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6. Pophof B, Stange G, Abrell L: Volatile organic compounds as signals in a plant-herbivore system: electrophysiological responses in olfactory sensilla of the moth Cactoblastis cactorum. Chem Senses; 2005 Jan;30(1):51-68
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  • [Title] Volatile organic compounds as signals in a plant-herbivore system: electrophysiological responses in olfactory sensilla of the moth Cactoblastis cactorum.
  • The male sensilla trichodea house a receptor cell responding to the putative pheromone component (9Z,12E)-tetradecadienyl acetate.
  • The sensilla trichodea of the females were much shorter than those of the males and contained specialized receptor cells responding to certain terpenoids, the most frequent being the nerolidol-sensitive cell.
  • Eight volatile organic compounds emitted by Opuntia stricta, a host plant of C. cactorum, were identified using gas chromatography-mass spectrometry, beta-caryophyllene being the major compound.
  • Five compounds identified by gas chromatography in the headspace of O. stricta elicited responses in olfactory receptor cells of C. cactorum, nonanal being the most active compound and therefore a candidate attractant of C. cactorum.
  • [MeSH-major] Moths / physiology. Organic Chemicals / analysis. Pheromones / analysis. Pheromones / physiology. Plant Oils / analysis. Receptors, Odorant / metabolism. Sense Organs / physiology

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  • [ErratumIn] Chem Senses. 2005 Mar;30(3):279
  • (PMID = 15647464.001).
  • [ISSN] 0379-864X
  • [Journal-full-title] Chemical senses
  • [ISO-abbreviation] Chem. Senses
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / Pheromones; 0 / Plant Oils; 0 / Receptors, Odorant
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7. Costa C, García-Lestón J, Costa S, Coelho P, Silva S, Pingarilho M, Valdiglesias V, Mattei F, Dall'Armi V, Bonassi S, Laffon B, Snawder J, Teixeira JP: Is organic farming safer to farmers' health? A comparison between organic and traditional farming. Toxicol Lett; 2014 Oct 15;230(2):166-76
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  • [Title] Is organic farming safer to farmers' health? A comparison between organic and traditional farming.
  • Recently, organic farming has been introduced as a consumer and environmental friendly agricultural system, although little is known about the effects on workers' health.
  • The aim of this work was to evaluate genetic damage and immunological alterations in workers of both traditional and organic farming.
  • Eighty-five farmers exposed to several pesticides, thirty-six organic farmers and sixty-one controls took part in the study.
  • Biomarkers of exposure (pyrethroids, organophosphates, carbamates, and thioethers in urine and butyrylcholinesterase activity in plasma), early effect (micronuclei in lymphocytes and reticulocytes, T-cell receptor mutation assay, chromosomal aberrations, comet assay and lymphocytes subpopulations) and susceptibility (genetic polymorphisms related to metabolism - EPHX1, GSTM1, GSTT1 and GSTP1 - and DNA repair-XRCC1 and XRCC2) were evaluated.
  • When compared to controls and organic farmers, pesticide farmers presented a significant increase of micronuclei in lymphocytes (frequency ratio, FR=2.80) and reticulocytes (FR=1.89), chromosomal aberrations (FR=2.19), DNA damage assessed by comet assay (mean ratio, MR=1.71), and a significant decrease in the proportion of B lymphocytes (MR=0.88).
  • Results were not consistent for organic farmers when compared to controls, with a 48% increase of micronuclei in lumphocytes frequency (p=0.016) contrasted by the significant decreases of TCR-Mf (p=0.001) and %T (p=0.001).
  • [MeSH-major] Occupational Exposure / adverse effects. Organic Agriculture. Pesticides / toxicity

  • MedlinePlus Health Information. consumer health - Occupational Health.
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  • [Copyright] Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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  • (PMID = 24576785.001).
  • [ISSN] 1879-3169
  • [Journal-full-title] Toxicology letters
  • [ISO-abbreviation] Toxicol. Lett.
  • [Language] eng
  • [Grant] United States / Intramural CDC HHS / / CC999999
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Pesticides; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
  • [Other-IDs] NLM/ HHSPA713526; NLM/ PMC4532340
  • [Keywords] NOTNLM ; Biomarkers / Genotoxicity / Immunotoxicity / Organic farming / Pesticides
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8. Katow H, Yaguchi S, Kyozuka K: Serotonin stimulates [Ca2+]i elevation in ciliary ectodermal cells of echinoplutei through a serotonin receptor cell network in the blastocoel. J Exp Biol; 2007 Feb;210(Pt 3):403-12
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  • [Title] Serotonin stimulates [Ca2+]i elevation in ciliary ectodermal cells of echinoplutei through a serotonin receptor cell network in the blastocoel.
  • A full-length serotonin receptor mRNA from the 5Hthpr gene was sequenced from larvae of the sea urchin, Hemicentrotus pulcherrimus.
  • Immunohistochemistry with anti-5HThpr antibodies indicated that the protein was expressed on blastocoelar cells that comprised the major blastocoelar network (serotonin receptor cell network).
  • The calcium transient propagated as a wave at about 175 microm s(-1), but was not detectable in the serotonin receptor-positive cell network.
  • In larvae treated with p-chlorophenylalanine, a potent and irreversible serotonin synthesis inhibitor, serotonin application did not stimulate [Ca(2+)](i), the serotonin receptor cell network did not develop properly, and the swimming behavior of the larvae was abnormal.
  • These results imply that serotonin secreted from the apical ganglion into the blastocoel stimulates the elevation of [Ca(2+)](i) in the larval ectodermal cells through the serotonin receptor cell network.
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Cilia / metabolism. Embryo, Nonmammalian / cytology. Embryo, Nonmammalian / drug effects. Embryo, Nonmammalian / metabolism. Fenclonine / pharmacology. Larva / drug effects. Larva / genetics. Larva / metabolism. Molecular Sequence Data. Neurites / drug effects. Neurites / metabolism. Organic Chemicals / analysis. Protein Structure, Tertiary. RNA, Messenger / chemistry. RNA, Messenger / metabolism. Sequence Analysis, DNA. Sequence Analysis, Protein. Serotonin Antagonists / pharmacology. Swimming / physiology

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  • (PMID = 17234609.001).
  • [ISSN] 0022-0949
  • [Journal-full-title] The Journal of experimental biology
  • [ISO-abbreviation] J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oregon Green BAPTA-dextran; 0 / Organic Chemicals; 0 / RNA, Messenger; 0 / Receptors, Serotonin; 0 / Serotonin Antagonists; 333DO1RDJY / Serotonin; R5J7E3L9SP / Fenclonine; SY7Q814VUP / Calcium
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9. Simon DT, Larsson KC, Nilsson D, Burström G, Galter D, Berggren M, Richter-Dahlfors A: An organic electronic biomimetic neuron enables auto-regulated neuromodulation. Biosens Bioelectron; 2015 Sep 15;71:359-64
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  • [Title] An organic electronic biomimetic neuron enables auto-regulated neuromodulation.
  • Here, we present an organic electronic biomimetic neuron, with the capacity to precisely intervene with the underlying malfunctioning signalling pathway using endogenous substances.
  • The fundamental function of neurons, defined as chemical-to-electrical-to-chemical signal transduction, is achieved by connecting enzyme-based amperometric biosensors and organic electronic ion pumps.
  • When exceeding defined threshold concentrations, biosensor output signals, connected via custom hardware/software, activated local or distant neurotransmitter delivery from the organic electronic ion pump.
  • Changes of 20 µM glutamate or acetylcholine triggered diffusive delivery of acetylcholine, which activated cells via receptor-mediated signalling.
  • This was observed in real-time by single-cell ratiometric Ca(2+) imaging.
  • The results demonstrate the potential of the organic electronic biomimetic neuron in therapies involving long-range neuronal signalling by mimicking the function of projection neurons.


10. Grung M, Lichtenthaler R, Ahel M, Tollefsen KE, Langford K, Thomas KV: Effects-directed analysis of organic toxicants in wastewater effluent from Zagreb, Croatia. Chemosphere; 2007 Feb;67(1):108-20
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  • [Title] Effects-directed analysis of organic toxicants in wastewater effluent from Zagreb, Croatia.
  • The organic toxicants present in the effluent of the main sewer of the city of Zagreb, Croatia were isolated and identified through the use of effects-directed characterisation techniques.
  • The organic load of the wastewater was isolated by solid phase extraction and toxicity profiles obtained using reverse-phase HPLC.
  • The steroid estrogens 17 beta-estradiol and estriol were identified by LC-MS/MS as estrogen receptor agonists in two of the estrogenic fractions.
  • [MeSH-minor] Animals. Cell Survival / drug effects. Cells, Cultured. Chromatography, High Pressure Liquid. Chromatography, Liquid. Croatia. Cytochrome P-450 CYP1A1 / metabolism. Environmental Monitoring / methods. Gas Chromatography-Mass Spectrometry. Mass Spectrometry. Molecular Structure. Trout / metabolism. Vitellogenins / metabolism

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  • (PMID = 17166550.001).
  • [ISSN] 0045-6535
  • [Journal-full-title] Chemosphere
  • [ISO-abbreviation] Chemosphere
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Sewage; 0 / Vitellogenins; 0 / Water Pollutants, Chemical; EC 1.14.14.1 / Cytochrome P-450 CYP1A1
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11. Anzai N, Jutabha P, Kanai Y, Endou H: Integrated physiology of proximal tubular organic anion transport. Curr Opin Nephrol Hypertens; 2005 Sep;14(5):472-9
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  • [Title] Integrated physiology of proximal tubular organic anion transport.
  • PURPOSE OF REVIEW: Renal organic anion transport proteins play important roles in the reabsorption and the secretion of endogenous and exogenous compounds.
  • RECENT FINDINGS: To date, molecular identification of organic anion transport proteins is still continuing: rodent organic anion transporter 5, organic anion-transporting polypeptide 4C1, voltage-driven organic anion transporter 1, multidrug resistance-associated protein 4, and sodium-coupled monocarboxylate transporter have yielded additional information in this field.
  • This novel aspect of renal organic anion transport, the potential modulation of signaling via dicarboxylate receptors, may be of significant relevance to renovascular hypertension and other renal diseases.
  • SUMMARY: Comprehensive understanding of the multimolecular complex, which is composed of transporters and their related signaling elements and is supported by the scaffold proteins underneath the plasma membrane, may be useful in clarifying complex transport phenomena such as renal apical organic anion handling.
  • [MeSH-minor] Animals. Carrier Proteins / metabolism. Cell Membrane / metabolism. Dicarboxylic Acids / metabolism. Humans. Ion Transport. Models, Biological. Multiprotein Complexes. Organic Anion Transporters / metabolism. Organic Cation Transport Proteins. Receptors, Cytoplasmic and Nuclear / metabolism. Signal Transduction. Sodium-Phosphate Cotransporter Proteins / metabolism

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  • (PMID = 16046907.001).
  • [ISSN] 1062-4821
  • [Journal-full-title] Current opinion in nephrology and hypertension
  • [ISO-abbreviation] Curr. Opin. Nephrol. Hypertens.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Dicarboxylic Acids; 0 / Multiprotein Complexes; 0 / Organic Anion Transporters; 0 / Organic Cation Transport Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 0 / SLC22A12 protein, human; 0 / Sodium-Phosphate Cotransporter Proteins; 0 / diazepam-binding inhibitor receptor
  • [Number-of-references] 57
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12. Liljefors T, Thelin B, Van Der Pers JN: Structure-activity relationships between stimulus molecule and response of a pheromone receptor cell in turnip moth,Agrotis segetum : Modifications of the acetate group. J Chem Ecol; 1984 Dec;10(12):1661-75
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  • [Title] Structure-activity relationships between stimulus molecule and response of a pheromone receptor cell in turnip moth,Agrotis segetum : Modifications of the acetate group.
  • The response of an antennal receptor cell of the turnip moth,Agrotis segetum, was recorded during stimulation with a series of (Z)-7-dodecenyl acetate analogs with structural variations of the acetate group.
  • The investigated receptor cell is known to be highly selective to (Z)-7-dodecenyl acetate.
  • The results indicate very strict requirements on the shape of the polar functional group, as well as on its electron distribution for a successful interaction with the antennal receptor cell.

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  • (PMID = 24318425.001).
  • [ISSN] 0098-0331
  • [Journal-full-title] Journal of chemical ecology
  • [ISO-abbreviation] J. Chem. Ecol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Balasubramanian S, Lynch JW, Barry PH: The permeation of organic cations through cAMP-gated channels in mammalian olfactory receptor neurons. J Membr Biol; 1995 Jul;146(2):177-91
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  • [Title] The permeation of organic cations through cAMP-gated channels in mammalian olfactory receptor neurons.
  • The permeation of monovalent organic cations through adenosine 3',5'-cyclic monophosphate-(cAMP) activated channels was studied by recording macroscopic currents in excised inside-out membrane patches from the dendritic knobs of isolated mammalian olfactory receptor neurons (ORNs).
  • Current-voltage relations were measured when bathing solution Na+ was replaced by monovalent organic cations.
  • Some of the small organic cations tested included ammonium (NH4+), hydroxylammonium and formamidinium, with relative permeability ratios of 1.41, 2.3 and 1.01 respectively.
  • (ii) the pore dimension must be at least 6.5 x 6.5 A, in order to allow TEA and Tris to permeate and (iii) molecular sieving must be an important mechanism for the permeation of large organic ions through the channels with specific ion binding playing a smaller role than in other structurally similar channels.
  • In addition, the results clearly indicate that cyclic nucleotide-gated (CNG) channels in different cells are not the same, the olfactory CNG channel being different from that of the photoreceptors, particularly with respect to the permeation of large organic cations, which the ORN channels allow to permeate readily.
  • [MeSH-major] Ion Channels / metabolism. Olfactory Receptor Neurons / metabolism
  • [MeSH-minor] Amidines / metabolism. Animals. Arginine / metabolism. Cations. Cell Membrane Permeability. Choline / metabolism. Cyclic AMP / metabolism. Cyclic Nucleotide-Gated Cation Channels. Electric Conductivity. Female. Methylation. Quaternary Ammonium Compounds / metabolism. Rats. Rats, Wistar. Tromethamine / metabolism


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4. Delfino RJ, Staimer N, Tjoa T, Arhami M, Polidori A, Gillen DL, Kleinman MT, Schauer JJ, Sioutas C: Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles. Environ Health Perspect; 2010 Jun;118(6):756-62
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  • [Title] Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles.
  • METHODS: Weekly biomarkers of inflammation were plasma interleukin-6 (IL-6) and soluble tumor necrosis factor-alpha receptor II (sTNF-RII) (n = 578).
  • Exposures included indoor and outdoor community organic PM0.25 constituents [polycyclic aromatic hydrocarbons (PAHs), hopanes, n-alkanes, organic acids, water-soluble organic carbon, and transition metals].
  • RESULTS: Indoor and outdoor PAHs (low-, medium-, and high-molecular-weight PAHs), followed by hopanes (vehicle emissions tracer), were positively associated with biomarkers, but other organic components and transition metals were not. sTNF-RII increased by 135 pg/mL [95% confidence interval (CI), 45-225 pg/mL], and IL-6 increased by 0.27 pg/mL (95% CI, 0.10-0.44 pg/mL) per interquartile range increase of 0.56 ng/m3 outdoor total PAHs.
  • CONCLUSIONS: Traffic emission sources of organic chemicals represented by PAHs are associated with increased systemic inflammation and explain associations with quasi-ultrafine particle mass.

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  • (PMID = 20123637.001).
  • [ISSN] 1552-9924
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES12243; United States / NCRR NIH HHS / RR / M01 RR00827
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Interleukin-6; 0 / Particulate Matter; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Receptors, Tumor Necrosis Factor, Type II; 0 / Triterpenes; 0 / Vehicle Emissions; 471-62-5 / hopane
  • [Other-IDs] NLM/ PMC2898850
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15. Aubert L, Motais R: Molecular features of organic anion permeablity in ox red blood cell. J Physiol; 1975 Mar;246(1):159-79
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  • [Title] Molecular features of organic anion permeablity in ox red blood cell.
  • 1. The penetration of organic anions into bovine red blood cells has been studied under experimental conditions where it could be distinguished from the penetration of undissociated acids which proceeds by diffusion through lipid zones of the membrane.
  • 2. Several lines of evidence suggest that the entry of organic anions cannot be ascribed to simple diffusion across aqueous channels limited by positive charges but needs a specific interaction of the penetrating anion with a component of the membrane.
  • Interaction between substrate and receptor requires at least a three point attachment involving three oxygen atoms in the substrate which react with complementary loci on the receptor to form ionic and hydrogen bonds.
  • 4. As suggested by the behaviour of the formate anion, in such a transport system any carboxylic acid could interact transiently with the receptor and therefore interfere with the transport of an organic anion even though such ionic interaction with the receptor were insufficient to produce transport of the acid itself.
  • [MeSH-major] Cell Membrane Permeability. Erythrocytes / metabolism

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  • [Cites] Eur J Biochem. 1970 May 1;14(1):120-6 [5447428.001]
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  • (PMID = 237121.001).
  • [ISSN] 0022-3751
  • [Journal-full-title] The Journal of physiology
  • [ISO-abbreviation] J. Physiol. (Lond.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Anions; 0 / Carboxylic Acids; 0 / Dicarboxylic Acids; 0 / Sulfonic Acids
  • [Other-IDs] NLM/ PMC1309408
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16. Campbell CG, Spray DC, Wolkoff AW: Extracellular ATP4- modulates organic anion transport by rat hepatocytes. J Biol Chem; 1993 Jul 25;268(21):15399-404
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  • [Title] Extracellular ATP4- modulates organic anion transport by rat hepatocytes.
  • The hepatocyte has an organic anion transport system that recognizes compounds such as bilirubin and sulfobromophthalein.
  • In this study, the influence of extracellular ATP on the hepatocyte organic anion transport mechanism has been characterized.
  • Decreased transport activity was rapidly reversible, was non-competitive with respect to ATP, did not require ATP hydrolysis, and did not correlate with P2y purinergic receptor activity.
  • Although an ATP4- receptor in macrophages mediates increased cellular permeability, reduced organic anion permeability is seen in hepatocytes.
  • This effect is not seen in the hepatoma cell line HepG2.
  • Modulation of activity of the organic anion transporter by extracellular ATP may have important pathophysiological consequences in conditions resulting in liver cell injury.

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  • (PMID = 8340370.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-23026; United States / NIDDK NIH HHS / DK / DK-41296
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Anions; 0 / Culture Media; 0C2P5QKL36 / Sulfobromophthalein; 8L70Q75FXE / Adenosine Triphosphate
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17. Anyatonwu GI, Ehrlich BE: Organic cation permeation through the channel formed by polycystin-2. J Biol Chem; 2005 Aug 19;280(33):29488-93
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  • [Title] Organic cation permeation through the channel formed by polycystin-2.
  • Polycystin-2 (PC2), a member of the transient receptor potential family of ion channels (TRPP2), forms a calcium-permeable cation channel.
  • Organic cations of increasing size were used as current carriers through the PC2 channel after PC2 was incorporated into lipid bilayers.
  • The slope conductance of the PC2 channel decreased as the ionic diameter of the organic cation increased.
  • For each organic cation tested, the currents were inhibited by gadolinium and anti-PC2 antibody.
  • [MeSH-minor] Animals. Cations / metabolism. Cell Line. Gadolinium / pharmacology. Organic Chemicals / metabolism. Permeability. Protein Conformation. Swine. TRPP Cation Channels

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  • (PMID = 15961385.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / 5F31DK062635; United States / NIGMS NIH HHS / GM / T32-GM07324
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / Cations; 0 / Membrane Proteins; 0 / Organic Chemicals; 0 / TRPP Cation Channels; 0 / polycystic kidney disease 2 protein; AU0V1LM3JT / Gadolinium
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18. Parales RE, Luu RA, Chen GY, Liu X, Wu V, Lin P, Hughes JG, Nesteryuk V, Parales JV, Ditty JL: Pseudomonas putida F1 has multiple chemoreceptors with overlapping specificity for organic acids. Microbiology; 2013 Jun;159(Pt 6):1086-96
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  • [Title] Pseudomonas putida F1 has multiple chemoreceptors with overlapping specificity for organic acids.
  • Previous studies have demonstrated that Pseudomonas putida strains are not only capable of growth on a wide range of organic substrates, but also chemotactic towards many of these compounds.
  • However, deletion of the gene encoding the P. putida F1 orthologue (locus tag Pput_4520, designated mcfS) of McpS, a known receptor for organic acids in P. putida KT2440, did not result in an obvious chemotaxis phenotype.
  • This screen resulted in the identification of a receptor, McfQ (locus tag Pput_4894), which responds to citrate and fumarate.
  • An additional receptor, McfR (locus tag Pput_0339), which detects succinate, malate and fumarate, was found by individually expressing each of the 18 genes encoding canonical MCPs from strain F1 in a KT2440 mcpS-deletion mutant.
  • Therefore, at least three receptors, McfR, McfS, and McfQ, work in concert to detect organic acids in P. putida F1.

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  • (PMID = 23618999.001).
  • [ISSN] 1465-2080
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / T32 GM007377; United States / NIGMS NIH HHS / GM / T32 GM007377
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Carboxylic Acids; 0 / Membrane Proteins; 0 / methyl-accepting chemotaxis proteins
  • [Other-IDs] NLM/ PMC4085986
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19. Tanimoto S, Takahashi D, Toshima K: Chemical methods for degradation of target proteins using designed light-activatable organic molecules. Chem Commun (Camb); 2012 Aug 11;48(62):7659-71
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  • [Title] Chemical methods for degradation of target proteins using designed light-activatable organic molecules.
  • Molecular design, chemical synthesis, and biological evaluation of several designed organic molecules, which target-selectively degrade proteins upon photo-irradiation, are introduced.
  • The designed molecules for protein photo-degradation include 2-phenylquinoline-steroid hormone hybrids and porphyrin derivatives, both of which selectively photo-degrade estrogen receptor-α, and fullerene-sugar and -sulfonic acid hybrids, which selectively photo-degrade HIV-1 protease and amyloid β, respectively.
  • [MeSH-minor] Amyloid beta-Peptides / chemistry. Animals. Cell Line. Estrogen Receptor alpha / chemistry. Fullerenes / chemistry. HIV Protease / chemistry. Humans. Monosaccharides / chemistry. Porphyrins / chemistry. Quinolines / chemistry. Rats. Steroids / chemistry. Sulfonic Acids / chemistry. Ultraviolet Rays

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  • (PMID = 22739361.001).
  • [ISSN] 1364-548X
  • [Journal-full-title] Chemical communications (Cambridge, England)
  • [ISO-abbreviation] Chem. Commun. (Camb.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2-phenylquinoline; 0 / Amyloid beta-Peptides; 0 / Estrogen Receptor alpha; 0 / Fullerenes; 0 / Monosaccharides; 0 / Photosensitizing Agents; 0 / Porphyrins; 0 / Quinolines; 0 / Steroids; 0 / Sulfonic Acids; 0 / estrogen receptor alpha, human; EC 3.4.23.- / HIV Protease; EC 3.4.23.- / p16 protease, Human immunodeficiency virus 1
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20. Myre M, Imbeault P: Persistent organic pollutants meet adipose tissue hypoxia: does cross-talk contribute to inflammation during obesity? Obes Rev; 2014 Jan;15(1):19-28
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  • [Title] Persistent organic pollutants meet adipose tissue hypoxia: does cross-talk contribute to inflammation during obesity?
  • Lipophilic persistent organic pollutants (POPs) accumulate in lipid-rich tissues such as human adipose tissue.
  • The aryl hydrocarbon receptor (AhR) mediates the cellular response to some pollutants, while hypoxia responses occur through the oxygen-sensitive transcription factor hypoxia-inducible factor (HIF)-1.
  • [MeSH-major] Adipose Tissue / metabolism. Cell Hypoxia / immunology. Environmental Pollutants / metabolism. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Inflammation Mediators / metabolism. Obesity / metabolism. Polychlorinated Biphenyls / metabolism. Receptors, Aryl Hydrocarbon / metabolism
  • [MeSH-minor] Adiposity. Animals. Female. Humans. Inflammation / immunology. Male. Rats. Receptor Cross-Talk / immunology. Signal Transduction

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  • [Copyright] © 2013 The Authors. obesity reviews © 2013 International Association for the Study of Obesity.
  • (PMID = 23998203.001).
  • [ISSN] 1467-789X
  • [Journal-full-title] Obesity reviews : an official journal of the International Association for the Study of Obesity
  • [ISO-abbreviation] Obes Rev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Environmental Pollutants; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Inflammation Mediators; 0 / Receptors, Aryl Hydrocarbon; DFC2HB4I0K / Polychlorinated Biphenyls
  • [Keywords] NOTNLM ; Aryl hydrocarbon receptor / hypoxia-inducible factor / oxygen deficit / xenobiotics
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21. Burckhardt G: Drug transport by Organic Anion Transporters (OATs). Pharmacol Ther; 2012 Oct;136(1):106-30
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  • [Title] Drug transport by Organic Anion Transporters (OATs).
  • Common to all so far functionally characterized Organic Anion Transporters (OATs) is their broad substrate specificity and their ability to exchange extracellular against intracellular organic anions.
  • In human kidneys, OAT1, OAT2, and OAT3 are localized in the basolateral membrane, and OAT4, OAT10, and URAT1 in the apical cell membrane of proximal tubule cells, respectively.
  • Several classes of drugs interact with human OAT1-3, including ACE inhibitors, angiotensin II receptor antagonists, diuretics, HMG CoA reductase inhibitors, β-lactam antibiotics, antineoplastic and antiviral drugs, and uricosuric drugs.
  • [MeSH-major] Organic Anion Transporters / physiology. Pharmaceutical Preparations / metabolism

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22841915.001).
  • [ISSN] 1879-016X
  • [Journal-full-title] Pharmacology & therapeutics
  • [ISO-abbreviation] Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Anion Transporters; 0 / Pharmaceutical Preparations
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22. Obara S: Effects of some organic cations on generator potential of crayfish stretch receptor. J Gen Physiol; 1968 Aug;52(2):363-86
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  • [Title] Effects of some organic cations on generator potential of crayfish stretch receptor.
  • The generator potential of both slowly and rapidly adapting crayfish stretch receptor cells can still be elicited by mechanical stimuli when all the Na of the bathing medium is replaced by various organic cations.
  • In the presence of tris(hydroxymethyl)aminomethane (Tris), the generator potential is particularly large, about 30-50 % of that in the control saline, while spike electrogenesis of the cell is abolished.
  • Thus, whereas the electrogenesis of the generator membrane must be due to an increased permeability to monovalent cations, the active receptor membrane appears to be less selective for different monovalent cations than is the receptor component of some other cells, or the conductile component of the stretch receptor neuron.
  • [MeSH-major] Sensory Receptor Cells / drug effects. Tromethamine / pharmacology
  • [MeSH-minor] Acetates / pharmacology. Amidines / pharmacology. Aminobutyrates / pharmacology. Animals. Calcium / pharmacology. Cell Membrane Permeability. Chlorides / pharmacology. Choline / pharmacology. Crustacea. Electrophysiology. Guanidines / pharmacology. Hydrazines / pharmacology. In Vitro Techniques. Quaternary Ammonium Compounds / pharmacology. Sucrose / pharmacology. Sulfonic Acids / pharmacology. Tetraethylammonium Compounds / pharmacology


23. Zhao X, Yang H, Yamoah EN, Lundberg YW: Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrix. Dev Biol; 2007 Apr 15;304(2):508-24
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  • [Title] Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrix.
  • A critical part of the functional development of our peripheral balance system is the embryonic formation of otoconia, composite crystals that overlie and provide optimal stimulus input to the sensory epithelium of the gravity receptor in the inner ear.
  • Using gene targeting and protein analysis strategies, we demonstrate that the predominant mammalian otoconin, otoconin-90/95 (Oc90), is essential for formation of the organic matrix of otoconia by specifically recruiting other matrix components, which includes otolin, a novel mammalian otoconin that we identified to be in wildtype murine otoconia.
  • During otoconia development, the organic matrix forms prior to CaCO3 deposition and provides optimal calcification efficiency.

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  • (PMID = 17300776.001).
  • [ISSN] 0012-1606
  • [Journal-full-title] Developmental biology
  • [ISO-abbreviation] Dev. Biol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 1P20RR018788-01; United States / NCRR NIH HHS / RR / P20 RR018788; United States / NCRR NIH HHS / RR / P20 RR018788-030004
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Extracellular Matrix Proteins; 0 / Oc90 protein, mouse
  • [Other-IDs] NLM/ NIHMS21769; NLM/ PMC1950278
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24. Huber RD, Gao B, Sidler Pfändler MA, Zhang-Fu W, Leuthold S, Hagenbuch B, Folkers G, Meier PJ, Stieger B: Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am J Physiol Cell Physiol; 2007 Feb;292(2):C795-806
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  • [Title] Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.
  • In the present study we isolated two splice variants of organic anion transporting polypeptide 3A1 (OATP3A1_v1 and OATP3A1_v2) from human brain.
  • Immunolocalization of OATP3A1_v2 included Sertoli cells in testis, apical and/or subapical membranes in choroid plexus epithelial cells, and neurons (cell bodies and axons) of the gray and white matter of human frontal cortex.
  • Transported substrates include prostaglandin (PG)E(1) and PGE(2), thyroxine, and the cyclic oligopeptides BQ-123 (endothelin receptor antagonist) and vasopressin.
  • [MeSH-major] Alternative Splicing. Brain / metabolism. Organic Anion Transporters / physiology
  • [MeSH-minor] Alprostadil / metabolism. Amino Acid Sequence. Animals. CHO Cells. Cricetinae. Cricetulus. Dinoprostone / metabolism. Endothelin Receptor Antagonists. Humans. Molecular Sequence Data. Organ Specificity. Rats. Vasopressins / metabolism. Xenopus laevis

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  • (PMID = 16971491.001).
  • [ISSN] 0363-6143
  • [Journal-full-title] American journal of physiology. Cell physiology
  • [ISO-abbreviation] Am. J. Physiol., Cell Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Endothelin Receptor Antagonists; 0 / Organic Anion Transporters; 0 / SLCO3A1 protein, human; 11000-17-2 / Vasopressins; F5TD010360 / Alprostadil; K7Q1JQR04M / Dinoprostone
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25. Cheng X, Quintás-Cardama A, Golemovic M, Zingaro R, Gao MZ, Freireich EJ, Andreeff M, Kantarjian HM, Verstovsek S: The organic arsenic derivative GMZ27 induces PML-RARα-independent apoptosis in myeloid leukemia cells. Anticancer Res; 2012 Jul;32(7):2871-80
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  • [Title] The organic arsenic derivative GMZ27 induces PML-RARα-independent apoptosis in myeloid leukemia cells.
  • However, organic arsenic derivatives (OAD) have a more favorable toxicity profile than ATO.
  • GMZ27 had potent antiproliferative activity against human acute myeloid leukemia (AML) cell lines that was higher than that of ATO.
  • In contrast to ATO, GMZ27 only marginally induced maturation of leukemia cells and had no effect on the cell cycle.
  • [MeSH-minor] Animals. Caspase 9 / metabolism. Cell Cycle / drug effects. Cell Growth Processes / drug effects. Cell Line, Tumor. Dose-Response Relationship, Drug. Enzyme Activation / drug effects. Female. HL-60 Cells. Humans. Mice. Oxides / pharmacology. Oxygen / metabolism

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  • (PMID = 22753750.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Arsenicals; 0 / Oncogene Proteins, Fusion; 0 / Oxides; 0 / promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; EC 3.4.22.- / Caspase 9; S7V92P67HO / arsenic trioxide; S88TT14065 / Oxygen
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26. Schaffner CA, Mwinyi J, Gai Z, Thasler WE, Eloranta JJ, Kullak-Ublick GA: The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes. Liver Int; 2015 Apr;35(4):1152-61
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  • [Title] The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes.
  • BACKGROUND & AIMS: The organic solute transporters alpha and beta (OSTα-OSTβ) form a heterodimeric transporter located at the basolateral membrane of intestinal epithelial cells and hepatocytes.
  • [MeSH-minor] Animals. Binding Sites. Cell Hypoxia. Cell Line. Chenodeoxycholic Acid / pharmacology. Disease Models, Animal. Humans. Hypoxia-Inducible Factor 1, alpha Subunit / genetics. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Kidney Failure, Chronic / metabolism. RNA Interference. Rats, Sprague-Dawley. Receptors, Cytoplasmic and Nuclear / genetics. Receptors, Cytoplasmic and Nuclear / metabolism. Response Elements. Transfection. Up-Regulation

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  • [Copyright] © 2014 The Authors. Liver International Published by John Wiley & Sons Ltd.
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  • (PMID = 24703425.001).
  • [ISSN] 1478-3231
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Membrane Transport Proteins; 0 / Ostalpha protein, rat; 0 / Ostbeta protein, rat; 0 / Receptors, Cytoplasmic and Nuclear; 0 / farnesoid X-activated receptor; 0 / organic solute transporter alpha, human; 0 / organic solute transporter beta, human; 0GEI24LG0J / Chenodeoxycholic Acid
  • [Other-IDs] NLM/ PMC4407926
  • [Keywords] NOTNLM ; bile acid transport / chronic renal failure / gene regulation / ligand / nephrectomy / nuclear receptor / organic anion transport / rat liver
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27. Yang XH, Liu SY, Xing AY: Molecular regulation of organic anion transporting polypeptide 1A2 (OATP1A2)by taurocholic acid in Bewo Cells. Cell Mol Biol (Noisy-le-grand); 2014;60(2):22-6
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  • [Title] Molecular regulation of organic anion transporting polypeptide 1A2 (OATP1A2)by taurocholic acid in Bewo Cells.
  • To characterize the mechanisms of action of taurocholic acid(TCA) and farnesoid X receptor(FXR) on organic anion transporting polypeptide 1A2(OATP1A2) expression in placental Bewo cell line.
  • TCA is one of the regulation factors for OATP1A2 in the Bewo cell line.
  • Farnesoid X receptor may act in synergy with TCA to increase the expression of OATP1A2.
  • [MeSH-major] Organic Anion Transporters / metabolism. Taurocholic Acid / chemistry
  • [MeSH-minor] Cell Line. Detergents / chemistry. Detergents / pharmacology. Gene Expression / drug effects. Humans. RNA, Messenger / metabolism. Receptors, Cytoplasmic and Nuclear / genetics. Receptors, Cytoplasmic and Nuclear / metabolism

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  • (PMID = 24970118.001).
  • [ISSN] 1165-158X
  • [Journal-full-title] Cellular and molecular biology (Noisy-le-Grand, France)
  • [ISO-abbreviation] Cell. Mol. Biol. (Noisy-le-grand)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Detergents; 0 / Organic Anion Transporters; 0 / RNA, Messenger; 0 / Receptors, Cytoplasmic and Nuclear; 0 / SLCO1A2 protein, human; 0 / farnesoid X-activated receptor; 5E090O0G3Z / Taurocholic Acid
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28. Sears ML: Regulation of aqueous flow by the adenylate cyclase receptor complex in the ciliary epithelium. Am J Ophthalmol; 1985 Jul 15;100(1):194-8
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  • [Title] Regulation of aqueous flow by the adenylate cyclase receptor complex in the ciliary epithelium.
  • The answer to how the beta-adrenergic receptor mediates a fall in intraocular pressure has been elusive.
  • On a molecular basis, stimulation of the beta-adrenergic receptor activates intracellular adenylate cyclase to produce increased cyclic adenosine monophosphate.
  • Acting by different cell-receptor mechanisms, but nonetheless potent, nonadrenergic stimulators of adenylate cyclase in the ciliary epithelium, such as cholera toxin and organic fluorides, have been studied in experimental animals.
  • [MeSH-minor] ADP-Ribosylation Factors. Adenylyl Cyclases / physiology. Adult. Aged. Anterior Chamber / metabolism. Cell Membrane Permeability. Colforsin. Cyclic AMP / biosynthesis. Epithelium / metabolism. Humans. Middle Aged. Receptors, Adrenergic, beta / physiology. Timolol / pharmacology

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  • (PMID = 2990214.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY-00237; United States / NEI NIH HHS / EY / EY-00785
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Diterpenes; 0 / Membrane Proteins; 0 / Receptors, Adrenergic, beta; 1F7A44V6OU / Colforsin; 817W3C6175 / Timolol; E0399OZS9N / Cyclic AMP; EC 3.6.5.2 / ADP-Ribosylation Factors; EC 4.6.1.1 / Adenylyl Cyclases
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29. Zhang Y, Csanaky IL, Selwyn FP, Lehman-McKeeman LD, Klaassen CD: Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Biochem Pharmacol; 2013 Aug 1;86(3):437-45
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  • [Title] Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism.
  • Organic anion transporting polypeptides (human: OATPs; rodent: Oatps) were thought to have important functions in bile acid (BA) transport.
  • [MeSH-major] Bile Acids and Salts / metabolism. Organic Cation Transport Proteins / metabolism

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  • [Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.
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  • (PMID = 23747753.001).
  • [ISSN] 1873-2968
  • [Journal-full-title] Biochemical pharmacology
  • [ISO-abbreviation] Biochem. Pharmacol.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES-019487; United States / NIEHS NIH HHS / ES / ES009649; United States / NIEHS NIH HHS / ES / R01 ES009649; United States / NIEHS NIH HHS / ES / R01 ES019487
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Oatp2 protein, mouse; 0 / Organic Cation Transport Proteins
  • [Other-IDs] NLM/ NIHMS501152; NLM/ PMC3774164
  • [Keywords] NOTNLM ; 7-oxo-deoxycholic acid / 7-oxoDCA / ATP-binding cassette transporter a1 / Abca1 / BA / Bile acid / Bsep / CA / CDCA / Cyp / DCA / Fxr / Gapdh / HDCA / IS / LCA / Liver / MCA / MDCA / Mrp / Ntcp / Oatp/OATP / Oatp1a4 / Ost / Rpl13a / Secondary bile acid / Shp / T-12-epiDCA / TCA / UDCA / UPLC / WT / bile acid / bile salt-export pump / chenodeoxycholic acid / cholic acid / cytochrome P450 / deoxycholic acid / farnesoid X receptor / glyceraldehyde 3-phosphate dehydrogenase / hyodeoxycholic acid / internal standard / lithocholic acid / multidrug resistance-associated protein / muricholic acid / murideoxycholic acid / organic anion transporting polypeptide / organic solute transporter / ribosomal protein L13a / small heterodimer partner / sodium taurocholate cotransporting polypeptide / tauro-12-epi deoxycholic acid / tauro-cholic acid / ultra performance liquid chromatography / ursodeoxycholic acid / wild type
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30. Ma L, Lu L, Zhu M, Wang Q, Gao F, Yuan C, Wu Y, Xing S, Fu X, Mei Y, Gao X: Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases. J Inorg Biochem; 2011 Sep;105(9):1138-47
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  • [Title] Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases.
  • Three dinuclear copper complexes of organic claw ligands (2,2',2″,2'''-(5-R-2-hydroxy-1,3-phenylene)bis(methylene)bis(azanetriyl)tetraacetic acid, R=methyl (H(5)L1), chloro (H(5)L2) and bromo (H(5)L3)): [Cu(2)NaL1(H(2)O)(2)] (1), [Cu(2)HL2(H(2)O)(2)] (2), [Cu(2)NaL3(H(2)O)(2)] (3), have been synthesized and characterized by elemental analyses, infrared spectra, thermo-gravimetric analyses, X-ray diffraction analysis, electrospray ionization mass spectra, pH-potentiometric titration, molar conductivity.
  • Their inhibitory effects against human protein tyrosine phosphatase 1B (PTP1B), T cell protein tyrosine phosphatase (TCPTP), Megakaryocyte protein tyrosinephosphatase 2 (PTP-MEG2), srchomology phosphatase 1 (SHP-1) and srchomology phosphatase 2 (SHP-2) are evaluated in vitro.
  • [MeSH-major] Acids, Heterocyclic / pharmacology. Chelating Agents / pharmacology. Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors. Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors. Protein Tyrosine Phosphatase, Non-Receptor Type 2 / antagonists & inhibitors. Protein Tyrosine Phosphatase, Non-Receptor Type 6 / antagonists & inhibitors. Protein Tyrosine Phosphatases, Non-Receptor / antagonists & inhibitors. Recombinant Proteins / antagonists & inhibitors

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 21708098.001).
  • [ISSN] 1873-3344
  • [Journal-full-title] Journal of inorganic biochemistry
  • [ISO-abbreviation] J. Inorg. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acids, Heterocyclic; 0 / Chelating Agents; 0 / Enzyme Inhibitors; 0 / Ligands; 0 / Recombinant Proteins; 789U1901C5 / Copper; EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / PTPN6 protein, human; EC 3.1.3.48 / PTPN9 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 1; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 2; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48 / Protein Tyrosine Phosphatases, Non-Receptor
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31. Trdan Lušin T, Stieger B, Marc J, Mrhar A, Trontelj J, Zavratnik A, Ostanek B: Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene. J Transl Med; 2012;10:76
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  • [Title] Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene.
  • BACKGROUND: Raloxifene, a selective estrogen receptor modulator, exhibits quite large and unexplained interindividual variability in pharmacokinetics and pharmacodynamics.
  • The aim of this study was to determine the role of organic-anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants in the pharmacokinetics and pharmacodynamics of raloxifene.
  • [MeSH-major] Genetic Variation. Organic Anion Transporters / physiology. Organic Anion Transporters, Sodium-Independent / physiology. Raloxifene Hydrochloride / pharmacology. Selective Estrogen Receptor Modulators / pharmacokinetics

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  • (PMID = 22533838.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Anion Transporters; 0 / Organic Anion Transporters, Sodium-Independent; 0 / SLCO1B1 protein, human; 0 / SLCO1B3 protein, human; 0 / Selective Estrogen Receptor Modulators; 4F86W47BR6 / Raloxifene Hydrochloride
  • [Other-IDs] NLM/ PMC3476964
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32. Lafont V, Liautard J, Sable-Teychene M, Sainte-Marie Y, Favero J: Isopentenyl pyrophosphate, a mycobacterial non-peptidic antigen, triggers delayed and highly sustained signaling in human gamma delta T lymphocytes without inducing eown-modulation of T cell antigen receptor. J Biol Chem; 2001 May 11;276(19):15961-7
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  • [Title] Isopentenyl pyrophosphate, a mycobacterial non-peptidic antigen, triggers delayed and highly sustained signaling in human gamma delta T lymphocytes without inducing eown-modulation of T cell antigen receptor.
  • The Vgamma9Vdelta2 T cell subset, which represents up to 90% of the circulating gammadelta T cells in humans, was shown to be activated, via the T cell receptor (TcR), by non-peptidic phosphorylated small organic molecules.
  • [MeSH-major] Antigens, Bacterial / pharmacology. Hemiterpenes. Mitogen-Activated Protein Kinases / metabolism. Organophosphorus Compounds / pharmacology. Receptors, Antigen, T-Cell / immunology. Receptors, Antigen, T-Cell, gamma-delta / immunology. Signal Transduction / immunology. T-Lymphocytes / immunology

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  • (PMID = 11278429.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / Hemiterpenes; 0 / Organophosphorus Compounds; 0 / Receptors, Antigen, T-Cell; 0 / Receptors, Antigen, T-Cell, gamma-delta; 0 / Tumor Necrosis Factor-alpha; 358-71-4 / isopentenyl pyrophosphate; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Lymphocyte Specific Protein Tyrosine Kinase p56(lck); EC 2.7.10.2 / ZAP-70 Protein-Tyrosine Kinase; EC 2.7.10.2 / ZAP70 protein, human; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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33. Hjelmborg PS, Andreassen TK, Bonefeld-Jørgensen EC: Cellular uptake of lipoproteins and persistent organic compounds--an update and new data. Environ Res; 2008 Oct;108(2):192-8
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  • [Title] Cellular uptake of lipoproteins and persistent organic compounds--an update and new data.
  • This paper will focus on the interactions between lipoproteins and persistent organic pollutants (POPs) and how these particles are taken up by cells.
  • Uptake of DDT by MEF cells was investigated using MEF1 cells carrying the receptors low-density lipoprotein receptor-related protein (LRP) and low-density lipoprotein receptor (LDLR) present and MEF4 cells with no LRP and LDLR expression.
  • The receptor function was further evaluated by adding the 40kDa receptor-associated protein (RAP) which blocks receptor activity.
  • There was no strong evidence for a receptor-mediated uptake of the [(14)C]DDT-lipoprotein complex.
  • To conclude, DDT travels in the blood stream and can cross cell membranes while being transported as a DDT-lipoprotein complex.
  • The lipoproteins do not need receptors to cross cell membranes since passive diffusion constitutes a major passageway.
  • [MeSH-major] Environmental Pollutants / pharmacokinetics. Fibroblasts / drug effects. Lipoproteins / metabolism. Organic Chemicals / pharmacokinetics
  • [MeSH-minor] Animals. Biological Transport. Cell Culture Techniques. Cell Line. Mice. Mice, Knockout. Receptors, LDL / genetics. Ultracentrifugation

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  • (PMID = 18762293.001).
  • [ISSN] 1096-0953
  • [Journal-full-title] Environmental research
  • [ISO-abbreviation] Environ. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Environmental Pollutants; 0 / Lipoproteins; 0 / Organic Chemicals; 0 / Receptors, LDL
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34. Sriarj W, Aoki K, Ohya K, Takagi Y, Shimokawa H: Bovine dentine organic matrix down-regulates osteoclast activity. J Bone Miner Metab; 2009;27(3):315-23
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  • [Title] Bovine dentine organic matrix down-regulates osteoclast activity.
  • These results could be because of different susceptibilities to acid and the different organic matrices between deciduous and permanent dentine.
  • TRAP positive cell number, TRAP activity, the areas of resorption pits, and mRNA levels of TRAP, v-ATPase, calcitonin receptor, cathepsin K, and MMP-9 were examined.
  • [MeSH-minor] Acid Phosphatase / metabolism. Animals. Bone Resorption / metabolism. Cattle. Cell Count. Cell Differentiation / drug effects. Coculture Techniques. Electrophoresis, Polyacrylamide Gel. Isoenzymes / metabolism. Mice. RNA, Messenger / genetics. RNA, Messenger / metabolism. Tissue Extracts / pharmacology. src-Family Kinases / antagonists & inhibitors

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  • (PMID = 19296049.001).
  • [ISSN] 0914-8779
  • [Journal-full-title] Journal of bone and mineral metabolism
  • [ISO-abbreviation] J. Bone Miner. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / RNA, Messenger; 0 / Tissue Extracts; EC 2.7.10.2 / src-Family Kinases; EC 3.1.3.- / tartrate-resistant acid phosphatase; EC 3.1.3.2 / Acid Phosphatase
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35. Wang F, Li C, Liu W, Jin Y: Modulation of microRNA expression by volatile organic compounds in mouse lung. Environ Toxicol; 2014 Jun;29(6):679-89
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  • [Title] Modulation of microRNA expression by volatile organic compounds in mouse lung.
  • Volatile organic compounds (VOCs) are one of main pollutants indoors.
  • Functional annotation analysis of the predicted miRNA transcript targets revealed that VOCs exposure potentially alters signaling pathways associated with cancer, chemokine signaling, Wnt signaling, neuroactive ligand-receptor interaction, and cell adhesion molecules.
  • [MeSH-major] Air Pollutants / toxicity. Lung / metabolism. MicroRNAs / metabolism. Volatile Organic Compounds / toxicity

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  • [Copyright] Copyright © 2012 Wiley Periodicals, Inc.
  • (PMID = 24733833.001).
  • [ISSN] 1522-7278
  • [Journal-full-title] Environmental toxicology
  • [ISO-abbreviation] Environ. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Interleukin-8; 0 / MicroRNAs; 0 / Volatile Organic Compounds; 0 / Xylenes; 1HG84L3525 / Formaldehyde; 3FPU23BG52 / Toluene; J64922108F / Benzene
  • [Keywords] NOTNLM ; VOCs mixture / gene regulation / lung / miRNA / pathways
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36. Murata Y, Kataoka-Shirasugi N, Amakawa T: Electrophysiological studies of salty taste modification by organic acids in the labellar taste cell of the blowfly. Chem Senses; 2002 Jan;27(1):57-65
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  • [Title] Electrophysiological studies of salty taste modification by organic acids in the labellar taste cell of the blowfly.
  • Using the labellar salt receptor cells of the blowfly, Phormia regina, we electrophysiologically showed that the response to NaCl and KCl aqueous solutions was enhanced and depressed by acetic, succinic and citric acids.
  • The organic acid concentrations at which the most enhanced salt response (MESR) was obtained were found to be different: 0.05-1 mM citric acid, 0.5-2 mM succinic acid and 5-50 mM acetic acid.
  • Another explanation for the enhancement is that the salty taste may also be enhanced by undissociated molecules of the organic acids, because the MESRs were obtained at the pH values lower than the pKa(1) or pKa(2) values of these organic acids.
  • On the other hand, the salty taste could be depressed by both the lower pH range (pH 2.5-2.0) and the dissociated organic anions from organic acid molecules with at least two carboxyl groups.

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  • (PMID = 11751469.001).
  • [ISSN] 0379-864X
  • [Journal-full-title] Chemical senses
  • [ISO-abbreviation] Chem. Senses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carboxylic Acids; 451W47IQ8X / Sodium Chloride; 660YQ98I10 / Potassium Chloride
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37. Feng G, Qin W, Hu Q, Tang BZ, Liu B: Cellular and Mitochondrial Dual-Targeted Organic Dots with Aggregation-Induced Emission Characteristics for Image-Guided Photodynamic Therapy. Adv Healthc Mater; 2015 Dec 9;4(17):2667-76
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  • [Title] Cellular and Mitochondrial Dual-Targeted Organic Dots with Aggregation-Induced Emission Characteristics for Image-Guided Photodynamic Therapy.
  • Here, cellular and mitochondrial dual-targeted organic dots for image-guided PDT are reported based on a fluorogen with aggregation-induced emission (AIEgen) characteristics.
  • The AIE dot surfaces are functionalized with folate and triphenylphosphine, which can selectively internalize into folate-receptor (FR) positive cancer cells, and subsequently accumulate at mitochondria.
  • The direct ROS generation at mitochondria sites is found to depolarize mitochondrial membrane, affect cell migration, and lead to cell apoptosis and death with enhanced PDT effects as compared to ROS generated randomly in cytoplasm.

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  • [Copyright] © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • (PMID = 26479020.001).
  • [ISSN] 2192-2659
  • [Journal-full-title] Advanced healthcare materials
  • [ISO-abbreviation] Adv Healthc Mater
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; aggregation-induced emission (AIE) / cancer cell targeting / drug delivery / mitochondrial imaging / photodynamic therapy
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38. Cohen BN, Labarca C, Davidson N, Lester HA: Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations. J Gen Physiol; 1992 Sep;100(3):373-400
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  • [Title] Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations.
  • We measured the permeability ratios (PX/PNa) of 3 wild-type, 1 hybrid, 2 subunit-deficient, and 22 mutant nicotinic receptors expressed in Xenopus oocytes for alkali metal and organic cations using shifts in the bi-ionic reversal potential of the macroscopic current.
  • Mutations at position 2' (alpha Thr244, beta Gly255, gamma Thr253, delta Ser258) near the intracellular end of M2 changed the organic cation permeability ratios as much as twofold and reduced PCs/PNa and PK/PNa by 16-18%.
  • The wild-type mouse receptor displayed a surprising interaction with the primary ammonium cations; relative permeability peaked at a chain length equal to four carbons.
  • Analysis of the organic permeability ratios for the wild-type mouse receptor shows that (a) the diameter of the narrowest part of the pore is 8.4 A;.
  • (b) the mouse receptor departs significantly from size selectivity for monovalent organic cations; and (c) lowering the temperature reduces Pguanidinium/PNa by 38% and Pbutylammonium/PNa more than twofold.
  • The results reinforce present views that positions -1' and 2' are the narrowest part of the pore and suggest that positions 6' and 10' align some permeant organic cations in the pore in an interaction similar to that with channel blocker, QX-222.
  • [MeSH-minor] Amino Acid Sequence. Ammonia / metabolism. Ammonia / pharmacokinetics. Animals. Cell Membrane Permeability / physiology. Cesium / metabolism. Cesium / pharmacokinetics. Female. Glycine / analogs & derivatives. Glycine / metabolism. Glycine / pharmacokinetics. Guanidine. Guanidines / metabolism. Guanidines / pharmacokinetics. Lidocaine / analogs & derivatives. Lidocaine / pharmacology. Mice. Molecular Sequence Data. Oocytes / chemistry. Oocytes / physiology. Oocytes / ultrastructure. Sodium / metabolism. Sodium / pharmacokinetics. Temperature. Torpedo. Xenopus


39. Kometani T, Ikeda Y, Kasai M: Acetylcholine-binding substance extracted by using organic solvent and acetylcholine receptor of electric organ of Narke japonica. Biochim Biophys Acta; 1975 Dec 16;413(3):415-24
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  • [Title] Acetylcholine-binding substance extracted by using organic solvent and acetylcholine receptor of electric organ of Narke japonica.
  • From the heaviest, the fractions were acetylcholine receptor rich, ATPase rich, and acetylcholinesterase rich.
  • 3. The membrane fraction having acetylcholine receptor showed the excitability, the increase of Na+ permeability by the application of cholinergic agonists.
  • However, the acetylcholine binding substance extracted by the organic solvent was richer in the lighter fraction.
  • This substance differed from the true acetylcholine receptor.
  • [MeSH-minor] Acetylcholinesterase / analysis. Adenosine Triphosphatases / analysis. Animals. Binding Sites. Biological Transport, Active. Cell Membrane / analysis. Cell Membrane / metabolism. Fishes. Lipoproteins / isolation & purification. Lipoproteins / metabolism. Nerve Tissue Proteins / isolation & purification. Nerve Tissue Proteins / metabolism. Sodium / metabolism


40. Poole JA, Wyatt TA, Kielian T, Oldenburg P, Gleason AM, Bauer A, Golden G, West WW, Sisson JH, Romberger DJ: Toll-like receptor 2 regulates organic dust-induced airway inflammation. Am J Respir Cell Mol Biol; 2011 Oct;45(4):711-9
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  • [Title] Toll-like receptor 2 regulates organic dust-induced airway inflammation.
  • Organic dust exposure in agricultural environments results in significant airway inflammatory diseases.
  • Gram-positive cell wall components are present in high concentrations in animal farming dusts, but their role in mediating dust-induced airway inflammation is not clear.
  • This study investigated the role of Toll-like receptor (TLR) 2, a pattern recognition receptor for gram-positive cell wall products, in regulating swine facility organic dust extract (DE)-induced airway inflammation in mice.
  • Collectively, these results demonstrate that the TLR2 pathway is important in regulating swine facility organic dust-induced airway inflammation, which suggests the importance of TLR2 agonists in mediating large animal farming-induced airway inflammatory responses.
  • [MeSH-major] Dust. Lung / immunology. Pneumonia / immunology. Toll-Like Receptor 2 / metabolism

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  • (PMID = 21278324.001).
  • [ISSN] 1535-4989
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES015522-03S1; United States / NIEHS NIH HHS / ES / K08 ES015522; United States / NIEHS NIH HHS / ES / K08 ES015522-01; United States / NIAAA NIH HHS / AA / K99 AA019499; United States / NIAAA NIH HHS / AA / R01 AA017993; United States / NIAAA NIH HHS / AA / R01 AA017993; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NINDS NIH HHS / NS / R01 NS055385; United States / NIOSH CDC HHS / OH / R01 OH008539-01
  • [Publication-type] Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bronchoconstrictor Agents; 0 / Chemokines; 0 / Cytokines; 0 / Dust; 0 / Inflammation Mediators; 0 / Lipopolysaccharides; 0 / Peptidoglycan; 0 / Tlr2 protein, mouse; 0 / Toll-Like Receptor 2; 0W5ETF9M2K / Methacholine Chloride; 31C4KY9ESH / Nitric Oxide
  • [Other-IDs] NLM/ PMC3208620
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41. Bauer C, Kielian T, Wyatt TA, Romberger DJ, West WW, Gleason AM, Poole JA: Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice. Am J Respir Cell Mol Biol; 2013 Jun;48(6):781-9
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  • [Title] Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice.
  • Organic dust exposure within agricultural environments results in airway diseases.
  • Toll-like receptor 2 (TLR2) and TLR4 only partly account for the innate response to these complex dust exposures.
  • To determine the central pathway in mediating complex organic dust-induced airway inflammation, this study targeted the common adaptor protein, myeloid differentiation factor 88 (MyD88), and investigated the relative contributions of receptors upstream from this adaptor.
  • Wild-type, MyD88, TLR9, TLR4, IL-1 receptor I (RI), and IL-18R knockout (KO) mice were challenged intranasally with organic dust extract (ODE) or saline, according to an established protocol.
  • Lung cell apoptosis was determined by a terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, and lymphocyte influx and intercellular adhesion molecule-1 (ICAM-1) expression were assessed by immunohistochemistry.
  • ODE-induced epithelial-cell ICAM-1 expression was diminished in MyD88 KO mice.
  • No difference was evident in the small degree of ODE-induced lung-cell apoptosis.
  • Collectively, the acute organic dust-induced airway inflammatory response is highly dependent on MyD88 signaling, and is dictated, in part, by important contributions from upstream TLRs and IL-18R.
  • [MeSH-major] Bronchial Hyperreactivity / pathology. Cell Differentiation. Dust / immunology. Inflammation / immunology. Myeloid Differentiation Factor 88 / metabolism
  • [MeSH-minor] Animals. Apoptosis. Immunohistochemistry. In Situ Nick-End Labeling. Inflammation Mediators / metabolism. Inhalation Exposure. Intercellular Adhesion Molecule-1 / genetics. Intercellular Adhesion Molecule-1 / metabolism. Lung / immunology. Lung / metabolism. Lung / pathology. Mice. Mice, Inbred C57BL. Mice, Knockout. Neutrophil Infiltration. Neutrophils / immunology. Neutrophils / metabolism. Receptors, Interleukin-1 / genetics. Receptors, Interleukin-1 / immunology. Receptors, Interleukin-1 / metabolism. Receptors, Interleukin-18 / genetics. Receptors, Interleukin-18 / metabolism. Respiratory Function Tests. Signal Transduction. Toll-Like Receptor 4 / genetics. Toll-Like Receptor 4 / immunology. Toll-Like Receptor 4 / metabolism. Toll-Like Receptor 9 / immunology. Toll-Like Receptor 9 / metabolism

  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
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  • (PMID = 23492189.001).
  • [ISSN] 1535-4989
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1U54OH010162-01; United States / NIEHS NIH HHS / ES / 2R01ES019325; United States / NIOSH CDC HHS / OH / 2R01OH008539-01; United States / NINDS NIH HHS / NS / 5R01NS40730; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NINDS NIH HHS / NS / R01 NS040730
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dust; 0 / Icam1 protein, mouse; 0 / Inflammation Mediators; 0 / Myd88 protein, mouse; 0 / Myeloid Differentiation Factor 88; 0 / Receptors, Interleukin-1; 0 / Receptors, Interleukin-18; 0 / Tlr4 protein, mouse; 0 / Tlr9 protein, mouse; 0 / Toll-Like Receptor 4; 0 / Toll-Like Receptor 9; 126547-89-5 / Intercellular Adhesion Molecule-1
  • [Other-IDs] NLM/ PMC3727869
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42. Wackers G, Vandenryt T, Cornelis P, Kellens E, Thoelen R, De Ceuninck W, Losada-Pérez P, van Grinsven B, Peeters M, Wagner P: Array formatting of the heat-transfer method (HTM) for the detection of small organic molecules by molecularly imprinted polymers. Sensors (Basel); 2014;14(6):11016-30
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  • [Title] Array formatting of the heat-transfer method (HTM) for the detection of small organic molecules by molecularly imprinted polymers.
  • In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM).
  • HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor.
  • A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate.
  • With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity.
  • [MeSH-major] Dimethylpolysiloxanes / chemistry. Microarray Analysis / instrumentation. Microfluidic Analytical Techniques / instrumentation. Molecular Imprinting / methods. Organic Chemicals / analysis. Organic Chemicals / chemistry. Thermography / instrumentation

  • Hazardous Substances Data Bank. POLYDIMETHYLSILOXANES .
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  • (PMID = 24955945.001).
  • [ISSN] 1424-8220
  • [Journal-full-title] Sensors (Basel, Switzerland)
  • [ISO-abbreviation] Sensors (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Dimethylpolysiloxanes; 0 / Organic Chemicals; 63148-62-9 / baysilon
  • [Other-IDs] NLM/ PMC4118400
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43. Uehara A, Hume JR: Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J Gen Physiol; 1985 May;85(5):621-47
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  • [Title] Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells.
  • Inhibition of whole-cell calcium currents in enzymatically dispersed frog atrial myocytes by D-600, diltiazem, and nifedipine was studied using a single-micropipette voltage-clamp technique.
  • The objective of these experiments was to test the applicability of a modulated-receptor hypothesis similar to that proposed for local anesthetic interactions with sodium channels to account for the tonic and frequency-dependent interactions of these organic compounds with myocardial calcium channels.
  • Experiments in which the pH was modified, however, reveal some important differences for the interaction of organic calcium antagonists with myocardial calcium channels.
  • It is concluded that two distinct receptor sites may be involved in block of iCa by some of these compounds: a proton-accessible site and a proton-inaccessible site.

  • Hazardous Substances Data Bank. Nifedipine .
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  • (PMID = 2582076.001).
  • [ISSN] 0022-1295
  • [Journal-full-title] The Journal of general physiology
  • [ISO-abbreviation] J. Gen. Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL30143
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Calcium Channel Blockers; 0 / Ion Channels; 39WPC8JHR8 / Gallopamil; EE92BBP03H / Diltiazem; I9ZF7L6G2L / Nifedipine; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2215823
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44. Lou Y, Li J, Lu Y, Wang X, Jiao R, Wang S, Kong L: Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats. Toxicol Lett; 2011 Feb 25;201(1):72-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats.
  • In order to study the unrecognized abnormalities of organic ion transporters and fatty acid metabolism indicators in AA nephropathy, Wistar rats were orally administrated with vehicle, 10 and 20mg/kg AA once daily for 7 days, respectively.
  • OCTN2 particularly transports l-carnitine through cell membrane.
  • Down-regulation of peroxisome proliferator-activated receptor alpha (rPPARα) and carnitine acyltransferase 1 (rCPT1), and up-regulation of acetyl coenzyme A carboxylase 1/2 (rACC1/2) in renal cortex were detected in AA-treated rats.
  • These results indicate that alterations of organic ion transportation and fatty acid metabolism are part of AA-induced nephropathy (AAN), contribute to the altered urinary metabolic profile and may lead to further proximal tubule injury in rats.
  • [MeSH-minor] Acetyltransferases / genetics. Animals. Blood Urea Nitrogen. Carnitine / analysis. Catecholamine Plasma Membrane Transport Proteins / genetics. Creatinine / blood. Male. Organic Anion Transport Protein 1 / genetics. Organic Anion Transporters, Sodium-Independent / genetics. Organic Cation Transport Proteins / genetics. Rats. Rats, Wistar

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 21167265.001).
  • [ISSN] 1879-3169
  • [Journal-full-title] Toxicology letters
  • [ISO-abbreviation] Toxicol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aristolochic Acids; 0 / Catecholamine Plasma Membrane Transport Proteins; 0 / Fatty Acids; 0 / Membrane Transport Proteins; 0 / Organic Anion Transport Protein 1; 0 / Organic Anion Transporters, Sodium-Independent; 0 / Organic Cation Transport Proteins; 0 / Slc22a1 protein, rat; 0 / Slc22a2 protein, rat; 0 / Slc22a5 protein, rat; 0 / Slc22a6 protein, rat; 0 / organic anion transport protein 3; 313-67-7 / aristolochic acid I; AYI8EX34EU / Creatinine; EC 2.3.1.- / Acetyltransferases; EC 2.3.1.- / aminoglycoside N1-acetyltransferase; S7UI8SM58A / Carnitine
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45. Sarma SN, Kim YJ, Ryu JC: Gene expression profiles of human promyelocytic leukemia cell lines exposed to volatile organic compounds. Toxicology; 2010 May 27;271(3):122-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression profiles of human promyelocytic leukemia cell lines exposed to volatile organic compounds.
  • Benzene, toluene, o-xylene, ethylbenzene, trichloroethylene and dichloromethane are the most widely used volatile organic compounds (VOCs), and their toxic mechanisms are still undefined.
  • At IC(20) doses identified genes were functionally categorized as being involved in cytokine-cytokine receptor interactions and the toll-like receptor signaling pathway, whereas exposure at IC(50) doses identified genes associated with the p53 signaling pathway, apoptosis, and natural killer cell-mediated cytotoxicity pathway.
  • In conclusion, both gene expression profiles and gene ontology analysis have elucidated potential gene-based biomarkers and provided insights into the mechanism underlying the response of human leukemia cell lines to VOC exposure.
  • [MeSH-major] Gene Expression Profiling / methods. Leukemia, Promyelocytic, Acute / genetics. Volatile Organic Compounds / pharmacology
  • [MeSH-minor] Apoptosis / genetics. Carrier Proteins / genetics. Cell Line, Tumor. Female. Genome, Human. HL-60 Cells. Humans. K562 Cells. Oligonucleotide Array Sequence Analysis / methods. Proteins / genetics. Reverse Transcriptase Polymerase Chain Reaction. Toluene / pharmacology. U937 Cells. Xylenes / pharmacology

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  • (PMID = 20359517.001).
  • [ISSN] 1879-3185
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / IFIT1 protein, human; 0 / Proteins; 0 / Volatile Organic Compounds; 0 / Xylenes; 3FPU23BG52 / Toluene; Z2474E14QP / 2-xylene
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46. Poole JA, Alexis NE, Parks C, MacInnes AK, Gentry-Nielsen MJ, Fey PD, Larsson L, Allen-Gipson D, Von Essen SG, Romberger DJ: Repetitive organic dust exposure in vitro impairs macrophage differentiation and function. J Allergy Clin Immunol; 2008 Aug;122(2):375-82, 382.e1-4
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  • [Title] Repetitive organic dust exposure in vitro impairs macrophage differentiation and function.
  • BACKGROUND: Organic dust exposure in the agricultural industry results in significant airway disease and lung function decrease.
  • OBJECTIVE: We sought to investigate the effect of organic dust extract (ODE) from modern swine operations on monocyte-derived macrophage (MDM) phenotype and function.
  • At 1 week, cells were analyzed by means of flow cytometry for cell-surface marker expression (HLA-DR, CD80, CD86, Toll-like receptor 2, Toll-like receptor 4, mCD14, and CD16), phagocytosis (IgG-opsonized zymosan particles), and intracellular killing of Streptococcus pneumoniae.
  • CONCLUSION: Repetitive organic dust exposure significantly decreases markers of antigen presentation and host defense function in MDMs.
  • Bacterial cell components appear to be driving these impaired responses.
  • [MeSH-minor] Animals. Antigens, CD80 / immunology. Antigens, CD80 / metabolism. Antigens, CD86 / immunology. Antigens, CD86 / metabolism. Cell Differentiation. HLA-DR Antigens / immunology. HLA-DR Antigens / metabolism. Housing, Animal. Humans. Lipopolysaccharides / immunology. Peptidoglycan / immunology. Swine

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  • (PMID = 18585769.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1R01OH008539-01; United States / NHLBI NIH HHS / HL / K01 HL084684; United States / NIEHS NIH HHS / ES / K08 ES015522; United States / NIEHS NIH HHS / ES / K08 ES015522-01; United States / NIEHS NIH HHS / ES / K08 ES015522-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD80; 0 / Antigens, CD86; 0 / Cytokines; 0 / Dust; 0 / HLA-DR Antigens; 0 / Lipopolysaccharides; 0 / Peptidoglycan; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
  • [Other-IDs] NLM/ NIHMS109320; NLM/ PMC2685162
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47. Ulrich K, Wölfle S, Mayer A, Heeg K, Braunbeck T, Erdinger L, Bartz H: Extractable organic matter of standard reference material 1649a influences immunological response induced by pathogen-associated molecular patterns. Environ Sci Pollut Res Int; 2010 Jul;17(6):1257-67
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  • [Title] Extractable organic matter of standard reference material 1649a influences immunological response induced by pathogen-associated molecular patterns.
  • Temporal increase of airborne particulate matter (APM), a potential carrier for extractable organic matter (EOM), degrades the situation of pulmonary patients.
  • The Ah receptor (AhR) has been described as an important factor influencing the immunological challenge by viral infections.
  • To mimic the activation of organic matter during contact of particles with the human lung, Soxhlet extraction of SRM was performed.
  • DISCUSSION: Organic compounds adsorbed on airborne particulate matter influence the cytokine secretion of lung epithelial cells induced by pathogen-associated molecular patterns.
  • [MeSH-minor] Benzo(a)pyrene. Benzoflavones / toxicity. Cell Line. Humans. Interleukin-6 / metabolism. Interleukin-8 / antagonists & inhibitors. Interleukin-8 / metabolism. Poly C / toxicity. Polycyclic Hydrocarbons, Aromatic / toxicity. Receptors, Aryl Hydrocarbon / antagonists & inhibitors. Receptors, Aryl Hydrocarbon / metabolism. Reference Standards. Transforming Growth Factor beta / metabolism

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  • (PMID = 20195909.001).
  • [ISSN] 1614-7499
  • [Journal-full-title] Environmental science and pollution research international
  • [ISO-abbreviation] Environ Sci Pollut Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Benzoflavones; 0 / Cytokines; 0 / Interleukin-6; 0 / Interleukin-8; 0 / Particulate Matter; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Receptors, Aryl Hydrocarbon; 0 / Transforming Growth Factor beta; 30811-80-4 / Poly C; 3417WMA06D / Benzo(a)pyrene; 604-59-1 / alpha-naphthoflavone
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48. Jansen J, De Napoli IE, Fedecostante M, Schophuizen CM, Chevtchik NV, Wilmer MJ, van Asbeck AH, Croes HJ, Pertijs JC, Wetzels JF, Hilbrands LB, van den Heuvel LP, Hoenderop JG, Stamatialis D, Masereeuw R: Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations. Sci Rep; 2015;5:16702
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  • [Title] Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations.
  • Here, unique human conditionally immortalized proximal tubule epithelial cell (ciPTEC) monolayers were cultured on biofunctionalized MicroPES (polyethersulfone) hollow fiber membranes (HFM) and functionally tested using microfluidics.
  • The activity of the organic cation transporter 2 (OCT2) in ciPTEC was evaluated in real-time using a perfusion system by confocal microscopy using 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP(+)) as a fluorescent substrate.
  • Initial ASP(+) uptake was inhibited by a cationic uremic metabolites mixture and by the histamine H2-receptor antagonist, cimetidine.
  • In conclusion, a 'living membrane' of renal epithelial cells on MicroPES HFM with demonstrated active organic cation transport was successfully established as a first step in BAK engineering.

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  • (PMID = 26567716.001).
  • [ISSN] 2045-2322
  • [Journal-full-title] Scientific reports
  • [ISO-abbreviation] Sci Rep
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4644946
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49. Ha Y, Choi HK: Recent conjugation strategies of small organic fluorophores and ligands for cancer-specific bioimaging. Chem Biol Interact; 2016 Mar 25;248:36-51
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  • [Title] Recent conjugation strategies of small organic fluorophores and ligands for cancer-specific bioimaging.
  • Herein, we present our review of recent studies relating to molecular fluorescent imaging techniques for various cancers in cell-based and animal-based models.
  • Various organic fluorophores, especially near-infrared (NIR) probes, have been employed with specific ligands.
  • Types of ligands used were small molecules, peptides, antibodies, and aptamers; each has specific affinities for cellular receptor proteins, cancer-specific antigens, enzymes, and nucleic acids.

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  • [Copyright] Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 26892219.001).
  • [ISSN] 1872-7786
  • [Journal-full-title] Chemico-biological interactions
  • [ISO-abbreviation] Chem. Biol. Interact.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Fluorescent Dyes
  • [Keywords] NOTNLM ; Cancer-specific biomarkers / Cancer-specific ligands / Cancer-specific receptors / Fluorescent diagnosis / Near-infrared
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50. Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA: The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Am J Physiol Gastrointest Liver Physiol; 2006 Mar;290(3):G476-85
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  • [Title] The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.
  • At the basolateral domain of ileal enterocytes, bile acids are extruded into portal blood by the heterodimeric organic solute transporter OSTalpha/OSTbeta.
  • We show here that human OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR).
  • [MeSH-minor] Base Sequence. Bile Acids and Salts / pharmacology. Cell Line, Tumor. Chenodeoxycholic Acid / pharmacology. Electrophoretic Mobility Shift Assay. Humans. Ileum / cytology. Isoxazoles / pharmacology. Molecular Sequence Data. Promoter Regions, Genetic. Receptors, Cytoplasmic and Nuclear. Repetitive Sequences, Nucleic Acid. Retinoid X Receptor alpha / physiology

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  • (PMID = 16269519.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / DNA-Binding Proteins; 0 / GW 4064; 0 / Isoxazoles; 0 / Membrane Transport Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Retinoid X Receptor alpha; 0 / Transcription Factors; 0 / farnesoid X-activated receptor; 0 / organic solute transporter alpha, human; 0 / organic solute transporter beta, human; 0GEI24LG0J / Chenodeoxycholic Acid
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51. Luci S, Geissler S, König B, Koch A, Stangl GI, Hirche F, Eder K: PPARalpha agonists up-regulate organic cation transporters in rat liver cells. Biochem Biophys Res Commun; 2006 Nov 24;350(3):704-8
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  • [Title] PPARalpha agonists up-regulate organic cation transporters in rat liver cells.
  • In this study, we observed for the first time that treatment of rats with the peroxisome proliferator activated receptor (PPAR)-alpha agonist clofibrate increases hepatic mRNA concentrations of organic cation transporters (OCTNs)-1 and -2 which act as transporters of carnitine into the cell.
  • We conclude that PPARalpha agonists increase carnitine concentrations in livers of rats and cells by an increased uptake of carnitine into the cell but not by an increased carnitine biosynthesis.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Catecholamine Plasma Membrane Transport Proteins / metabolism. Clofibrate / administration & dosage. Hepatocytes / metabolism. Organic Cation Transport Proteins / metabolism. PPAR alpha / antagonists & inhibitors

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  • (PMID = 17011512.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Catecholamine Plasma Membrane Transport Proteins; 0 / Organic Cation Transport Proteins; 0 / PPAR alpha; 0 / Slc22a1 protein, rat; 0 / Slc22a2 protein, rat; HPN91K7FU3 / Clofibrate
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52. Leung SL, Zha Z, Cohn C, Dai Z, Wu X: Anti-EGFR antibody conjugated organic-inorganic hybrid lipid nanovesicles selectively target tumor cells. Colloids Surf B Biointerfaces; 2014 Sep 1;121:141-9
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  • [Title] Anti-EGFR antibody conjugated organic-inorganic hybrid lipid nanovesicles selectively target tumor cells.
  • Chemical conjugation of anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR mAbs) to organic-inorganic hybrid liposomal immunocerasomes via maleimide-thiol coupling chemistry is explored as a mechanism for selectively targeting cancer cells.
  • The internalization study reveals a strong correlation between the receptor-mediated endocytosis of immunocerasomes and the membrane expression of EGFR.
  • [MeSH-major] Antibodies, Monoclonal / pharmacology. Inorganic Chemicals / chemistry. Lipids / chemistry. Nanoparticles / chemistry. Organic Chemicals / chemistry. Receptor, Epidermal Growth Factor / immunology. Unilamellar Liposomes / chemistry
  • [MeSH-minor] Cell Line, Tumor. Cell Proliferation / drug effects. Endocytosis / drug effects. Humans. Spectrometry, Fluorescence

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  • [Copyright] Copyright © 2014 Elsevier B.V. All rights reserved.
  • (PMID = 24967549.001).
  • [ISSN] 1873-4367
  • [Journal-full-title] Colloids and surfaces. B, Biointerfaces
  • [ISO-abbreviation] Colloids Surf B Biointerfaces
  • [Language] eng
  • [Grant] United States / NIBIB NIH HHS / EB / R21EB009160; United States / NHLBI NIH HHS / HL / T32 HL007955
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Inorganic Chemicals; 0 / Lipids; 0 / Organic Chemicals; 0 / Unilamellar Liposomes; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Keywords] NOTNLM ; Anti-EGFR antibody / Cancer cells / Organic–inorganic hybrid lipid nanovesicles / Selective targeting
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53. Shang Y, Fan L, Feng J, Lv S, Wu M, Li B, Zang YS: Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: the role of quinones. Toxicol In Vitro; 2013 Mar;27(2):922-31
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  • [Title] Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: the role of quinones.
  • In present study we aimed to examine the genotoxic and inflammatory impacts of organic extracts from traffic-related PM (oTRP) in human lung epithelial A549 cells, and reveal the contributions from quinones.
  • The pro-inflammatory genes, interleukin-6 (Il-6), interleukin-8 (Il-8) and tumor necrosis factor (Tnf), and two aromatic hydrocarbon receptor-regulated genes, Cyp1a1 and 1b1, were significantly up-regulated by oTRP.
  • [MeSH-minor] Cell Line, Tumor. Cell Survival / drug effects. Comet Assay. Cytokines / genetics. DNA Damage. Epithelial Cells / drug effects. Epithelial Cells / metabolism. Humans. L-Lactate Dehydrogenase / metabolism. Lung / cytology. RNA, Messenger / metabolism. Reactive Oxygen Species / metabolism

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  • [Copyright] Copyright © 2013 Elsevier Ltd. All rights reserved.
  • (PMID = 23333790.001).
  • [ISSN] 1879-3177
  • [Journal-full-title] Toxicology in vitro : an international journal published in association with BIBRA
  • [ISO-abbreviation] Toxicol In Vitro
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Anthraquinones; 0 / Cytokines; 0 / Naphthoquinones; 0 / Particulate Matter; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0 / Vehicle Emissions; 030MS0JBDO / 9,10-anthraquinone; EC 1.1.1.27 / L-Lactate Dehydrogenase; RBF5ZU7R7K / 1,4-naphthoquinone
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54. Zhang Y, Csanaky IL, Cheng X, Lehman-McKeeman LD, Klaassen CD: Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Toxicol Sci; 2012 Jun;127(2):451-62
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  • [Title] Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.
  • Organic anion transporting polypeptide 1a1 (Oatp1a1) is predominantly expressed in livers of mice and is thought to transport bile acids (BAs) from blood into liver.
  • Oatp1a1-null BDL mice had similar basolateral BA uptake (Na(+)-taurocholate cotransporting polypeptide and Oatp1b2) and BA-efflux (multidrug resistance-associated protein [Mrp]-3, Mrp4, and organic solute transporter α/β) transporters, as well as BA-synthetic enzyme (Cyp7a1) in livers as WT BDL mice.
  • Hepatic expression of small heterodimer partner Cyp3a11, Cyp4a14, and Nqo1, which are target genes of farnesoid X receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and NF-E2-related factor 2, respectively, were increased in WT BDL mice but not in Oatp1a1-null BDL mice.
  • [MeSH-major] Bile Acids and Salts / metabolism. Cholestasis / complications. Liver / metabolism. Liver Diseases / etiology. Organic Cation Transport Proteins / deficiency


55. Líbalová H, Krčková S, Uhlířová K, Kléma J, Ciganek M, Rössner P Jr, Šrám RJ, Vondráček J, Machala M, Topinka J: Analysis of gene expression changes in A549 cells induced by organic compounds from respirable air particles. Mutat Res; 2014 Dec;770:94-105
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  • [Title] Analysis of gene expression changes in A549 cells induced by organic compounds from respirable air particles.
  • A number of toxic effects of respirable ambient air particles (genotoxic effects, inflammation, oxidative damage) have been attributed to organic compounds bound onto the particle surface.
  • In this study, we analyzed global gene expression changes caused by the extractable organic matters (EOMs) from respirable airborne particles <2.5μm (PM2.5), collected at 3 localities from heavily polluted areas of the Czech Republic and a control locality with low pollution levels, in human lung epithelial A549 cells.
  • We found numerous commonly deregulated genes and pathways related to activation of the aryl hydrocarbon receptor (AhR) and metabolism of xenobiotics and endogenous compounds.
  • No cell cycle arrest, DNA repair or pro-apoptotic responses were identified at the transcriptional level after the treatment of A549 cells with EOMs.
  • [MeSH-major] Gene Expression / drug effects. Organic Chemicals / pharmacology. Particulate Matter / pharmacology

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  • [Copyright] Copyright © 2014 Elsevier B.V. All rights reserved.
  • (PMID = 25771875.001).
  • [ISSN] 1873-135X
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / Particulate Matter; Adenocarcinoma of lung
  • [Keywords] NOTNLM ; A549 cells / Ah receptor / Gene expression profile / PAHs / PM2.5
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56. Gutleb AC, Freitas J, Murk AJ, Verhaegen S, Ropstad E, Udelhoven T, Hoffmann L, Audinot JN: NanoSIMS50 - a powerful tool to elucidate cellular localization of halogenated organic compounds. Anal Bioanal Chem; 2012 Nov;404(9):2693-8
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  • [Title] NanoSIMS50 - a powerful tool to elucidate cellular localization of halogenated organic compounds.
  • Persistent organic pollutants are widely distributed in the environment and lots of toxicological data are available.
  • Of the model compounds tested, TBBPA was homogenously distributed in the cell membrane of the H295R cells while PFOS accumulated in very distinct locations in the cell membrane.
  • These differences may partly explain that observed effect concentrations for 4-OH-BDEs in in vitro experiments are usually lower than what would be expected based on receptor binding studies.
  • [MeSH-minor] Cell Line, Tumor. Humans

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  • (PMID = 22566200.001).
  • [ISSN] 1618-2650
  • [Journal-full-title] Analytical and bioanalytical chemistry
  • [ISO-abbreviation] Anal Bioanal Chem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Environmental Pollutants; 0 / Hydrocarbons, Halogenated
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57. Soroka CJ, Ballatori N, Boyer JL: Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis. Semin Liver Dis; 2010 May;30(2):178-85
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  • [Title] Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.
  • Organic solute transporter alpha-beta (OSTalpha-OSTbeta) is a unique heteromeric transporter localized to the basolateral membrane of epithelial cells involved in sterol transport.
  • OSTalpha-OSTbeta is directly regulated by the bile acid sensing nuclear receptor, farnesoid X receptor (FXR).

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  • (PMID = 20422499.001).
  • [ISSN] 1098-8971
  • [Journal-full-title] Seminars in liver disease
  • [ISO-abbreviation] Semin. Liver Dis.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK034989; United States / NIDDK NIH HHS / DK / R37 DK025636
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Membrane Transport Proteins; 0 / P-Glycoproteins; 0 / organic solute transporter alpha, human; 0 / organic solute transporter alpha, mouse; 0 / organic solute transporter beta, human; 0 / organic solute transporter beta, mouse
  • [Number-of-references] 60
  • [Other-IDs] NLM/ NIHMS483705; NLM/ PMC3713633
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58. Pereira-Fernandes A, Dirinck E, Dirtu AC, Malarvannan G, Covaci A, Van Gaal L, Vanparys C, Jorens PG, Blust R: Expression of obesity markers and Persistent Organic Pollutants levels in adipose tissue of obese patients: reinforcing the obesogen hypothesis? PLoS One; 2014;9(1):e84816
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  • [Title] Expression of obesity markers and Persistent Organic Pollutants levels in adipose tissue of obese patients: reinforcing the obesogen hypothesis?
  • INTRODUCTION: Persistent Organic Pollutants (POPs) accumulate in adipose tissue and some are described to possess endocrine disrupting capacities.
  • OBJECTIVES: THE AIM IS TWOFOLD: (i) evaluate gene expression levels of obesity marker genes, i.e. the adipokines leptin (LEP), adiponectin (ADIPOQ) and Tumor Necrosis Factor α (TNFα) and the nuclear receptor, Peroxisome Proliferator Activated Receptor γ (PPARγ) in paired subcutaneous (SAT) and visceral (VAT) AT of obese subjects (n = 50) and to relate these values to serum concentrations of LEP and ADIPOQ (ii) evaluate the association of expression levels of marker genes in AT and serum with POP concentrations in AT.

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  • (PMID = 24427296.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
  • [Other-IDs] NLM/ PMC3888404
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59. Bonefeld-Jørgensen EC, Ghisari M, Wielsøe M, Bjerregaard-Olesen C, Kjeldsen LS, Long M: Biomonitoring and hormone-disrupting effect biomarkers of persistent organic pollutants in vitro and ex vivo. Basic Clin Pharmacol Toxicol; 2014 Jul;115(1):118-28
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  • [Title] Biomonitoring and hormone-disrupting effect biomarkers of persistent organic pollutants in vitro and ex vivo.
  • Persistent organic pollutants (POPs) include lipophilic legacy POPs and the amphiphilic perfluorinated alkyl acids (PFAAs).
  • In vitro and ex vivo cell systems have been introduced for the assessment of the integrated level of xenobiotic cellular effects in human beings.
  • Xenohormone receptor transactivities can be used as an ex vivo integrated biomarker of POP exposure and effects.

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  • [Copyright] © 2014 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
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  • (PMID = 24797035.001).
  • [ISSN] 1742-7843
  • [Journal-full-title] Basic & clinical pharmacology & toxicology
  • [ISO-abbreviation] Basic Clin. Pharmacol. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Endocrine Disruptors; 0 / Environmental Pollutants; 0 / Xenobiotics; 0 / polychlorodibenzo-4-dioxin; DFC2HB4I0K / Polychlorinated Biphenyls; DO80M48B6O / Tetrachlorodibenzodioxin
  • [Other-IDs] NLM/ PMC4270256
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60. Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL: Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology; 2010 Jan;51(1):181-90
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  • [Title] Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.
  • Organic solute transporter alpha-beta (Ostalpha-Ostbeta) is a heteromeric bile acid and sterol transporter that facilitates the enterohepatic and renal-hepatic circulation of bile acids.
  • Livers of Ostalpha(-/-) mice had higher messenger RNA levels of constitutive androstane receptor (Car) than wild-type BDL mice and increased expression of Phase I enzymes (Cyp7a1, Cyp2b10, Cyp3a11), Phase II enzymes (Sult2a1, Ugt1a1), and Phase III transporters (Mrp2, Mrp3).
  • CONCLUSION: These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine and through detoxification pathways most likely mediated by the nuclear receptor Car.

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  • (PMID = 19902485.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK 25636; United States / NIDDK NIH HHS / DK / DK067214; United States / NIDDK NIH HHS / DK / DK34989; United States / NIDDK NIH HHS / DK / P30 DK034989; United States / NIDDK NIH HHS / DK / P30 DK034989-25; United States / NIDDK NIH HHS / DK / R01 DK025636; United States / NIDDK NIH HHS / DK / R01 DK025636-31; United States / NIDDK NIH HHS / DK / R01 DK067214; United States / NIDDK NIH HHS / DK / R01 DK067214-05; United States / NIDDK NIH HHS / DK / R37 DK025636; United States / NIDDK NIH HHS / DK / R37 DK025636-33
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Membrane Transport Proteins; 0 / organic solute transporter alpha, mouse
  • [Other-IDs] NLM/ NIHMS170423; NLM/ PMC2819820
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61. Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA: FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res; 2006 Jan;47(1):201-14
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  • [Title] FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.
  • Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland.
  • Several putative FXR target genes were identified, including the organic solute transporters alpha and beta (OSTalpha and OSTbeta).
  • Electromobility shift assays and promoter-reporter studies identified functional farnesoid X receptor response elements (FXREs) in the promoters of both human genes.
  • [MeSH-minor] Adrenal Glands / metabolism. Animals. Base Sequence. Bile Acids and Salts / pharmacology. Cell Line. Conserved Sequence. Female. Gene Expression Profiling. Gene Expression Regulation / drug effects. Genes, Reporter. Humans. Intestines / metabolism. Isoxazoles / pharmacology. Kidney / metabolism. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Molecular Sequence Data. Oligonucleotide Array Sequence Analysis. Promoter Regions, Genetic. RNA, Messenger / genetics. RNA, Messenger / metabolism. Receptors, Cytoplasmic and Nuclear. Transfection

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  • (PMID = 16251721.001).
  • [ISSN] 0022-2275
  • [Journal-full-title] Journal of lipid research
  • [ISO-abbreviation] J. Lipid Res.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM-07185; United States / NHLBI NIH HHS / HL / HL-30568; United States / NHLBI NIH HHS / HL / HL-68445; United States / NHLBI NIH HHS / HL / R01 HL-072367
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / DNA-Binding Proteins; 0 / GW 4064; 0 / Isoxazoles; 0 / Membrane Transport Proteins; 0 / RNA, Messenger; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Transcription Factors; 0 / farnesoid X-activated receptor; 0 / organic solute transporter alpha, human; 0 / organic solute transporter alpha, mouse; 0 / organic solute transporter beta, human; 0 / organic solute transporter beta, mouse
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62. Frankenberg T, Rao A, Chen F, Haywood J, Shneider BL, Dawson PA: Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids. Am J Physiol Gastrointest Liver Physiol; 2006 May;290(5):G912-22
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  • [Title] Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids.
  • The mechanisms responsible for bile acid regulation of mouse intestinal organic solute transporter alpha-beta (Ostalpha-Ostbeta) expression were investigated.
  • Sequence analysis revealed potential cis-acting elements for farnesoid X receptor (FXR) and liver receptor homolog-1 (LRH-1) in the mouse Ostalpha and Ostbeta promoters and reporter constructs containing Ostalpha and Ostbeta 5'-flanking sequences were positively regulated by bile acids.
  • [MeSH-minor] Animals. Cell Line, Tumor. DNA-Binding Proteins / genetics. Male. Mice. Mice, Inbred C57BL. Models, Biological. Promoter Regions, Genetic. Receptors, Cytoplasmic and Nuclear / genetics. Transcription Factors / genetics

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  • (PMID = 16357058.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK 069942; United States / NIDDK NIH HHS / DK / DK 47987; United States / NIDDK NIH HHS / DK / DK 54165; United States / NIDDK NIH HHS / DK / R01 DK047987
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / DNA-Binding Proteins; 0 / Membrane Transport Proteins; 0 / Nr5a2 protein, mouse; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Transcription Factors; 0 / farnesoid X-activated receptor; 0 / nuclear receptor subfamily 0, group B, member 2; 0 / organic solute transporter alpha, mouse; 0 / organic solute transporter beta, mouse
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63. Zhang L, Nichols RG, Correll J, Murray IA, Tanaka N, Smith PB, Hubbard TD, Sebastian A, Albert I, Hatzakis E, Gonzalez FJ, Perdew GH, Patterson AD: Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation. Environ Health Perspect; 2015 Jul;123(7):679-88
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  • [Title] Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation.
  • Because most exposure to environmentally persistent organic pollutants (POPs) occurs through the diet, the host gastrointestinal tract and commensal gut microbiota are likely to be exposed to POPs.
  • Further, dietary TCDF inhibited the farnesoid X receptor (FXR) signaling pathway, triggered significant inflammation and host metabolic disorders as a result of activation of bacterial fermentation, and altered hepatic lipogenesis, gluconeogenesis, and glycogenolysis in an AHR-dependent manner.
  • CONCLUSION: These findings provide new insights into the biochemical consequences of TCDF exposure involving the alteration of the gut microbiota, modulation of nuclear receptor signaling, and disruption of host metabolism.

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  • (PMID = 25768209.001).
  • [ISSN] 1552-9924
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES004869; United States / NIEHS NIH HHS / ES / ES019964; United States / NIEHS NIH HHS / ES / ES022186; United States / NIEHS NIH HHS / ES / R01 ES004869; United States / NIEHS NIH HHS / ES / R01 ES019964; United States / NIEHS NIH HHS / ES / R01 ES022186; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Bile Acids and Salts; 0 / Environmental Pollutants; 0 / RNA, Ribosomal, 16S; 0 / Receptors, Aryl Hydrocarbon; 0 / Receptors, Cytoplasmic and Nuclear; 0 / farnesoid X-activated receptor; XZJ41GQI5D / 2,3,7,8-tetrachlorodibenzofuran
  • [Other-IDs] NLM/ PMC4492271
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64. Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y: Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos; 2005 Oct;33(10):1477-81
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  • [Title] Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans.
  • Fexofenadine hydrochloride (FEX), a second generation H(1)-receptor antagonist, is mainly eliminated from the liver into bile in unchanged form.
  • Recent studies have shown that FEX can be accepted by human MDR1 (P-glycoprotein), OATP1A2 [organic anion-transporting polypeptide (OATP)-A, and OATP2B1 (OATP-B)] expression systems.
  • [MeSH-major] Histamine H1 Antagonists / pharmacology. Organic Anion Transport Protein 1 / metabolism. Terfenadine / analogs & derivatives
  • [MeSH-minor] Cell Line. Estradiol / analogs & derivatives. Estradiol / metabolism. Estrone / analogs & derivatives. Estrone / metabolism. Humans. Liver / metabolism. Organic Anion Transport Polypeptide C / genetics. Organic Anion Transport Polypeptide C / metabolism. Sincalide / metabolism

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  • (PMID = 16014768.001).
  • [ISSN] 0090-9556
  • [Journal-full-title] Drug metabolism and disposition: the biological fate of chemicals
  • [ISO-abbreviation] Drug Metab. Dispos.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists; 0 / Organic Anion Transport Polypeptide C; 0 / Organic Anion Transport Protein 1; 1806-98-0 / estradiol-17 beta-glucuronide; 2DI9HA706A / Estrone; 4TI98Z838E / Estradiol; 7BA5G9Y06Q / Terfenadine; E6582LOH6V / fexofenadine; M03GIQ7Z6P / Sincalide; QTL48N278K / estrone sulfate
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65. Wang P, Wang JJ, Xiao Y, Murray JW, Novikoff PM, Angeletti RH, Orr GA, Lan D, Silver DL, Wolkoff AW: Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. J Biol Chem; 2005 Aug 26;280(34):30143-9
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  • [Title] Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface.
  • Although many organic anion transport protein (Oatp) family members have PDZ consensus binding sites at their C termini, the functional significance is unknown.
  • Oatp1a1 bound predominantly to the first and third PDZ binding domains of PDZK1, whereas the high density lipoprotein receptor, scavenger receptor B type I binds to the first domain.
  • Because its ability to transport substances into the cell requires surface expression, this must be considered in any assessment of physiologic function.
  • [MeSH-major] Hepatocytes / cytology. Membrane Proteins / metabolism. Neoplasm Proteins / metabolism. Organic Anion Transporters / metabolism
  • [MeSH-minor] Amino Acid Sequence. Animals. Cell Line. Cell Membrane / metabolism. DNA, Complementary / metabolism. Gene Expression Regulation. Humans. Immunoprecipitation. Ligands. Liver / metabolism. Mass Spectrometry. Mice. Mice, Knockout. Microscopy, Fluorescence. Molecular Sequence Data. Peptides / chemistry. Protein Binding. Protein Structure, Tertiary. Rats. Sulfobromophthalein / chemistry. Transfection

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  • (PMID = 15994332.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA06576; United States / NIDDK NIH HHS / DK / DK23026; United States / NIDDK NIH HHS / DK / DK41296; United States / NCRR NIH HHS / RR / S10 RR019352; United States / NCRR NIH HHS / RR / S10 RR019352-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Ligands; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Organic Anion Transporters; 0 / PDZK1IP1 protein, human; 0 / Pdzk1ip1 protein, mouse; 0 / Pdzk1ip1 protein, rat; 0 / Peptides; 0C2P5QKL36 / Sulfobromophthalein
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66. Jacometo CB, Osorio JS, Socha M, Corrêa MN, Piccioli-Cappelli F, Trevisi E, Loor JJ: Maternal consumption of organic trace minerals alters calf systemic and neutrophil mRNA and microRNA indicators of inflammation and oxidative stress. J Dairy Sci; 2015 Nov;98(11):7717-29
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  • [Title] Maternal consumption of organic trace minerals alters calf systemic and neutrophil mRNA and microRNA indicators of inflammation and oxidative stress.
  • Organic trace mineral (ORG) supplementation to dairy cows in substitution of sulfate (INO) sources has been associated with improvement in immune function during stressful states such as the peripartal period.
  • Forty multiparous cows were supplemented for 30d prepartum with 40 mg/kg of Zn, 20 mg/kg of Mn, 5 mg/kg of Cu, and 1mg/kg of Co from either organic (ORG) or sulfate (INO) sources (total diet contained supplemental 75 mg/kg of Zn, 65 mg/kg of Mn, 11 mg/kg of Cu, and 1 mg/kg of Co, and additional Zn, Mn, and Co provided by sulfates), and a subset of calves (n=8/treatment) was used for blood immunometabolic marker and polymorphonuclear leukocyte (PMNL) gene and miRNA expression analyses.
  • The PMNL expression of toll-like receptor pathway genes indicated a pro-inflammatory state in INO calves, with greater expression of the inflammatory mediators MYD88, IRAK1, TRAF6, NFKB, and NFKBIA.
  • The lower expression of miR-155 and miR-125b in ORG calves indicated the potential for maternal organic trace minerals in regulating the PMNL inflammatory response at least via alterations in mRNA and miRNA expression.
  • Overall, these results indicate that maternal nutrition with organic trace minerals could alter the neonatal innate immune response at least in part via changes in gene and miRNA expression.
  • Further studies involving inflammatory challenges during the neonatal period should be performed to determine the functional benefit of maternal organic trace minerals on the neonatal immune response.
  • [MeSH-minor] Animal Feed / analysis. Animal Nutritional Physiological Phenomena. Animals. Biomarkers / blood. Cattle. Cell Adhesion / drug effects. Diet / veterinary. Female. Gene Expression Regulation. Immunity, Innate / drug effects. Maternal Nutritional Physiological Phenomena. Pregnancy

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  • [Copyright] Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.
  • (PMID = 26319761.001).
  • [ISSN] 1525-3198
  • [Journal-full-title] Journal of dairy science
  • [ISO-abbreviation] J. Dairy Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / MicroRNAs; 0 / RNA, Messenger; 0 / Trace Elements
  • [Keywords] NOTNLM ; epigenetics / fetal programming / nutrition / transcriptomics
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67. Yitbarek A, Echeverry H, Brady J, Hernandez-Doria J, Camelo-Jaimes G, Sharif S, Guenter W, House JD, Rodriguez-Lecompte JC: Innate immune response to yeast-derived carbohydrates in broiler chickens fed organic diets and challenged with Clostridium perfringens. Poult Sci; 2012 May;91(5):1105-12
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  • [Title] Innate immune response to yeast-derived carbohydrates in broiler chickens fed organic diets and challenged with Clostridium perfringens.
  • The effect of mannan-oligosaccharide (MOS) supplementation in organic diets of broilers challenged with C. perfringens on performance, gut morphology, and innate immunity was investigated.
  • Three hundred Ross-308 broilers were fed antibiotic-free certified organic starter and grower diets.
  • Quantitative real-time PCR showed that, in the ileum, the MOS diet resulted in an upregulation of toll-like receptor (TLR)2b, TLR4, interleukin (IL)-12p35, and interferon (IFN)-γ compared with CO (P = 0.003, P = 0.018, and P = 0.024, respectively).
  • However, MOS was capable of altering TLR and cytokine profiles, where dual TLR2 and TLR4 pathways were associated with MOS supplementation with subsequent upregulation of ileal IL-12p35 and IFN-γ, implying that MOS supplementation in C. perfringens-challenged chickens supports a proinflammatory effect via T-helper cell-1 associated pathways.

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  • (PMID = 22499867.001).
  • [ISSN] 0032-5791
  • [Journal-full-title] Poultry science
  • [ISO-abbreviation] Poult. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbohydrates; 0 / Cytokines; 0 / Toll-Like Receptors
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68. Choi JH, Murray JW, Wolkoff AW: PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1. Am J Physiol Gastrointest Liver Physiol; 2011 Mar;300(3):G384-93
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  • [Title] PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1.
  • Although perturbation of organic anion transport protein (oatp) cell surface expression can result in drug toxicity, little is known regarding mechanisms regulating its subcellular distribution.
  • Cotransfection with a plasmid encoding PDZK1 revealed that oatp1a1(AA) was now expressed largely on the cell surface, while oatp1a1(EE) remained intracellular.
  • To examine a physiological role for phosphorylation in oatp1a1 subcellular distribution, studies were performed in rat hepatocytes exposed to extracellular ATP, a condition that stimulates serine phosphorylation of oatp1a1 via activity of a purinergic receptor.
  • Thus, although PDZK1 binding is required for optimal cell surface expression of oatp1a1, phosphorylation provides a mechanism for fast regulation of the distribution of oatp1a1 between the cell surface and intracellular vesicular pools.
  • [MeSH-major] Carrier Proteins / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Organic Anion Transporters / metabolism
  • [MeSH-minor] Adenosine Triphosphate / metabolism. Alanine. Animals. Cell Line, Tumor. Cell Membrane / metabolism. Cytoplasmic Vesicles / metabolism. Glutamic Acid. HEK293 Cells. Hepatocytes / metabolism. Humans. Mice. Mutagenesis, Site-Directed. Mutation. Phosphorylation. Protein Binding. Protein Transport. Rats. Recombinant Fusion Proteins / metabolism. Serine. Time Factors. Transfection

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  • (PMID = 21183661.001).
  • [ISSN] 1522-1547
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-23026; United States / NIDDK NIH HHS / DK / DK-41296; United States / NIGMS NIH HHS / GM / T32GM-007288
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Organic Anion Transporters; 0 / PDZK1 protein, human; 0 / PDZK1 protein, mouse; 0 / Recombinant Fusion Proteins; 3KX376GY7L / Glutamic Acid; 452VLY9402 / Serine; 8L70Q75FXE / Adenosine Triphosphate; OF5P57N2ZX / Alanine
  • [Other-IDs] NLM/ PMC3064118
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69. Midthun KM, Taylor PG, Newby C, Chatzichristidi M, Petrou PS, Lee JK, Kakabakos SE, Baird BA, Ober CK: Orthogonal patterning of multiple biomolecules using an organic fluorinated resist and imprint lithography. Biomacromolecules; 2013 Apr 8;14(4):993-1002
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  • [Title] Orthogonal patterning of multiple biomolecules using an organic fluorinated resist and imprint lithography.
  • We further showcase this method's capacity for fabricating patterns of receptor-specific ligands for fundamental cell studies.
  • [MeSH-minor] Animals. Antibodies, Monoclonal / metabolism. Cell Line, Tumor. Hybridization, Genetic. Leukemia, Basophilic, Acute. Methacrylates / chemistry. Methacrylates / metabolism. Nanotechnology. Rats. Streptavidin / metabolism. Surface Properties

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  • (PMID = 23439033.001).
  • [ISSN] 1526-4602
  • [Journal-full-title] Biomacromolecules
  • [ISO-abbreviation] Biomacromolecules
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI018306; United States / NIAID NIH HHS / AI / R01 AI018306
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Methacrylates; 0 / Proteins; 9007-49-2 / DNA; 9013-20-1 / Streptavidin
  • [Other-IDs] NLM/ NIHMS453567; NLM/ PMC3672400
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70. Yang G, Zhou Z, Cen Y, Gui X, Zeng Q, Ao Y, Li Q, Wang S, Li J, Zhang A: Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water. Drug Des Devel Ther; 2015;9:4719-33
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  • [Title] Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water.
  • Persistent organic pollutants in drinking water impose a substantial risk to the health of human beings, but the evidence for liver toxic effect and the underlying mechanism is scarce.
  • This study aimed to examine the liver toxicity and elucidate the molecular mechanism of organic pollutants in drinking water in normal human liver cell line L02 cells and rats.
  • The data showed that organic extraction from drinking water remarkably impaired rat liver function, evident from the increase in the serum level of alanine aminotransferase, aspartate aminotransferase, and cholinesterase, and decrease in the serum level of total protein and albumin.
  • Organic extraction dose-dependently induced apoptotic cell death in rat liver and L02 cells.
  • Administration of rats with organic extraction promoted death receptor signaling pathway through the increase in gene and protein expression level of Fas and FasL.
  • Treatment of rats with organic extraction also induced mitochondria-mediated apoptosis via increasing the expression level of proapoptotic protein, Bax, but decreasing the expression level of antiapoptotic protein, Bcl-2, resulting in an upregulation of cytochrome c and activation of caspase cascade at both transcriptional and post-transcriptional levels.
  • Moreover, organic extraction enhanced rat liver glutathione S-transferases activity and reactive oxygen species generation, and upregulated aryl hydrocarbon receptor and glutathione S-transferase A1 at both transcriptional and translational levels.
  • Collectively, the results indicate that organic extraction from drinking water impairs liver function, with the involvement of death receptor and mitochondria-mediated apoptosis in rats.
  • The results provide evidence and molecular mechanisms for organic pollutants in drinking water-induced liver dysfunction, which may help prevent and treat organic extraction-induced liver injury.
  • [MeSH-major] Antigens, CD95 / metabolism. Apoptosis / drug effects. Drinking Water. Drug-Induced Liver Injury / etiology. Hepatocytes / drug effects. Liver / drug effects. Mitochondria, Liver / drug effects. Organic Chemicals / toxicity. Water Pollutants, Chemical / toxicity
  • [MeSH-minor] Animals. Apoptosis Regulatory Proteins / metabolism. Cell Line. Dose-Response Relationship, Drug. Fas Ligand Protein / metabolism. Female. Gene Expression Regulation. Humans. Male. Oxidative Stress / drug effects. Rats, Sprague-Dawley. Signal Transduction / drug effects

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  • (PMID = 26316710.001).
  • [ISSN] 1177-8881
  • [Journal-full-title] Drug design, development and therapy
  • [ISO-abbreviation] Drug Des Devel Ther
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / Apoptosis Regulatory Proteins; 0 / Drinking Water; 0 / Fas Ligand Protein; 0 / Organic Chemicals; 0 / Tnfrsf6 protein, rat; 0 / Tnfsf6 protein, rat; 0 / Water Pollutants, Chemical
  • [Other-IDs] NLM/ PMC4547633
  • [Keywords] NOTNLM ; Fas/FasL pathway / liver injury / mitochondrial pathway
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71. Golden GA, Wyatt TA, Romberger DJ, Reiff D, McCaskill M, Bauer C, Gleason AM, Poole JA: Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences. J Biochem Mol Toxicol; 2013 Jan;27(1):77-86
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  • [Title] Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences.
  • Exposure to organic dusts elicits airway inflammatory diseases.
  • Vitamin D recently has been associated with various airway inflammatory diseases, but its role in agricultural organic dust exposures is unknown.
  • This study investigated whether vitamin D reduces organic dust-induced inflammatory outcomes in cell culture and animal models.
  • Organic dust extracts obtained from swine confinement facilities induced neutrophil chemokine production (human IL-8, murine CXCL1/CXCL2).
  • Intranasal inhalation of organic dust extract induced neutrophil influx, and CXCL1/CXCL2 release was also decreased in mice fed a relatively high vitamin D diet as compared to mice fed a low vitamin D diet.
  • These findings were associated with reduced tracheal epithelial cell PKCα and PKCε activity and whole lung TLR2 and TLR4 gene expression.
  • Collectively, vitamin D plays a role in modulating organic dust-induced airway inflammatory outcomes.
  • [MeSH-minor] Administration, Intranasal. Animals. Cell Line. Chemokine CXCL1 / metabolism. Chemokine CXCL2 / metabolism. Disease Models, Animal. Humans. In Vitro Techniques. Interleukin-8 / metabolism. Lung / drug effects. Male. Mice. Mice, Inbred C57BL. Monocytes / drug effects. Organic Agriculture. Protein Kinase C / metabolism. Swine. Toll-Like Receptor 2 / genetics. Toll-Like Receptor 4 / genetics

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  • [Copyright] © 2012 Wiley Periodicals, Inc.
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  • (PMID = 23281135.001).
  • [ISSN] 1099-0461
  • [Journal-full-title] Journal of biochemical and molecular toxicology
  • [ISO-abbreviation] J. Biochem. Mol. Toxicol.
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1U54OH010162-01; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NIEHS NIH HHS / ES / R01: ES019325
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokine CXCL1; 0 / Chemokine CXCL2; 0 / Chemokines; 0 / Cxcl1 protein, mouse; 0 / Cxcl2 protein, mouse; 0 / Dust; 0 / Interleukin-8; 0 / TLR2 protein, human; 0 / TLR4 protein, human; 0 / Toll-Like Receptor 2; 0 / Toll-Like Receptor 4; 1406-16-2 / Vitamin D; EC 2.7.11.13 / Protein Kinase C
  • [Other-IDs] NLM/ NIHMS573909; NLM/ PMC4004104
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72. Sauvant C, Hesse D, Holzinger H, Evans KK, Dantzler WH, Gekle M: Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells. Am J Physiol Renal Physiol; 2004 Apr;286(4):F774-83
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  • [Title] Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells.
  • We recently showed that, in a proximal tubule cell line (opossum kidney cells), epithelial growth factor (EGF) stimulates basolateral organic anion transport (OAT) via ERK1/2, arachidonic acid, phospholipase A2, and generation of prostaglandins.
  • PGE2 binds the prostanoid receptor and, thus, activates adenylate cyclase and PKA, which stimulate basolateral organic anion uptake.
  • In the present study, we investigated whether this regulatory cascade is also true 1) for ex vivo conditions in isolated renal proximal (S2) tubules from rabbit and 2) in a human renal epithelial cell line stably expressing human OAT1 (IHKE-hOAT1).
  • In S2 tubules and IHKE-hOAT1, EGF led to an increase of organic anion uptake, which again was inhibited by U-0126.
  • PGE2 stimulated basolateral organic anion uptake in rabbit S2 tubules and IHKE-hOAT1.
  • EGF- and PGE2-mediated stimulation of organic anion uptake was abolished by inhibition of PKA in rabbit S2 tubules and IHKE-hOAT1, respectively.
  • We conclude that 1) stimulation of basolateral organic anion uptake by EGF or PGE2 is a widespread (if not general) regulatory mechanism, 2) the signal transduction pathway involved seems to be general, 3) stimulation of basolateral organic anion uptake by EGF or PGE2 is also present under ex vivo conditions and, thus, is not a cell culture artifact, 4) activation of OAT1 is sufficient to explain the stimulatory effects of EGF and PGE2 in opossum kidney cells and rabbit S2 segments, and 5) stimulation of basolateral OAT1 by EGF or PGE2 is also important in humans and, thus, may have clinical implications.
  • [MeSH-major] Dinoprostone / pharmacology. Epidermal Growth Factor / pharmacology. Epithelial Cells / metabolism. Kidney Tubules, Proximal / metabolism. Organic Anion Transport Protein 1 / metabolism. Sulfonamides

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  • (PMID = 14644751.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-56224; United States / NIEHS NIH HHS / ES / ES-0492; United States / NIEHS NIH HHS / ES / ES-06694
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Isoquinolines; 0 / Organic Anion Transport Protein 1; 0 / Sulfonamides; 127243-85-0 / N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide; 62229-50-9 / Epidermal Growth Factor; EC 2.7.11.11 / Cyclic AMP-Dependent Protein Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; K7Q1JQR04M / Dinoprostone; Y79XT83BJ9 / p-Aminohippuric Acid
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73. Bittner M, Macikova P, Giesy JP, Hilscherova K: Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter. Environ Int; 2011 Jul;37(5):960-4
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  • [Title] Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter.
  • Dissolved organic matter (DOM) in freshwaters is present at concentrations ranging from 0.5 to 50 mg L⁻¹, and consists of various organic compounds, including humic substances (HS).
  • HS exert a variety of direct and indirect biological effects, including interaction with the aryl hydrocarbon receptor (AhR).
  • AhR is a cytosolic receptor that binds various hydrophobic organic compounds (HOCs) and mediates some of their toxic effects.
  • In simultaneous exposures of H4IIE-luc cells to DOM (17 mg L⁻¹) and each of the model compounds, 2,3,7,8-TCDD, PCB126, PCB169, benzo[a]pyrene, benzo[a]anthracene, dibenz[a,h]anthracene, fluoranthene, a mixture of persistent organic pollutants (POPs), a mixture of polycyclic aromatic hydrocarbons (PAHs), and a mixture of all HOCs, either significant additive or facilitative effects were observed when compared to activities of single HOCs.
  • [MeSH-major] Environmental Pollutants / toxicity. Organic Chemicals / metabolism. Receptors, Aryl Hydrocarbon / metabolism
  • [MeSH-minor] Animals. Anthracenes / chemistry. Anthracenes / metabolism. Anthracenes / toxicity. Benzo(a)pyrene / chemistry. Benzo(a)pyrene / metabolism. Benzo(a)pyrene / toxicity. Cell Line, Tumor. Fluorenes / chemistry. Fluorenes / metabolism. Fluorenes / toxicity. Fresh Water / chemistry. Humic Substances / analysis. Hydrophobic and Hydrophilic Interactions. Polycyclic Hydrocarbons, Aromatic / chemistry. Polycyclic Hydrocarbons, Aromatic / metabolism. Polycyclic Hydrocarbons, Aromatic / toxicity. Rats. Tetrachlorodibenzodioxin / chemistry. Tetrachlorodibenzodioxin / metabolism. Tetrachlorodibenzodioxin / toxicity

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  • [Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.
  • (PMID = 21489634.001).
  • [ISSN] 1873-6750
  • [Journal-full-title] Environment international
  • [ISO-abbreviation] Environ Int
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anthracenes; 0 / Environmental Pollutants; 0 / Fluorenes; 0 / Humic Substances; 0 / Organic Chemicals; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Receptors, Aryl Hydrocarbon; 3417WMA06D / Benzo(a)pyrene; 360UOL779Z / fluoranthene; DO80M48B6O / Tetrachlorodibenzodioxin; EH46A1TLD7 / anthracene
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74. Cui Z, Li P, Liu J, Liu S: [Induction of CYP1A1 expression of H4IIE cell after treated with the water organic pollutants from the Yangtze River and Jialing River]. Wei Sheng Yan Jiu; 2008 Sep;37(5):540-2
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  • [Title] [Induction of CYP1A1 expression of H4IIE cell after treated with the water organic pollutants from the Yangtze River and Jialing River].
  • OBJECTIVE: To take Cuntan (Yangtze River) and Daxigou (Jialing River) as the representative, in order to study the cytochrome P450 1A1 (CYP1A1) gene expression in H4IIE cell treated with the organic pollutants in Chongqing source water between 2004 and 2005.
  • METHODS: The organic pollutants were extracted with solid phase extraction, dissolved the organic pollutants in dimethyl sulphoxide (DMSO) .
  • The H4IIE cell was treated with the extracts.
  • The aryl hydrocarbon receptor-aryl hydrocarbon receptor nuclear translocator (AhR-ARNT) heterdimers were observed in all groups at the time of 24h.
  • [MeSH-major] Cytochrome P-450 CYP1A1 / metabolism. Liver Neoplasms / metabolism. Organic Chemicals / toxicity. Water Pollutants, Chemical / toxicity
  • [MeSH-minor] Animals. Cell Line, Tumor. China. Cities. RNA, Messenger / genetics. RNA, Messenger / metabolism. Rats. Rivers / chemistry

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  • (PMID = 19069647.001).
  • [ISSN] 1000-8020
  • [Journal-full-title] Wei sheng yan jiu = Journal of hygiene research
  • [ISO-abbreviation] Wei Sheng Yan Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / RNA, Messenger; 0 / Water Pollutants, Chemical; EC 1.14.14.1 / Cytochrome P-450 CYP1A1
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75. Maeda T, Oyabu M, Yotsumoto T, Higashi R, Nagata K, Yamazoe Y, Tamai I: Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats. Drug Metab Dispos; 2007 Sep;35(9):1580-6
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  • [Title] Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats.
  • Because rat organic cation transporter 1 (Oct1, SLC22a1) is expressed mainly in the liver and mediates drug transport, its activity may determine the hepatic handling of cationic drugs.
  • In vitro studies using cultured hepatocytes indicated that expression of Oct1 was up-regulated by treatment with pregnenolone-16 alpha-carbonitrile (PCN) and by overexpression of rat pregnane X receptor (PXR).
  • Thus, PXR ligands appear to regulate the expression of organic cation transporters in rats and thereby to influence the pharmacokinetic properties of cationic drugs.
  • [MeSH-major] Organic Cation Transporter 1 / metabolism. Pharmaceutical Preparations / metabolism. Receptors, Steroid / drug effects
  • [MeSH-minor] Animals. Area Under Curve. Cations / metabolism. Cell Separation. Cells, Cultured. Digoxin / metabolism. Hepatocytes / drug effects. Hepatocytes / metabolism. In Vitro Techniques. Kinetics. Ligands. Liver / drug effects. Liver / metabolism. Male. Pregnenolone Carbonitrile / pharmacology. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Rats. Rats, Wistar. Reverse Transcriptase Polymerase Chain Reaction. Transfection. Trichloroacetic Acid / metabolism

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  • (PMID = 17553914.001).
  • [ISSN] 0090-9556
  • [Journal-full-title] Drug metabolism and disposition: the biological fate of chemicals
  • [ISO-abbreviation] Drug Metab. Dispos.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cations; 0 / Ligands; 0 / Organic Cation Transporter 1; 0 / Pharmaceutical Preparations; 0 / RNA, Messenger; 0 / Receptors, Steroid; 0 / pregnane X receptor; 1434-54-4 / Pregnenolone Carbonitrile; 5V2JDO056X / Trichloroacetic Acid; 73K4184T59 / Digoxin
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76. Stevenson RO, Taylor RM, Wiley JS, Sluyter R: The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types. Purinergic Signal; 2009 Sep;5(3):385-94
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  • [Title] The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types.
  • We previously demonstrated that canine erythrocytes express the P2X(7) receptor, and that the function and expression of this receptor is greatly increased compared with human erythrocytes.
  • Using (86)Rb(+) (K(+)) and organic cation flux measurements, we further compared P2X(7) in erythrocytes and mononuclear leukocytes from these species.
  • KN-62 inhibited the ATP-induced ethidium(+) uptake in each cell type.
  • P2X(7)-mediated uptake of organic cations was 40- and fivefold greater in canine erythrocytes and lymphocytes (T- and B-cells), respectively, compared to equivalent human cell types.
  • Thus, P2X(7) activation can induce the uptake of organic cations into canine erythrocytes and mononuclear leukocytes, but the relative levels of P2X(7) function differ to that of equivalent human cell types.


77. Maeda T, Yotsumoto T, Oyabu M, Tamai I: Effect of glucocorticoid receptor ligand dexamethasone on the expression of organic cation transporter in rat liver. Drug Metab Pharmacokinet; 2008;23(1):67-72
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  • [Title] Effect of glucocorticoid receptor ligand dexamethasone on the expression of organic cation transporter in rat liver.
  • Since rat organic cation transporter 1 (Oct1, Slc22a1) is expressed mainly in the liver and mediates drug transport, its activity may determine the hepatic handling of cationic drugs.
  • In the present study, dexamethasone, a ligand of glucocorticoid receptor, down-regulated the expression of rat Oct1.
  • In conclusion, these observations suggested that the expression of rat Oct1 gene and the apparent organic cation uptake activity of rat hepatocytes are down-regulated by dexamethasone presumably via a glucocorticoid receptor.
  • [MeSH-major] Dexamethasone / metabolism. Dexamethasone / pharmacology. Liver / metabolism. Organic Cation Transporter 1 / biosynthesis. Organic Cation Transporter 1 / genetics. Receptors, Glucocorticoid / metabolism
  • [MeSH-minor] Animals. Cell Line, Tumor. Cells, Cultured. Dose-Response Relationship, Drug. Ligands. Male. Rats. Rats, Wistar

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  • (PMID = 18305376.001).
  • [ISSN] 1880-0920
  • [Journal-full-title] Drug metabolism and pharmacokinetics
  • [ISO-abbreviation] Drug Metab. Pharmacokinet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ligands; 0 / Organic Cation Transporter 1; 0 / Receptors, Glucocorticoid; 7S5I7G3JQL / Dexamethasone
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78. Ito T, Nagai H, Lin TM, Peterson RE, Tohyama C, Kobayashi T, Nohara K: Organic Chemicals Adsorbed onto Diesel Exhaust Particles Directly Alter the Differentiation of Fetal Thymocytes Through Arylhydrocarbon Receptor but Not Oxidative Stress Responses. J Immunotoxicol; 2006 Jan 1;3(1):21-30
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  • [Title] Organic Chemicals Adsorbed onto Diesel Exhaust Particles Directly Alter the Differentiation of Fetal Thymocytes Through Arylhydrocarbon Receptor but Not Oxidative Stress Responses.
  • DEP consist of a carbon core to which many organic compounds are adsorbed, including polyaromatic hydrocarbons (PAHs) and their derivatives (e.g., dioxins and quinones).
  • Although it has been suggested that these organic compounds were responsible for mediating the effects of DEP through their regulation of gene expression, the molecular mechanism of action of DEP has not been fully elucidated.
  • DEP extracts up-regulated several genes known as arylhydrocarbon receptor (AhR)-target genes, including cytochrome P450 1a1 (Cyp1a1), 1b1 (Cyp1b1), TCDD-inducible poly(ADP-ribose) polymerase (Tiparp), and scinderin (Scin).
  • Furthermore, DEP extracts skewed thymic T-cell differentiation in favor of the production of CD8 T-cells, which was also observed when exposed to AhR ligands.
  • Our results suggest that organic compounds adsorbed onto DEP alter thymic gene expression and directly affect thymocyte development by activating the AhR.

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  • (PMID = 18958682.001).
  • [ISSN] 1547-6901
  • [Journal-full-title] Journal of immunotoxicology
  • [ISO-abbreviation] J Immunotoxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Preising C, Schneider R, Bucher M, Gekle M, Sauvant C: Regulation of Expression of Renal Organic Anion Transporters OAT1 and OAT3 in a Model of Ischemia/Reperfusion Injury. Cell Physiol Biochem; 2015;37(1):1-13
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  • [Title] Regulation of Expression of Renal Organic Anion Transporters OAT1 and OAT3 in a Model of Ischemia/Reperfusion Injury.
  • METHODS: (i) Basolateral organic anion uptake into proximal tubular cells after model ischemia and reperfusion (I/R) was investigated by fluorescein uptake.
  • RESULTS: By using inhibitors of PKA (H89) and PLC (U73122), antagonists of E prostanoid receptor type 2 (AH6809) and type 4 (L161,982), we gained evidence that I/R induced down regulation of organic anion transport is mediated by COX1 metabolites via E prostanoid receptor type 4.
  • CONCLUSION: Our data show (a) that COX1 metabolites are involved in the regulation of renal organic anion transport(ers) after I/R via the EP4 receptor and (b) that this is due to transcriptional regulation of the respective transporters.
  • As the promoter sequences cloned were of human origin and expressed in a human renal epithelial cell line we (c) hypothesize that the regulatory mechanisms described after I/R is meaningful for humans as well.
  • [MeSH-major] Kidney Tubules, Proximal / metabolism. Organic Anion Transport Protein 1 / genetics. Organic Anion Transport Protein 1 / metabolism. Organic Anion Transporters, Sodium-Independent / genetics. Organic Anion Transporters, Sodium-Independent / metabolism. Reperfusion Injury / genetics. Reperfusion Injury / metabolism
  • [MeSH-minor] Biological Transport / drug effects. Biological Transport / genetics. Cell Line. Cyclooxygenase 1 / genetics. Cyclooxygenase 1 / metabolism. Cyclooxygenase 2 / genetics. Cyclooxygenase 2 / metabolism. Cyclooxygenase 2 Inhibitors / pharmacology. Down-Regulation / drug effects. Down-Regulation / genetics. Epithelial Cells / drug effects. Epithelial Cells / metabolism. HEK293 Cells. Humans. Phosphodiesterase Inhibitors / pharmacology. Promoter Regions, Genetic / drug effects. Promoter Regions, Genetic / genetics. Prostaglandin Antagonists / pharmacology. Protein Kinase Inhibitors / pharmacology. Receptors, Prostaglandin E, EP4 Subtype / genetics. Receptors, Prostaglandin E, EP4 Subtype / metabolism. Signal Transduction / drug effects. Signal Transduction / genetics. Transcription, Genetic / drug effects. Transcription, Genetic / genetics

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  • [Copyright] © 2015 S. Karger AG, Basel.
  • (PMID = 26277839.001).
  • [ISSN] 1421-9778
  • [Journal-full-title] Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • [ISO-abbreviation] Cell. Physiol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Organic Anion Transport Protein 1; 0 / Organic Anion Transporters, Sodium-Independent; 0 / Phosphodiesterase Inhibitors; 0 / Prostaglandin Antagonists; 0 / Protein Kinase Inhibitors; 0 / Receptors, Prostaglandin E, EP4 Subtype; 0 / organic anion transport protein 3; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS1 protein, human; EC 1.14.99.1 / PTGS2 protein, human
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80. Poole JA, Anderson L, Gleason AM, West WW, Romberger DJ, Wyatt TA: Pattern recognition scavenger receptor A/CD204 regulates airway inflammatory homeostasis following organic dust extract exposures. J Immunotoxicol; 2015 Jan-Mar;12(1):64-73
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  • [Title] Pattern recognition scavenger receptor A/CD204 regulates airway inflammatory homeostasis following organic dust extract exposures.
  • Exposure to agriculture organic dusts, comprised of a diversity of pathogen-associated molecular patterns, results in chronic airway diseases.
  • The multi-functional class A macrophage scavenger receptor (SRA)/CD204 has emerged as an important class of pattern recognition receptors with broad ligand binding ability.
  • The objective was to determine the role of SRA in mediating repetitive and post-inflammatory organic dust extract (ODE)-induced airway inflammation.
  • Overall, the data demonstrate that SRA/CD204 plays an important role in the normative inflammatory lung response to ODE, as evidenced by the enhanced dust-mediated injury viewed in the absence of this receptor.

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  • (PMID = 24491035.001).
  • [ISSN] 1547-6901
  • [Journal-full-title] Journal of immunotoxicology
  • [ISO-abbreviation] J Immunotoxicol
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / R01 AA017993; United States / NIEHS NIH HHS / ES / R01 ES019325; United States / NIAAA NIH HHS / AA / R01AA017993; United States / NIEHS NIH HHS / ES / R01ES019325; United States / NIOSH CDC HHS / OH / R01OH008539; United States / NIOSH CDC HHS / OH / U54OH010162
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / Antigens, Fungal; 0 / Cytokines; 0 / Dust; 0 / Msr1 protein, mouse; 0 / Receptors, Pattern Recognition; 0 / Scavenger Receptors, Class A
  • [Other-IDs] NLM/ NIHMS574286; NLM/ PMC4119855
  • [Keywords] NOTNLM ; Farm / TH17 / inflammation / lung / lymphocyte / toll-like receptor
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81. Herranz H, Morata G, Milán M: calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. Development; 2006 Jul;133(14):2617-25
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  • [Title] calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues.
  • The insulin receptor (InR) signalling pathway controls growth and metabolism in response to nutrient availability.
  • We identified calderón, a gene that encodes a protein with highest homology with organic cation transporters of the major facilitator superfamily, as a new transcriptional target of the InR pathway.
  • These transporters are believed to function mainly in the uptake of sugars, as well as other organic metabolites.
  • Genetic experiments demonstrate that calderón is required cell autonomously and downstream of the InR pathway for normal growth and proliferation of larval tissues.
  • Our results indicate that growth of imaginal cells may be modulated by two distinct, but coordinated, nutrient-sensing mechanisms: one cell-autonomous and the other humoral.
  • [MeSH-major] Cell Proliferation. Drosophila Proteins / metabolism. Drosophila melanogaster. Organic Cation Transport Proteins / metabolism
  • [MeSH-minor] Amino Acid Sequence. Animals. Embryonic Structures / anatomy & histology. Embryonic Structures / metabolism. Humans. Insulin / metabolism. Molecular Sequence Data. Phenotype. Receptor, Insulin / metabolism. Sequence Alignment. Sequence Homology, Nucleic Acid. Signal Transduction / physiology

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  • (PMID = 16774996.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drosophila Proteins; 0 / Insulin; 0 / Organic Cation Transport Proteins; 0 / calderon protein, Drosophila; EC 2.7.10.1 / Receptor, Insulin
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82. Holm JB, Grygorczyk R, Lambert IH: Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase. Am J Physiol Cell Physiol; 2013 Jul 1;305(1):C48-60
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  • [Title] Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase.
  • Pathophysiological conditions challenge cell volume homeostasis and perturb cell volume regulatory mechanisms leading to alterations of cell metabolism, active transepithelial transport, cell migration, and death.
  • We report that inhibition of the 5-lipoxygenase (5-LO) with AA861 or ETH 615-139, the cysteinyl leukotriene 1 receptor (CysLT₁) with the antiasthmatic drug Zafirlukast, or the volume-sensitive organic anion channel (VSOAC) with DIDS blocks the release of organic osmolytes (taurine, meAIB) and the concomitant cell volume restoration following hypoosmotic swelling of human type II-like lung epithelial cells (A549).
  • Reactive oxygen species (ROS) are produced in A549 cells upon hypotonic cell swelling by a diphenylene iodonium-sensitive NADPH oxidase.
  • [MeSH-minor] 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / pharmacology. Adenocarcinoma. Adenosine Triphosphate. Anti-Asthmatic Agents / pharmacology. Calcium. Cell Line, Tumor. Cell Size / drug effects. Cell Survival. Dose-Response Relationship, Drug. Electrolytes. Gene Expression Regulation, Enzymologic. Humans. Leukotriene Antagonists / pharmacology. Lipoxygenase Inhibitors / pharmacology. Lung Neoplasms. Osmolar Concentration. Osmotic Pressure / physiology. Reactive Oxygen Species / metabolism. Taurine / metabolism. Tosyl Compounds / pharmacology. Water / metabolism

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  • [CommentIn] Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C24-5 [23657572.001]
  • (PMID = 23485709.001).
  • [ISSN] 1522-1563
  • [Journal-full-title] American journal of physiology. Cell physiology
  • [ISO-abbreviation] Am. J. Physiol., Cell Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Anti-Asthmatic Agents; 0 / Electrolytes; 0 / Leukotriene Antagonists; 0 / Lipoxygenase Inhibitors; 0 / Reactive Oxygen Species; 0 / Tosyl Compounds; 059QF0KO0R / Water; 107753-78-6 / zafirlukast; 1EQV5MLY3D / Taurine; 8L70Q75FXE / Adenosine Triphosphate; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; Q1O6DSW23R / 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; SY7Q814VUP / Calcium
  • [Keywords] NOTNLM ; 5-lipoxygenase / cell volume regulation / cysteinyl leukotriene 1 receptor / hypoxia / ischemia / lung adenocarcinoma / reactive oxygen species / taurine homeostasis
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83. Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther; 2003 Jan;304(1):223-8
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  • [Title] Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation.
  • Rifampin, a member of the rifamycin class of antibiotics, is well known for its ability to induce drug-metabolizing enzymes and transporters, through activation of the pregnane X receptor.
  • In this study, we expressed an array of known hepatic uptake transporters to show the key hepatic rifampin uptake transporters are liver-specific members of the organic anion transporting polypeptide family (OATP).
  • In cell-based, transactivation assays, OATP-C expression was associated with increased cellular rifampin retention as well as potentiation of PXR reporter gene activity.
  • [MeSH-major] Adenosine Triphosphate / analogs & derivatives. Antibiotics, Antitubercular / pharmacology. Membrane Transport Proteins. Organic Anion Transport Polypeptide C / metabolism. Receptors, Cytoplasmic and Nuclear / drug effects. Receptors, Steroid / drug effects. Rifampin / pharmacology
  • [MeSH-minor] Animals. Carrier Proteins / metabolism. Cytochrome P-450 CYP3A. Cytochrome P-450 Enzyme System / biosynthesis. Cytochrome P-450 Enzyme System / genetics. DNA, Complementary / biosynthesis. DNA, Complementary / genetics. Estradiol / metabolism. Genes, Reporter / drug effects. Genes, Reporter / genetics. Hepatocytes / drug effects. Hepatocytes / metabolism. Humans. In Vitro Techniques. Kinetics. Organic Anion Transporters, Sodium-Dependent. Organic Cation Transporter 1 / metabolism. Plasmids / genetics. Rats. Symporters. Transcriptional Activation. Transfection

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  • (PMID = 12490595.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK23026; United States / NIDDK NIH HHS / DK / DK41296; United States / NIGMS NIH HHS / GM / GM31304; United States / NIGMS NIH HHS / GM / GM54724
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antitubercular; 0 / Carrier Proteins; 0 / DNA, Complementary; 0 / Membrane Transport Proteins; 0 / Organic Anion Transport Polypeptide C; 0 / Organic Anion Transporters, Sodium-Dependent; 0 / Organic Cation Transporter 1; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Receptors, Steroid; 0 / Symporters; 0 / pregnane X receptor; 145420-23-1 / sodium-bile acid cotransporter; 4TI98Z838E / Estradiol; 54970-91-1 / 2',3'-dialdehyde ATP; 8L70Q75FXE / Adenosine Triphosphate; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 1.14.14.1 / CYP3A protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP3A; VJT6J7R4TR / Rifampin
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84. Song YS, Koontz JL, Juskelis RO, Zhao Y: Static liquid permeation cell method for determining the migration parameters of low molecular weight organic compounds in polyethylene terephthalate. Food Addit Contam Part A Chem Anal Control Expo Risk Assess; 2013;30(10):1837-48
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  • [Title] Static liquid permeation cell method for determining the migration parameters of low molecular weight organic compounds in polyethylene terephthalate.
  • The migration of low molecular weight organic compounds through polyethylene terephthalate (PET) films was determined by using a custom permeation cell assembly.
  • Fatty food simulant (Miglyol 812) was added to the receptor chamber, while the donor chamber was filled with 1% and 10% (v/v) migrant compounds spiked in simulant.
  • The permeation cell was maintained at 40°C, 66°C, 100°C or 121°C for up to 25 days of polymer film exposure time.
  • Therefore, it may be necessary further to refine "upper-bound" Áp values for PET such that Piringer's model does not significantly underestimate or overestimate the migration of organic compounds dependent upon the temperature condition of the food contact material.
  • [MeSH-major] Food Contamination / analysis. Food Packaging. Organic Chemicals / analysis. Polyethylene Terephthalates

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  • (PMID = 23883310.001).
  • [ISSN] 1944-0057
  • [Journal-full-title] Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
  • [ISO-abbreviation] Food Addit Contam Part A Chem Anal Control Expo Risk Assess
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / Polyethylene Terephthalates
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85. Neale PA, Escher BI, Leusch FD: Understanding the implications of dissolved organic carbon when assessing antagonism in vitro: An example with an estrogen receptor assay. Chemosphere; 2015 Sep;135:341-6
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  • [Title] Understanding the implications of dissolved organic carbon when assessing antagonism in vitro: An example with an estrogen receptor assay.
  • Some studies have suggested that dissolved organic carbon (DOC), which can be co-extracted during sample enrichment, contributes to the apparent antagonistic effect.
  • DOC has a high sorption capacity for the estrogen receptor (ER) agonist 17β-estradiol, which may reduce the available 17β-estradiol concentration in the antagonist testing mode and potentially lead to apparent antagonism.

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  • [Copyright] Copyright © 2015 Elsevier Ltd. All rights reserved.
  • (PMID = 25978675.001).
  • [ISSN] 1879-1298
  • [Journal-full-title] Chemosphere
  • [ISO-abbreviation] Chemosphere
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogens; 0 / Receptors, Estrogen; 0 / Water Pollutants, Chemical; 2DI9HA706A / Estrone; 4TI98Z838E / Estradiol; 7440-44-0 / Carbon
  • [Keywords] NOTNLM ; Antagonism / Dissolved organic carbon / Estrogen receptor / In vitro
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86. Schneberger D, Cloonan D, DeVasure JM, Bailey KL, Romberger DJ, Wyatt TA: Effect of elevated carbon dioxide on bronchial epithelial innate immune receptor response to organic dust from swine confinement barns. Int Immunopharmacol; 2015 Jul;27(1):76-84
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  • [Title] Effect of elevated carbon dioxide on bronchial epithelial innate immune receptor response to organic dust from swine confinement barns.
  • Cell culture systems demonstrate this in both macrophages and alveolar cell lines, suggesting that the alveoli are affected by changes in CO2 levels.
  • We hypothesized that hypercapnia would also modulate human bronchial epithelial cell immune responses.
  • Innate immune responses to Pam3CSK4 (TLR2 ligand), LPS (TLR4 ligand) and a complex innate immune stimulus, an extract from the organic dust of swine confinement barns (barn dust extract or BDE), were tested in a human bronchial epithelial cell line, BEAS-2B.
  • This change was not reflected in expression levels of TLR receptor RNA which remained unchanged in response to elevated CO2.
  • Our results show that airway epithelial cell immune responses to barn dust respond differently to hypercapnic conditions than individual TLR ligands.

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  • [Copyright] Copyright © 2015. Published by Elsevier B.V.
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  • (PMID = 25921030.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1U54OH010162-01; United States / NIAAA NIH HHS / AA / R01 AA017993; United States / NIOSH CDC HHS / OH / R01 OH008539; United States / NIAAA NIH HHS / AA / R01AA017993; United States / NIOSH CDC HHS / OH / R01OH008539-01; United States / NIOSH CDC HHS / OH / U54 OH010162; United States / NIOSH CDC HHS / OH / U54OH010162
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS691634; NLM/ PMC4465527
  • [Keywords] NOTNLM ; Barn dust / Bronchial epithelium / Carbon dioxide / Hypercapnia / LPS / Lung / TLR
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87. Misaki K, Suzuki M, Nakamura M, Handa H, Iida M, Kato T, Matsui S, Matsuda T: Aryl hydrocarbon receptor and estrogen receptor ligand activity of organic extracts from road dust and diesel exhaust particulates. Arch Environ Contam Toxicol; 2008 Aug;55(2):199-209
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aryl hydrocarbon receptor and estrogen receptor ligand activity of organic extracts from road dust and diesel exhaust particulates.
  • A wide variety of contaminants derived from diesel and gasoline engines, tire, asphalt, and natural organic compounds is found in road dust.
  • In the present study, aryl hydrocarbon receptor (AhR) ligand activity was confirmed in the extract of both road dust and DEPs.
  • In the separation of the extracts for both road dust and DEPs with reversed-phase HPLC, it was found that polar fractions contributed to significant AhR ligand activity in both a mouse hepatoma (H1L1) cell system and a yeast system.
  • Additionally, remarkable estrogen receptor (ER) ligand activity was detected in the highly polar region separated with normal-phase HPLC.

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  • (PMID = 18180859.001).
  • [ISSN] 1432-0703
  • [Journal-full-title] Archives of environmental contamination and toxicology
  • [ISO-abbreviation] Arch. Environ. Contam. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Dust; 0 / Ligands; 0 / Particulate Matter; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Receptors, Aryl Hydrocarbon; 0 / Receptors, Estrogen; 0 / Vehicle Emissions
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88. Li N, Choudhuri S, Cherrington NJ, Klaassen CD: Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4). Drug Metab Dispos; 2004 Nov;32(11):1265-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4).
  • Many biological effects produced by LPS are thought to be mediated by Toll-like receptor 4 (TLR4).
  • Organic anion-transporting polypeptide 4 (Oatp4; Slc21a10) mediates hepatic uptake of bile acids and other organic anions.
  • [MeSH-major] Down-Regulation / physiology. Lipopolysaccharides / pharmacology. Organic Anion Transporters, Sodium-Independent / metabolism. RNA, Messenger / metabolism
  • [MeSH-minor] Animals. Male. Membrane Glycoproteins / genetics. Membrane Glycoproteins / metabolism. Mice. Mice, Inbred C3H. Mutation. Receptors, Cell Surface / genetics. Receptors, Cell Surface / metabolism. Toll-Like Receptor 4. Toll-Like Receptors

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  • [Copyright] Copyright 2004 The American Society for Pharmacology and Experimental Therapeutics
  • (PMID = 15483194.001).
  • [ISSN] 0090-9556
  • [Journal-full-title] Drug metabolism and disposition: the biological fate of chemicals
  • [ISO-abbreviation] Drug Metab. Dispos.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES09649; United States / NIEHS NIH HHS / ES / F32 ES005883
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipopolysaccharides; 0 / Membrane Glycoproteins; 0 / Organic Anion Transporters, Sodium-Independent; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / Slco1b2 protein, mouse; 0 / Toll-Like Receptor 4; 0 / Toll-Like Receptors
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89. Kaimoto T, Hatakeyama Y, Takahashi K, Imagawa T, Tominaga M, Ohta T: Involvement of transient receptor potential A1 channel in algesic and analgesic actions of the organic compound limonene. Eur J Pain; 2016 Aug;20(7):1155-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Involvement of transient receptor potential A1 channel in algesic and analgesic actions of the organic compound limonene.
  • Recent reports show that some monoterpenes, a group of naturally occurring organic compounds, modulate TRP channel activity.

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  • [Copyright] © 2016 European Pain Federation - EFIC®
  • (PMID = 27030509.001).
  • [ISSN] 1532-2149
  • [Journal-full-title] European journal of pain (London, England)
  • [ISO-abbreviation] Eur J Pain
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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90. Höpner S, Dickhaut K, Hofstätter M, Krämer H, Rückerl D, Söderhäll JA, Gupta S, Marin-Esteban V, Kühne R, Freund C, Jung G, Falk K, Rötzschke O: Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket. J Biol Chem; 2006 Dec 15;281(50):38535-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.
  • We have shown that certain organic compounds can amplify immune responses by catalyzing the peptide loading of human class II MHC molecules HLA-DR.
  • Here we show now that they achieve this by interacting with a defined binding site of the HLA-DR peptide receptor.
  • Apparently, transient occupation of this pocket by the organic compound stabilizes the peptide-receptive conformation permitting rapid antigen loading.
  • This interaction appeared restricted to the larger Gly(beta86) pocket and allowed striking enhancements of T cell responses for antigens presented by these "adamantyl-susceptible" MHC molecules.
  • [MeSH-major] Histocompatibility Antigens Class II / immunology. Organic Chemicals / pharmacology. Polymorphism, Genetic

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  • (PMID = 17005558.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Histocompatibility Antigens Class II; 0 / Organic Chemicals; PJY633525U / Adamantane
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91. Knetter SM, Tuggle CK, Wannemuehler MJ, Ramer-Tait AE: Organic barn dust extract exposure impairs porcine macrophage function in vitro: implications for respiratory health. Vet Immunol Immunopathol; 2014 Jan 15;157(1-2):20-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Organic barn dust extract exposure impairs porcine macrophage function in vitro: implications for respiratory health.
  • As measures of macrophage function, we evaluated the activation of NF-κB, cytokine production, cell surface marker expression and the phagocytic and antibacterial capabilities of porcine macrophages after in vitro exposure to an organic swine barn dust extract (ODE).
  • ODE exposure also enhanced the expression of several cell surface markers of activation, including a receptor for the porcine reproductive and respiratory syndrome virus.
  • Taken together, these results demonstrate, for the first time, that organic dust extract exposure negatively affects pig macrophage activation and function, potentially enhancing host susceptibility to a variety of respiratory infections.

  • MedlinePlus Health Information. consumer health - Lung Diseases.
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  • [Copyright] Copyright © 2013 Elsevier B.V. All rights reserved.
  • (PMID = 24275039.001).
  • [ISSN] 1873-2534
  • [Journal-full-title] Veterinary immunology and immunopathology
  • [ISO-abbreviation] Vet. Immunol. Immunopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cytokines; 0 / Dust; 0 / NF-kappa B; 63231-63-0 / RNA
  • [Keywords] NOTNLM ; Airway inflammation / Macrophage / Organic dust extract / Pig / Respiratory disease
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92. Adson A, Burton PS, Raub TJ, Barsuhn CL, Audus KL, Ho NF: Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers. J Pharm Sci; 1995 Oct;84(10):1197-204
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers.
  • A systematic approach was used to demonstrate the quantitative interplay of pH, pKa, lipophilicity, charged and uncharged molecular species, molecular size, aqueous diffusivity, and stirring in passive transport across the aqueous boundary layer, microporous filter support, and transcellular and paracellular barriers in Caco-2 cell monolayers.
  • Adrenergic receptor antagonists including propranolol (PPL), alprenolol (APL), pindolol (PDL), and atenolol (ATL) represented the model series of structurally similar weak bases with pKa values between 8.8 and 9.65.
  • This study emphasized a generally applicable approach to quantitatively analyze passive transport data on weak organic electrolytes and neutral molecules generated using cell culture monolayers.
  • [MeSH-minor] Biological Transport. Carbon Radioisotopes. Cell Membrane Permeability. Chemistry, Physical. Diffusion. Humans. Hydrogen-Ion Concentration. Kinetics. Mathematical Computing. Physicochemical Phenomena

  • Hazardous Substances Data Bank. TESTOSTERONE .
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  • (PMID = 8801334.001).
  • [ISSN] 0022-3549
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Carbon Radioisotopes; 0 / Electrolytes; 3XMK78S47O / Testosterone
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93. Burvall K, Palmberg L, Larsson K: Metabolic activation of A549 human airway epithelial cells by organic dust: a study based on microphysiometry. Life Sci; 2002 Jun 7;71(3):299-309