUSION: Repetitive organic dust exposure significantly decreases markers of antigen presentation and host defense function in MDMs.
  • Bacterial cell components appear to be driving these impaired responses.
  • [MeSH-minor] Animals. Antigens, CD80 / immunology. Antigens, CD80 / metabolism. Antigens, CD86 / immunology. Antigens, CD86 / metabolism. Cell Differentiation. HLA-DR Antigens / immunology. HLA-DR Antigens / metabolism. Housing, Animal. Humans. Lipopolysaccharides / immunology. Peptidoglycan / immunology. Swine

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  • (PMID = 18585769.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1R01OH008539-01; United States / NHLBI NIH HHS / HL / K01 HL084684-05; United States / NIEHS NIH HHS / ES / K08 ES015522-01; United States / NIEHS NIH HHS / ES / K08 ES015522-01; United States / NIEHS NIH HHS / ES / K08 ES015522-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD80; 0 / Antigens, CD86; 0 / Cytokines; 0 / Dust; 0 / HLA-DR Antigens; 0 / Lipopolysaccharides; 0 / Peptidoglycan; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
  • [Other-IDs] NLM/ NIHMS109320; NLM/ PMC2685162
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26. |||....... 32%  Bittner M, Macikova P, Giesy JP, Hilscherova K: Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter. Environ Int; 2011 Jul;37(5):960-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter.
  • Dissolved organic matter (DOM) in freshwaters is present at concentrations ranging from 0.5 to 50 mg L⁻¹, and consists of various organic compounds, including humic substances (HS).
  • HS exert a variety of direct and indirect biological effects, including interaction with the aryl hydrocarbon receptor (AhR).
  • AhR is a cytosolic receptor that binds various hydrophobic organic compounds (HOCs) and mediates some of their toxic effects.
  • In simultaneous exposures of H4IIE-luc cells to DOM (17 mg L⁻¹) and each of the model compounds, 2,3,7,8-TCDD, PCB126, PCB169, benzo[a]pyrene, benzo[a]anthracene, dibenz[a,h]anthracene, fluoranthene, a mixture of persistent organic pollutants (POPs), a mixture of polycyclic aromatic hydrocarbons (PAHs), and a mixture of all HOCs, either significant additive or facilitative effects were observed when compared to activities of single HOCs.
  • [MeSH-major] Environmental Pollutants / toxicity. Organic Chemicals / metabolism. Receptors, Aryl Hydrocarbon / metabolism
  • [MeSH-minor] Animals. Anthracenes / chemistry. Anthracenes / metabolism. Anthracenes / toxicity. Benzo(a)pyrene / chemistry. Benzo(a)pyrene / metabolism. Benzo(a)pyrene / toxicity. Cell Line, Tumor. Fluorenes / chemistry. Fluorenes / metabolism. Fluorenes / toxicity. Fresh Water / chemistry. Humic Substances / analysis. Hydrophobic and Hydrophilic Interactions. Polycyclic Hydrocarbons, Aromatic / chemistry. Polycyclic Hydrocarbons, Aromatic / metabolism. Polycyclic Hydrocarbons, Aromatic / toxicity. Rats. Tetrachlorodibenzodioxin / chemistry. Tetrachlorodibenzodioxin / metabolism. Tetrachlorodibenzodioxin / toxicity


27. |||....... 32%  Kometani T, Ikeda Y, Kasai M: Acetylcholine-binding substance extracted by using organic solvent and acetylcholine receptor of electric organ of Narke japonica. Biochim Biophys Acta; 1975 Dec 16;413(3):415-24
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  • [Title] Acetylcholine-binding substance extracted by using organic solvent and acetylcholine receptor of electric organ of Narke japonica.
  • From the heaviest, the fractions were acetylcholine receptor rich, ATPase rich, and acetylcholinesterase rich.
  • 3. The membrane fraction having acetylcholine receptor showed the excitability, the increase of Na+ permeability by the application of cholinergic agonists.
  • However, the acetylcholine binding substance extracted by the organic solvent was richer in the lighter fraction.
  • This substance differed from the true acetylcholine receptor.
  • [MeSH-major] Acetylcholine / metabolism. Electric Organ / metabolism. Receptors, Cholinergic
  • [MeSH-minor] Acetylcholinesterase / analysis. Adenosine Triphosphatases / analysis. Animals. Binding Sites. Biological Transport, Active. Cell Membrane / analysis. Cell Membrane / metabolism. Fishes. Lipoproteins / isolation & purification. Lipoproteins / metabolism. Nerve Tissue Proteins / isolation & purification. Nerve Tissue Proteins / metabolism. Sodium / metabolism

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  • (PMID = 127623.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Lipoproteins; 0 / Nerve Tissue Proteins; 0 / Receptors, Cholinergic; 9NEZ333N27 / Sodium; EC 3.1.1.7 / Acetylcholinesterase; EC 3.6.1.- / Adenosine Triphosphatases; N9YNS0M02X / Acetylcholine
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28. |||....... 32%  Bauer C, Kielian T, Wyatt TA, Romberger DJ, West WW, Gleason AM, Poole JA: Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice. Am J Respir Cell Mol Biol; 2013 Jun;48(6):781-9
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  • [Title] Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice.
  • Organic dust exposure within agricultural environments results in airway diseases.
  • Toll-like receptor 2 (TLR2) and TLR4 only partly account for the innate response to these complex dust exposures.
  • To determine the central pathway in mediating complex organic dust-induced airway inflammation, this study targeted the common adaptor protein, myeloid differentiation factor 88 (MyD88), and investigated the relative contributions of receptors upstream from this adaptor.
  • Wild-type, MyD88, TLR9, TLR4, IL-1 receptor I (RI), and IL-18R knockout (KO) mice were challenged intranasally with organic dust extract (ODE) or saline, according to an established protocol.
  • Lung cell apoptosis was determined by a terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, and lymphocyte influx and intercellular adhesion molecule-1 (ICAM-1) expression were assessed by immunohistochemistry.
  • ODE-induced epithelial-cell ICAM-1 expression was diminished in MyD88 KO mice.
  • No difference was evident in the small degree of ODE-induced lung-cell apoptosis.
  • Collectively, the acute organic dust-induced airway inflammatory response is highly dependent on MyD88 signaling, and is dictated, in part, by important contributions from upstream TLRs and IL-18R.
  • [MeSH-major] Bronchial Hyperreactivity / pathology. Cell Differentiation. Dust / immunology. Inflammation / immunology. Myeloid Differentiation Factor 88 / metabolism
  • [MeSH-minor] Animals. Apoptosis. Immunohistochemistry. In Situ Nick-End Labeling. Inflammation Mediators / metabolism. Inhalation Exposure. Intercellular Adhesion Molecule-1 / genetics. Intercellular Adhesion Molecule-1 / metabolism. Lung / immunology. Lung / metabolism. Lung / pathology. Mice. Mice, Inbred C57BL. Mice, Knockout. Neutrophil Infiltration. Neutrophils / immunology. Neutrophils / metabolism. Receptors, Interleukin-1 / genetics. Receptors, Interleukin-1 / immunology. Receptors, Interleukin-1 / metabolism. Receptors, Interleukin-18 / genetics. Receptors, Interleukin-18 / metabolism. Respiratory Function Tests. Signal Transduction. Toll-Like Receptor 4 / genetics. Toll-Like Receptor 4 / immunology. Toll-Like Receptor 4 / metabolism. Toll-Like Receptor 9 / immunology. Toll-Like Receptor 9 / metabolism

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  • (PMID = 23492189.001).
  • [ISSN] 1535-4989
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1U54OH010162-01; United States / NIEHS NIH HHS / ES / 2R01ES019325; United States / NIOSH CDC HHS / OH / 2R01OH008539-01; United States / NINDS NIH HHS / NS / 5R01NS40730; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NINDS NIH HHS / NS / R01 NS040730
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dust; 0 / Icam1 protein, mouse; 0 / Inflammation Mediators; 0 / Myd88 protein, mouse; 0 / Myeloid Differentiation Factor 88; 0 / Receptors, Interleukin-1; 0 / Receptors, Interleukin-18; 0 / Tlr4 protein, mouse; 0 / Tlr9 protein, mouse; 0 / Toll-Like Receptor 4; 0 / Toll-Like Receptor 9; 126547-89-5 / Intercellular Adhesion Molecule-1
  • [Other-IDs] NLM/ PMC3727869 [Available on 06/01/14]
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29. |||....... 32%  Poole JA, Wyatt TA, Kielian T, Oldenburg P, Gleason AM, Bauer A, Golden G, West WW, Sisson JH, Romberger DJ: Toll-like receptor 2 regulates organic dust-induced airway inflammation. Am J Respir Cell Mol Biol; 2011 Oct;45(4):711-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Toll-like receptor 2 regulates organic dust-induced airway inflammation.
  • Organic dust exposure in agricultural environments results in significant airway inflammatory diseases.
  • Gram-positive cell wall components are present in high concentrations in animal farming dusts, but their role in mediating dust-induced airway inflammation is not clear.
  • This study investigated the role of Toll-like receptor (TLR) 2, a pattern recognition receptor for gram-positive cell wall products, in regulating swine facility organic dust extract (DE)-induced airway inflammation in mice.
  • Collectively, these results demonstrate that the TLR2 pathway is important in regulating swine facility organic dust-induced airway inflammation, which suggests the importance of TLR2 agonists in mediating large animal farming-induced airway inflammatory responses.
  • [MeSH-major] Dust. Lung / immunology. Pneumonia / immunology. Toll-Like Receptor 2 / metabolism

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  • (PMID = 21278324.001).
  • [ISSN] 1535-4989
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES015522-03S1; United States / NIEHS NIH HHS / ES / K08 ES015522-01; United States / NIEHS NIH HHS / ES / K08 ES015522-05; United States / NIAAA NIH HHS / AA / K99 AA019499-02; United States / NIAAA NIH HHS / AA / R01 AA017993; United States / NIAAA NIH HHS / AA / R01 AA017993; United States / NIAAA NIH HHS / AA / R01 AA017993-04; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NIEHS NIH HHS / ES / R01 ES019325-03; United States / NINDS NIH HHS / NS / R01 NS055385; United States / NIOSH CDC HHS / OH / R01 OH008539-01
  • [Publication-type] Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bronchoconstrictor Agents; 0 / Chemokines; 0 / Cytokines; 0 / Dust; 0 / Inflammation Mediators; 0 / Lipopolysaccharides; 0 / Peptidoglycan; 0 / Tlr2 protein, mouse; 0 / Toll-Like Receptor 2; 0W5ETF9M2K / Methacholine Chloride; 31C4KY9ESH / Nitric Oxide
  • [Other-IDs] NLM/ PMC3208620
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30. |||....... 32%  Ulrich K, Wölfle S, Mayer A, Heeg K, Braunbeck T, Erdinger L, Bartz H: Extractable organic matter of standard reference material 1649a influences immunological response induced by pathogen-associated molecular patterns. Environ Sci Pollut Res Int; 2010 Jul;17(6):1257-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extractable organic matter of standard reference material 1649a influences immunological response induced by pathogen-associated molecular patterns.
  • Temporal increase of airborne particulate matter (APM), a potential carrier for extractable organic matter (EOM), degrades the situation of pulmonary patients.
  • The Ah receptor (AhR) has been described as an important factor influencing the immunological challenge by viral infections.
  • To mimic the activation of organic matter during contact of particles with the human lung, Soxhlet extraction of SRM was performed.
  • DISCUSSION: Organic compounds adsorbed on airborne particulate matter influence the cytokine secretion of lung epithelial cells induced by pathogen-associated molecular patterns.
  • [MeSH-minor] Benzo(a)pyrene. Benzoflavones / toxicity. Cell Line. Humans. Interleukin-6 / metabolism. Interleukin-8 / antagonists & inhibitors. Interleukin-8 / metabolism. Poly C / toxicity. Polycyclic Hydrocarbons, Aromatic / toxicity. Receptors, Aryl Hydrocarbon / antagonists & inhibitors. Receptors, Aryl Hydrocarbon / metabolism. Reference Standards. Transforming Growth Factor beta / metabolism

  • HSDB. structure - POLYCYCLIC AROMATIC HYDROCARBONS.
  • HSDB. structure - BENZO(A)PYRENE.
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  • (PMID = 20195909.001).
  • [ISSN] 1614-7499
  • [Journal-full-title] Environmental science and pollution research international
  • [ISO-abbreviation] Environ Sci Pollut Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Benzoflavones; 0 / Cytokines; 0 / Interleukin-6; 0 / Interleukin-8; 0 / Particulate Matter; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Receptors, Aryl Hydrocarbon; 0 / Transforming Growth Factor beta; 30811-80-4 / Poly C; 3417WMA06D / Benzo(a)pyrene; 604-59-1 / alpha-naphthoflavone
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31. |||....... 32%  Lou Y, Li J, Lu Y, Wang X, Jiao R, Wang S, Kong L: Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats. Toxicol Lett; 2011 Feb 25;201(1):72-9
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  • [Title] Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats.
  • In order to study the unrecognized abnormalities of organic ion transporters and fatty acid metabolism indicators in AA nephropathy, Wistar rats were orally administrated with vehicle, 10 and 20mg/kg AA once daily for 7 days, respectively.
  • OCTN2 particularly transports l-carnitine through cell membrane.
  • Down-regulation of peroxisome proliferator-activated receptor alpha (rPPARα) and carnitine acyltransferase 1 (rCPT1), and up-regulation of acetyl coenzyme A carboxylase 1/2 (rACC1/2) in renal cortex were detected in AA-treated rats.
  • These results indicate that alterations of organic ion transportation and fatty acid metabolism are part of AA-induced nephropathy (AAN), contribute to the altered urinary metabolic profile and may lead to further proximal tubule injury in rats.
  • [MeSH-minor] Acetyltransferases / genetics. Animals. Blood Urea Nitrogen. Carnitine / analysis. Catecholamine Plasma Membrane Transport Proteins / genetics. Creatinine / blood. Male. Organic Anion Transport Protein 1 / genetics. Organic Anion Transporters, Sodium-Independent / genetics. Organic Cation Transport Proteins / genetics. Rats. Rats, Wistar

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 21167265.001).
  • [ISSN] 1879-3169
  • [Journal-full-title] Toxicology letters
  • [ISO-abbreviation] Toxicol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aristolochic Acids; 0 / Catecholamine Plasma Membrane Transport Proteins; 0 / Fatty Acids; 0 / Membrane Transport Proteins; 0 / Organic Anion Transport Protein 1; 0 / Organic Anion Transporters, Sodium-Independent; 0 / Organic Cation Transport Proteins; 0 / Slc22a1 protein, rat; 0 / Slc22a2 protein, rat; 0 / Slc22a5 protein, rat; 0 / Slc22a6 protein, rat; 0 / organic anion transport protein 3; 313-67-7 / aristolochic acid I; 541-15-1 / Carnitine; AYI8EX34EU / Creatinine; EC 2.3.1.- / Acetyltransferases; EC 2.3.1.- / aminoglycoside N1-acetyltransferase
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32. |||....... 32%  Sarma SN, Kim YJ, Ryu JC: Gene expression profiles of human promyelocytic leukemia cell lines exposed to volatile organic compounds. Toxicology; 2010 May 27;271(3):122-30
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  • [Title] Gene expression profiles of human promyelocytic leukemia cell lines exposed to volatile organic compounds.
  • Benzene, toluene, o-xylene, ethylbenzene, trichloroethylene and dichloromethane are the most widely used volatile organic compounds (VOCs), and their toxic mechanisms are still undefined.
  • At IC(20) doses identified genes were functionally categorized as being involved in cytokine-cytokine receptor interactions and the toll-like receptor signaling pathway, whereas exposure at IC(50) doses identified genes associated with the p53 signaling pathway, apoptosis, and natural killer cell-mediated cytotoxicity pathway.
  • In conclusion, both gene expression profiles and gene ontology analysis have elucidated potential gene-based biomarkers and provided insights into the mechanism underlying the response of human leukemia cell lines to VOC exposure.
  • [MeSH-major] Gene Expression Profiling / methods. Leukemia, Promyelocytic, Acute / genetics. Volatile Organic Compounds / pharmacology
  • [MeSH-minor] Apoptosis / genetics. Carrier Proteins / genetics. Cell Line, Tumor. Female. Genome, Human. HL-60 Cells. Humans. K562 Cells. Oligonucleotide Array Sequence Analysis / methods. Proteins / genetics. Reverse Transcriptase Polymerase Chain Reaction. Toluene / pharmacology. U937 Cells. Xylenes / pharmacology

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  • (PMID = 20359517.001).
  • [ISSN] 1879-3185
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / IFIT1 protein, human; 0 / Proteins; 0 / Volatile Organic Compounds; 0 / Xylenes; 3FPU23BG52 / Toluene; Z2474E14QP / 2-xylene
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33. |||....... 31%  Zhang Y, Csanaky IL, Cheng X, Lehman-McKeeman LD, Klaassen CD: Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Toxicol Sci; 2012 Jun;127(2):451-62
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  • [Title] Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.
  • Organic anion transporting polypeptide 1a1 (Oatp1a1) is predominantly expressed in livers of mice and is thought to transport bile acids (BAs) from blood into liver.
  • Oatp1a1-null BDL mice had similar basolateral BA uptake (Na(+)-taurocholate cotransporting polypeptide and Oatp1b2) and BA-efflux (multidrug resistance-associated protein [Mrp]-3, Mrp4, and organic solute transporter α/β) transporters, as well as BA-synthetic enzyme (Cyp7a1) in livers as WT BDL mice.
  • Hepatic expression of small heterodimer partner Cyp3a11, Cyp4a14, and Nqo1, which are target genes of farnesoid X receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and NF-E2-related factor 2, respectively, were increased in WT BDL mice but not in Oatp1a1-null BDL mice.
  • [MeSH-major] Bile Acids and Salts / metabolism. Cholestasis / complications. Liver / metabolism. Liver Diseases / etiology. Organic Cation Transport Proteins / deficiency

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  • (PMID = 22461449.001).
  • [ISSN] 1096-0929
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES009649; United States / NCRR NIH HHS / RR / RR021940
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Bile Acids and Salts; 0 / Biological Markers; 0 / Oatp1a1 protein, mouse; 0 / Organic Cation Transport Proteins; EC 2.6.1.2 / Alanine Transaminase
  • [Other-IDs] NLM/ PMC3355319
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34. |||....... 31%  Líbalová H, Uhlířová K, Kléma J, Machala M, Šrám RJ, Ciganek M, Topinka J: Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles. Part Fibre Toxicol; 2012;9:1
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  • [Title] Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles.
  • BACKGROUND: Recently, we used cell-free assays to demonstrate the toxic effects of complex mixtures of organic extracts from urban air particles (PM2.5) collected in four localities of the Czech Republic (Ostrava-Bartovice, Ostrava-Poruba, Karvina and Trebon) which differed in the extent and sources of air pollution.
  • To obtain further insight into the biological mechanisms of action of the extractable organic matter (EOM) from ambient air particles, human embryonic lung fibroblasts (HEL12469) were treated with the same four EOMs to assess changes in the genome-wide expression profiles compared to DMSO treated controls.
  • CONCLUSION: The microarray data suggested a prominent role of activation of aryl hydrocarbon receptor-dependent gene expression.
  • [MeSH-major] Air Pollutants / pharmacology. Fibroblasts / drug effects. Fibroblasts / physiology. Gene Expression / drug effects. Lung / cytology. Organic Chemicals / pharmacology. Particulate Matter / pharmacology

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  • (PMID = 22239852.001).
  • [ISSN] 1743-8977
  • [Journal-full-title] Particle and fibre toxicology
  • [ISO-abbreviation] Part Fibre Toxicol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Organic Chemicals; 0 / Particulate Matter
  • [Other-IDs] NLM/ PMC3275518
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35. |||....... 31%  Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA: The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Am J Physiol Gastrointest Liver Physiol; 2006 Mar;290(3):G476-85
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  • [Title] The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.
  • At the basolateral domain of ileal enterocytes, bile acids are extruded into portal blood by the heterodimeric organic solute transporter OSTalpha/OSTbeta.
  • We show here that human OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR).
  • [MeSH-minor] Base Sequence. Bile Acids and Salts / pharmacology. Cell Line, Tumor. Chenodeoxycholic Acid / pharmacology. Electrophoretic Mobility Shift Assay. Humans. Ileum / cytology. Isoxazoles / pharmacology. Molecular Sequence Data. Promoter Regions, Genetic. Receptors, Cytoplasmic and Nuclear. Repetitive Sequences, Nucleic Acid. Retinoid X Receptor alpha / physiology

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  • (PMID = 16269519.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / DNA-Binding Proteins; 0 / GW 4064; 0 / Isoxazoles; 0 / Membrane Transport Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Retinoid X Receptor alpha; 0 / Transcription Factors; 0 / farnesoid X-activated receptor; 0 / organic solute transporter alpha, human; 0 / organic solute transporter beta, human; 0GEI24LG0J / Chenodeoxycholic Acid
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36. |||....... 31%  Hescheler J, Pelzer D, Trube G, Trautwein W: Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane? Pflugers Arch; 1982 Jun;393(4):287-91
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  • [Title] Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane?
  • These results support the hypothesis that the organic calcium channel blocker D600 enters the cell in the uncharged lipid soluble form and reaches its receptor associated with the calcium channel from inside.
  • Because of its inability to pass the hydrophobic cell membrane, D890 is ineffective from outside but displays blocking effects on intracellular application.

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  • (PMID = 6289248.001).
  • [ISSN] 0031-6768
  • [Journal-full-title] Pflügers Archiv : European journal of physiology
  • [ISO-abbreviation] Pflugers Arch.
  • [Language] eng
  • [Publication-type] In Vitro; Journal Article
  • [Publication-country] GERMANY, WEST
  • [Chemical-registry-number] 0 / Ion Channels; 39WPC8JHR8 / Gallopamil; CJ0O37KU29 / Verapamil; SY7Q814VUP / Calcium
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37. |||....... 31%  Soroka CJ, Ballatori N, Boyer JL: Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis. Semin Liver Dis; 2010 May;30(2):178-85
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  • [Title] Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.
  • Organic solute transporter alpha-beta (OSTalpha-OSTbeta) is a unique heteromeric transporter localized to the basolateral membrane of epithelial cells involved in sterol transport.
  • OSTalpha-OSTbeta is directly regulated by the bile acid sensing nuclear receptor, farnesoid X receptor (FXR).

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  • (PMID = 20422499.001).
  • [ISSN] 1098-8971
  • [Journal-full-title] Seminars in liver disease
  • [ISO-abbreviation] Semin. Liver Dis.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK034989; United States / NIDDK NIH HHS / DK / R37 DK025636; United States / NIDDK NIH HHS / DK / R37 DK025636-35
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Membrane Transport Proteins; 0 / P-Glycoproteins; 0 / organic solute transporter alpha, human; 0 / organic solute transporter alpha, mouse; 0 / organic solute transporter beta, human; 0 / organic solute transporter beta, mouse
  • [Number-of-references] 60
  • [Other-IDs] NLM/ NIHMS483705; NLM/ PMC3713633
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38. |||....... 31%  Shang Y, Fan L, Feng J, Lv S, Wu M, Li B, Zang YS: Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: the role of quinones. Toxicol In Vitro; 2013 Mar;27(2):922-31
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  • [Title] Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: the role of quinones.
  • In present study we aimed to examine the genotoxic and inflammatory impacts of organic extracts from traffic-related PM (oTRP) in human lung epithelial A549 cells, and reveal the contributions from quinones.
  • The pro-inflammatory genes, interleukin-6 (Il-6), interleukin-8 (Il-8) and tumor necrosis factor (Tnf), and two aromatic hydrocarbon receptor-regulated genes, Cyp1a1 and 1b1, were significantly up-regulated by oTRP.
  • [MeSH-minor] Cell Line, Tumor. Cell Survival / drug effects. Comet Assay. Cytokines / genetics. DNA Damage. Epithelial Cells / drug effects. Epithelial Cells / metabolism. Humans. L-Lactate Dehydrogenase / metabolism. Lung / cytology. RNA, Messenger / metabolism. Reactive Oxygen Species / metabolism

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  • [Copyright] Copyright © 2013 Elsevier Ltd. All rights reserved.
  • (PMID = 23333790.001).
  • [ISSN] 1879-3177
  • [Journal-full-title] Toxicology in vitro : an international journal published in association with BIBRA
  • [ISO-abbreviation] Toxicol In Vitro
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Anthraquinones; 0 / Cytokines; 0 / Naphthoquinones; 0 / Particulate Matter; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0 / Vehicle Emissions; 030MS0JBDO / 9,10-anthraquinone; EC 1.1.1.27 / L-Lactate Dehydrogenase; RBF5ZU7R7K / 1,4-naphthoquinone
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39. |||....... 31%  Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL: Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology; 2010 Jan;51(1):181-90
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  • [Title] Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.
  • Organic solute transporter alpha-beta (Ostalpha-Ostbeta) is a heteromeric bile acid and sterol transporter that facilitates the enterohepatic and renal-hepatic circulation of bile acids.
  • Livers of Ostalpha(-/-) mice had higher messenger RNA levels of constitutive androstane receptor (Car) than wild-type BDL mice and increased expression of Phase I enzymes (Cyp7a1, Cyp2b10, Cyp3a11), Phase II enzymes (Sult2a1, Ugt1a1), and Phase III transporters (Mrp2, Mrp3).
  • CONCLUSION: These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine and through detoxification pathways most likely mediated by the nuclear receptor Car.

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  • (PMID = 19902485.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK 25636; United States / NIDDK NIH HHS / DK / DK067214; United States / NIDDK NIH HHS / DK / DK34989; United States / NIDDK NIH HHS / DK / P30 DK034989-25; United States / NIDDK NIH HHS / DK / R01 DK025636-31; United States / NIDDK NIH HHS / DK / R01 DK067214-05; United States / NIDDK NIH HHS / DK / R01 DK067214-07; United States / NIDDK NIH HHS / DK / R37 DK025636-33; United States / NIDDK NIH HHS / DK / R37 DK025636-35
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Membrane Transport Proteins; 0 / organic solute transporter alpha, mouse
  • [Other-IDs] NLM/ NIHMS170423; NLM/ PMC2819820
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40. |||....... 31%  Gutleb AC, Freitas J, Murk AJ, Verhaegen S, Ropstad E, Udelhoven T, Hoffmann L, Audinot JN: NanoSIMS50 - a powerful tool to elucidate cellular localization of halogenated organic compounds. Anal Bioanal Chem; 2012 Nov;404(9):2693-8
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  • [Title] NanoSIMS50 - a powerful tool to elucidate cellular localization of halogenated organic compounds.
  • Persistent organic pollutants are widely distributed in the environment and lots of toxicological data are available.
  • Of the model compounds tested, TBBPA was homogenously distributed in the cell membrane of the H295R cells while PFOS accumulated in very distinct locations in the cell membrane.
  • These differences may partly explain that observed effect concentrations for 4-OH-BDEs in in vitro experiments are usually lower than what would be expected based on receptor binding studies.
  • [MeSH-minor] Cell Line, Tumor. Humans

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  • (PMID = 22566200.001).
  • [ISSN] 1618-2650
  • [Journal-full-title] Analytical and bioanalytical chemistry
  • [ISO-abbreviation] Anal Bioanal Chem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Environmental Pollutants; 0 / Hydrocarbons, Halogenated
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41. |||....... 31%  Choi JH, Murray JW, Wolkoff AW: PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1. Am J Physiol Gastrointest Liver Physiol; 2011 Mar;300(3):G384-93
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  • [Title] PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1.
  • Although perturbation of organic anion transport protein (oatp) cell surface expression can result in drug toxicity, little is known regarding mechanisms regulating its subcellular distribution.
  • Cotransfection with a plasmid encoding PDZK1 revealed that oatp1a1(AA) was now expressed largely on the cell surface, while oatp1a1(EE) remained intracellular.
  • To examine a physiological role for phosphorylation in oatp1a1 subcellular distribution, studies were performed in rat hepatocytes exposed to extracellular ATP, a condition that stimulates serine phosphorylation of oatp1a1 via activity of a purinergic receptor.
  • Thus, although PDZK1 binding is required for optimal cell surface expression of oatp1a1, phosphorylation provides a mechanism for fast regulation of the distribution of oatp1a1 between the cell surface and intracellular vesicular pools.
  • [MeSH-major] Carrier Proteins / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Organic Anion Transporters / metabolism
  • [MeSH-minor] Adenosine Triphosphate / metabolism. Alanine. Animals. Cell Line, Tumor. Cell Membrane / metabolism. Cytoplasmic Vesicles / metabolism. Glutamic Acid. HEK293 Cells. Hepatocytes / metabolism. Humans. Mice. Mutagenesis, Site-Directed. Mutation. Phosphorylation. Protein Binding. Protein Transport. Rats. Recombinant Fusion Proteins / metabolism. Serine. Time Factors. Transfection


42. |||....... 31%  Lan T, Rao A, Haywood J, Kock ND, Dawson PA: Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism. J Hepatol; 2012 Aug;57(2):359-65
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  • [Title] Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism.
  • In contrast, blocking intestinal BA absorption by inactivating the basolateral BA transporter, organic solute transporter alpha-beta (Ostα-Ostβ) is associated with an altered homeostatic response and decreased hepatic BA synthesis.
  • The aim of this study was to determine the mechanisms underlying this phenotype, including the role of the farnesoid X receptor (FXR) and fibroblast growth factor 15 (FGF15).
  • Total ileal FGF15 expression was elevated almost 20-fold in Ostα(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression.
  • [MeSH-minor] Animals. Cholesterol / metabolism. Cholesterol 7-alpha-Hydroxylase / genetics. Intestine, Small / metabolism. Intestine, Small / pathology. Male. Mice. Mice, Inbred C57BL. RNA, Messenger / analysis. Receptors, Cytoplasmic and Nuclear / physiology

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  • [Copyright] Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 22542490.001).
  • [ISSN] 1600-0641
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK047987; United States / NIDDK NIH HHS / DK / F32 DK079576; United States / NIDDK NIH HHS / DK / F32 DK079576; United States / NIDDK NIH HHS / DK / R01 DK047987
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Membrane Transport Proteins; 0 / RNA, Messenger; 0 / Receptors, Cytoplasmic and Nuclear; 0 / farnesoid X-activated receptor; 0 / fibroblast growth factor 15, mouse; 0 / organic solute transporter alpha, mouse; 62031-54-3 / Fibroblast Growth Factors; 97C5T2UQ7J / Cholesterol; EC 1.14.13.17 / Cholesterol 7-alpha-Hydroxylase; EC 1.14.13.17 / Cyp7a1 protein, mouse
  • [Other-IDs] NLM/ NIHMS373208; NLM/ PMC3575595
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43. |||....... 31%  Chiba S, Ikawa T, Takeshita H, Kanno S, Nagai T, Takada M, Mukai T, Wempe MF: Human organic cation transporter 2 (hOCT2): Inhibitor studies using S2-hOCT2 cells. Toxicology; 2013 Aug 9;310:98-103
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  • [Title] Human organic cation transporter 2 (hOCT2): Inhibitor studies using S2-hOCT2 cells.
  • Highly expressed in kidney and located on the basolateral membrane, human organic cation transporter 2 (hOCT2) can transport various compounds (i.e. drugs and toxins) into the proximal tubular cell.
  • S2-hOCT2 cells), we sought to probe different compound classes (e.g. analgesics, anti-depressants, anti-psychotics, disinfectant, herbicides, insecticides, local anesthetic, muscarinic acetylcholine receptor antagonist, sedatives, steroid hormone, stimulants and toxins) for their ability to inhibit (14)C-TEA uptake, a prototypical OCT2 substrate.
  • [MeSH-major] Kidney Tubules, Proximal / metabolism. Organic Cation Transport Proteins / antagonists & inhibitors. Pharmaceutical Preparations
  • [MeSH-minor] Cell Culture Techniques. Cell Line. Chromatography, Liquid. Humans. Kinetics. Molecular Structure. Substrate Specificity. Tandem Mass Spectrometry. Tetraethylammonium / analysis. Tetraethylammonium / pharmacokinetics. Transfection

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  • [Copyright] Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 23770354.001).
  • [ISSN] 1879-3185
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5UL1RR025780
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Organic Cation Transport Proteins; 0 / Pharmaceutical Preparations; 0 / SLC22A2 protein, human; 66-40-0 / Tetraethylammonium
  • [Keywords] NOTNLM ; Human organic cation transporter 2 (hOCT2) / Inhibitors / Renal excretion
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44. |||....... 30%  Wang P, Wang JJ, Xiao Y, Murray JW, Novikoff PM, Angeletti RH, Orr GA, Lan D, Silver DL, Wolkoff AW: Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. J Biol Chem; 2005 Aug 26;280(34):30143-9
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  • [Title] Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface.
  • Although many organic anion transport protein (Oatp) family members have PDZ consensus binding sites at their C termini, the functional significance is unknown.
  • Oatp1a1 bound predominantly to the first and third PDZ binding domains of PDZK1, whereas the high density lipoprotein receptor, scavenger receptor B type I binds to the first domain.
  • Because its ability to transport substances into the cell requires surface expression, this must be considered in any assessment of physiologic function.
  • [MeSH-major] Hepatocytes / cytology. Membrane Proteins / metabolism. Neoplasm Proteins / metabolism. Organic Anion Transporters / metabolism
  • [MeSH-minor] Amino Acid Sequence. Animals. Cell Line. Cell Membrane / metabolism. DNA, Complementary / metabolism. Gene Expression Regulation. Humans. Immunoprecipitation. Ligands. Liver / metabolism. Mass Spectrometry. Mice. Mice, Knockout. Microscopy, Fluorescence. Molecular Sequence Data. Peptides / chemistry. Protein Binding. Protein Structure, Tertiary. Rats. Sulfobromophthalein / chemistry. Transfection

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  • (PMID = 15994332.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA06576; United States / NIDDK NIH HHS / DK / DK23026; United States / NIDDK NIH HHS / DK / DK41296; United States / NCRR NIH HHS / RR / S10 RR019352; United States / NCRR NIH HHS / RR / S10 RR019352-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Ligands; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Organic Anion Transporters; 0 / PDZK1IP1 protein, human; 0 / Pdzk1ip1 protein, mouse; 0 / Pdzk1ip1 protein, rat; 0 / Peptides; 0C2P5QKL36 / Sulfobromophthalein
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45. |||....... 30%  Luci S, Geissler S, König B, Koch A, Stangl GI, Hirche F, Eder K: PPARalpha agonists up-regulate organic cation transporters in rat liver cells. Biochem Biophys Res Commun; 2006 Nov 24;350(3):704-8
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  • [Title] PPARalpha agonists up-regulate organic cation transporters in rat liver cells.
  • In this study, we observed for the first time that treatment of rats with the peroxisome proliferator activated receptor (PPAR)-alpha agonist clofibrate increases hepatic mRNA concentrations of organic cation transporters (OCTNs)-1 and -2 which act as transporters of carnitine into the cell.
  • We conclude that PPARalpha agonists increase carnitine concentrations in livers of rats and cells by an increased uptake of carnitine into the cell but not by an increased carnitine biosynthesis.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Catecholamine Plasma Membrane Transport Proteins / metabolism. Clofibrate / administration & dosage. Hepatocytes / metabolism. Organic Cation Transport Proteins / metabolism. PPAR alpha / antagonists & inhibitors

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  • (PMID = 17011512.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Catecholamine Plasma Membrane Transport Proteins; 0 / Organic Cation Transport Proteins; 0 / PPAR alpha; 0 / Slc22a1 protein, rat; 0 / Slc22a2 protein, rat; HPN91K7FU3 / Clofibrate
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46. |||....... 30%  Ronaldson PT, Finch JD, Demarco KM, Quigley CE, Davis TP: Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier. J Pharmacol Exp Ther; 2011 Mar;336(3):827-39
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  • [Title] Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier.
  • One approach that may improve central nervous system (CNS) delivery is to target endogenous BBB transporters such as organic anion-transporting polypeptide 1a4 (Oatp1a4).
  • In addition, diclofenac prevented changes in the peripheral signaling cytokine transforming growth factor-β1 (TGF-β1) levels and brain microvascular TGF-β receptor expression induced by inflammatory pain.
  • Pretreatment with the pharmacological TGF-β receptor inhibitor 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide (SB431542) increased Oatp1a4 functional expression in λ-carrageenan-treated animals and saline controls, suggesting that TGF-β signaling is involved in Oatp1a4 regulation at the BBB.
  • [MeSH-major] Blood-Brain Barrier / metabolism. Organic Anion Transporters / physiology. Pain / metabolism. Signal Transduction / physiology

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  • (PMID = 21131267.001).
  • [ISSN] 1521-0103
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / R01 DA011271; United States / NINDS NIH HHS / NS / R01 NS042652; United States / NIDA NIH HHS / DA / R01-DA11271; United States / NINDS NIH HHS / NS / R01-NS42652
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Inflammation Mediators; 0 / Organic Anion Transporters; 0 / Slco1a4 protein, rat; 0 / Transforming Growth Factor beta1
  • [Other-IDs] NLM/ PMC3061523
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47. |||....... 30%  Yitbarek A, Echeverry H, Brady J, Hernandez-Doria J, Camelo-Jaimes G, Sharif S, Guenter W, House JD, Rodriguez-Lecompte JC: Innate immune response to yeast-derived carbohydrates in broiler chickens fed organic diets and challenged with Clostridium perfringens. Poult Sci; 2012 May;91(5):1105-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Innate immune response to yeast-derived carbohydrates in broiler chickens fed organic diets and challenged with Clostridium perfringens.
  • The effect of mannan-oligosaccharide (MOS) supplementation in organic diets of broilers challenged with C. perfringens on performance, gut morphology, and innate immunity was investigated.
  • Three hundred Ross-308 broilers were fed antibiotic-free certified organic starter and grower diets.
  • Quantitative real-time PCR showed that, in the ileum, the MOS diet resulted in an upregulation of toll-like receptor (TLR)2b, TLR4, interleukin (IL)-12p35, and interferon (IFN)-γ compared with CO (P = 0.003, P = 0.018, and P = 0.024, respectively).
  • However, MOS was capable of altering TLR and cytokine profiles, where dual TLR2 and TLR4 pathways were associated with MOS supplementation with subsequent upregulation of ileal IL-12p35 and IFN-γ, implying that MOS supplementation in C. perfringens-challenged chickens supports a proinflammatory effect via T-helper cell-1 associated pathways.
  • [MeSH-minor] Animal Feed. Animals. Body Weight. Chickens. Cytokines / genetics. Cytokines / metabolism. Gene Expression Profiling / veterinary. Gene Expression Regulation. Poultry Diseases / immunology. Toll-Like Receptors / genetics. Toll-Like Receptors / metabolism

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  • (PMID = 22499867.001).
  • [ISSN] 0032-5791
  • [Journal-full-title] Poultry science
  • [ISO-abbreviation] Poult. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbohydrates; 0 / Cytokines; 0 / Toll-Like Receptors
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48. |||....... 30%  Frankenberg T, Rao A, Chen F, Haywood J, Shneider BL, Dawson PA: Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids. Am J Physiol Gastrointest Liver Physiol; 2006 May;290(5):G912-22
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  • [Title] Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids.
  • The mechanisms responsible for bile acid regulation of mouse intestinal organic solute transporter alpha-beta (Ostalpha-Ostbeta) expression were investigated.
  • Sequence analysis revealed potential cis-acting elements for farnesoid X receptor (FXR) and liver receptor homolog-1 (LRH-1) in the mouse Ostalpha and Ostbeta promoters and reporter constructs containing Ostalpha and Ostbeta 5'-flanking sequences were positively regulated by bile acids.
  • [MeSH-minor] Animals. Cell Line, Tumor. DNA-Binding Proteins / genetics. Male. Mice. Mice, Inbred C57BL. Models, Biological. Promoter Regions, Genetic. Receptors, Cytoplasmic and Nuclear / genetics. Transcription Factors / genetics

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  • (PMID = 16357058.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK 069942; United States / NIDDK NIH HHS / DK / DK 47987; United States / NIDDK NIH HHS / DK / DK 54165; United States / NIDDK NIH HHS / DK / R01 DK047987
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / DNA-Binding Proteins; 0 / Membrane Transport Proteins; 0 / Nr5a2 protein, mouse; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Transcription Factors; 0 / farnesoid X-activated receptor; 0 / nuclear receptor subfamily 0, group B, member 2; 0 / organic solute transporter alpha, mouse; 0 / organic solute transporter beta, mouse
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49. |||....... 30%  Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y: Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos; 2005 Oct;33(10):1477-81
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  • [Title] Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans.
  • Fexofenadine hydrochloride (FEX), a second generation H(1)-receptor antagonist, is mainly eliminated from the liver into bile in unchanged form.
  • Recent studies have shown that FEX can be accepted by human MDR1 (P-glycoprotein), OATP1A2 [organic anion-transporting polypeptide (OATP)-A, and OATP2B1 (OATP-B)] expression systems.
  • [MeSH-major] Histamine H1 Antagonists / pharmacology. Organic Anion Transport Protein 1 / metabolism. Terfenadine / analogs & derivatives
  • [MeSH-minor] Cell Line. Estradiol / analogs & derivatives. Estradiol / metabolism. Estrone / analogs & derivatives. Estrone / metabolism. Humans. Liver / metabolism. Organic Anion Transport Polypeptide C / genetics. Organic Anion Transport Polypeptide C / metabolism. Sincalide / metabolism

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  • (PMID = 16014768.001).
  • [ISSN] 0090-9556
  • [Journal-full-title] Drug metabolism and disposition: the biological fate of chemicals
  • [ISO-abbreviation] Drug Metab. Dispos.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists; 0 / Organic Anion Transport Polypeptide C; 0 / Organic Anion Transport Protein 1; 138452-21-8 / fexofenadine; 1806-98-0 / estradiol-17 beta-glucuronide; 2DI9HA706A / Estrone; 4TI98Z838E / Estradiol; 7BA5G9Y06Q / Terfenadine; M03GIQ7Z6P / Sincalide; QTL48N278K / estrone sulfate
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50. |||....... 30%  Golden GA, Wyatt TA, Romberger DJ, Reiff D, McCaskill M, Bauer C, Gleason AM, Poole JA: Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences. J Biochem Mol Toxicol; 2013 Jan;27(1):77-86
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  • [Title] Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences.
  • Exposure to organic dusts elicits airway inflammatory diseases.
  • Vitamin D recently has been associated with various airway inflammatory diseases, but its role in agricultural organic dust exposures is unknown.
  • This study investigated whether vitamin D reduces organic dust-induced inflammatory outcomes in cell culture and animal models.
  • Organic dust extracts obtained from swine confinement facilities induced neutrophil chemokine production (human IL-8, murine CXCL1/CXCL2).
  • Intranasal inhalation of organic dust extract induced neutrophil influx, and CXCL1/CXCL2 release was also decreased in mice fed a relatively high vitamin D diet as compared to mice fed a low vitamin D diet.
  • These findings were associated with reduced tracheal epithelial cell PKCα and PKCε activity and whole lung TLR2 and TLR4 gene expression.
  • Collectively, vitamin D plays a role in modulating organic dust-induced airway inflammatory outcomes.
  • [MeSH-minor] Administration, Intranasal. Animals. Cell Line. Chemokine CXCL1 / metabolism. Chemokine CXCL2 / metabolism. Disease Models, Animal. Humans. Interleukin-8 / metabolism. Lung / drug effects. Male. Mice. Mice, Inbred C57BL. Monocytes / drug effects. Organic Agriculture. Protein Kinase C / metabolism. Swine. Toll-Like Receptor 2 / genetics. Toll-Like Receptor 4 / genetics

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  • [Copyright] © 2012 Wiley Periodicals, Inc.
  • (PMID = 23281135.001).
  • [ISSN] 1099-0461
  • [Journal-full-title] Journal of biochemical and molecular toxicology
  • [ISO-abbreviation] J. Biochem. Mol. Toxicol.
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1U54OH010162-01; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NIEHS NIH HHS / ES / R01: ES019325
  • [Publication-type] In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokine CXCL1; 0 / Chemokine CXCL2; 0 / Chemokines; 0 / Cxcl1 protein, mouse; 0 / Cxcl2 protein, mouse; 0 / Dust; 0 / Interleukin-8; 0 / TLR2 protein, human; 0 / TLR4 protein, human; 0 / Toll-Like Receptor 2; 0 / Toll-Like Receptor 4; 1406-16-2 / Vitamin D; EC 2.7.11.13 / Protein Kinase C
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51. |||....... 29%  Midthun KM, Taylor PG, Newby C, Chatzichristidi M, Petrou PS, Lee JK, Kakabakos SE, Baird BA, Ober CK: Orthogonal patterning of multiple biomolecules using an organic fluorinated resist and imprint lithography. Biomacromolecules; 2013 Apr 8;14(4):993-1002
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  • [Title] Orthogonal patterning of multiple biomolecules using an organic fluorinated resist and imprint lithography.
  • We further showcase this method's capacity for fabricating patterns of receptor-specific ligands for fundamental cell studies.
  • [MeSH-minor] Animals. Antibodies, Monoclonal / metabolism. Cell Line, Tumor. Hybridization, Genetic. Leukemia, Basophilic, Acute. Methacrylates / chemistry. Methacrylates / metabolism. Nanotechnology. Rats. Streptavidin / metabolism. Surface Properties

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  • (PMID = 23439033.001).
  • [ISSN] 1526-4602
  • [Journal-full-title] Biomacromolecules
  • [ISO-abbreviation] Biomacromolecules
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI018306; United States / NIAID NIH HHS / AI / R01 AI018306
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Methacrylates; 0 / Proteins; 9007-49-2 / DNA; 9013-20-1 / Streptavidin
  • [Other-IDs] NLM/ NIHMS453567; NLM/ PMC3672400
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52. |||....... 29%  Wang F, Li C, Liu W, Jin Y: Modulation of microrna expression by volatile organic compounds in mouse lung. Environ Toxicol; 2014 Jun;29(6):679-89
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  • [Title] Modulation of microrna expression by volatile organic compounds in mouse lung.
  • Volatile organic compounds (VOCs) are one of main pollutants indoors.
  • Functional annotation analysis of the predicted miRNA transcript targets revealed that VOCs exposure potentially alters signaling pathways associated with cancer, chemokine signaling, Wnt signaling, neuroactive ligand-receptor interaction, and cell adhesion molecules.

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  • [Copyright] Copyright © 2012 Wiley Periodicals, Inc.
  • (PMID = 24733833.001).
  • [ISSN] 1522-7278
  • [Journal-full-title] Environmental toxicology
  • [ISO-abbreviation] Environ. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; VOCs mixture / gene regulation / lung / miRNA / pathways
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53. |||....... 29%  Cui Z, Li P, Liu J, Liu S: [Induction of CYP1A1 expression of H4IIE cell after treated with the water organic pollutants from the Yangtze River and Jialing River]. Wei Sheng Yan Jiu; 2008 Sep;37(5):540-2
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  • [Title] [Induction of CYP1A1 expression of H4IIE cell after treated with the water organic pollutants from the Yangtze River and Jialing River].
  • OBJECTIVE: To take Cuntan (Yangtze River) and Daxigou (Jialing River) as the representative, in order to study the cytochrome P450 1A1 (CYP1A1) gene expression in H4IIE cell treated with the organic pollutants in Chongqing source water between 2004 and 2005.
  • METHODS: The organic pollutants were extracted with solid phase extraction, dissolved the organic pollutants in dimethyl sulphoxide (DMSO) .
  • The H4IIE cell was treated with the extracts.
  • The aryl hydrocarbon receptor-aryl hydrocarbon receptor nuclear translocator (AhR-ARNT) heterdimers were observed in all groups at the time of 24h.
  • [MeSH-major] Cytochrome P-450 CYP1A1 / metabolism. Liver Neoplasms / metabolism. Organic Chemicals / toxicity. Water Pollutants, Chemical / toxicity
  • [MeSH-minor] Animals. Cell Line, Tumor. China. Cities. RNA, Messenger / genetics. RNA, Messenger / metabolism. Rats. Rivers / chemistry

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  • (PMID = 19069647.001).
  • [ISSN] 1000-8020
  • [Journal-full-title] Wei sheng yan jiu = Journal of hygiene research
  • [ISO-abbreviation] Wei Sheng Yan Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / RNA, Messenger; 0 / Water Pollutants, Chemical; EC 1.14.14.1 / Cytochrome P-450 CYP1A1
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54. |||....... 29%  Stevenson RO, Taylor RM, Wiley JS, Sluyter R: The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types. Purinergic Signal; 2009 Sep;5(3):385-94
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  • [Title] The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types.
  • We previously demonstrated that canine erythrocytes express the P2X(7) receptor, and that the function and expression of this receptor is greatly increased compared with human erythrocytes.
  • Using (86)Rb(+) (K(+)) and organic cation flux measurements, we further compared P2X(7) in erythrocytes and mononuclear leukocytes from these species.
  • KN-62 inhibited the ATP-induced ethidium(+) uptake in each cell type.
  • P2X(7)-mediated uptake of organic cations was 40- and fivefold greater in canine erythrocytes and lymphocytes (T- and B-cells), respectively, compared to equivalent human cell types.
  • Thus, P2X(7) activation can induce the uptake of organic cations into canine erythrocytes and mononuclear leukocytes, but the relative levels of P2X(7) function differ to that of equivalent human cell types.

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  • (PMID = 19533417.001).
  • [ISSN] 1573-9538
  • [Journal-full-title] Purinergic signalling
  • [ISO-abbreviation] Purinergic Signal.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2717320
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55. |||....... 28%  Sauvant C, Hesse D, Holzinger H, Evans KK, Dantzler WH, Gekle M: Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells. Am J Physiol Renal Physiol; 2004 Apr;286(4):F774-83
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  • [Title] Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells.
  • We recently showed that, in a proximal tubule cell line (opossum kidney cells), epithelial growth factor (EGF) stimulates basolateral organic anion transport (OAT) via ERK1/2, arachidonic acid, phospholipase A2, and generation of prostaglandins.
  • PGE2 binds the prostanoid receptor and, thus, activates adenylate cyclase and PKA, which stimulate basolateral organic anion uptake.
  • In the present study, we investigated whether this regulatory cascade is also true 1) for ex vivo conditions in isolated renal proximal (S2) tubules from rabbit and 2) in a human renal epithelial cell line stably expressing human OAT1 (IHKE-hOAT1).
  • In S2 tubules and IHKE-hOAT1, EGF led to an increase of organic anion uptake, which again was inhibited by U-0126.
  • PGE2 stimulated basolateral organic anion uptake in rabbit S2 tubules and IHKE-hOAT1.
  • EGF- and PGE2-mediated stimulation of organic anion uptake was abolished by inhibition of PKA in rabbit S2 tubules and IHKE-hOAT1, respectively.
  • We conclude that 1) stimulation of basolateral organic anion uptake by EGF or PGE2 is a widespread (if not general) regulatory mechanism, 2) the signal transduction pathway involved seems to be general, 3) stimulation of basolateral organic anion uptake by EGF or PGE2 is also present under ex vivo conditions and, thus, is not a cell culture artifact, 4) activation of OAT1 is sufficient to explain the stimulatory effects of EGF and PGE2 in opossum kidney cells and rabbit S2 segments, and 5) stimulation of basolateral OAT1 by EGF or PGE2 is also important in humans and, thus, may have clinical implications.
  • [MeSH-major] Dinoprostone / pharmacology. Epidermal Growth Factor / pharmacology. Epithelial Cells / metabolism. Kidney Tubules, Proximal / metabolism. Organic Anion Transport Protein 1 / metabolism. Sulfonamides

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  • (PMID = 14644751.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-56224; United States / NIEHS NIH HHS / ES / ES-0492; United States / NIEHS NIH HHS / ES / ES-06694
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Isoquinolines; 0 / Organic Anion Transport Protein 1; 0 / Sulfonamides; 127243-85-0 / N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide; 62229-50-9 / Epidermal Growth Factor; EC 2.7.11.11 / Cyclic AMP-Dependent Protein Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; K7Q1JQR04M / Dinoprostone; Y79XT83BJ9 / p-Aminohippuric Acid
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56. |||....... 28%  Herranz H, Morata G, Milán M: calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. Development; 2006 Jul;133(14):2617-25
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  • [Title] calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues.
  • The insulin receptor (InR) signalling pathway controls growth and metabolism in response to nutrient availability.
  • We identified calderón, a gene that encodes a protein with highest homology with organic cation transporters of the major facilitator superfamily, as a new transcriptional target of the InR pathway.
  • These transporters are believed to function mainly in the uptake of sugars, as well as other organic metabolites.
  • Genetic experiments demonstrate that calderón is required cell autonomously and downstream of the InR pathway for normal growth and proliferation of larval tissues.
  • Our results indicate that growth of imaginal cells may be modulated by two distinct, but coordinated, nutrient-sensing mechanisms: one cell-autonomous and the other humoral.
  • [MeSH-major] Cell Proliferation. Drosophila Proteins / metabolism. Drosophila melanogaster. Organic Cation Transport Proteins / metabolism
  • [MeSH-minor] Amino Acid Sequence. Animals. Embryonic Structures / anatomy & histology. Embryonic Structures / metabolism. Humans. Insulin / metabolism. Molecular Sequence Data. Phenotype. Receptor, Insulin / metabolism. Sequence Alignment. Sequence Homology, Nucleic Acid. Signal Transduction / physiology

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  • (PMID = 16774996.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drosophila Proteins; 0 / Insulin; 0 / Organic Cation Transport Proteins; 0 / calderon protein, Drosophila; EC 2.7.10.1 / Receptor, Insulin
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57. |||....... 28%  Maeda T, Yotsumoto T, Oyabu M, Tamai I: Effect of glucocorticoid receptor ligand dexamethasone on the expression of organic cation transporter in rat liver. Drug Metab Pharmacokinet; 2008;23(1):67-72
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  • [Title] Effect of glucocorticoid receptor ligand dexamethasone on the expression of organic cation transporter in rat liver.
  • Since rat organic cation transporter 1 (Oct1, Slc22a1) is expressed mainly in the liver and mediates drug transport, its activity may determine the hepatic handling of cationic drugs.
  • Here, we studied the regulation mechanism of the expression of rat Oct1, focusing on the nuclear receptors.
  • Various nuclear receptors are considered to regulate expressions of many genes for membrane transporters and enzymes that are involved in the drug absorption and disposition.
  • Previously, we demonstrated that some ligands of nuclear receptors affected the transcriptional regulation of rat Oct1 when examined in the primary cultured rat hepatocytes.
  • In the present study, dexamethasone, a ligand of glucocorticoid receptor, down-regulated the expression of rat Oct1.
  • In conclusion, these observations suggested that the expression of rat Oct1 gene and the apparent organic cation uptake activity of rat hepatocytes are down-regulated by dexamethasone presumably via a glucocorticoid receptor.
  • [MeSH-major] Dexamethasone / metabolism. Dexamethasone / pharmacology. Liver / metabolism. Organic Cation Transporter 1 / biosynthesis. Organic Cation Transporter 1 / genetics. Receptors, Glucocorticoid / metabolism
  • [MeSH-minor] Animals. Cell Line, Tumor. Cells, Cultured. Dose-Response Relationship, Drug. Ligands. Male. Rats. Rats, Wistar

  • HSDB. structure - DEXAMETHASONE.
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  • (PMID = 18305376.001).
  • [ISSN] 1880-0920
  • [Journal-full-title] Drug metabolism and pharmacokinetics
  • [ISO-abbreviation] Drug Metab. Pharmacokinet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ligands; 0 / Organic Cation Transporter 1; 0 / Receptors, Glucocorticoid; 7S5I7G3JQL / Dexamethasone
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58. |||....... 28%  Holm JB, Grygorczyk R, Lambert IH: Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase. Am J Physiol Cell Physiol; 2013 Jul 1;305(1):C48-60
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  • [Title] Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase.
  • Pathophysiological conditions challenge cell volume homeostasis and perturb cell volume regulatory mechanisms leading to alterations of cell metabolism, active transepithelial transport, cell migration, and death.
  • We report that inhibition of the 5-lipoxygenase (5-LO) with AA861 or ETH 615-139, the cysteinyl leukotriene 1 receptor (CysLT₁) with the antiasthmatic drug Zafirlukast, or the volume-sensitive organic anion channel (VSOAC) with DIDS blocks the release of organic osmolytes (taurine, meAIB) and the concomitant cell volume restoration following hypoosmotic swelling of human type II-like lung epithelial cells (A549).
  • Reactive oxygen species (ROS) are produced in A549 cells upon hypotonic cell swelling by a diphenylene iodonium-sensitive NADPH oxidase.
  • [MeSH-minor] 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / pharmacology. Adenocarcinoma. Adenosine Triphosphate. Anti-Asthmatic Agents / pharmacology. Calcium. Cell Line, Tumor. Cell Size / drug effects. Cell Survival. Dose-Response Relationship, Drug. Electrolytes. Gene Expression Regulation, Enzymologic. Humans. Leukotriene Antagonists / pharmacology. Lipoxygenase Inhibitors / pharmacology. Lung Neoplasms. Osmolar Concentration. Osmotic Pressure / physiology. Reactive Oxygen Species / metabolism. Taurine / metabolism. Tosyl Compounds / pharmacology. Water / metabolism

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  • [CommentIn] Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C24-5 [23657572.001]
  • (PMID = 23485709.001).
  • [ISSN] 1522-1563
  • [Journal-full-title] American journal of physiology. Cell physiology
  • [ISO-abbreviation] Am. J. Physiol., Cell Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Anti-Asthmatic Agents; 0 / Electrolytes; 0 / Leukotriene Antagonists; 0 / Lipoxygenase Inhibitors; 0 / Reactive Oxygen Species; 0 / Tosyl Compounds; 059QF0KO0R / Water; 107753-78-6 / zafirlukast; 1EQV5MLY3D / Taurine; 8L70Q75FXE / Adenosine Triphosphate; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; Q1O6DSW23R / 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; SY7Q814VUP / Calcium
  • [Keywords] NOTNLM ; 5-lipoxygenase / cell volume regulation / cysteinyl leukotriene 1 receptor / hypoxia / ischemia / lung adenocarcinoma / reactive oxygen species / taurine homeostasis
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59. |||....... 28%  Ito T, Nagai H, Lin TM, Peterson RE, Tohyama C, Kobayashi T, Nohara K: Organic Chemicals Adsorbed onto Diesel Exhaust Particles Directly Alter the Differentiation of Fetal Thymocytes Through Arylhydrocarbon Receptor but Not Oxidative Stress Responses. J Immunotoxicol; 2006 Jan 1;3(1):21-30
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  • [Title] Organic Chemicals Adsorbed onto Diesel Exhaust Particles Directly Alter the Differentiation of Fetal Thymocytes Through Arylhydrocarbon Receptor but Not Oxidative Stress Responses.
  • DEP consist of a carbon core to which many organic compounds are adsorbed, including polyaromatic hydrocarbons (PAHs) and their derivatives (e.g., dioxins and quinones).
  • Although it has been suggested that these organic compounds were responsible for mediating the effects of DEP through their regulation of gene expression, the molecular mechanism of action of DEP has not been fully elucidated.
  • DEP extracts up-regulated several genes known as arylhydrocarbon receptor (AhR)-target genes, including cytochrome P450 1a1 (Cyp1a1), 1b1 (Cyp1b1), TCDD-inducible poly(ADP-ribose) polymerase (Tiparp), and scinderin (Scin).
  • Furthermore, DEP extracts skewed thymic T-cell differentiation in favor of the production of CD8 T-cells, which was also observed when exposed to AhR ligands.
  • Our results suggest that organic compounds adsorbed onto DEP alter thymic gene expression and directly affect thymocyte development by activating the AhR.

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  • (PMID = 18958682.001).
  • [ISSN] 1547-6901
  • [Journal-full-title] Journal of immunotoxicology
  • [ISO-abbreviation] J Immunotoxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. |||....... 28%  Burvall K, Palmberg L, Larsson K: Metabolic activation of A549 human airway epithelial cells by organic dust: a study based on microphysiometry. Life Sci; 2002 Jun 7;71(3):299-309
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  • [Title] Metabolic activation of A549 human airway epithelial cells by organic dust: a study based on microphysiometry.
  • A Cytosensor microphysiometer, which measures extracellular acidification rate (ECAR), was used to study the early metabolic activation by organic dust from a swine confinement building in a human airway epithelial cell line, A549.
  • Dimethyl amiloride (DMA) was used to study sodium/proton exchanger (NHE) activity in cells growing at different cell densities.
  • Pretreatment with pertussis toxin (PTX), an inhibitor of receptor/G(i alpha)-coupled signal transductions did not affect ECAR in low and medium density cells, but abolished the inhibition of ECAR in high-density cells.
  • The ECAR response to organic dust was similar to that of lipopolysaccharide (LPS) except for high-density cells where PTX did not influence the LPS-induced decrease in ECAR below baseline.
  • In summary, the organic dust induces PTX-sensitive (cAMP independent) signalling in near-confluent A549 epithelial cells and, depending on cell density opposing effects on NHE activity during exposure.

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  • (PMID = 12034348.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lipopolysaccharides; 0 / Sodium-Hydrogen Antiporter; 0 / Virulence Factors, Bordetella; 1214-79-5 / 5-dimethylamiloride; 7DZO8EB0Z3 / Amiloride; E0399OZS9N / Cyclic AMP; EC 2.4.2.31 / Pertussis Toxin; TBT296U68M / 1-Methyl-3-isobutylxanthine
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61. |||....... 28%  Höpner S, Dickhaut K, Hofstätter M, Krämer H, Rückerl D, Söderhäll JA, Gupta S, Marin-Esteban V, Kühne R, Freund C, Jung G, Falk K, Rötzschke O: Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket. J Biol Chem; 2006 Dec 15;281(50):38535-42
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  • [Title] Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.
  • Encoded by the MHC they are a family of highly polymorphic peptide receptors presenting peptide antigens for the surveillance by T cells.
  • We have shown that certain organic compounds can amplify immune responses by catalyzing the peptide loading of human class II MHC molecules HLA-DR.
  • Here we show now that they achieve this by interacting with a defined binding site of the HLA-DR peptide receptor.
  • Apparently, transient occupation of this pocket by the organic compound stabilizes the peptide-receptive conformation permitting rapid antigen loading.
  • This interaction appeared restricted to the larger Gly(beta86) pocket and allowed striking enhancements of T cell responses for antigens presented by these "adamantyl-susceptible" MHC molecules.
  • [MeSH-major] Histocompatibility Antigens Class II / immunology. Organic Chemicals / pharmacology. Polymorphism, Genetic

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  • (PMID = 17005558.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Histocompatibility Antigens Class II; 0 / Organic Chemicals; PJY633525U / Adamantane
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62. |||....... 28%  Maeda T, Oyabu M, Yotsumoto T, Higashi R, Nagata K, Yamazoe Y, Tamai I: Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats. Drug Metab Dispos; 2007 Sep;35(9):1580-6
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  • [Title] Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats.
  • Because rat organic cation transporter 1 (Oct1, SLC22a1) is expressed mainly in the liver and mediates drug transport, its activity may determine the hepatic handling of cationic drugs.
  • Here, we studied the regulation mechanism of the expression of Oct1, focusing on the nuclear receptors.
  • In vitro studies using cultured hepatocytes indicated that expression of Oct1 was up-regulated by treatment with pregnenolone-16 alpha-carbonitrile (PCN) and by overexpression of rat pregnane X receptor (PXR).
  • Thus, PXR ligands appear to regulate the expression of organic cation transporters in rats and thereby to influence the pharmacokinetic properties of cationic drugs.
  • [MeSH-major] Organic Cation Transporter 1 / metabolism. Pharmaceutical Preparations / metabolism. Receptors, Steroid / drug effects
  • [MeSH-minor] Animals. Area Under Curve. Cations / metabolism. Cell Separation. Cells, Cultured. Digoxin / metabolism. Hepatocytes / drug effects. Hepatocytes / metabolism. Kinetics. Ligands. Liver / drug effects. Liver / metabolism. Male. Pregnenolone Carbonitrile / pharmacology. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Rats. Rats, Wistar. Reverse Transcriptase Polymerase Chain Reaction. Transfection. Trichloroacetic Acid / metabolism

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  • (PMID = 17553914.001).
  • [ISSN] 0090-9556
  • [Journal-full-title] Drug metabolism and disposition: the biological fate of chemicals
  • [ISO-abbreviation] Drug Metab. Dispos.
  • [Language] eng
  • [Publication-type] In Vitro; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cations; 0 / Ligands; 0 / Organic Cation Transporter 1; 0 / Pharmaceutical Preparations; 0 / RNA, Messenger; 0 / Receptors, Steroid; 0 / pregnane X receptor; 1434-54-4 / Pregnenolone Carbonitrile; 5V2JDO056X / Trichloroacetic Acid; 73K4184T59 / Digoxin
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63. |||....... 27%  Misaki K, Suzuki M, Nakamura M, Handa H, Iida M, Kato T, Matsui S, Matsuda T: Aryl hydrocarbon receptor and estrogen receptor ligand activity of organic extracts from road dust and diesel exhaust particulates. Arch Environ Contam Toxicol; 2008 Aug;55(2):199-209
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  • [Title] Aryl hydrocarbon receptor and estrogen receptor ligand activity of organic extracts from road dust and diesel exhaust particulates.
  • A wide variety of contaminants derived from diesel and gasoline engines, tire, asphalt, and natural organic compounds is found in road dust.
  • In the present study, aryl hydrocarbon receptor (AhR) ligand activity was confirmed in the extract of both road dust and DEPs.
  • In the separation of the extracts for both road dust and DEPs with reversed-phase HPLC, it was found that polar fractions contributed to significant AhR ligand activity in both a mouse hepatoma (H1L1) cell system and a yeast system.
  • Additionally, remarkable estrogen receptor (ER) ligand activity was detected in the highly polar region separated with normal-phase HPLC.
  • [MeSH-major] Air Pollutants / analysis. Particulate Matter / analysis. Receptors, Aryl Hydrocarbon / metabolism. Receptors, Estrogen / metabolism. Vehicle Emissions / analysis

  • HSDB. structure - POLYCYCLIC AROMATIC HYDROCARBONS.
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  • (PMID = 18180859.001).
  • [ISSN] 1432-0703
  • [Journal-full-title] Archives of environmental contamination and toxicology
  • [ISO-abbreviation] Arch. Environ. Contam. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Dust; 0 / Ligands; 0 / Particulate Matter; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Receptors, Aryl Hydrocarbon; 0 / Receptors, Estrogen; 0 / Vehicle Emissions
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64. |||....... 27%  Li N, Choudhuri S, Cherrington NJ, Klaassen CD: Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4). Drug Metab Dispos; 2004 Nov;32(11):1265-71
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  • [Title] Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4).
  • Many biological effects produced by LPS are thought to be mediated by Toll-like receptor 4 (TLR4).
  • Organic anion-transporting polypeptide 4 (Oatp4; Slc21a10) mediates hepatic uptake of bile acids and other organic anions.
  • [MeSH-major] Down-Regulation / physiology. Lipopolysaccharides / pharmacology. Organic Anion Transporters, Sodium-Independent / metabolism. RNA, Messenger / metabolism
  • [MeSH-minor] Animals. Male. Membrane Glycoproteins / genetics. Membrane Glycoproteins / metabolism. Mice. Mice, Inbred C3H. Mutation. Receptors, Cell Surface / genetics. Receptors, Cell Surface / metabolism. Toll-Like Receptor 4. Toll-Like Receptors

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  • [Copyright] Copyright 2004 The American Society for Pharmacology and Experimental Therapeutics
  • (PMID = 15483194.001).
  • [ISSN] 0090-9556
  • [Journal-full-title] Drug metabolism and disposition: the biological fate of chemicals
  • [ISO-abbreviation] Drug Metab. Dispos.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES09649; United States / NIEHS NIH HHS / ES / F32 ES005883
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipopolysaccharides; 0 / Membrane Glycoproteins; 0 / Organic Anion Transporters, Sodium-Independent; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / Slco1b2 protein, mouse; 0 / Toll-Like Receptor 4; 0 / Toll-Like Receptors
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65. |||....... 27%  Poole JA, Gleason AM, Bauer C, West WW, Alexis N, Reynolds SJ, Romberger DJ, Kielian T: αβ T cells and a mixed Th1/Th17 response are important in organic dust-induced airway disease. Ann Allergy Asthma Immunol; 2012 Oct;109(4):266-273.e2
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  • [Title] αβ T cells and a mixed Th1/Th17 response are important in organic dust-induced airway disease.
  • BACKGROUND: Organic dust exposure in agricultural environments induces an inflammatory response that attenuates over time, yet repetitive dust exposures result in chronic lung diseases.
  • OBJECTIVE: Because mice repetitively exposed to organic dust extracts (DE) display increased CD3+ T cell lung infiltrates, we sought to determine the phenotype and importance of these cells.
  • T cell receptor (TCR) αβ knockouts were used to determine the functional importance of αβ-expressing T cells.
  • [MeSH-major] Dust / immunology. Receptors, Antigen, T-Cell, alpha-beta / physiology. Respiratory Hypersensitivity / immunology. Respiratory Hypersensitivity / pathology. Th1 Cells / immunology. Th1 Cells / pathology. Th17 Cells / immunology. Th17 Cells / pathology
  • [MeSH-minor] Animals. Cell Aggregation / genetics. Cell Aggregation / immunology. Lung / immunology. Lung / pathology. Mice. Mice, Inbred C57BL. Mice, Knockout. Monocytes / immunology. Monocytes / pathology. Neutrophil Infiltration / genetics. Neutrophil Infiltration / immunology

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  • [Copyright] Copyright © 2012 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Allergy Asthma Immunol. 2012 Oct;109(4):231-2 [23010226.001]
  • (PMID = 23010233.001).
  • [ISSN] 1534-4436
  • [Journal-full-title] Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • [ISO-abbreviation] Ann. Allergy Asthma Immunol.
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1R01OH008539-01; United States / NINDS NIH HHS / NS / 3R01NS040730; United States / NIOSH CDC HHS / OH / 5U50 OH008085; United States / NIEHS NIH HHS / ES / ES015522-03S1; United States / NIEHS NIH HHS / ES / K08 ES015522; United States / NIEHS NIH HHS / ES / K08 ES015522-01; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NINDS NIH HHS / NS / R01 NS040730
  • [Publication-type] Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dust; 0 / Receptors, Antigen, T-Cell, alpha-beta
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66. |||....... 27%  Muller-Suur C, Larsson K, Grunewald J: Organic dust-induced interleukin-12 production activates T- and natural killer cells. Eur Respir J; 2002 Sep;20(3):686-90
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  • [Title] Organic dust-induced interleukin-12 production activates T- and natural killer cells.
  • To further clarify the T-cell activation, the present in vitro study focused on intracellular cytokine production following exposure to organic dust from swine houses.
  • Cells were double stained for specific cell surface markers on T-cells (CD3+, CD4+, CD8+), natural killer (NK) cells (CD56+ CD16+) and monocytes (defined as CD14+ cells).
  • When antibodies that block the IL-12 receptor were added to whole blood incubated with swine dust, NK cell production of IFN-gamma was attenuated and CD69 expression on CD3+ cells decreased.

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  • (PMID = 12358348.001).
  • [ISSN] 0903-1936
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] In Vitro; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Dust; 0 / Tumor Necrosis Factor-alpha; 187348-17-0 / Interleukin-12; 207137-56-2 / Interleukin-4; 82115-62-6 / Interferon-gamma
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67. |||....... 27%  Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther; 2003 Jan;304(1):223-8
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  • [Title] Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation.
  • Rifampin, a member of the rifamycin class of antibiotics, is well known for its ability to induce drug-metabolizing enzymes and transporters, through activation of the pregnane X receptor.
  • In this study, we expressed an array of known hepatic uptake transporters to show the key hepatic rifampin uptake transporters are liver-specific members of the organic anion transporting polypeptide family (OATP).
  • In cell-based, transactivation assays, OATP-C expression was associated with increased cellular rifampin retention as well as potentiation of PXR reporter gene activity.
  • [MeSH-major] Adenosine Triphosphate / analogs & derivatives. Antibiotics, Antitubercular / pharmacology. Membrane Transport Proteins. Organic Anion Transport Polypeptide C / metabolism. Receptors, Cytoplasmic and Nuclear / drug effects. Receptors, Steroid / drug effects. Rifampin / pharmacology
  • [MeSH-minor] Animals. Carrier Proteins / metabolism. Cytochrome P-450 CYP3A. Cytochrome P-450 Enzyme System / biosynthesis. Cytochrome P-450 Enzyme System / genetics. DNA, Complementary / biosynthesis. DNA, Complementary / genetics. Estradiol / metabolism. Genes, Reporter / drug effects. Genes, Reporter / genetics. Hepatocytes / drug effects. Hepatocytes / metabolism. Humans. Kinetics. Organic Anion Transporters, Sodium-Dependent. Organic Cation Transporter 1 / metabolism. Plasmids / genetics. Rats. Symporters. Transcriptional Activation. Transfection

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  • (PMID = 12490595.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK23026; United States / NIDDK NIH HHS / DK / DK41296; United States / NIGMS NIH HHS / GM / GM31304; United States / NIGMS NIH HHS / GM / GM54724
  • [Publication-type] In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antitubercular; 0 / Carrier Proteins; 0 / DNA, Complementary; 0 / Membrane Transport Proteins; 0 / Organic Anion Transport Polypeptide C; 0 / Organic Anion Transporters, Sodium-Dependent; 0 / Organic Cation Transporter 1; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Receptors, Steroid; 0 / Symporters; 0 / pregnane X receptor; 145420-23-1 / sodium-bile acid cotransporter; 4TI98Z838E / Estradiol; 54970-91-1 / 2',3'-dialdehyde ATP; 8L70Q75FXE / Adenosine Triphosphate; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 1.14.14.1 / CYP3A protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP3A; VJT6J7R4TR / Rifampin
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68. |||....... 27%  Adson A, Burton PS, Raub TJ, Barsuhn CL, Audus KL, Ho NF: Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers. J Pharm Sci; 1995 Oct;84(10):1197-204
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  • [Title] Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers.
  • A systematic approach was used to demonstrate the quantitative interplay of pH, pKa, lipophilicity, charged and uncharged molecular species, molecular size, aqueous diffusivity, and stirring in passive transport across the aqueous boundary layer, microporous filter support, and transcellular and paracellular barriers in Caco-2 cell monolayers.
  • Adrenergic receptor antagonists including propranolol (PPL), alprenolol (APL), pindolol (PDL), and atenolol (ATL) represented the model series of structurally similar weak bases with pKa values between 8.8 and 9.65.
  • This study emphasized a generally applicable approach to quantitatively analyze passive transport data on weak organic electrolytes and neutral molecules generated using cell culture monolayers.
  • [MeSH-minor] Biological Transport. Carbon Radioisotopes. Cell Membrane Permeability. Chemistry, Physical. Diffusion. Humans. Hydrogen-Ion Concentration. Kinetics. Mathematical Computing. Physicochemical Phenomena

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  • (PMID = 8801334.001).
  • [ISSN] 0022-3549
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Carbon Radioisotopes; 0 / Electrolytes; 3XMK78S47O / Testosterone
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69. |||....... 27%  Yang YJ, Song H: [Study on BEAS-2B cell line exposure to extractable organic matter from ambient fine particles for inflammatory damages]. Wei Sheng Yan Jiu; 2006 Nov;35(6):687-9
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  • [Title] [Study on BEAS-2B cell line exposure to extractable organic matter from ambient fine particles for inflammatory damages].
  • OBJECTIVE: To ascertain the effect of extractable organic matters(EOM) of PM2.5 on inducing inflammation through observing the alteration of IL-8, IL-1p, sICAM-1 that BEAS-2B release. and study the expression of surface molecule CD25 on lymphocyte to find the role of PM2.5 in the process of immunity.
  • [MeSH-minor] Bronchi / cytology. Bronchi / metabolism. Cell Line. Dose-Response Relationship, Drug. Humans. Inflammation / pathology. Interleukin-2 Receptor alpha Subunit / biosynthesis. T-Lymphocytes / drug effects. T-Lymphocytes / metabolism

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  • (PMID = 17290741.001).
  • [ISSN] 1000-8020
  • [Journal-full-title] Wei sheng yan jiu = Journal of hygiene research
  • [ISO-abbreviation] Wei Sheng Yan Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Cytokines; 0 / Interleukin-2 Receptor alpha Subunit
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70. |||....... 27%  Meyer zu Schwabedissen HE, Tirona RG, Yip CS, Ho RH, Kim RB: Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. Cancer Res; 2008 Nov 15;68(22):9338-47
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  • [Title] Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer.
  • The ligand-activated nuclear receptor pregnane X receptor (PXR) is known to play a role in the regulated expression of drug metabolizing enzymes and transporters.
  • In this study, we show that mRNA expression of organic anion transporter polypeptide 1A2 (OATP1A2), a transporter capable of mediating the cellular uptake of estrogen metabolites, is nearly 10-fold greater in breast cancer compared with adjacent healthy breast tissues.
  • These data provide important new insights into the interplay between a xenobiotic nuclear receptor PXR and OATP1A2 that could contribute to the pathogenesis of breast cancer and may also prove to be heretofore unrecognized targets for breast cancer treatment.
  • [MeSH-major] Breast Neoplasms / etiology. Estrogens / pharmacology. Organic Anion Transporters / physiology. Receptors, Steroid / physiology
  • [MeSH-minor] Breast / chemistry. Cell Line, Tumor. Cell Proliferation. Chromatin Immunoprecipitation. Dipeptides / pharmacology. Estrone / analogs & derivatives. Estrone / pharmacology. Female. Humans. Neoplasm Staging. Promoter Regions, Genetic. Pyridines / pharmacology. RNA, Messenger / analysis. Receptors, Cytoplasmic and Nuclear / physiology. Receptors, Estrogen / physiology. Rifampin / pharmacology. Transcription Factors / physiology

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  • (PMID = 19010908.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM31304; United States / NIGMS NIH HHS / GM / GM54724; United States / NIGMS NIH HHS / GM / K08 GM081363-02; United States / NIGMS NIH HHS / GM / P01 GM031304-240022; United States / NIGMS NIH HHS / GM / R01 GM054724-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dipeptides; 0 / Estrogens; 0 / Organic Anion Transporters; 0 / Pyridines; 0 / RNA, Messenger; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Receptors, Estrogen; 0 / Receptors, Steroid; 0 / SLCO1A2 protein, human; 0 / Transcription Factors; 0 / constitutive androstane receptor; 0 / methyl 1-(5-(2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanamido)-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate; 0 / pregnane X receptor; 2DI9HA706A / Estrone; QTL48N278K / estrone sulfate; VJT6J7R4TR / Rifampin
  • [Other-IDs] NLM/ NIHMS70609; NLM/ PMC2597047
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71. |||....... 27%  Pasini P, Powar N, Gutierrez-Osuna R, Daunert S, Roda A: Use of a gas-sensor array for detecting volatile organic compounds (VOC) in chemically induced cells. Anal Bioanal Chem; 2004 Jan;378(1):76-83
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  • [Title] Use of a gas-sensor array for detecting volatile organic compounds (VOC) in chemically induced cells.
  • An array of temperature-modulated semiconductor sensors was used to characterize the headspace above a cell culture.
  • Yeast cells had the DNA sequence of the human estrogen receptor stably integrated into the genome, and contained expression plasmids carrying estrogen-responsive sequences and the reporter gene lac-Z, encoding the enzyme beta-galactosidase.
  • The sensor-response profiles showed small but noticeable discrimination between cell samples induced with 17 beta-estradiol and non-induced cell samples.
  • The sensor array was capable of detecting changes in the volatile organic compound composition of the headspace above the cultured cells, which can be associated with metabolic changes induced by a chemical compound.
  • This finding suggests the possibility of using cross-selective gas-sensor arrays for analysis of drugs or bioactive molecules through their interaction with cell systems, with the advantage of providing information on their bioavailability.
  • [MeSH-major] Biosensing Techniques / methods. Gases / analysis. Organic Chemicals / analysis. Organic Chemicals / pharmacology. Saccharomyces cerevisiae / chemistry. Saccharomyces cerevisiae / drug effects

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  • (PMID = 14615863.001).
  • [ISSN] 1618-2642
  • [Journal-full-title] Analytical and bioanalytical chemistry
  • [ISO-abbreviation] Anal Bioanal Chem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Gases; 0 / Organic Chemicals; 4TI98Z838E / Estradiol; EC 3.2.1.23 / beta-Galactosidase
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72. |||....... 27%  Golemovic M, Quintás-Cardama A, Manshouri T, Orsolic N, Duzkale H, Johansen M, Freireich EJ, Kantarjian H, Zingaro RA, Verstovsek S: MER1, a novel organic arsenic derivative, has potent PML-RARalpha-independent cytotoxic activity against leukemia cells. Invest New Drugs; 2010 Aug;28(4):402-12
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  • [Title] MER1, a novel organic arsenic derivative, has potent PML-RARalpha-independent cytotoxic activity against leukemia cells.
  • We synthesized an organic arsenic derivative (OAD), S-dimethylarsino-thiosuccinic acid (MER1), which offers a superior toxicity profile and comparable in vitro activity relative to ATO.
  • We demonstrated that MER1 induced apoptosis and dose- and time-dependent inhibition of survival and growth in a panel of myeloid leukemia cell lines.
  • At the same time, MER1 induced generation of reactive oxygen species (ROS) and cell cycle arrest in G2/M phase and proved to be more potent than ATO at inducing apoptosis.
  • ROS generation and intracellular glutathione levels were key modulators of MER1-induced cytotoxicity as evidenced by abrogation of apoptosis in myeloid leukemia cell lines pretreated with the disulfide bond-reducing agent dithiothreitol or the radical scavenger N-acetyl-L-cysteine.
  • [MeSH-minor] Animals. Apoptosis / drug effects. Caspases / drug effects. Cell Cycle / drug effects. Cell Line, Tumor. Dose-Response Relationship, Drug. Drug Screening Assays, Antitumor. Humans. Maximum Tolerated Dose. Membrane Potential, Mitochondrial / drug effects. Mice. Oxides / pharmacology. Reactive Oxygen Species / metabolism

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  • (PMID = 19468689.001).
  • [ISSN] 1573-0646
  • [Journal-full-title] Investigational new drugs
  • [ISO-abbreviation] Invest New Drugs
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Arsenicals; 0 / Oncogene Proteins, Fusion; 0 / Oxides; 0 / Reactive Oxygen Species; 0 / S-dimethylaminoarsino-thiosuccinic acid; 0 / Succinates; 0 / promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; 1327-53-3 / arsenic trioxide; EC 3.4.22.- / Caspases
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73. |||....... 27%  Knetter SM, Tuggle CK, Wannemuehler MJ, Ramer-Tait AE: Organic barn dust extract exposure impairs porcine macrophage function in vitro: implications for respiratory health. Vet Immunol Immunopathol; 2014 Jan 15;157(1-2):20-30
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  • [Title] Organic barn dust extract exposure impairs porcine macrophage function in vitro: implications for respiratory health.
  • As measures of macrophage function, we evaluated the activation of NF-κB, cytokine production, cell surface marker expression and the phagocytic and antibacterial capabilities of porcine macrophages after in vitro exposure to an organic swine barn dust extract (ODE).
  • ODE exposure also enhanced the expression of several cell surface markers of activation, including a receptor for the porcine reproductive and respiratory syndrome virus.
  • Taken together, these results demonstrate, for the first time, that organic dust extract exposure negatively affects pig macrophage activation and function, potentially enhancing host susceptibility to a variety of respiratory infections.

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  • [Copyright] Copyright © 2013 Elsevier B.V. All rights reserved.
  • (PMID = 24275039.001).
  • [ISSN] 1873-2534
  • [Journal-full-title] Veterinary immunology and immunopathology
  • [ISO-abbreviation] Vet. Immunol. Immunopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Airway inflammation / Macrophage / Organic dust extract / Pig / Respiratory disease
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74. |||....... 26%  Colton IJ, Carbeck JD, Rao J, Whitesides GM: Affinity capillary electrophoresis: a physical-organic tool for studying interactions in biomolecular recognition. Electrophoresis; 1998 Mar;19(3):367-82
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  • [Title] Affinity capillary electrophoresis: a physical-organic tool for studying interactions in biomolecular recognition.
  • Affinity capillary electrophoresis (ACE) is a technique that is used to measure the binding affinity of receptors to neutral and charged ligands.
  • ACE experiments are based on differences in the values of electrophoretic mobility of free and bound receptor.
  • Scatchard analysis of the fraction of bound receptor, at equilibrium, as a function of the concentration of free ligand yields the dissociation constant of the receptor-ligand complex.
  • ACE experiments are most conveniently performed on fused silica capillaries using a negatively charged receptor (molecular mass < 50 kDa) and increasing concentrations of a low molecular weight, charged ligand in the running buffer.
  • ACE experiments that involve high molecular weight receptors may require the use of running buffers containing zwitterionic additives to prevent the receptors from adsorbing appreciably to the wall of the capillary.
  • Dissociation constants determined from ACE experiments performed with charged receptors and ligands can often be rationalized using electrostatic arguments.
  • The combination of differently charged derivatives of proteins - protein charge ladders - and ACE is a physical-organic tool that is used to investigate electrostatic effects.
  • [MeSH-minor] Animals. Carbonic Anhydrases / chemistry. Carbonic Anhydrases / metabolism. Cattle. Dinitrobenzenes / immunology. Dinitrobenzenes / metabolism. Dipeptides / chemistry. Dipeptides / metabolism. Immunoglobulin G / chemistry. Immunoglobulin G / metabolism. Kinetics. Ligands. Molecular Weight. Rats. Receptors, Cell Surface / chemistry. Receptors, Cell Surface / metabolism. Receptors, Cytoplasmic and Nuclear / chemistry. Receptors, Cytoplasmic and Nuclear / metabolism. Static Electricity. Sulfonamides / chemistry. Sulfonamides / metabolism. Thermodynamics. Vancomycin / chemistry. Vancomycin / metabolism

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  • (PMID = 9551788.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM 30367; United States / NIGMS NIH HHS / GM / GM 51559
  • [Publication-type] In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] GERMANY
  • [Chemical-registry-number] 0 / Dinitrobenzenes; 0 / Dipeptides; 0 / Immunoglobulin G; 0 / Ligands; 0 / Receptors, Cell Surface; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Sulfonamides; 6Q205EH1VU / Vancomycin; EC 4.2.1.1 / Carbonic Anhydrases
  • [Number-of-references] 69
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75. |||....... 26%  Saborowski M, Kullak-Ublick GA, Eloranta JJ: The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha. J Pharmacol Exp Ther; 2006 May;317(2):778-85
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  • [Title] The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha.
  • The organic cation transporter-1 (OCT1) mediates the hepatocellular uptake of cationic drugs and endobiotics from sinusoidal blood.
  • By computer analysis, we identified two adjacent putative DNA-response elements for the liver-enriched homodimeric nuclear receptor hepatocyte nuclear factor-4alpha (HNF-4alpha) in the hOCT1 promoter.
  • [MeSH-major] Hepatocyte Nuclear Factor 4 / physiology. Hepatocytes / metabolism. Organic Cation Transporter 1 / genetics. Transcriptional Activation / physiology
  • [MeSH-minor] Base Sequence. Bile Acids and Salts / physiology. Cell Line, Tumor. Humans. Molecular Sequence Data. Promoter Regions, Genetic. Response Elements

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  • (PMID = 16436500.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / HNF4A protein, human; 0 / Hepatocyte Nuclear Factor 4; 0 / Organic Cation Transporter 1
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76. |||....... 26%  Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA: FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res; 2006 Jan;47(1):201-14
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  • [Title] FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.
  • Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland.
  • Several putative FXR target genes were identified, including the organic solute transporters alpha and beta (OSTalpha and OSTbeta).
  • Electromobility shift assays and promoter-reporter studies identified functional farnesoid X receptor response elements (FXREs) in the promoters of both human genes.
  • [MeSH-minor] Adrenal Glands / metabolism. Animals. Base Sequence. Bile Acids and Salts / pharmacology. Cell Line. Conserved Sequence. Female. Gene Expression Profiling. Gene Expression Regulation / drug effects. Genes, Reporter. Humans. Intestines / metabolism. Isoxazoles / pharmacology. Kidney / metabolism. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Molecular Sequence Data. Oligonucleotide Array Sequence Analysis. Promoter Regions, Genetic. RNA, Messenger / genetics. RNA, Messenger / metabolism. Receptors, Cytoplasmic and Nuclear. Transfection

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  • (PMID = 16251721.001).
  • [ISSN] 0022-2275
  • [Journal-full-title] Journal of lipid research
  • [ISO-abbreviation] J. Lipid Res.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM-07185; United States / NHLBI NIH HHS / HL / HL-30568; United States / NHLBI NIH HHS / HL / HL-68445; United States / NHLBI NIH HHS / HL / R01 HL-072367
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / DNA-Binding Proteins; 0 / GW 4064; 0 / Isoxazoles; 0 / Membrane Transport Proteins; 0 / RNA, Messenger; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Transcription Factors; 0 / farnesoid X-activated receptor; 0 / organic solute transporter alpha, human; 0 / organic solute transporter alpha, mouse; 0 / organic solute transporter beta, human; 0 / organic solute transporter beta, mouse
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77. |||....... 26%  Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, Kim RB: Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. J Biol Chem; 2005 Mar 11;280(10):9610-7
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  • [Title] Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.
  • Organic anion-transporting polypeptide 1A2 (OATP1A2) is a drug uptake transporter known for broad substrate specificity, including many drugs in clinical use.
  • In vitro functional assessment revealed that the A516C and A404T variants had markedly reduced capacity for mediating the cellular uptake of OATP1A2 substrates, estrone 3-sulfate and two delta-opioid receptor agonists, deltorphin II, and [D-penicillamine(2,5)]-enkephalin.
  • Cell surface biotinylation and immunofluorescence confocal microscopy suggested that altered plasma membrane expression of the transporter may contribute to reduced transport activity associated with the A516C, A404T, and C2003G variants.
  • [MeSH-major] Estrone / analogs & derivatives. Organic Anion Transport Polypeptide C / genetics. Polymorphism, Genetic

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  • (PMID = 15632119.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM31304; United States / NIGMS NIH HHS / GM / GM54724; United States / NCRR NIH HHS / RR / RR00095; United States / NHLBI NIH HHS / HL / U01 HL65962; United States / NIGMS NIH HHS / GM / U01GM61374
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oligopeptides; 0 / Organic Anion Transport Polypeptide C; 122752-16-3 / deltorphin II, Ala(2)-; 2DI9HA706A / Estrone; 88373-73-3 / Enkephalin, D-Penicillamine (2,5)-; QTL48N278K / estrone sulfate
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78. |||....... 26%  Pereira-Fernandes A, Dirinck E, Dirtu AC, Malarvannan G, Covaci A, Van Gaal L, Vanparys C, Jorens PG, Blust R: Expression of obesity markers and Persistent Organic Pollutants levels in adipose tissue of obese patients: reinforcing the obesogen hypothesis? PLoS One; 2014;9(1):e84816
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  • [Title] Expression of obesity markers and Persistent Organic Pollutants levels in adipose tissue of obese patients: reinforcing the obesogen hypothesis?
  • INTRODUCTION: Persistent Organic Pollutants (POPs) accumulate in adipose tissue and some are described to possess endocrine disrupting capacities.
  • OBJECTIVES: THE AIM IS TWOFOLD: (i) evaluate gene expression levels of obesity marker genes, i.e. the adipokines leptin (LEP), adiponectin (ADIPOQ) and Tumor Necrosis Factor α (TNFα) and the nuclear receptor, Peroxisome Proliferator Activated Receptor γ (PPARγ) in paired subcutaneous (SAT) and visceral (VAT) AT of obese subjects (n = 50) and to relate these values to serum concentrations of LEP and ADIPOQ (ii) evaluate the association of expression levels of marker genes in AT and serum with POP concentrations in AT.

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  • (PMID = 24427296.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3888404
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79. |||....... 25%  Fuentes-Mattei E, Rivera E, Gioda A, Sanchez-Rivera D, Roman-Velazquez FR, Jimenez-Velez BD: Use of human bronchial epithelial cells (BEAS-2B) to study immunological markers resulting from exposure to PM(2.5) organic extract from Puerto Rico. Toxicol Appl Pharmacol; 2010 Mar 15;243(3):381-9
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  • [Title] Use of human bronchial epithelial cells (BEAS-2B) to study immunological markers resulting from exposure to PM(2.5) organic extract from Puerto Rico.
  • Fine particulate air pollutants, mainly their organic fraction, have been demonstrated to be associated with cardiovascular and respiratory health problems.
  • The aim of this study was to assess, for the first time, the immunological response of human bronchial epithelial cells (BEAS-2B) to organic extracts isolated from airborne particulate matter (PM(2.5)) in Puerto Rico.
  • Organic extracts from PM(2.5) collected throughout an 8-month period (2000-2001) were pooled (composite) in order to perform chemical analysis and biological activity testing.
  • BEAS-2B cells were exposed to PM(2.5) organic extract to assess cytotoxicity, levels of cytokines and relative gene expression of MHC-II, hPXR and CYP3A5.
  • Our findings show that organic PM(2.5) consist of toxic as well as bioactive components that can regulate the secretion of cytokines in BEAS-2B, which could modulate inflammatory response in the lung.
  • Trace element analyses confirmed the presence of metals in organic extracts highlighting the relative high abundance of Cu and Zn in polar organic extracts.
  • Polar organic extracts exhibited dose-dependant toxicity and were found to significantly induce the release of interleukin 6 (IL-6), IL-1beta and IL-7 while significantly inhibiting the secretion of IL-8, G-CSF and MCP-1.
  • This research provides a new insight into the effects of PM(2.5) organic fractions on specific effectors and their possible role in the development of respiratory inflammatory diseases in Puerto Rico.
  • [MeSH-minor] Cell Line. Cytochrome P-450 CYP3A / biosynthesis. Cytokines / analysis. Environmental Monitoring. Genes, MHC Class II / drug effects. HLA-DR2 Antigen / biosynthesis. Humans. Puerto Rico. RNA, Messenger / biosynthesis. RNA, Messenger / isolation & purification. Receptors, Steroid / biosynthesis. Reverse Transcriptase Polymerase Chain Reaction. Suppression, Genetic / drug effects. Trace Elements / toxicity. Transcriptional Activation

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  • [Copyright] 2009 Elsevier Inc. All rights reserved.
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  • (PMID = 20026096.001).
  • [ISSN] 1096-0333
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / 2R25GM061838-09; United States / NIGMS NIH HHS / GM / 5R25GM061838-08; United States / NIGMS NIH HHS / GM / 5S06-GM008224; United States / NCRR NIH HHS / RR / G12RR03051; United States / NIGMS NIH HHS / GM / R25 GM061838-06; United States / NIGMS NIH HHS / GM / R25 GM061838-07; United States / NIGMS NIH HHS / GM / R25 GM061838-08; United States / NIGMS NIH HHS / GM / R25 GM061838-09; United States / NIGMS NIH HHS / GM / R25 GM061838-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Biological Markers; 0 / Cytokines; 0 / HLA-DR2 Antigen; 0 / Particulate Matter; 0 / RNA, Messenger; 0 / Receptors, Steroid; 0 / Trace Elements; 0 / pregnane X receptor; EC 1.14.14.1 / CYP3A5 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP3A
  • [Other-IDs] NLM/ NIHMS173021; NLM/ PMC2925116
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80. ||........ 24%  Ishiguro N, Maeda K, Saito A, Kishimoto W, Matsushima S, Ebner T, Roth W, Igarashi T, Sugiyama Y: Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide. Drug Metab Dispos; 2008 Apr;36(4):796-805
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  • [Title] Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide.
  • In the hepatic uptake of organic anions, organic anion transporting polypeptide (OATP) 1B1 is believed to be mainly involved.
  • Telmisartan acylglucuronide (tel-glu) is a main metabolite of telmisartan, an angiotensin II receptor antagonist.
  • Therefore, the newly established set of double transfectants expressing OATP1B3 combined with OATP1B1-expressing double transfectants can be used as a powerful tool for the rapid identification of hepatic uptake and efflux transporters of organic anions.
  • [MeSH-major] Benzimidazoles / metabolism. Benzoates / metabolism. Biliary Tract / metabolism. Gene Expression Regulation / physiology. Glucuronides / metabolism. Liver / metabolism. Organic Anion Transporters / biosynthesis. Organic Anion Transporters, Sodium-Independent / biosynthesis
  • [MeSH-minor] Animals. Biological Transport / physiology. Cell Line. Cells, Cultured. Dogs. Humans. Rats. Rats, Sprague-Dawley. Transfection / methods. Transfection / trends

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  • (PMID = 18180273.001).
  • [ISSN] 1521-009X
  • [Journal-full-title] Drug metabolism and disposition: the biological fate of chemicals
  • [ISO-abbreviation] Drug Metab. Dispos.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzimidazoles; 0 / Benzoates; 0 / Glucuronides; 0 / Organic Anion Transporters; 0 / Organic Anion Transporters, Sodium-Independent; 0 / SLCO1B1 protein, human; 0 / SLCO1B3 protein, human; U5SYW473RQ / telmisartan
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81. ||........ 24%  Wolkoff AW, Chung CT: Identification, purification, and partial characterization of an organic anion binding protein from rat liver cell plasma membrane. J Clin Invest; 1980 May;65(5):1152-61
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  • [Title] Identification, purification, and partial characterization of an organic anion binding protein from rat liver cell plasma membrane.
  • Uptake of bilirubin, sulfobromophthalein (BSP), and other organic anions by the liver is a process with kinetics consistent with carrier mediation.
  • In the search for the putative organic anion carrier or receptor, the interaction of BSP with rat liver cell plasma membrane (LPM) has been studied.
  • Although the high affinity of this LPM protein for organic anions suggests that it may function as a hepatocellular organic anion receptor, its role in transport of these compounds is unknown.
  • [MeSH-minor] Animals. Cell Membrane / metabolism. Chromatography, Affinity. Male. Photochemistry. Protein Binding. Rats. Sulfobromophthalein / metabolism

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  • (PMID = 7364942.001).
  • [ISSN] 0021-9738
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Anions; 0 / Carrier Proteins; 0 / Membrane Proteins; 0C2P5QKL36 / Sulfobromophthalein
  • [Other-IDs] NLM/ PMC371449
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82. ||........ 24%  Hodge EM, Diamond ML, McCarry BE, Stern GA, Harper PA: Sticky windows: chemical and biological characteristics of the organic film derived from particulate and gas-phase air contaminants found on an urban impervious surface. Arch Environ Contam Toxicol; 2003 May;44(4):421-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sticky windows: chemical and biological characteristics of the organic film derived from particulate and gas-phase air contaminants found on an urban impervious surface.
  • A novel environmentally derived mixture that integrates exposure to atmospherically derived gas- and particle-phase compounds in urban areas-namely, the organic film that develops as a thin layer on urban impervious surfaces-was investigated for its ability to induce gene expression via the aryl hydrocarbon receptor (AhR).
  • The organic film on window glass from 21 sites in downtown Toronto (Ontario, Canada) was found to contain a complex mixture of environmental contaminants typical of urban environments, notably PAHs, n-alkanes, PCBs, organochlorine (OC) pesticides, and polar constituents.
  • Using a stably transfected reporter cell line, we found that the crude extract of organic film induces AhR-dependent gene expression in a dose-dependent fashion.
  • Our results suggest that organic film makes up a diverse array of compounds active at the AhR and that these compounds may not interact in a strictly additive manner.
  • [MeSH-major] Air Pollutants / toxicity. Gene Expression / drug effects. Glass / chemistry. Organic Chemicals / toxicity. Receptors, Aryl Hydrocarbon / genetics

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  • (PMID = 12712271.001).
  • [ISSN] 0090-4341
  • [Journal-full-title] Archives of environmental contamination and toxicology
  • [ISO-abbreviation] Arch. Environ. Contam. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Organic Chemicals; 0 / Receptors, Aryl Hydrocarbon; EC 1.13.12.- / Luciferases
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83. ||........ 24%  Tikhonova TB, Barygin OI, Gmiro VE, Tikhonov DB, Magazanik LG: Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm. Neuropharmacology; 2008 Mar;54(4):653-64
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  • [Title] Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm.
  • The voltage-dependent block of AMPA receptor (AMPAR) channels by a series of dicationic compounds was studied on native GluR2-lacking receptors of striatal giant interneurons isolated from rat brain slices.
  • Dicationic compounds were shown to block open and closed AMPAR channels from the inside of the cell.
  • [MeSH-major] Cytoplasm / metabolism. Ion Channel Gating / physiology. Neurons / cytology. Receptors, AMPA / physiology

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  • (PMID = 18178227.001).
  • [ISSN] 0028-3908
  • [Journal-full-title] Neuropharmacology
  • [ISO-abbreviation] Neuropharmacology
  • [Language] eng
  • [Publication-type] In Vitro; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Agonists; 0 / Quaternary Ammonium Compounds; 0 / Receptors, AMPA; SIV03811UC / Kainic Acid
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84. ||........ 24%  Gregoraszczuk EL, Ptak A, Skaare JU, Mularz K, Chmielowiec A, Wojtowicz A, Ropstad E: Mechanisms of action of two different natural mixtures of persistent organic pollutants (POPs) in ovarian follicles. Xenobiotica; 2009 Jan;39(1):80-9
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  • [Title] Mechanisms of action of two different natural mixtures of persistent organic pollutants (POPs) in ovarian follicles.
  • The present work investigated the effects of two different natural mixtures on aryl hydrocarbon receptor (AhR) and oestrogen receptor (ER)beta protein levels, as well as on the activity of cytochrome P450 (CYP) 1A1 and CYP2B.
  • Media were collected and used for steroid analysis and cell viability assays.
  • [MeSH-major] Environmental Pollutants / toxicity. Estrogen Receptor beta / agonists. Halogenated Diphenyl Ethers / toxicity. Ovarian Follicle / drug effects. Polychlorinated Biphenyls / toxicity. Receptors, Aryl Hydrocarbon / agonists
  • [MeSH-minor] Animals. Cell Extracts / toxicity. Cell Survival / physiology. Cells, Cultured. Complex Mixtures / chemistry. Complex Mixtures / toxicity. Cytochrome P-450 Enzyme System / chemistry. Cytochrome P-450 Enzyme System / metabolism. Enzyme Activation. Estradiol / metabolism. Female. Gonadotropins / pharmacology. Swine

  • HSDB. structure - POLYCHLORINATED BIPHENYLS.
  • HSDB. structure - PENTABROMODIPHENYL ETHERS.
  • HSDB. structure - ESTRADIOL.
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  • (PMID = 19219750.001).
  • [ISSN] 1366-5928
  • [Journal-full-title] Xenobiotica; the fate of foreign compounds in biological systems
  • [ISO-abbreviation] Xenobiotica
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Extracts; 0 / Complex Mixtures; 0 / Environmental Pollutants; 0 / Estrogen Receptor beta; 0 / Gonadotropins; 0 / Halogenated Diphenyl Ethers; 0 / Receptors, Aryl Hydrocarbon; 32534-81-9 / pentabromodiphenyl ether; 4TI98Z838E / Estradiol; 9035-51-2 / Cytochrome P-450 Enzyme System; DFC2HB4I0K / Polychlorinated Biphenyls
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85. ||........ 24%  Lan T, Haywood J, Rao A, Dawson PA: Molecular mechanisms of altered bile acid homeostasis in organic solute transporter-alpha knockout mice. Dig Dis; 2011;29(1):18-22
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  • [Title] Molecular mechanisms of altered bile acid homeostasis in organic solute transporter-alpha knockout mice.
  • We hypothesized that the altered bile acid homeostasis resulted from ileal trapping of bile acids that act via the farnesoid X receptor (FXR) to induce overexpression of FGF15.
  • [MeSH-minor] Animals. Feces / chemistry. Gene Expression Regulation. Intestines / metabolism. Liver / metabolism. Mice. Mice, Knockout. Models, Biological. Phenotype. Receptors, Cytoplasmic and Nuclear / deficiency. Receptors, Cytoplasmic and Nuclear / metabolism

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
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  • (PMID = 21691100.001).
  • [ISSN] 1421-9875
  • [Journal-full-title] Digestive diseases (Basel, Switzerland)
  • [ISO-abbreviation] Dig Dis
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK047987; United States / NIDDK NIH HHS / DK / F32 DK079576; United States / NIDDK NIH HHS / DK / F32 DK079576; United States / NIDDK NIH HHS / DK / R01 DK047987
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Membrane Transport Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 0 / farnesoid X-activated receptor; 0 / organic solute transporter alpha, mouse
  • [Other-IDs] NLM/ PMC3202926
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86. ||........ 24%  Sobolevsky AI: Two-component blocking kinetics of open NMDA channels by organic cations. Biochim Biophys Acta; 1999 Jan 12;1416(1-2):69-91
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  • [Title] Two-component blocking kinetics of open NMDA channels by organic cations.
  • NMDA receptor channel responses were recorded from acutely isolated rat hippocampal neurons, using whole-cell patch-clamp techniques.
  • [MeSH-major] Cations / chemistry. Pyramidal Cells / metabolism. Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors

  • HSDB. structure - 9-AMINOACRIDINE HYDROCHLORIDE.
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  • (PMID = 9889324.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Cations; 0 / Quaternary Ammonium Compounds; 0 / Receptors, N-Methyl-D-Aspartate; 66-40-0 / Tetraethylammonium; 78OY3Z0P7Z / Aminacrine; CBU2X6BBJR / tetrabutylammonium
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87. ||........ 24%  Kleefstra T, Wortmann SB, Rodenburg RJ, Bongers EM, Hadzsiev K, Noordam C, van den Heuvel LP, Nillesen WM, Hollody K, Gillessen-Kaesbach G, Lammens M, Smeitink JA, van der Burgt I, Morava E: Mitochondrial dysfunction and organic aciduria in five patients carrying mutations in the Ras-MAPK pathway. Eur J Hum Genet; 2011 Feb;19(2):138-44
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  • [Title] Mitochondrial dysfunction and organic aciduria in five patients carrying mutations in the Ras-MAPK pathway.
  • [MeSH-minor] Abnormalities, Multiple / genetics. Abnormalities, Multiple / metabolism. Abnormalities, Multiple / pathology. Adolescent. Child, Preschool. Craniofacial Abnormalities / genetics. Craniofacial Abnormalities / pathology. DNA, Mitochondrial / genetics. Female. Heart Defects, Congenital / genetics. Heart Defects, Congenital / pathology. Humans. Infant. LEOPARD Syndrome / genetics. LEOPARD Syndrome / pathology. Middle Aged. Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics. Proto-Oncogene Proteins p21(ras) / genetics. Skin Abnormalities / genetics. Skin Abnormalities / pathology

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  • (PMID = 21063443.001).
  • [ISSN] 1476-5438
  • [Journal-full-title] European journal of human genetics : EJHG
  • [ISO-abbreviation] Eur. J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ PMC3025797
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88. ||........ 24%  Inglot AD, Piasecki E, Zaczyńska E, Zielińska-Jenczylik J: Seleno-organic compounds induce interferon and tumor necrosis factor in human but not in rat or mouse lymphoid cells. Arch Immunol Ther Exp (Warsz); 1992;40(2):169-73
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  • [Title] Seleno-organic compounds induce interferon and tumor necrosis factor in human but not in rat or mouse lymphoid cells.
  • The seleno-organic compounds are highly active in several anti-inflammatory assays performed in mice and rats.
  • Furthermore, ebselen and analogs are potent anti-oxidants in many animal cell cultures.
  • We have discovered that the seleno-organic compounds induce interferon gamma (IFN-gamma), IFN-alpha, tumor necrosis factor alpha (TNF-alpha) and other cytokines in human peripheral blood leukocytes (PBL).
  • We suggest that the induction of IFN by ebselen and analogs is species specific and it may depend on interaction of the drugs with a specific receptor and/or signal-transducing system present in human but not in some animal cells.

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  • [ErratumIn] Arch Immunol Ther Exp (Warsz) 1993;41(1):following 103
  • (PMID = 1284366.001).
  • [ISSN] 0004-069X
  • [Journal-full-title] Archivum immunologiae et therapiae experimentalis
  • [ISO-abbreviation] Arch. Immunol. Ther. Exp. (Warsz.)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] POLAND
  • [Chemical-registry-number] 0 / Azoles; 0 / Interferon Inducers; 0 / Mitogens; 0 / Organoselenium Compounds; 0 / Tumor Necrosis Factor-alpha; 40X2P7DPGH / ebselen; 9008-11-1 / Interferons
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89. ||........ 24%  Andrysík Z, Vondráček J, Marvanová S, Ciganek M, Neča J, Pěnčíková K, Mahadevan B, Topinka J, Baird WM, Kozubík A, Machala M: Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons. Mutat Res; 2011 Sep 1;714(1-2):53-62
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  • [Title] Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons.
  • The carcinogenic properties of PAHs in complex organic mixtures derived from PM have been chiefly attributed to their mutagenicity.
  • Nevertheless, PAHs are also potent activators of the aryl hydrocarbon receptor (AhR), which may contribute to their nongenotoxic effects, including tumor promotion.
  • In the present study, we used an organic extract of the urban dust standard reference material, SRM1649a, as a model mixture to study a range of toxic effects related to DNA damage and AhR activation.
  • Both the organic extract and its neutral aromatic fraction formed a low number of DNA adducts per nucleotide in the liver epithelial WB-F344 cells model, without inducing DNA damage response, such as tumor suppressor p53 activation and apoptosis.
  • In contrast, we found that this extract, as well as its neutral and polar fractions, were potent inducers of a range of AhR-mediated responses, including induction of the AhR-mediated transcription, such as cytochrome P450 1A1/1B1 expression, and the AhR-dependent cell proliferation.
  • [MeSH-major] DNA Damage / drug effects. Mutagens / toxicity. Organic Chemicals / toxicity. Particulate Matter / toxicity. Polycyclic Hydrocarbons, Aromatic / toxicity. Receptors, Aryl Hydrocarbon / metabolism
  • [MeSH-minor] Animals. Apoptosis / drug effects. Cell Line. Cell Proliferation / drug effects. Cytochrome P-450 CYP1A1 / metabolism. DNA Adducts / drug effects. Dose-Response Relationship, Drug. Genes, p53 / drug effects. Liver / drug effects. Rats

  • HSDB. structure - POLYCYCLIC AROMATIC HYDROCARBONS.
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  • [Copyright] Copyright © 2011 Elsevier B.V. All rights reserved.
  • (PMID = 21762708.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / P42ES016465
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Adducts; 0 / Mutagens; 0 / Organic Chemicals; 0 / Particulate Matter; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Receptors, Aryl Hydrocarbon; EC 1.14.14.1 / Cytochrome P-450 CYP1A1
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90. ||........ 24%  Xu H, Peng J, Tang HW, Li Y, Wu QS, Zhang ZL, Zhou G, Chen C, Li Y: Hadamard transform spectral microscopy for single cell imaging using organic and quantum dot fluorescent probes. Analyst; 2009 Mar;134(3):504-11
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  • [Title] Hadamard transform spectral microscopy for single cell imaging using organic and quantum dot fluorescent probes.
  • In addition, based on immunostaining with quantum dots (QDs) emitting at 550 and 610 nm to tag and trace two breast cancer biomarkers human epidermal growth factor receptor 2 (HER-2) and estrogen receptor (ER) in human breast cancer tissue with in situ dual-color fluorescence imaging, sensitive spectra and images were obtained and show that the system can be applied to visualize and quantitatively measure the subcellular proteins inside the tumor tissues, especially when a single laser line is used as the illuminating source for multi-components with different emission peaks.

  • HSDB. structure - GLYOXAL.
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  • (PMID = 19238287.001).
  • [ISSN] 1364-5528
  • [Journal-full-title] The Analyst
  • [ISO-abbreviation] Analyst
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromogenic Compounds; 0 / Fluorescent Dyes; 0 / Tumor Markers, Biological; 50NP6JJ975 / Glyoxal
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91. ||........ 24%  Bláha L, Hilscherová K, Mazurová E, Hecker M, Jones PD, Newsted JL, Bradley PW, Gracia T, Duris Z, Horká I, Holoubek I, Giesy JP: Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects. Environ Int; 2006 Aug;32(6):749-57
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects.
  • A novel bioassay with the human adrenocortical carcinoma cell line H295R can be used to screen for endocrine disrupting chemicals that affect the expression of genes important in steroidogenesis.
  • This assay was employed to study the effects of organic contaminants associated with the freshwater pond sediments collected in the Ostrava-Karvina region, Czech Republic.
  • Comparison of the results with other mechanistically based bioassays (arylhydrocarbon receptor, AhR, mediated responses in H4IIE-luc cells, and estrogen receptor mediated effects in MVLN cells) revealed significant endocrine disrupting potencies of organic contaminants present in the sediments (most likely antiestrogenicity).
  • [MeSH-minor] Cell Line, Tumor. Geologic Sediments / chemistry. Humans. Hydrocarbons, Chlorinated / analysis. Hydrocarbons, Chlorinated / toxicity. Insecticides. Polycyclic Hydrocarbons, Aromatic / analysis. Polycyclic Hydrocarbons, Aromatic / toxicity. Receptors, Aryl Hydrocarbon / metabolism. Receptors, Estrogen / metabolism

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  • (PMID = 16650473.001).
  • [ISSN] 0160-4120
  • [Journal-full-title] Environment international
  • [ISO-abbreviation] Environ Int
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Endocrine Disruptors; 0 / Hydrocarbons, Chlorinated; 0 / Insecticides; 0 / Phosphoproteins; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Receptors, Aryl Hydrocarbon; 0 / Receptors, Estrogen; 0 / Water Pollutants, Chemical; 0 / steroidogenic acute regulatory protein; EC 1.- / Oxidoreductases
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92. ||........ 24%  Asaka J, Terada T, Okuda M, Katsura T, Inui K: Androgen receptor is responsible for rat organic cation transporter 2 gene regulation but not for rOCT1 and rOCT3. Pharm Res; 2006 Apr;23(4):697-704
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Androgen receptor is responsible for rat organic cation transporter 2 gene regulation but not for rOCT1 and rOCT3.
  • PURPOSE: Organic cation transporters 1-3 (OCT1-3; Slc22a1-3) mediate the membrane transport of organic cations in the kidney.
  • METHODS: Approximately 3000-bp fragments of the rOCT1-3 promoter region were isolated, and promoter activities were measured in the renal epithelial cell line LLC-PK1 with the coexpression of rat androgen receptor.
  • [MeSH-major] Catecholamine Plasma Membrane Transport Proteins / biosynthesis. Gene Expression Regulation / physiology. Organic Cation Transport Proteins / biosynthesis. Receptors, Androgen / physiology

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  • (PMID = 16550473.001).
  • [ISSN] 0724-8741
  • [Journal-full-title] Pharmaceutical research
  • [ISO-abbreviation] Pharm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgens; 0 / Catecholamine Plasma Membrane Transport Proteins; 0 / Imidazolidines; 0 / Organic Cation Transport Proteins; 0 / Receptors, Androgen; 0 / Slc22a1 protein, rat; 0 / Slc22a2 protein, rat; 0 / solute carrier family 22 (organic cation transporter), member 3; 3XMK78S47O / Testosterone; 63612-50-0 / nilutamide; EC 1.13.12.- / Luciferases
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93. ||........ 24%  Huang YF, Liu H, Xiong X, Chen Y, Tan W: Nanoparticle-mediated IgE-receptor aggregation and signaling in RBL mast cells. J Am Chem Soc; 2009 Dec 2;131(47):17328-34
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  • [Title] Nanoparticle-mediated IgE-receptor aggregation and signaling in RBL mast cells.
  • Complex cell behaviors are usually triggered by multivalent ligands that first bind to membrane receptors and then promote receptor clustering, thus altering intracellular signal transduction.
  • Specifically, the average spacing between two binding sites within an antibody and the average distance between receptors on the cell membrane are usually larger than most organic molecules.
  • We found that both nanoparticle size and surface ligand density play key regulatory roles in the process of membrane antibody-receptor (IgE-Fc epsilonRI) binding and cross-linking, which, in turn, leads to degranulation and consequent release of chemical mediators on rat basophilic leukemia cells.
  • As such, the findings we report here may provide insight into the use of nanoparticles as a comprehensive tool for use in detailed receptor/ligand interaction studies and in the design of nanoscale delivery and therapeutic systems.
  • [MeSH-major] Mast Cells / metabolism. Nanoparticles. Receptors, IgE / metabolism
  • [MeSH-minor] Animals. Cell Line, Tumor. Rats

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  • (PMID = 19929020.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM079359-01; United States / NIGMS NIH HHS / GM / R01 GM079359-01S1; United States / NIGMS NIH HHS / GM / R01 GM079359-02; United States / NIGMS NIH HHS / GM / R01 GM079359-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, IgE
  • [Other-IDs] NLM/ NIHMS158340; NLM/ PMC2786779
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94. ||........ 24%  Xia XR, Monteiro-Riviere NA, Riviere JE: Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicol Appl Pharmacol; 2010 Jan 1;242(1):29-37
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  • [Title] Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents.
  • In vitro flow-through diffusion cell experiments were conducted in pig skin and fullerenes were not detected in the receptor solutions by 24 h.
  • The limit of detection was 0.001 microg/mL of fullerenes in 2 mL of the receptor solutions.

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  • (PMID = 19796651.001).
  • [ISSN] 1096-0333
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fullerenes; 0 / Solvents
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95. ||........ 24%  Yamashita F, Ohtani H, Koyabu N, Ushigome F, Satoh H, Murakami H, Uchiumi T, Nakamura T, Kuwano M, Tsujimoto M, Sawada Y: Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4. J Pharm Pharmacol; 2006 Nov;58(11):1499-505
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.
  • Human organic anion transporter 4 (OAT4) is the only member of the OAT family that is expressed in the placenta and also expressed in kidney.
  • Although OAT4 has been shown to transport certain organic anions as well as other members of the OAT family, fewer numbers of substrates have been identified for OAT4 compared with OAT1 and OAT3, suggesting that the substrate specificity of OAT4 is greater than other OAT members.
  • The above angiotensin II receptor antagonists and leukotriene receptor antagonists share a common structural feature, that is the tetrazole group.
  • [MeSH-major] Angiotensin II Type 1 Receptor Blockers / pharmacology. Leukotriene Antagonists / pharmacology. Organic Anion Transporters, Sodium-Independent / physiology
  • [MeSH-minor] Acetates / chemistry. Acetates / pharmacology. Benzimidazoles / chemistry. Benzimidazoles / pharmacology. Biological Transport / drug effects. Biphenyl Compounds / chemistry. Biphenyl Compounds / pharmacology. Blotting, Western. Cell Line. Chromones / chemistry. Chromones / pharmacology. Dose-Response Relationship, Drug. Estrone / analogs & derivatives. Estrone / metabolism. Estrone / pharmacokinetics. Humans. Imidazoles / chemistry. Imidazoles / pharmacology. Losartan / chemistry. Losartan / pharmacology. Molecular Structure. Quinolines / chemistry. Quinolines / pharmacology. Structure-Activity Relationship. Tetrazoles / chemistry. Tetrazoles / pharmacology. Tosyl Compounds / chemistry. Tosyl Compounds / pharmacology. Transfection. Tritium. Valine / analogs & derivatives. Valine / chemistry. Valine / pharmacology